Clopidogrel bisulfate is an anti-platelet drug, that is, a drug that inhibits the ability of platelets to clump together as part of a blood clot. Clopidogrel prevents blood clots by irreversibly binding to the P2Y12 receptor on platelets, preventing adenosine diphosphate (ADP)...
What is the difference between clopidogrel bisulfate and hydrogen sulfate?
Clopidogrel bisulfate is useful in treating the symptoms of acute coronary syndrome, including stroke, blood clots, and serious heart problems that follows a heart attack, severe chest pain, or circulation problems, whereas clopidogrel hydrogen sulfate is useful to prevent atherothrombotic events in adults.
What is the difference between clopidogrel and Plavix?
Clopidogrel may be given to reduce the risk of a heart attack or stroke in certain cardiovascular conditions or following a heart attack or ischemic stroke. People who are poor metabolizers at... Plavix may be given to reduce the risk of a heart attack or stroke in certain cardiovascular conditions or following a heart attack or ischemic stroke.
What is clopidogrel bisulfate used for?
Clopidogrel tablets are indicated to reduce the rate of myocardial infarction and stroke in patients with acute ST-elevation myocardial infarction (STEMI) who are to be managed medically. Clopidogrel bisulfate should be administered in conjunction with aspirin.
Is clopidogrel hydrogensulfate a new drug in Germany?
Background: Clopidogrel hydrogensulfate is a thienopyridine acting as an important antiplatelet agent alone or in combination with acetyl salicylic acid to prevent cardiovascular complications. A different clopidogrel salt, clopidogrel besylate, was approved in Germany as a "new drug" in May 2008.
What is another name for clopidogrel bisulfate?
Plavix (clopidogrel bisulfate) is a thienopyridine class of drug that inhibits platelet aggregation and thus inhibits aspects of blood clotting used to treat patients with acute coronary syndrome, myocardial infarction (MI), peripheral vascular disease and some stroke (ischemic type) patients.
Does clopidogrel have another name?
It is an antiplatelet drug. It helps keep blood flowing smoothly in your body. Clopidogrel is available under the following different brand names: Plavix.
What is clopidogrel bisulfate generic for?
Costs. Plavix and Brilinta are both brand-name drugs. A generic form of Plavix, called clopidogrel, is available for use.
What is clopidogrel bisulfate tablets for?
Clopidogrel is an antiplatelet medicine. It prevents platelets (a type of blood cell) from sticking together and forming a dangerous blood clot. Taking clopidogrel helps prevent blood clots if you have an increased risk of having them.
What are the long term effects of taking clopidogrel?
Patients should not stop taking clopidogrel or other antiplatelet medicines because doing so may result in an increased risk of heart attacks and blood clots.
How long should you stay on clopidogrel?
The standard recommendation is typically at least 12 months of Plavix.
What is the brand name of clopidogrel?
Clopidogrel oral tablet is available as both a generic and brand-name drug. Brand name: Plavix. Clopidogrel only comes in the form of a tablet you take by mouth. Clopidogrel is used to prevent heart attack and stroke.
What happens when you stop taking clopidogrel?
Feb. 5, 2008 -- Heart attack survivors and other heart patients may be more likely to die or suffer a heart attack in the first three months after stopping the drug Plavix, new research shows. Plavix is an antiplatelet drug.
Does clopidogrel affect the kidneys?
Conclusions. In summary, among patients hospitalized with ACS and treated with clopidogrel, lower levels of kidney function were associated with a greater risk of death, hospitalization for AMI, and major bleeding.
Which is safer aspirin or clopidogrel?
Aspirin combined with the antiplatelet drug clopidogrel is no better than aspirin alone for stroke prevention in people with a history of lacunar strokes, and the combination carries a greater risk of gastrointestinal bleeding, according to results of a trial funded by the National Institutes of Health.
What foods should I avoid when taking clopidogrel?
Foods to avoid when taking heart medicationsAsparagus.Broccoli.Brussels sprouts.Cauliflower.Green onions.Kale.Parsley.Spinach.
When is the best time to take clopidogrel?
You can take clopidogrel at whatever time of day you find easiest to remember, but take your doses at the same time of day each day. Most people prefer to take it in the morning, as they find this helps them to remember to take it regularly. You can take the tablet either before or after a meal.
Is clopidogrel and aspirin the same?
Clopidogrel is another guideline‐recommended antiplatelet agent21 and has been shown to be superior to aspirin in preventing composite vascular events and reducing hemorrhagic complications in a randomized controlled trial, CAPRIE (Clopidogrel versus Aspirin in Patients at Risk of Ischaemic Events).
What foods should I avoid while taking clopidogrel?
Foods to avoid when taking heart medicationsAsparagus.Broccoli.Brussels sprouts.Cauliflower.Green onions.Kale.Parsley.Spinach.
Can I take clopidogrel and atorvastatin at the same time?
The investigators concluded that patients who took atorvastatin and clopidogrel together had almost a 2-fold—increased risk of major adverse events at 30 days compared with patients on clopidogrel alone.
Can I take aspirin instead of clopidogrel?
Aspirin combined with the antiplatelet drug clopidogrel is no better than aspirin alone for stroke prevention in people with a history of lacunar strokes, and the combination carries a greater risk of gastrointestinal bleeding, according to results of a trial funded by the National Institutes of Health.
What is the molar equivalent of clopidogrel?
The tablets contain 392.0 mg of clopidogrel bisulfate, which is the molar equivalent of 300 mg of clopidogrel base.
What is clopidogrel 1.1?
1.1 Acute Coronary Syndrome (ACS) Clopidogrel tablets are indicated to reduce the rate of myocardial infarction (MI) and stroke in patients with non-ST-segment elevation ACS (unstable angina ...
How many mg of clopidogrel is in a tablet?
The tablets contain 97.875 mg of clopidogrel bisulfate, which is the molar equivalent of 75 mg of clopidogrel base.
How is clopidogrel metabolized?
Clopidogrel is extensively metabolized by two main metabolic pathways: one mediated by esterases and leading to hydrolysis into an inactive carboxylic acid derivative (85% of circulating metabolites) and one mediated by multiple cytochrome P450 enzymes.
Is clopidogrel bisulfate an antiplatelet?
The effectiveness of clopidogrel bisulfate results from its antiplatelet activity, which is dependent on its conversion to an active metabolite by the cytochrome P450 (CYP) system, principally ...
Is clopidogrel lethal to mice?
Overdose following clopidogrel administration may result in bleeding complications. A single oral dose of clopidogrel at 1,500 or 2,000 mg/kg was lethal to mice and to rats and at 3,000 mg/kg to baboons.
Does Clopidogrel cause bleeding?
Platelet inhibition by clopidogrel is irreversible and will last for the life of the platelet. Overdose following clopidogrel administration may result in bleeding complications. A single oral ...
Is clopidogrel a CHS?
Recently several alternative forms of the original clopidogrel hydro gensulfate (CHS) were spread worldwide. A large amount of such drugs turned out to be clo pidogrel besylate (CB). Only three studies, involving healthy volunteers, investigated the antiplatelet effect of CB, whereas its attribute remained unexplored in the case of patients with cardiovascular diseases. This retrospective study aimed to evaluate the difference between the antiplatelet effects of two clopidogrel formulas, CHS and CB, on patients with coronary artery diseases.
Does CB affect ADP?
Our results indicated that both CB and CHS had an identical inhibitory effect on ADP induced platelet aggregation in patients with cardiovascular diseases . Moreover their efficiency showed no overall significant difference in the case of dual antiplatelet therapy with aspirin as well. However there might be an inter- and intraindividual variability between the two clopidogrel formulas.
Does clopidogrel inhibit platelet aggregation?
Consequently, the platelet aggregation inhibition is maintained during the whole life-span of platelets (cc. 7–10 days) and the normal operation is only resto red following the formation of new platelets. The clopidogrel molecule is instabile as a base so it is released in salt forms as a peroral drug: clopidogrel hydrogensulfate (CHS) and clopidogrel besylate (CB).
How much clopidogrel should I take for STEMI?
In patients with STEMI, oral clopidogrel is recommended for the reduction of atherothrombotic events. The recommended dosage of clopidogrel is 75mg once daily , administered in combination with aspirin, with or without thrombolytics. [ 9] Treatment may be initiated with or without a loading dose, such as the 300mg loading dose used in CLARITY-TIMI 28 (section 2). Clopidogrel is contraindicated in patients with active pathologic bleeding, such as peptic ulcer or intracranial hemorrhage. Clopidogrel prolongs the bleeding time and therefore should be used with caution in patients who may be at risk of increased bleeding from trauma, surgery, or other pathologic conditions (particularly gastrointestinal and intraocular). If a patient is to undergo elective surgery and an antiplatelet effect is not desired, clopidogrel should be discontinued 5 days prior to surgery. Local prescribing information should be consulted for detailed information, including contraindications, warnings, precautions, and drug interactions.
Does antiplatelet therapy decrease the number of morbid events?
Antiplatelet agents have been shown to decrease the number of morbid events in patients with established cardiovascular atherosclerotic disease. [ 8] This suggests a potential role for platelet aggregation in initiation and/or the progression of these events. [ 9]
Is clopidogrel tolerated in STEMI?
Data on the tolerability of clopidogrel are mainly from the US prescribing information, [ 9] which includes information from COMMIT/CCS-2, CLARITY-TIMI 28, and other large clinical trials. Overall, clopidogrel was generally well tolerated in patients with STEMI.