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What are phenothiazine derivatives drugs?
Examples of phenothiazines include: chlorpromazine (brand name: Thorazine), fluphenazine (Duraclon), mesoridazine (Serentil), perphenazine (Etrafon and Trilafon), prochlorperazine (Compazine), promazine (Robinul and Anectine), thioridazine (Mellaril), trifluoperazine (Stelazine) and triflupromazine (Robinul).
What are examples of phenothiazines?
Description and Brand NamesCompazine.Compro.Mellaril.Permitil.Phenadoz.Prolixin.Serentil.Sparine.More items...
What is the best known phenothiazine?
Among the most widely used phenothiazines are chlorpromazine (marketed under Thorazine and other trade names), thioridazine (Mellaril), and trifluoperazine (Stelazine).
Which antipsychotics are phenothiazines?
Generic and brand names of phenothiazine antipsychotic drugs include:chlorpromazine.Compro (prochlorperazine maleate rectal suppository)fluphenazine.perphenazine.prochlorperazine.prochlorperazine edisylate.prochlorperazine mesylate.Procomp (prochlorperazine rectal suppository)More items...
Is Zofran a phenothiazine?
Zofran and Compazine belong to different drug classes. Zofran is a selective 5-HT3 receptor antagonist and Compazine is a phenothiazine anti-psychotic.
Is Xanax a phenothiazine?
Compazine is a phenothiazine anti-psychotic and Xanax is a benzodiazepine.
What is the oldest antipsychotic drug?
Chlorpromazine was the first antipsychotic and was followed by a large number of other antipsychotics, many with diverse chemical structures. However, so far, no antipsychotic has been shown to be significantly more effective than chlorpromazine in treating schizophrenia with the notable exception of clozapine.
Are phenothiazines antihistamines?
Phenothiazine (FEE-noe-THYE-a-zeen)-derivative antihistamines are used to relieve or prevent the symptoms of hay fever and other types of allergy. They work by preventing the effects of a substance called histamine, which is produced by the body.
What is the most potent antipsychotic?
Key pointsHigh-potency: haloperidol, fluphenazine.Mid-potency: perphenazine, loxapine.Low-potency: chlorpromazine.
Are phenothiazines typical antipsychotics?
Antipsychotics have been broadly classified into classical/typical, which includes phenothiazines and butyrophenones, and atypical antipsychotics, which includes benzamides. The psychiatric effects of all the progeners of these groups were discovered serendipitously.
What phenothiazines are used as antiemetics?
Phenothiazines, including prochlorperazine, chlorpromazine, and promethazine, are commonly employed in the emergency department to treat severe nausea and vomiting accompanying migraine.
What are the common adverse effects of phenothiazines?
Constipation, trouble urinating, dryness of mouth, confusion, problems with memory, dizziness or fainting, drowsiness, trembling of the hands and fingers, and problems with muscle movement, such as decreased or unusual movements, are especially likely to occur in elderly patients, who are usually more sensitive than ...
Are phenothiazines antihistamines?
Phenothiazine (FEE-noe-THYE-a-zeen)-derivative antihistamines are used to relieve or prevent the symptoms of hay fever and other types of allergy. They work by preventing the effects of a substance called histamine, which is produced by the body.
Is Haldol a phenothiazine?
Micromolar concentrations of the phenothiazines, fluphenazine and trifluoperazine, and haloperidol, a non-phenothiazine antipsychotic and calmodulin antagonist, selectively inhibited the Ca-activated K channels.
Is metoclopramide a phenothiazine?
Phenothiazine/Metoclopramide In addition, they act as an alpha-adrenergic antagonist. Phenothiazines, including prochlorperazine, chlorpromazine, and promethazine, are commonly employed in the emergency department to treat severe nausea and vomiting accompanying migraine.
Are phenothiazines typical antipsychotics?
Antipsychotics have been broadly classified into classical/typical, which includes phenothiazines and butyrophenones, and atypical antipsychotics, which includes benzamides. The psychiatric effects of all the progeners of these groups were discovered serendipitously.
What is phenothiazine used for?
Phenothiazine derivatives are willingly used owing to their intense luminescence, high photo responsibility, reversible oxidation processes, and nonplanar structure inhibiting intermolecular interaction [ [3], [4], [5] ]. Recently, phenothiazine derivatives have been applied in the context of donor-acceptor (D-A) systems where phenothiazine act as a strong electron-donor unit (D). The D-A type molecules where phenothiazine is functionalized with benzoyl and imidazole groups are tested for reversible mechanofluorochromic (MFC) behavior and as emitting layers in OLED devices [ [6], [7], [8] ]. However, compounds with donor-π-bridge-acceptor (D-π-A) architecture with phenothiazine acing as a donor and cyanoacryclic acid as the acceptor unit connected via double bond are extensively explored and has attracted significant interest in solar cells technology [ [9], [10], [11], [12] ]. The phenothiazine derivatives based on D-A and D-π-A architecture are explored as fluorescence probes in the living cells showing high photostability and selectivity, and low cytotoxicity [ [13], [14], [15] ]. Among phenothiazine derivatives, compounds with D/A-π-D-A construction where phenothiazine is connected via acetylene linker with donor or/and acceptor units are hardly known [ [16], [17], [18], [19] ]. The ethynylated derivatives of phenothiazine with various electron donating and withdrawing groups at 7-position were tested as fluorescent boronic acid probes [ 16 ]. The character of end-capped groups considerably tuned the optical behavior of PTZ derivatives, the intramolecular charge transfer (ICT) drastically impacted the emission maxima by sensitivity towards solvent polarity and the photo-induced electron transfer (PeT) of the probes [ 16 ]. The symmetrically and asymmetrically phenothiazine connected directly via ethynyl spacer with BODIPY were synthesized. The study showed that the acetylene linked phenothiazine functionalized BODIPYs exhibit bathochromic shift as compared to directly linked phenothiazine functionalized BODIPYs and incorporation of acetylene linkage between phenothiazine, and BODIPYs induces coplanarity and results in lower band gap which leads to red-shifted absorption [ 18 ]. R. Dhamodharan reported two phenothiazines of A-π-D-π-A type connected via acetylene linker with 3,4-ethylenedioxythiophene (EDOT) containing aldehyde and the dicyanovinyl units to reduce the band-gap. Compounds exhibit solid-state emission in the deep red and NIR regions with quantum efficiency in the range of 0.9 to 8.9% [ 19 ].
Is phenothiazine a heterocycle?
Phenothiazine (PTZ) and its derivatives are a very appealing family of sulfur‑nitrogen heterocycles that can be applied in many versatile fields. Phenothiazine and particularly its substituted derivatives are well-known for their wide range of biological and pharmacological activities [ 1, 2 ].
Phenothiazine-derivative drugs
The term "phenothiazines" is used to describe the largest of the five main classes of neuroleptic antipsychotic drugs.
Further reading
Hendricks, Christensen, J.B., and Kristiansen, Jette E. Sonderborg, Denmark. " Antibakterielle Eigenschaften der Phenothiazine: Eine Behandlungsoption für die Zukunft? " Chemotherapie Journal. 13.5. (2004): 203–205. Wissenschaftliche Verlagsgesesellschaft mbH. 21 August 2005. (PDF).
What is phenothiazine used for?
Phenothiazine antipsychotics may be used in the treatment of psychotic symptoms associated with schizophrenia or bipolar disorder. Some phenothiazines (such as prochlorperazine and chlorpromazine) are also effective at relieving other symptoms unrelated to psychosis, such as nausea, vomiting, prolonged hiccups, ...
What are Phenothiazine antipsychotics?
Phenothiazine antipsychotics are a type of antipsychotic. Antipsychotics are medicines that are used to reduce hallucinations and delusions associated with psychosis. Phenothiazine antipsychotics are thought to work by blocking the action of dopamine in the brain; however, their exact mechanism of action is unknown.
What is phenothiazine derivative?
A phenothiazine derivative antihistamine indicated in the treatment of allergies.
What is antihistamine used for?
An antihistamine agent used to prevent and relieve allergic conditions which cause pruritus and other allergic skin conditions, including urticaria.
