Precautions
What anaerobes does zosyn cover? Piperacillin/tazobactam is a beta-lactam/beta-lactamase inhibitor combination with a broad spectrum of antibacterial activity encompassing most Gram-positive and Gram-negative aerobic bacteria and anaerobic bacteria, including many pathogens producing beta-lactamases.
Does Zosyn have anaerobic coverage?
Cleocin (clindamycin hydrochloride) and Zithromax Z-PAK (azithromycin) are antibiotics used to treat various infections caused by bacteria. Cleocin and Zithromax are different types of antibiotics. Cleocin is a lincomycin antibiotic and Zithromax is a macrolide antibiotic. Subsequently, question is, is clindamycin a powerful antibiotic? Clindamycin is an effective antibiotic for a variety of serious infections.
Are clindamycin and Zithromax related?
No they are not the same. Doxycycline and Clindamycin are both antibiotics used to treat bacterial infections but they belong to different classes of antibiotics. Doxycycline is a Tetracycline antibiotic and Clindamycin is a Lincosamide antibiotic.
Is doxycycline in the same family as clindamycin?
No, clindamycin is not a penicillin antibiotic. Instead, it belongs to a class of medications known as lincomycin antibiotics, or lincosamides. Clindamycin is a broad-spectrum antibiotic, with the ability to impact many types of bacteria in the body. Continue reading
Is clindamycin a penicillin based antibiotic?
What is Zosyn not compatible with?
ZOSYN is not compatible with tobramycin for simultaneous co-administration via Y-site infusion. Compatibility of ZOSYN with other aminoglycosides has not been established.
What should not be mixed with clindamycin?
You should not use clindamycin and tretinoin topical if you are also taking another antibiotic called erythromycin, or using other skin medications that contain erythromycin.
Which drug can be administered with Zosyn?
Table 5: Compatibility with AminoglycosidesAminoglycosideZOSYN Dose (grams)Aminoglycoside Concentration Range† (mg/mL)Amikacin2.251.75 – 7.53.3754.5Gentamicin2.250.7 – 3.323 more rows
Is Zosyn compatible with doxycycline?
doxycycline piperacillin Combining these medications may reduce the effectiveness of piperacillin. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs.
What can you mix clindamycin with?
The combination of clindamycin and benzoyl peroxide is used to treat acne. Clindamycin and benzoyl peroxide are in a class of medications called topical antibiotics. The combination of clindamycin and benzoyl peroxide works by killing the bacteria that cause acne.
When is clindamycin contraindicated?
Clindamycin is contraindicated in patients who have had an allergic reaction to it, and it should be used with caution in those who have a history of regional enteritis, ulcerative colitis, or antibiotic-associated colitis.
Is Zosyn a broad spectrum antibiotic?
Zosyn (piperacillin / tazobactam) is a broad spectrum antibiotic, which means that it works against many types of bacteria. This is why it is often used for people who are very sick or have serious infections.
Why do you infuse Zosyn over 4 hours?
Summary: EI β-lactam therapy is now considered a key aspect of antimicrobial stewardship, and published evidence indicates that i.v. infusion of piperacillin-tazobactam over extended periods (e.g., four hours) instead of the traditionally recommended 30 minutes may offer several advantages, including reduced mortality ...
When should you hold Zosyn?
Warnings. You should not use Zosyn if you have ever had an allergic reaction to certain antibiotics (especially a penicillin antibiotic).
Is vancomycin and clindamycin compatible?
Conclusions: Combination therapy with vancomycin and clindamycin was associated with decreased hospital LOS for patients with an abscess. The 90-day hospital readmission rates for those with ABSSSIs may be reduced when combination therapy is utilized.
Can you give Zosyn and vancomycin at the same time?
Conclusions: A combination of vancomycin 10 mg/mL and piperacillin/tazobactam 112.5 mg/mL demonstrated precipitation immediately upon mixing. Co-infusion of vancomycin and piperacillin/tazobactam via Y-site should be considered incompatible.
Is Ancef compatible with clindamycin?
The combination of clindamycin phosphate 900 mg, gentamicin sulfate 80 mg, and cefazolin sodium 1 g in D5W 100 ml was found to be compatible for up to 4 hours. The duration of compatibility for these three drugs in 100 ml of NaCl 0.9% was 12 hours.
Can you eat dairy products while taking clindamycin?
Calcium from food or supplements can interfere in the proper absorption of some classes of antibiotic medications. However, calcium is not known to interact with clindamycin.
Is it OK to eat yogurt while taking clindamycin?
Interactions between your drugs No interactions were found between clindamycin and yogurt.
Why can't you lay down after clindamycin?
Official answer. You should avoid lying down after taking the antibiotic clindamycin because it may prolong the time it takes for the medication to move through your esophagus into your stomach, potentially irritating your esophagus.
Can I eat cheese while taking clindamycin?
It's recommended that dairy products such as cheese, milk, butter, and yogurt should not be consumed until 3 hours after a dose of antibiotics is taken. Likewise, juices or supplements containing calcium may also reduce effectiveness.
What is a Zosyn?
ZOSYN (piperacillin and tazobactam) for Injection and ZOSYN (piperacillin and tazobactam) Injection are injectable antibacterial combination products consisting of the semisynthetic antibacterial piperacillin...
What is the best medicine to monitor kidney function?
Monitor kidney function in patients concomitantly administered with piperacillin/tazobactam and vancomycin .
Does probenecid prolong the half life of tazobactam?
Probenecid administered concomitantly with ZOSYN prolongs the half-life of piperacillin by 21% and that of tazobactam by 71% because probenecid inhibits tubular renal secretion of both piperacillin and tazobactam. Probenecid should not be co-administered with ZOSYN unless the benefit outweighs the risk.
Can you take Zosyn and Aminoglycosides separately?
ZOSYN and aminoglycosides should be reconstituted, diluted, and administered separately when concomitant therapy with aminoglycosides is indicated. ZOSYN, which contains EDTA, is compatible with amikacin and gentamicin for simultaneous Y-site infusion in certain diluents and at specific concentrations. ZOSYN is not compatible with tobramycin for simultaneous Y-site infusion [see Dosage and Administration (2.8)].
Does ZOSYN decrease tobramycin?
Sequential administration of ZOSYN and tobramycin to patients with either normal renal function or mild to moderate renal impairment has been shown to modestly decrease serum concentrations of tobramycin but no dosage adjustment is considered necessary .
Is Zosyn contraindicated?
ZOSYN is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or beta-lactamase inhibitors.
Does piperacillin inactivate aminoglycosides?
Piperacillin may inactivate aminoglycosides by converting them to microbiologically inert amides.
Why was Zosyn discontinued?
However, in 3.2% of the patients treated worldwide, Zosyn was discontinued because of adverse events primarily involving the skin (1.3%), including rash and pruritus; the gastrointestin al system (0.9%) , including diarrhea, nausea, and vomiting; and allergic reactions (0.5%).
What is Zosyn used for?
Zosyn is a combination product consisting of a penicillin-class antibacterial, piperacillin, and a β-lactamase inhibitor, tazobactam, indicated for the treatment of patients with moderate to severe infections caused by susceptible isolates of the designated bacteria in the conditions listed below .
How much sodium is in Zosyn?
Zosyn contains a total of 2.84 mEq (65 mg) of Na + (sodium) per gram of piperacillin in the combination product. This should be considered when treating patients requiring restricted salt intake. Periodic electrolyte determinations should be performed in patients with low potassium reserves, and the possibility of hypokalemia should be kept in mind with patients who have potentially low potassium reserves and who are receiving cytotoxic therapy or diuretics.
How much tazobactam is in Zosyn?
Each Zosyn 2.25 g vial provides piperacillin sodium equivalent to 2 grams of piperacillin and tazobactam sodium equivalent to 0.25 g of tazobactam. Each Zosyn 3.375 g vial provides piperacillin sodium equivalent to 3 grams of piperacillin and tazobactam sodium equivalent to 0.375 g of tazobactam.
How long does Zosyn take to infuse?
Zosyn should be administered by intravenous infusion over 30 minutes.
Can you take Zosyn and Aminoglycosides separately?
Zosyn and aminoglycosides should be reconstituted, diluted, and administered separately when concomitant therapy with aminoglycosides is indicated [ see Drug Interactions (7.1) ].
Can Zosyn be taken with renal impairment?
In patients with renal impairment (creatinine clearance ≤ 40 mL/min) and dialysis patients ( hemodialysis and CAPD), the intravenous dose of Zosyn should be reduced to the degree of actual renal function impairment. The recommended daily doses of Zosyn for patients with renal impairment are as follows:
