Precautions
“Unasyn and Flagyl” for suspected intra-abdominal infections provides unnecessary double coverage for anaerobes, while providing suboptimal coverage for gram-negative rods due to increasing resistance to ampicillin/sulbactam among gram-negative aerobes. 2. Staphylococcus aureus bacteremia “always” gets at least 2 weeks of IV antibiotics.
What Bugs does Unasyn cover?
UNASYN® and other antibacterial drugs, UNASYN should be used only to treat infections that are proven or strongly suspected to be caused by bacteria. DESCRIPTION . UNASYN is an injectable antibacterial combination consisting of the semisynthetic antibacterial ampicillin sodium and the beta-lactamase inhibitor sulbactam sodium for intravenous and
What does Unasyn cover?
Types of Antibiotics
- The first penicillin gave rise to an entire class of antibiotics known as penicillins. Penicillins are derived from a specific mold (a type of fungi)— Penicillium.
- Cephalosporins are related to penicillins. They both belong to a larger class called beta lactams. ...
- Macrolides are a completely different class of antibiotics from the beta lactams. ...
What are the different types of antibiotic treatment?
Antonyms for antibiotic include disease, poison, toxin, venom, toxicant, venin, toxic substance, contaminated, dirty and impure. Find more opposite words at wordhippo ...
What is the antonym of antibiotic?
What infections does Unasyn treat?
What Conditions does Unasyn Intravenous Treat?meningococcal meningitis.a bacterial infection.bacterial meningitis caused by Streptococcus.infection of the biliary tract.pneumonia caused by bacteria.diverticulitis.E. ... Klebsiella pneumoniae infection of abdominal cavity lining.More items...
What class of antibiotic is Unasyn?
It is known as a penicillin-type antibiotic. It works by stopping the growth of bacteria.
What bacteria does Unasyn not cover?
It is active against a wide range of bacterial groups, including Staphylococcus aureus, Enterobacteriaceae, and anaerobic bacteria. Importantly, it is not active against Pseudomonas aeruginosa and should not be used alone when infection with this organism is suspected or known.
What are the side effects of Unasyn?
Common side effects of Unasyn include:fever,sore throat,headache,rash,diarrhea,body aches,nausea,vomiting,More items...
How long does Unasyn stay in your system?
The majority of Unasyn (ampicillin / sulbactam) stays in your body for up to 8 hours and is then removed when you urinate. Immediately after receiving the medication, it will start working right away to fight the infection in your body.
How long is a course of Unasyn?
The course of intravenous therapy should not routinely exceed 14 days.
Can you take Unasyn on an empty stomach?
The therapeutic effect of the antimicrobial may be reduced. MANAGEMENT: The interacting penicillin should be administered one hour before or two hours after meals. Penicillin V and amoxicillin are not affected by food and may be given without regard to meals.
Will Unasyn cover UTI?
Some that are considered appropriate, include: Trimethoprim-Sulfamethoxazole This is considered an effective treatment of UTIs in men. Fluoroquinolones Specifically, Cipro and Levaquin are recommended. Unasyn This is a combo of the bactericidal antibiotic ampicillin and sulbactam, a beta-lactamases inhibitor.
What is another name for Unasyn?
Unasyn (ampicillin sodium/sulbactam sodium) is a combination antibiotic indicated for the treatment of infections due to susceptible strains of microorganisms.
Is Unasyn expensive?
The cost for Unasyn injectable powder for injection (1 g-0.5 g) is around $91 for a supply of 10 powder for injection, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
What is the oral equivalent of Unasyn?
Are Augmentin and Unasyn the Same Thing? Augmentin (amoxicillin/clavulanate) and Unasyn (ampicillin sodium/sulbactam sodium) are both a combinations of penicillin-type antibiotics and beta-lactamase inhibitors used to treat various types of infections.
Is Unasyn a broad spectrum antibiotic?
Thus, UNASYN possesses the properties of a broad-spectrum antibacterial and a beta-lactamase inhibitor.
What class of antibiotic is ampicillin sulbactam?
Ampicillin is in a class of medications called penicillin-like antibiotics. It works by stopping the growth of bacteria. Sulbactam is in a class of medications called beta-lactamase inhibitors. It works by preventing bacteria from destroying ampicillin.
Is Unasyn a cephalosporin?
Unasyn and Rocephin are different types of antibiotics. Unasyn is a combination of a penicillin-type antibiotic and a beta-lactamase inhibitor and Rocephin is a cephalosporin antibiotic.
What is another name for Unasyn?
Unasyn (ampicillin sodium/sulbactam sodium) is a combination antibiotic indicated for the treatment of infections due to susceptible strains of microorganisms.
What class of antibiotic is Augmentin?
Augmentin belongs to the penicillin class of antibiotics. Augmentin contains two drugs: amoxicillin and clavulanic acid. This combination makes Augmentin work against more types of bacteria than antibiotics that contain amoxicillin alone.
Is Unasyn (ampicillin / sulbactam) a broad spectrum antibiotic?
Unasyn (ampicillin / sulbactam) is considered a broad spectrum antibiotic that can treat many types of bacteria normally resistant to it. This is b...
Is Unasyn (ampicillin / sulbactam) good for a UTI?
A clinical study used Unasyn (ampicillin / sulbactam) to treat 36 people with reproductive organ infections. It showed that they improved in their...
How long does Unasyn (ampicillin / sulbactam) stay in your system?
The majority of Unasyn (ampicillin / sulbactam) stays in your body for up to 8 hours and is then removed when you urinate. Immediately after receiv...
How often is Unasyn (ampicillin / sulbactam) given?
It is given by injection into a vein every 6 hours. The frequency depends on your medical condition, response to therapy, and kidney function.
What is unasyn used for?
What is Unasyn and how is it used? Unasyn (ampicillin sodium/sulbactam sodium) is a combination antibiotic indicated for the treatment of infections due to susceptible strains of microorganisms.
What is the effect of UNASYN on skin?
UNASYN may cause severe skin reactions, such as toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome ( SJS ), dermatitis exfoliative, erythema multiforme, and Acute generalized exanthematous pustulosis (AGEP). If patients develop a skin rash they should be monitored closely and UNASYN discontinued if lesions progress (see CONTRAINDICATIONS and ADVERSE REACTIONS sections).
Can you use UNASYN powder in piggyback bottles?
If piggyback bottles are unavailable, standard vials of UNASYN sterile powder may be used. Initially, the vials may be reconstituted with Sterile Water for Injection to yield solutions containing 375 mg UNASYN per mL (250 mg ampicillin/125 mg sulbactam per mL). An appropriate volume should then be immediately diluted with a suitable parenteral diluent to yield solutions containing 3 to 45 mg UNASYN per mL (2 to 30 mg ampicillin/1 to 15 mg sulbactam/per mL).
Can UNASYN be reconstituted?
When concomitant therapy with aminoglycosides is indicated, UNASYN and aminoglycosides should be reconstituted and administered separately, due to the in vitro inactivation of aminoglycosides by any of the aminopenicillins.
Does probenecid affect UNASYN?
Probenecid decreases the renal tubular secretion of ampicillin and sulbactam. Concurrent use of probenecid with UNASYN may result in increased and prolonged blood levels of ampicillin and sulbactam. The concurrent administration of allopurinol and ampicillin increases substantially the incidence of rashes in patients receiving both drugs as compared to patients receiving ampicillin alone. It is not known whether this potentiation of ampicillin rashes is due to allopurinol or the hyperuricemia present in these patients. There are no data with UNASYN and allopurinol administered concurrently. UNASYN and aminoglycosides should not be reconstituted together due to the in vitro inactivation of aminoglycosides by the ampicillin component of UNASYN.
Does UNASYN cause diarrhea?
Clostridium difficile associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including UNASYN, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. difficile.
Is UNASYN reversible?
Hepatic dysfunction, including hepatitis and cholestatic jaundice has been associated with the use of UNASYN. Hepatic toxicity is usually reversible; however, deaths have been reported. Hepatic function should be monitored at regular intervals in patients with hepatic impairment.
Why is Unasyn used?
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Unasyn® and other antibacterial drugs, Unasyn should be used only to treat infections that are proven or strongly suspected to be caused by bacteria.
What is the effect of Unasyn on skin?
Unasyn may cause severe skin reactions, such as toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome (SJS), dermatitis exfoliative, erythema multiforme, and Acute generalized exanthematous pustulosis (AGEP). If patients develop a skin rash they should be monitored closely and Unasyn discontinued if lesions progress (see CONTRAINDICATIONS and ADVERSE REACTIONS sections).
What is the name of the antibacterial drug that is derived from penicillin?
Unasyn Description. Unasyn is an injectable antibacterial combination consisting of the semisynthetic antibacterial ampicillin sodium and the beta-lactamase inhibitor sulbactam sodium for intravenous and intramuscular administration. Ampicillin sodium is derived from the penicillin nucleus, 6-aminopenicillanic acid.
What temperature should Unasyn be stored at?
Unasyn sterile powder is to be stored at or below 30°C (86°F) prior to reconstitution.
How long does it take to administer Unasyn?
Unasyn should be administered by slow intravenous injection over at least 10–15 minutes or can also be delivered in greater dilutions with 50–100 mL of a compatible diluent as an intravenous infusion over 15–30 minutes.
Does Unasyn have sulbactam?
The presence of sulbactam in the Unasyn formulation effectively extends the antibacterial spectrum of ampicillin to include many bacteria normally resistant to it and to other beta-lactam antibacterials. Thus, Unasyn possesses the properties of a broad-spectrum antibacterial and a beta-lactamase inhibitor.
Does sulbactam inhibit beta-lactamase?
A wide range of beta-lactamases found in microorganisms resistant to penicillins and cephalosporins have been shown in biochemical studies with cell free bacterial systems to be irreversibly inhibited by sulbactam. Although sulbactam alone possesses little useful antibacterial activity except against the Neisseriaceae, whole organism studies have shown that sulbactam restores ampicillin activity against beta-lactamase producing strains. In particular, sulbactam has good inhibitory activity against the clinically important plasmid mediated beta-lactamases most frequently responsible for transferred drug resistance. Sulbactam has no effect on the activity of ampicillin against ampicillin susceptible strains.
What is unasyn used for?
It is used to treat a wide variety of bacterial infections.
What is Unasyn (ampicillin / sulbactam)?
Unasyn (ampicillin / sulbactam) is a combination of 2 antibiotic medications, ampicillin and sulbactam. Ampicillin is an antibiotic that kills bacteria by preventing them from making their own protective covering. Sulbactam, a beta-lactamase inhibitor, helps in blocking enzymes that often contribute to antibiotic resistance.
How long to keep unasyn in fridge?
Keep Unasyn (ampicillin / sulbactam) in the fridge before you use it, but take it out for 30 minutes before using it to warm it to room temperature to lower risk of injection site side effects.
What is the drug used to treat reproductive organ infections?
A clinical study used Unasyn (ampicillin / sulbactam) to treat 36 people with reproductive organ infections. It showed that they improved in their symptoms when taking Unasyn (ampicillin / sulbactam).
How long does unasyn stay in your system?
The majority of Unasyn (ampicillin / sulbactam) stays in your body for up to 8 hours and is then removed when you urinate. Immediately after receiving the medication, it will start working right away to fight the infection in your body.
What are the side effects of a syringe?
The following side effects have also been reported: Side effects that you should report to your doctor or health care professional as soon as possible: allergic reactions like skin rash or hives, swelling of the face, lips, or tongue. chest pain. difficulty breathing.
Where to store unasyn?
If you're taking Unasyn (ampicillin / sulbactam) at home, you have to store Unasyn (ampicillin / sulbactam) in the fridge and a nurse might have to see you often to do blood tests.
What drugs interact with gentamicin?
Some products that may interact with this drug include: aminoglycosides (such as gentamicin ), " blood thinners " (such as warfarin ), methotrexate, tetracyclines.
Can you mix gentamicin and aminoglycosides?
Give aminoglycosides (such as gentamicin) separately from this medication. Do not mix together in the same IV fluid.
Can ampicillin cause a rash?
Ampicillin can commonly cause a mild rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe allergic reaction. Therefore, get medical help right away if you develop any rash. This is not a complete list of possible side effects.
Are you currently using Unasyn Solution, Reconstituted (Recon Soln)?
This survey is being conducted by the WebMD marketing sciences department.
What is Unasyn?
Unasyn (ampicillin sodium/sulbactam sodium) is a combination antibiotic indicated for the treatment of infections due to susceptible strains of microorganisms.
What Drugs Interact With Unasyn?
Unasyn may interact with allopurinol, probenecid, or other antibiotics.
How Should Zosyn Be Taken?
The usual total daily dose of Zosyn for adults is 3.375 g every six hours totaling 13.5 g (12.0 g piperacillin/1.5 g tazobactam).
Does Zosyn cause bruising?
Tell your doctor if you have serious side effects of Zosyn including muscle cramps or spasms, swelling of the arms /legs/hands/ feet, easy bruising or bleeding, chest pain, confusion, new signs of infection (such as fever, persistent sore throat), severe abdominal or stomach pain, slow/fast/irregular heartbeat, persistent nausea or vomiting, seizures, extreme tiredness, dark or cloudy urine, change in the amount of urine, yellowing eyes or skin, or serious skin reactions (rash, peeling, sores, or blisters).
Are Unasyn and Zosyn the Same Thing?
Unasyn ( ampicillin sodium /sulbactam sodium) and Zosyn ( piperacillin and tazobactam for injection) are combination antibiotics indicated to treat bacterial infections.
What is unasyn used for?
UNASYN is indicated for the treatment of infections due to susceptible strains of the designated microorganisms in the conditions listed below.
Can penicillin cause hypersensitivity?
Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients on penicillin therapy. These...
Does ampicillin affect renal function?
In patients with impairment of renal function the elimination kinetics of ampicillin and sulbactam are similarly affected, hence the ratio of one to the other will remain constant whatever the renal function.
Is UNASYN contraindicated for Stevens-Johnson syndrome?
The use of UNASYN is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam...
Unasyn Description
This combination medication is used to treat a wide variety of bacterial infections.
May Treat: Bacteroides gynecological infections · Bacteroides peritonitis · E. coli gynecological infections · E. coli peritonitis · Enterobacter peritonitis and more
Drug Class: Aminopenicillin Antibiotic - Beta-lactamase Inhibitor Combinations
Availability: Prescription Required
Pregnancy: Consult a doctor before using
Lactation: Consult a doctor before using
May Treat: Bacteroides gynecological infections · Bacteroides peritonitis · E. coli gynecological infections · E. coli peritonitis · Enterobacter peritonitis and more
Drug Class: Aminopenicillin Antibiotic - Beta-lactamase Inhibitor Combinations
Availability: Prescription Required
Pregnancy: Consult a doctor before using
Lactation: Consult a doctor before using
Alcohol: Limit intake while taking this medication
Driving: May cause drowsiness or dizziness. Use caution
Manufacturer: PFIZER US PHARM
- Do not take if you are allergic to penicillin
- Tell pharmacist if you are on a low-sodium diet
- Take at the same time(s) daily as directed
- Do not take if you are allergic to penicillin
- Tell pharmacist if you are on a low-sodium diet
- Take at the same time(s) daily as directed
- Call your doctor if you get a rash
- Success is dependent on completing therapy course
- Report severe diarrhea or abdominal pain to doctor.
- Watch for oral thrush or vaginal yeast infections.
- Tell doctor your complete medical history
Unasyn - Clinical Pharmacology
Indications and Usage For Unasyn
Contraindications
Warnings
Precautions
- General
Immediately after completion of a 15-minute intravenous infusion of Unasyn, peak serum concentrations of ampicillin and sulbactam are attained. Ampicillin serum levels are similar to those produced by the administration of equivalent amounts of ampicillin alone. Peak ampicillin … - MICROBIOLOGY
Ampicillin is similar to benzyl penicillin in its bactericidal action against susceptible organisms during the stage of active multiplication. It acts through the inhibition of cell wall mucopeptide biosynthesis. Ampicillin has a broad spectrum of bactericidal activity against many gram-positiv…
Adverse Reactions
- Unasyn is indicated for the treatment of infections due to susceptible strains of the designated microorganisms in the conditions listed below. Skin and Skin Structure Infections caused by beta-lactamase producing strains of Staphylococcus aureus, Escherichia coli,2 Klebsiella spp.2 (including K. pneumoniae2), Proteus mirabilis,2 Bacteroides fragilis,2 Enterobacter spp.,2 and A…
Overdosage
- The use of Unasyn is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins). Unasyn is contraindicated in patients with a previous history of cholestatic jaundice/hepatic dysfunction associated with Unas…
Clinical Studies
- Hypersensitivity
Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients on penicillin therapy. These reactions are more apt to occur in individuals with a history of penicillin hypersensitivity and/or hypersensitivity reactions to multiple allergens. There have bee… - Hepatotoxicity
Hepatic dysfunction, including hepatitis and cholestatic jaundice has been associated with the use of Unasyn. Hepatic toxicity is usually reversible; however, deaths have been reported. Hepatic function should be monitored at regular intervals in patients with hepatic impairment.
Unasyn Dosage and Administration
- General
A high percentage of patients with mononucleosis who receive ampicillin develop a skin rash. Thus, ampicillin class antibacterials should not be administered to patients with mononucleosis. In patients treated with Unasyn the possibility of superinfections with mycotic or bacterial pathogen… - Information for Patients
Patients should be counseled that antibacterial drugs including Unasyn should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When Unasyn is prescribed to treat a bacterial infection, patients should be told that although it is common to f…