What is Arixtra used to treat?
INDICATIONS AND USAGE ARIXTRA is a Factor Xa inhibitor (anticoagulant) indicated for: •. Prophylaxis of deep vein thrombosis (DVT) in patients undergoing hip fracture surgery (including extended prophylaxis), hip replacement surgery, knee replacement surgery, or abdominal surgery.
What happens if I miss a dose of Arixtra?
Arixtra is given by injection under the skin (subcutaneous injection). If you miss a dose of Arixtra, take your dose as soon as you remember. Do not take 2 doses at the same time. If you take too much Arixtra, call your doctor right away.
What is the minimum dose of Arixtra for DVT prophylaxis?
Dosing protocols for DVT prophylaxis and treatment of DVT/PE have been validated by empiric clinical trials. Clinical monitoring with Arixtra levels is not necessary for most patients. Normal individuals have no Arixtra activity. Trough: 0.14-0.19 mg/L drawn just prior to next dose. Trough: 0.46-0.62 mg/L drawn just prior to next dose.
How soon after surgery can I take Arixtra?
Administer the initial dose no earlier than 6 to 8 hours after surgery. Administration of ARIXTRA earlier than 6 hours after surgery increases the risk of major bleeding. The usual duration of therapy is 5 to 9 days; up to 11 days of therapy was administered in clinical trials.
Is there an antidote for fondaparinux?
Contrary to UFH or LMWHs, fondaparinux is not neutralized by protamine sulfate, and no antidote is available to counteract bleeding disorders associated with overdosing.
Is fondaparinux reversible?
The binding between fondaparinux and antithrombin is non-covalent and reversible. Also, when antithrombin in plasma has been saturated, circulating free fondaparinux has no anticoagulant effect by itself and is renally excreted.
How long does Arixtra stay in system?
The usual duration of administration of ARIXTRA is 5 to 9 days; up to 26 days of ARIXTRA injection was administered in clinical trials [see WARNINGS AND PRECAUTIONS, ADVERSE REACTIONS, and Clinical Studies].
What is the half life of Arixtra?
In healthy individuals up to 75 years of age, up to 77% of a single subcutaneous or intravenous fondaparinux dose is eliminated in urine as unchanged drug in 72 hours. The elimination half-life is 17-21 hours.
Can protamine reverse fondaparinux?
Protamine only partially neutralizes anti-factor Xa activity (~60%). Fondaparinux: Has only anti-Xa activity and protamine will have no significant effect. Very limited data to recommend these agents to reverse fondaparinux.
When should I stop Arixtra before surgery?
Apixaban. Apixaban should be stopped at least 48 hours before planned surgery or invasive procedures with a moderate to high risk of bleeding.
Does Arixtra affect platelet count?
Severe thrombocytopenia (platelet counts less than 50,000/mm3) occurred at a rate of 0.2% in patients given Arixtra 2.5 mg in these clinical trials. During extended prophylaxis, no cases of moderate or severe thrombocytopenia were reported.
What are the side effects of fondaparinux?
Side EffectsBlack, tarry stools.bladder pain.blood in the urine or stools.chest pain.collection of blood under the skin.convulsions.decreased or cloudy urine.deep, dark purple bruise.More items...•
Is Arixtra the same as Lovenox?
Are Arixtra and Lovenox the Same Thing? Lovenox (enoxaparin sodium) and Arixtra (fondaparinux) are blood thinners (anticoagulants) used to prevent blood clots. Lovenox is typically used to prevent blood clots that cause deep vein thrombosis (DVT), which can lead to blood clots in the lungs.
Can fondaparinux cause HIT?
HIT most commonly occurs after exposure to unfractionated heparin but has also been reported with low-molecular-weight heparin. To date, there have been very few reports of HIT with the pentasaccharide fondaparinux, and some have proposed fondaparinux as a treatment for HIT.
What drug class is Arixtra?
Arixtra, a "blood thinner", belongs to a group of drugs called factor Xa (ten A) inhibitor anticoagulants. These medications work by decreasing the ability of blood to form clots.
Is Arixtra made from pork?
Arixtra (fondaparinux) works on a specific protein called factor Xa. It can be monitored with anti-Xa levels, but monitoring is usually not needed in practice. Does Arixtra (fondaparinux) contain pork? No, Arixtra (fondaparinux) is not made from pork unlike heparin.
What are the side effects of fondaparinux?
Side EffectsBlack, tarry stools.bladder pain.blood in the urine or stools.chest pain.collection of blood under the skin.convulsions.decreased or cloudy urine.deep, dark purple bruise.More items...•
Can fondaparinux cause HIT?
HIT most commonly occurs after exposure to unfractionated heparin but has also been reported with low-molecular-weight heparin. To date, there have been very few reports of HIT with the pentasaccharide fondaparinux, and some have proposed fondaparinux as a treatment for HIT.
What is the difference between fondaparinux and enoxaparin?
Fondaparinux is a factor Xa inhibitor and does not inhibit thrombin (IIa) [8]. Enoxaparin on the other hand, binds to antithrombin to form a complex molecule that can irreversibly inactivate clotting factor Xa and it has less activity against thrombin [9]. This is how these two anticoagulants work.
What type of anticoagulant is fondaparinux?
Fondaparinux (Arixtra) is a synthetic anticoagulant based on the pentasaccharide sequence that makes up the minimal antithrombin (AT) binding region of heparin. Similar to low molecular weight heparins, it is an indirect inhibitor of factor Xa, but it does not inhibit thrombin at all.
Is Arixtra (fondaparinux) a heparin product?
No, Arixtra (fondaparinux) is not a type of heparin or low molecular weight heparin. Similar to heparin or heparin-like products, Arixtra (fondapar...
Does Arixtra (fondaparinux) affect INR (blood clotting time)?
No, Arixtra (fondaparinux) doesn't affect INR, which is a lab value monitored for people taking warfarin (Coumadin) to measure the speed at which b...
Does Arixtra (fondaparinux) contain pork?
No, Arixtra (fondaparinux) is not made from pork unlike heparin. It's a good injectable anticoagulant option for people who avoid pork for religiou...
Can I take Arixtra (fondaparinux) and warfarin (Coumadin) at the same time?
Yes, Arixtra (fondaparinux) and warfarin (Coumadin) can be taken at the same time for blood clot treatment for a short period of time when you are...
How do you reverse Arixtra (fondaparinux)?
Arixtra (fondaparinux) doesn't have a specific antidote like warfarin (Coumadin) and heparin, but healthcare providers can treat and manage serious...
What is Arixtra (fondaparinux)?
Arixtra (fondaparinux) is an anticoagulant (blood thinner). When you bleed, a protein complex called factor Xa is activated to help make a clot to stop the bleeding. Arixtra (fondaparinux) blocks this protein complex, which helps prevent blood clots from forming in your body.
What are the side effects of Arixtra (fondaparinux)?
With any medication, there are risks and benefits. Even if the medication is working, you may experience some unwanted side effects.
How much does Arixtra (fondaparinux) cost?
Unless there is a specific reason you need the brand, the generic medication will be a better value. For even more savings, use a GoodRx coupon and pay just a fraction of the retail price.
What is Arixtra blood thinner?
Arixtra (fondaparinux) is an injectable blood thinner that helps prevent blood clots from forming in the legs (deep vein thrombosis or DVT) or from traveling to your lungs (pulmonary embolism or PE). It doesn't require frequent blood tests like some other blood thinners, but it can be expensive.
What is Fondaparinux used for?
Overview TOP. Fondaparinux is used to prevent deep vein thrombosis, a condition in which harmful blood clots form in the blood vessels of the legs. These blood clots can travel to the lungs and can become lodged in the blood vessels of the lungs, causing a condition called pulmonary embolism.
Can fondaparinux cause bleeding?
Blood tests will be needed to check for unwanted effects. Be sure to keep all appointments. Fondaparinux may cause bleeding problems. This risk is higher if you have a catheter in your back for pain medicine or anesthesia (sometimes called an "epidural"), or if you have kidney problems.
Where to inject Arixtra?
Inject Arixtra (fondaparinux) in your lower stomach, 2 inches below your belly button. Alternate the sites from left to right every day to avoid side effects at the injection site.
How much arixtra is in a syringe?
ARIXTRA (fondaparinux sodium injection, USP) is available in the following strengths: 2.5 mg ARIXTRA in 0.5 mL single-dose prefilled syringe, affixed with a 27-gauge x ½‑inch needle and an ...
Is there an antidote for arixtra?
There is no known antidote for ARIXTRA. Overdose of ARIXTRA may lead to hemorrhagic complications. Discontinue treatment and initiate appropriate therapy if bleeding complications associated with ...
Can fondaparinux sodium be used during labor?
All patients receiving anticoagulants, including pregnant women, are at risk for bleeding. Fondaparinux sodium use during labor or delivery in women who are receiving neuraxial anesthesia may result in epidural or spinal hematomas.
Can hematomas be neuraxial?
Epidural or spinal hematomas may occur in patients who are anticoagulated with low molecular weight heparins (LMWH), heparinoids, or fondaparinux sodium and are receiving neuraxial anesthesia or undergoing spinal puncture. These hematomas may result in long-term or permanent paralysis.
Is arixtra contraindicated?
ARIXTRA is contraindicated in the following conditions: • Severe renal impairment (creatinine clearance [CrCl] <30 mL/min) [see Warnings and Precautions (5.3) and Use in Specific Populations ...
Can you mix arixtra with other medications?
2.1 Important Dosing Information - Do not mix other medications or solutions with ARIXTRA. Administer ARIXTRA only subcutaneously. Discard unused portion. 2.2 Deep Vein Thrombosis ...
Is Fondaparinux sodium genotoxic?
Fondaparinux sodium was not genotoxic in the Ames test, the mouse lymphoma cell (L5178Y/TK +/-) forward mutation test, the human lymphocyte chromosome aberration test, the rat hepatocyte unscheduled DNA synthesis (UDS) test, or the rat micronucleus test.
How long after hip replacement can you take arixtra?
In the hip fracture, hip replacement, knee replacement, or abdominal surgery clinical studies, the administration of ARIXTRA before 6 hours after surgery has been associated with an increased risk of major bleeding (see ADVERSE REACTIONS: Hemorrhage and DOSAGE AND ADMINISTRATION).
What is the mechanism of action of fondaparinux sodium?
Pharmacodynamics: Mechanism of Action: The antithrombotic activity of fondaparinux sodium is the result of antithrombin III (ATIII)-mediated selective inhibition of Factor Xa. By selectively binding to ATIII, fondaparinux sodium potentiates (about 300 times) the innate neutralization of Factor Xa by ATIII. Neutralization of Factor Xa interrupts the blood coagulation cascade and thus inhibits thrombin formation and thrombus development.
Is there an antidote for arixtra?
Symptoms/Treatment: There is no known antidote for ARIXTRA Injection . Overdose of ARIXTRA may lead to hemorrhagic complications. Overdosage associated with bleeding complications should lead to treatment discontinuation and initiation of appropriate therapy. Data obtained in patients undergoing chronic intermittent hemodialysis suggest that ARIXTRA clearance can increase by 20% during hemodialysis.
How should I take Arixtra?
See the detailed Instructions for Use that comes with Arixtra for information about how to give an Arixtra injection.
What are the possible side effects of Arixtra?
Arixtra can cause serious side effects. See “ What is the most important information I should know about Arixtra? ”
How long after Arixtra 2.5 mg qd?
Normal individuals have no Arixtra activity.#N#Expected Therapeutic Ranges:#N#DVT prophylaxis (Arixtra 2.5mg qd)#N#3 hours after dose: 0.39-0.50mg/L#N#Trough: 0.14-0.19 mg/L drawn just prior to next dose.#N#Treatment of thrombosis (Arixtra 5-10mg qd)#N#3 hours after dose: 1.20-1.26 mg/L#N#Trough: 0.46-0.62 mg/L drawn just prior to next dose.
Can you test for heparin if you are on anti Xa?
Test is not indicated if the patient is receiving unfractionated heparin or other Anti-Xa drugs.
Is Arixtra needed for DVT?
Dosing protocols for DVT prophylaxis and treatment of DVT/PE have been validated by empiric clinical trials. Clinical monitoring with Arixtra levels is not necessary for most patients.
Does fondaparinux interact with platelets?
Fondaparinux has a longer half-life than heparin and does not interact with platelets, both of which may be advantageous in certain settings. This topic review discusses the dosing and adverse effects associated with fondaparinux, including dosing in patients with renal insufficiency and management of bleeding.
Is Fondaparinux an inhibitor of thrombin?
Similar to low molecular weight heparins, it is an indirect inhibitor of factor Xa, but it does not inhibit thrombin at all. Fondaparinux has a longer half-life than heparin and does not interact with platelets, both of which may be advantageous in certain settings.
How are companies managing risks of animal-derived products?
In some cases, companies are managing risks of animal-derived products by using animals from specially controlled herds.
Do scientists worry about animal derived drugs?
Medical and drug scientists have long worried about animal-derived drugs, but they also know that the search for synthetic alternatives has often ended in frustration.