Precautions
Zosyn is a combination medication that contains two drugs, piperacillin and tazobactam. Piperacillin is an antibiotic, and tazobactam is a beta-lactamase inhibitor, which prevents resistance to the antibiotic. Likewise, what class of drug is piperacillin? Piperacillin is in a class of medications called penicillin antibiotics. It works by killing bacteria that cause infection.
What is Zosyn (piperacillin and tazobactam) used for?
Sep 01, 2020 · Zosyn contains a combination of piperacillin and tazobactam. Piperacillin and tazobactam are penicillin antibiotics that fight bacteria in the body. Zosyn is used to treat many different infections caused by bacteria, such as stomach infections, skin infections, pneumonia, and severe uterine infections.
Is Zosyn a penicillin?
Dec 02, 2020 · ZOSYN (piperacillin and tazobactam) for Injection and ZOSYN (piperacillin and tazobactam) Injection are injectable antibacterial combination products consisting of the semisynthetic antibacterial piperacillin sodium and the β-lactamase inhibitor tazobactam sodium for intravenous administration. Piperacillin sodium is derived from D (-)-α-aminobenzyl- penicillin.
How many grams of piperacillin are in a Zosyn injection?
ZOSYN (piperacillin and tazobactam for injection, USP) is an injectable antibacterial combination product consisting of the semisynthetic antibiotic piperacillin sodium and the β lactamase...
What is Zosyn made of?
Zosyn (piperacillin and tazobactam for injection) is a combination of two antibiotics used to treat many different infections caused by bacteria, such as urinary tract infections, bone and joint infections, severe vaginal infections, stomach infections, skin infections, and pneumonia. Zosyn is available in generic form.
What is the generic name of piperacillin?
Piperacillin/Tazobactam(Zosyn) generic is an antibacterial agent, prescribed for various infections such as Nosocomial pneumonia. It blocks the bacteria's cell wall growth, which kills the bacteria.
What antibiotic is equivalent to Zosyn?
Zosyn (piperacillin and tazobactam for injection) and Augmentin (amoxicillin/clavulanate) are combinations of a penicillin antibiotic and a beta-lactamase inhibitor used to treat many different infections caused by bacteria, such as urinary tract infections (UTIs), skin infections, and respiratory tract infections.
When should you not use Zosyn?
You should not use Zosyn if you have ever had an allergic reaction to certain antibiotics (especially a penicillin antibiotic).Sep 1, 2020
What is piperacillin used to treat?
Piperacillin and tazobactam combination injection is used to treat bacterial infections in many different parts of the body (eg, stomach or bowel, lungs, skin, female reproductive organs).Feb 1, 2022
Is piperacillin the same as penicillin?
Piperacillin is in a class of medications called penicillin antibiotics. It works by killing bacteria that cause infection.Oct 15, 2016
What is another name for Piperacillin Tazobactam?
Zosyn (piperacillin / tazobactam) is a combination antibiotic medication used to treat a wide variety of bacterial infections.
Is Zosyn hard on the kidneys?
If alternative treatment options are inadequate or unavailable, monitor renal function during treatment with Zosyn. Precautions section stating that combined use of these two drugs may be associated with an increased incidence of acute kidney injury.May 5, 2017
Can you take piperacillin if allergic to penicillin?
Most patients with penicillin allergy can likely tolerate piperacillin-tazobactam.Jul 30, 2021
What infections is Zosyn used for?
Piperacillin and tazobactam is a combination penicillin antibiotic that is used to treat many different infections caused by bacteria, such as stomach infections, skin infections, pneumonia, and severe uterine infections.Jul 22, 2020
Is piperacillin and tazobactam safe?
In all trials, piperacillin/tazobactam was found to be safe and well tolerated. One death was deemed possibly drug-related. Thirty-eight patients were withdrawn from the trials because of adverse experiences, most often diarrhoea and allergic skin reactions.
What type of bacteria does Piperacillin Tazobactam affect?
Piperacillin/tazobactam is a beta-lactam/beta lactamase inhibitor with coverage against gram-negative organisms (including Pseudomonas aeruginosa), gram-positive organisms, and anaerobic bacterial organisms.
What are the side effects of piperacillin tazobactam?
SIDE EFFECTS: Swelling, redness, pain, and soreness at the injection site may occur. Dizziness, trouble sleeping, nausea, vomiting, diarrhea, and headache may also occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Before Taking This Medicine
You should not use Zosyn if you are allergic to: 1. piperacillin or any other penicillin antibiotic (amoxicillin, ampicillin, Augmentin, dicloxacil...
What Happens If I Miss A Dose?
Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to m...
What Should I Avoid While Using Zosyn?
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. D...
What Other Drugs Will Affect Zosyn?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may in...
What is a Zosyn?
ZOSYN is a combination product consisting of a penicillin-class antibacterial, piperacillin, and a beta-lactamase inhibitor, tazobactam, indicated for the treatment of patients with moderate to severe infections caused by susceptible isolates of the designated bacteria in the conditions listed below.
How much tazobactam is in a Zosyn vial?
Each ZOSYN 2.25 g vial provides piperacillin sodium equivalent to 2 grams of piperacillin and tazobactam sodium equivalent to 0.25 g of tazobactam. Each ZOSYN 3.375 g vial provides piperacillin sodium equivalent to 3 grams of piperacillin and tazobactam sodium equivalent to 0.375 g of tazobactam.
What is the chemical structure of tazobactam?
The chemical structure of tazobactam sodium is: ZOSYN (piperacillin and tazobactam) for Injection, is a white to off-white sterile, cryodesiccated powder consisting of piperacillin and tazobactam as their sodium salts packaged in glass vials.
How much sodium is in ZOSYN?
Dextrose hydrous, sodium citrate dihydrate, and edetate disodium dihydrate amounts are approximate. ZOSYN contains a total of 2.84 mEq (65 mg) of sodium (Na+) per gram of piperacillin in the combination product.
What is a Zosyn injection?
ZOSYN (piperacillin and tazobactam) for Injection and ZOSYN (piperacillin and tazobactam) Injection are injectable antibacterial combination products consisting of the semisynthetic antibacterial piperacillin sodium and the β-lactamase inhibitor tazobactam so dium for intravenous administration.
Where is piperacillin found in the body?
Piperacillin and tazobactam are widely distributed into tissues and body fluids including intestinal mucosa, gallbladder, lung, female reproductive tissues (uterus, ovary, and fallopian tube), interstitial fluid, and bile. Mean tissue concentrations are generally 50% to 100% of those in plasma.
Can you take probenecid with Zosyn?
Probenecid should not be co-administered with ZOSYN unless the benefit outweighs the risk.
What is USP in a zosyn?
ZOSYN (piperacillin and tazobactam for injection, USP) is indicated for the treatment of patients with moderate to severe infections caused by piperacillin-resistant, piperacillin/tazobactamsusceptible, β-lactamase producing strains of the designated microorganisms in the specified conditions listed below:
How many patients were treated with Zosyn?
During the initial clinical investigations, 2621 patients worldwide were treated with ZOSYN (piperacillin and tazobactam for injection, USP) in phase 3 trials. In the key North American clinical trials (n=830 patients), 90% of the adverse events reported were mild to moderate in severity and transient in nature. However, in 3.2% of the patients treated worldwide, ZOSYN was discontinued because of adverse events primarily involving the skin (1.3%), including rash and pruritus; the gastrointestinal system (0.9%), including diarrhea, nausea, and vomiting; and allergic reactions (0.5%).
What is standardized susceptibility test?
Standardized susceptibility test procedures require the use of laboratory control microorganisms to control the technical aspects of the test procedures.1,2,3,4 Standard piperacillin/tazobactam powder should provide the following ranges of values noted in Table 3. Quality control microorganisms are specific strains of microorganisms with intrinsic biological properties relating to resistance mechanisms and their genetic expression within the microorganism; the specific strains used for microbiological quality control are not clinically significant.
What is a bulk vale?
The PHARMACY BULK VIAL is a container of sterile preparation which contains many single doses for parenteral use. The contents are intended for use in a pharmacy admixture program and are restricted to the preparation of admixtures for intravenous infusion.
What is Zosyn 2040?
ZOSYN (piperacillin and tazobactam injection) in Galaxy® Containers (PL 2040 Plastic) is a sterile injectable antibacterial combination product consisting of the semisynthetic antibiotic piperacillin sodium and the β-lactamase inhibitor tazobactam sodium for intravenous administration.
How much ZOSYN should I take for nosocomial pneumonia?
Initial presumptive treatment of patients with nosocomial pneumonia should start with ZOSYN at a dosage of 4.5 g every six hours plus an aminoglycoside, totaling 18.0 g (16.0 g piperacillin/2.0 g tazobactam). Treatment with the aminoglycoside should be continued in patients from whom Pseudomonas aeruginosa is isolated. If Pseudomonas aeruginosa is not isolated, the aminoglycoside may be discontinued at the discretion of the treating physician.
What is USP in medicine?
ZOSYN (piperacillin and tazobactam for injection, USP) is an injectable antibacterial combination product consisting of the semisynthetic antibiotic piperacillin sodium and the βlactamase inhibitor tazobactam sodium for intravenous administration.
What is the trade name for tazocin?
Apart from Tazocin and Zosyn, the drug is marketed in various countries under other trade names such as Tazact, Biopiper TZ, Brodactam, Piptaz, Maxitaz, Kilbac, Trezora, Du-Tazop, Tazopen, Sytaz, Tazin, and Inzalin TZ.
What is the name of the drug that contains tazobactam?
Piperacillin/tazobactam. Piperacillin/tazobactam, sold under the brand names Tazocin and Zosyn among others, is a combination medication containing the antibiotic piperacillin and the β-lactamase inhibitor tazobactam.
What are the side effects of -lactam?
Common adverse effects include headache, trouble sleeping, rash, nausea, constipation, and diarrhea. Serious adverse effects include Clostridium difficile infection and allergic reactions including anaphylaxis. Those who are allergic to other β-lactam are more likely to be allergic to piperacillin/tazobactam.
How often is a syringe administered?
The drug is administered intravenously every 6 or 8 hr, typically over 3–30 min. It may also be administered by continuous infusion over four hours. Prolonged infusions are thought to maximize the time that serum concentrations are above the minimum inhibitory concentration (MIC) of the bacteria implicated in infection.
When was tazobactam approved for use?
Piperacillin/tazobactam was approved for medical use in the United States in 1993. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication.
Is piperacillin a first line antibiotic?
Piperaci llin-tazobactam is recommended by the National Institute for Health and Care Excellence as first line therapy for the treatment of bloodstream infections in neutropenic cancer patients. For β-lactam antipseudomonal antibiotics, including piperacillin/tazobactam, prolonged intravenous infusion is associated with lower mortality ...
What is Zosyn used for?
Zosyn (piperacillin and tazobactam for injection) is a combination of two antibiotics used to treat many different infections caused by bacteria, such as urinary tract infections, bone and joint infections, severe vaginal infections, stomach infections, skin infections, and pneumonia. Zosyn is available in generic form.
How much clavulanic acid is in augmentin?
The 250-mg tablet of Augmentin contains 125 mg of clavulanic acid, whereas the 250-mg chewable tablet contains 62.5 mg of clavulanic acid. Based on the amoxicillin component, Augmentin should be dosed as follows: The recommended dose of Augmentin is 30 mg/kg/day divided every 12 hours, based on the amoxicillin component.
What are the side effects of Augmentin?
Vaginal yeast infection (itching or discharge) Rare and severe side effects of Augmentin can include: watery or bloody diarrhea; pale or yellowed skin, dark colored urine, fever, confusion or weakness; easy bruising or bleeding;
Does augmentin interact with allopurinol?
Zosyn may also interact with antibiotics or any other medication used to prevent blood clots. Augmentin may also interact with allopurinol.
What does it mean when you have a red rash on your face?
severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Does Zosyn cause itching?
vaginal discharge or itching. Tell your doctor if you have serious side effects of Zosyn including muscle cramps or spasms, swelling of the arms /legs/hands/ feet, easy bruising or bleeding, chest pain, confusion, new signs of infection (such as fever, persistent sore throat ), severe abdominal or stomach pain, slow/fast/irregular heartbeat, ...
Is augmentin safe for children?
It is not known if Augmentin is safe and effective in children.
so what about nafcillin and piperacillin-tazobactam?
The chemical structure of the side chains on nafcillin and piperacillin are quite dissimilar from the structure of natural penicillins. Therefore, we would expect an absence of cross-allergy between nafcillin, piperacillin, or natural penicillins.
so where does this leave us?
There doesn’t seem to be consistent allergic cross-reaction between piperacillin-tazobactam and penicillin:
