is rocephin bad for kidneys

Precautions

A small number of cases of fatal outcomes in which a crystalline material was observed in the lungs and kidneys at autopsy have been reported in neonates receiving Rocephin and calcium-containing fluids.

Does Rocephin cause crystalline material in the lungs and kidneys?

Along with its needed effects, ceftriaxone (the active ingredient contained in Rocephin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor or nurse immediately if any of the following side effects occur while taking ceftriaxone:

Are there any side effects to taking Rocephin?

Rocephin has an average rating of 9.2 out of 10 from a total of 36 ratings for the treatment of Urinary Tract Infection. 92% of reviewers reported a positive experience, while 3% reported a negative experience. 36 ratings from 40 user reviews. Compare all 284 medications used in the treatment of Urinary Tract Infection.

What are the reviews of Rocephin for urinary tract infection?

Dosage adjustments should not be necessary in patients with hepatic dysfunction; however, in patients with both hepatic dysfunction and significant renal disease, caution should be exercised and the Rocephin dosage should not exceed 2 gm daily.

Is Rocephin safe in patients with hepatic dysfunction and renal disease?

Does Rocephin damage kidneys?

A small number of cases of fatal outcomes in which a crystalline material was observed in the lungs and kidneys at autopsy have been reported in neonates receiving Rocephin and calcium-containing fluids.

Which antibiotics damage kidneys?

Aminoglycosides (gentamicin and amikacin), amphotericin B, vancomycin, beta-lactam antibiotics (cefazolin and ceftriaxone) in monotherapy and combination therapy were the causes of acute kidney injury in most of the patients.

Can ceftriaxone cause kidney failure?

Ceftriaxone used at therapeutic doses is linked to renal stones and pediatric acute renal failure (PARF), with recovery possible on early treatment, according to a retrospective study published online March 24 in Pediatrics.

Can antibiotics make your kidneys worse?

Antibiotics. These drugs affect your kidneys in different ways. For example, some can make crystals that don't break down and can block your urine flow. Others have substances that can damage certain kidney cells when they try to filter them out.

How can I protect my kidneys while on antibiotics?

Adequate hydration is needed for kidneys to function correctly and avoiding dehydration might avoid kidney injury. We will consider the use of enteral and intravenous fluids alongside intravenous antibiotics to see if this reduces the risk of kidney injury.

What drugs protect the kidneys?

Angiotensin-converting enzyme inhibitors (ACE inhibitors) or Angiotensin II Receptor Blockers (ARBs) are medicines that help protect the kidneys.Having high pressure causes an increase of pressure in the blood vessels of the kidneys. ... ACE and ARB medicines lower the pressure inside of the kidneys to a better level.More items...

Can Rocephin cause liver damage?

Likelihood score: B (ceftriaxone is a very likely cause of clinically apparent liver injury and can also lead to biliary sludge and “pseudolithiasis” caused by crystallization of ceftriaxone in bile present in the gallbladder or biliary tree).

Does ceftriaxone increase creatinine?

Compared with the rats in the NC group, the rats (group 1) that were administered with ceftriaxone (1000 mg/kg)+CaCl2 (800 mg/kg) revealed a severe increase in BUN (Figure 1(a)) and creatinine (Figure 1(b)), consistent with renal failure ( ).

Can Rocephin be given during dialysis?

Ceftriaxone, a third-generation cephalosporin, is widely used to treat bacterial infections in patients undergoing dialysis because it has a long half-life and broad spectrum of action and does not require dose reduction.

What drugs affect the kidneys the most?

Most street drugs, including heroin, cocaine and ecstasy can cause high blood pressure, stroke, heart failure and even death, in some cases from only one use. Cocaine, heroin and amphetamines also can cause kidney damage.

Can kidney patients take antibiotics?

Antibiotics with Kidney Disease: If you need to receive any antibiotics, the dose may need to be adjusted and likely decreased to match your lower kidney function. Some antibiotics are safe to take when you have kidney disease and others should be avoided.

What are the warning signs of kidney infection?

SymptomsFever.Chills.A burning feeling or pain when urinating.Having to urinate often.A strong, lasting urge to urinate.Back, side or groin pain.Nausea and vomiting.Pus or blood in the urine.More items...

What drugs affect the kidneys the most?

Most street drugs, including heroin, cocaine and ecstasy can cause high blood pressure, stroke, heart failure and even death, in some cases from only one use. Cocaine, heroin and amphetamines also can cause kidney damage.

Is amoxicillin harmful to kidneys?

Antibiotics. Amoxicillin, Ciprofloxacin and other antibiotics can be dangerous for those with kidney disease and can cause further damage. People who have kidney disease must take smaller doses of antibiotics than people who have healthy kidneys.

Can amoxicillin damage kidneys?

Amoxicillin (AMX) has been associated with acute kidney injury (AKI). Two distinct mechanisms have been described: acute interstitial nephritis and crystal nephropathy, the latter of which has been the primary focus of anecdotal reports.

What is harmful to kidneys?

Diabetes and high blood pressure are the most common risk factors for kidney disease. However, obesity, smoking, genetics, gender, and age can also increase the risk ( 3 ). Uncontrolled blood sugar and high blood pressure cause damage to blood vessels in the kidneys, reducing their ability to function optimally ( 4 ).

Before Taking This Medicine

Do not use Rocephin in a child without a doctor's advice, and never give more than the child's prescribed dose. Rocephin injection can be dangerous...

How Should I Use Rocephin?

Use Rocephin exactly as prescribed by your doctor. Rocephin is injected into a muscle, or into a vein through an IV.A healthcare provider will give...

What Should I Avoid While Using Rocephin?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. D...

What Other Drugs Will Affect Rocephin?

Other drugs may interact with ceftriaxone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor a...

What is Rocephin?

Rocephin has active ingredients of ceftriaxone sodium. It is often used in infection. eHealthMe is studying from 14,901 Rocephin users for its effectiveness, alternative drugs and more.

What is phase IV of rocephin?

The phase IV clinical study analyzes which people take Rocephin and have Acute kidney failure. It is created by eHealthMe based on reports of 14,542 people who have side effects when taking Rocephin from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

What is Acute kidney failure?

Acute kidney failure is found to be associated with 3,464 drugs and 3,275 conditions by eHealthMe.

What are the side effects of ceftriaxone?

Check with your doctor or nurse immediately if any of the following side effects occur while taking ceftriaxone: More common. Black, tarry stools. chest pain.

Is there a cross sensitivity with cephalosporins?

Cross-sensitivity with other cephalosporins and penicillins has occurred; however, the incidence is unknown. [ Ref]

Does ceftriaxone go away?

Some side effects of ceft riaxone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Can cephalosporin cause seizures?

Several cephalosporins have been implicated in triggering seizures, especially in patients with renal dysfunction when dose was not reduced. [ Ref]

What are the side effects of rocephin?

Common side effects of Rocephin include: 1 injection site reactions (swelling, redness, pain, a hard lump, or soreness), 2 loss of appetite, 3 nausea, 4 vomiting, 5 upset stomach, 6 diarrhea, 7 headache, 8 dizziness, 9 overactive reflexes, 10 pain or swelling in your tongue, 11 sweating, or 12 vaginal itching or discharge.

What is a rocephin?

Rocephin ( ceftriaxone sodium) for Injection is a cephalosporin antibiotic used to treat many kinds of bacterial infections, including severe or life-threatening forms such as meningitis. Rocephin is available in generic form.

Is crystalline material found in kidneys?

A small number of cases of fatal outcomes in which a crystalline material was observed in the lungs and kidneys at autopsy have been reported in neonates receiving Rocephin and calcium-containing fluids. In some of these cases, the same intravenous infusion line was used for both Rocephin and calcium-containing fluids and in some a precipitate was observed in the intravenous infusion line. At least one fatality has been reported in a neonate in whom Rocephin and calcium-containing fluids were administered at different time points via different intravenous lines; no crystalline material was observed at autopsy in this neonate. There have been no similar reports in patients other than neonates.

Can cephalosporin cause seizures?

Several cephalosporins have been implicated in triggering seizures, particularly in patients with renal impairment when the dosage was not reduced (see DOSAGE AND ADMINISTRATION ). If seizures associated with drug therapy occur, the drug should be discontinued. Anticonvulsant therapy can be given if clinically indicated.

Can you take rocephin while pregnant?

Rocephin During Pregnancy and Breastfeeding. During pregnancy, Rocephin should be used only if prescribed. This medication passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast -feeding.

What to do if your child has renal failure after taking ceftriaxone?

For more information, please fill out our online form or call 1-800-YOURLAWYER (1-800-968-7529) to speak with an experienced drug injury attorney today .

Is ceftriaxone a renal failure?

A separate analysis conducted by AdverseEvents, Inc. showed that renal failure was associated with ceftriaxone, as well as other similar antibiotic class. Based on this, renal risks should be analyzed for the entire class of third-generation cephalosporin antibiotics, the AdverseEvents Research Team said. The research team also identified a number of adverse events not currently on the drug label, including: drug rash with eosinophilia and systemic symptoms (DRESS), cyanosis, hepatitis, altered state of consciousness, acute respiratory distress syndrome, acute renal failure, respiratory arrest, respiratory failure, wheezing, blood pressure decreased, hepatomegaly (enlarged liver), hypocalcemia (low calcium levels), metabolic acidosis, eyelid swelling, tachycardia, and dyspnea (shortness of breath).

Is ceftriaxone a kidney failure medication?

Ceftriaxone Linked To Kidney Failure. Ceftriaxone (Rocephin) is an antibiotic medication that is often used to treat childhood infections.

Can ceftriaxone cause PARF?

Based on their findings, the authors of the study concluded “Ceftriaxone therapy in children may cause PARF. Early diagnosis and prompt pharmacological therapy are important in relieving the condition. Retrograde ureteral catheterization is an effective treatment of those who fail to respond to pharmacotherapy.”

Does ceftriaxone cause kidney stones?

On March 24, 2014 a retrospective study published in the journal Pediatrics linked ceftriaxone use to renal stones and renal pediatric acute renal failure (PARF). ‘Ceftriaxone’ has already been linked to biliary pseudolithiasis (pain in the bile ducts), nephrolithiasis (kidney stones) and bladder sludge. Previous research has shown that urine crystals form and cling to renal tubular cells during treatment with the antibiotic.

Why is rocephin used?

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Rocephin and other antibacterial drugs, Rocephin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

When is rocephin contraindicated?

Rocephin is contraindicated in premature neonates up to a postmenstrual age of 41 weeks (gestation al age + chronological age).

How long should you take rocephin before surgery?

For preoperative use (surgical prophylaxis), a single dose of 1 gram administered intravenously 1/2 to 2 hours before surgery is recommended. Generally, Rocephin therapy should be continued for at least 2 days after the signs and symptoms of infection have disappeared.

How does ceftriaxone cause resistance?

Resistance to ceftriaxone is primarily through hydrolysis by beta-lactamase, alteration of penicillin-binding proteins (PBPs), and decreased permeability.

How long does ceftriaxone stay in your system?

Based on middle ear fluid ceftriaxone concentrations in the 23 to 25 hour and the 46 to 50 hour sampling time intervals, a half-life of 25 hours was calculated. Ceftriaxone is highly bound to plasma proteins. The extent of binding to proteins in the middle ear fluid is unknown.

Where is ceftriaxone found in dogs?

Concretions consisting of the precipitated calcium salt of ceftriaxone have been found in the gallbladder bile of dogs and baboons treated with ceftriaxone.

What should be done before instituting treatment with Rocephin?

Before instituting treatment with Rocephin, appropriate specimens should be obtained for isolation of the causative organism and for determination of its susceptibility to the drug. Therapy may be instituted prior to obtaining results of susceptibility testing.

How many drugs are associated with acute kidney failure?

Acute kidney failure is found to be associated with 3,418 drugs and 3,251 conditions by eHealthMe.

Can Ceftriaxone cause kidney failure?

Acute kidney failure is found among people who take Ceftriaxone, especially for people who are male, 60+ old, have been taking the drug for < 1 month.

Is ceftriaxone sodium a typhoid?

Ceftriaxone has active ingredients of ceftriaxone sodium . It is often used in typhoid fever. eHealthMe is studying from 26,270 Ceftriaxone users for its effectiveness, alternative drugs and more.

Which antibiotics are toxic to the kidney?

Aminoglycoside antibiotics are known for causing kidney injury—even at low doses. People with chronic kidney disease, dehydration, or those who have been taking these antibiotics for a long time are at particularly high risk. The most toxic aminoglycoside is neomycin, followed by gentamicin, tobramycin, and amikacin. Streptomycin is the least toxic. Although these medications are typically used in hospitals, they are important to keep at the back of your mind!

Is ACE good for kidneys?

ACE inhibitors can be good and bad for your kidneys. These are medications that tend to end in “-il,” like lisinopril, enalapril, and ramipril. ACE inhibitors are popular drugs for high blood pressure and heart failure.

Can nephrotoxic medications cause kidney damage?

Medications that can damage the kidneys are known as “nephrotoxic medications.” These drugs can cause direct damage to the kidneys. Some of these medications mildly worsen kidney function and others can cause acute kidney injuries. The risk for kidney damage depends on your individual health and other medications you are taking. For people with even mild kidney failure, you might want to talk to your doctor about the pros and cons of these medications.

Can NSAIDS cause kidney failure?

NSAIDS are used to treat a host of conditions such as fever, rheumatoid arthritis, menstrual pain, and inflammation, but they can also reduce the amount of blood flow to the kidneys, resulting in a potential for kidney damage or failure. People with heart failure, liver disease, or previous kidney problems are at even higher risk when taking NSAIDS.

Can ACE inhibitors cause kidney damage?

Because ACE inhibitors are metabolized by the kidneys, they do come with a risk of causing kidney damage, especially if you are dehydrated, which is often the case in people with existing kidney problems—like chronic kidney disease. If you are at a higher risk for kidney damage but need an ACE inhibitor, you will likely start on a low dose, and your doctor may need you to come in for routine blood creatinine tests to monitor the health of your kidneys.

Is Foscarnet toxic to kidneys?

Foscarnet, also given by IV, is a rarely used drug that treats viral infections in patients with weakened immune systems. It can be highly toxic to the kidneys, so if you need it, your doctor will closely monitor your kidney function.

Does Jardiance cause kidney failure?

Jardiance is a diabetes medication that may protect the kidneys in patients with diabetes but has also been reported in rare cases to cause kidney failure. Importantly, Jardiance has diuretic effects and interacts with other nephrotoxic drugs (drugs on this list), raising the risk for toxic kidney effects. Again, rare, but it can happen.

For Healthcare Professionals

Frequently Asked Questions

Further Information