The four Starling�s forces are:
- hydrostatic pressure in the capillary (Pc)
- hydrostatic pressure in the interstitium (Pi)
- oncotic pressure in the capillary (pc )
- oncotic pressure in the interstitium (pi )
- Pc = hydrostatic pressure of the capillary.
- Pi = hydrostatic pressure of the interstitium.
- pc = osmotic pressure of the capillary.
- pi = oncotic pressure of the interstitium.
What are the Starling forces of pressure?
The Starling forces are summarized in Figure CR.22. The pressure acting to force fluid out of the capillary is made up of the hydrostatic pressure in the capillary and the colloid osmotic pressure in the interstitial fluid:
What is Starling's hypothesis in fluid mechanics?
Starling's hypothesis states that the fluid movement due to filtration across the wall of a capillary is dependent on the balance between the hydrostatic pressure gradient and the oncotic pressure gradient across the capillary. The four Starling's forces are: The balance of these forces allows calculation of the net driving pressure for filtration.
What are typical values of Starling forces in systemic capillaries (mmHg)?
Typical values of Starling Forces in Systemic Capillaries (mmHg) Arteriolar end of capillary Venous end of capillary Capillary hydrostatic pressure 25 10 Interstitial hydrostatic pressure -6 -6 Capillary oncotic pressure 25 25 2 more rows ...
What is Starling’s equation?
The Starling equation, is an equation that illustrates the role of hydrostatic and oncotic forces (the so-called Starling forces) in the movement of fluid across capillary membranes. Starling’s equation only refers to fluid movement across the capillary membrane that occurs as a result of filtration.
What balances outward fluid filtration?
What is the oncotic pressure gradient?
Why does oncotic pressure decrease?
What determines the direction of water exchange between plasma and interstitial fluid?
Why does the P-C decrease in the venous side of the microcirculation?
What are the Starling forces?
What determines the permeability of a capillary?
See 2 more
What are different Starling forces?
The four Starling's forces are: hydrostatic pressure in the capillary (Pc) hydrostatic pressure in the interstitium (Pi) oncotic pressure in the capillary (pc ) oncotic pressure in the interstitium (pi )
What are the Starling forces of capillary exchange?
The Starling Principle states that fluid movements between blood and tissues are determined by differences in hydrostatic and colloid osmotic (oncotic) pressures between plasma inside microvessels and fluid outside them.
What are Starling forces in lungs?
Starling forces control the net flow of fluid across the alveolar membrane and are proportional to the permeability and surface area of the alveolar membrane, as well as the balance between hydrostatic and oncotic pressures of both the capillaries and alveoli.
Why are Starling forces important?
The term 'Starling's Forces' refers to this movement, after the scientist who first described it. Movement of fluid across capillary walls is essential for maintaining a continuous exchange of oxygen and carbon dioxide between the body's cells and the blood supply.
What are the four forces that influence fluid movement across the capillary wall?
The four Starling s forces are:hydrostatic pressure in the capillary (Pc)hydrostatic pressure in the interstitium (Pi)oncotic pressure in the capillary (pc )oncotic pressure in the interstitium (pi )
How Starling forces cause edema?
Edema is defined as a clinically apparent increase in the interstitial fluid volume, which develops when Starling forces are altered so that there is increased flow of fluid from the vascular system into the interstitium.
Which Starling force is the most important in causing filtration at capillaries?
The main driving force for filtration is the hydrostatic pressure of the blood.
What does Frank Starling law state?
The Frank-Starling law states that the force or tension developed in a muscle fiber depends on the extent to which the fiber is stretched. In a clinical situation, when increased quantities of blood flow into the heart (increasing preload), the walls of the heart stretch.
What is oncotic pressure and hydrostatic pressure?
Hydrostatic Pressure: Hydrostatic pressure refers to the force that is exerted by the fluid inside the blood capillaries against the capillary wall. Oncotic Pressure: Oncotic pressure refers to the force that is exerted by albumin and other proteins in the blood vessels.
What is Starling flow?
November 2020) (Learn how and when to remove this template message) The Starling equation describes the net flow of fluid across a semipermeable membrane. It is named after Ernest Starling. It describes the balance between capillary pressure, interstitial pressure, and osmotic pressure.
What is JV in Starling equation?
As predicted by the Starling equation (defined earlier), net fluid flux (Jv) across a capillary membrane is determined by two separate pressure gradients. The difference between capillary (Pc) and interstitial (Pt) hydrostatic pressures drives fluid extravasation.
What is the difference between oncotic and osmotic pressure?
The main difference between Osmotic Pressure and Oncotic Pressure is that osmotic pressure is the pressure needed to stop the net movement of water across a permeable membrane which separates the solvent and solution whereas oncotic pressure is the contribution made to total osmolality by colloids.
What are the forces acting across capillary walls?
And Starling forces, named after British physiologist Ernest Starling, sometimes called Starling pressures, are the forces that drive the exchange of fluid through the walls of the capillaries. The capillaries have a single layer of endothelial cells lining their walls with clefts between these cells.
Which of these Starling forces changes from the beginning to the end of the glomerular capillaries?
To answer this question, compare the Starling pressures at the beginning of the glomerular capillary with those at the end of the capillary. The only pressure that changes is πGC, the oncotic pressure of glomerular capillary blood.
What is capillary exchange?
Capillary exchange refers to the exchange of material from the blood into the tissues in the capillary. There are three mechanisms that facilitate capillary exchange: diffusion, transcytosis and bulk flow.
How does the Frank Starling mechanism work?
According to the Frank–Starling mechanism, the left ventricle is able to increase its force of contraction and therefore stroke volume in response to increases in venous return and hence preload (2,4) (Figure 37.2). Perturbations in afterload or inotropy move the Frank–Starling curve up or down.
What would a leaky capillary have?
A leaky capillary (eg due to histamine) would have a high filtration coefficient. The glomerular capillaries are naturally very leaky as this is necessary for their function; they have a high filtration coefficient
What is the reflection coefficient?
The reflection coefficient is used to correct the magnitude of the measured gradient to take account of the effective oncotic pressure. It can have a value from 0 to 1. For example, CSF & the glomerular filtrate have very low protein concentrations and the reflection coefficient for protein in these capillaries is close to 1. Proteins cross the walls of the hepatic sinusoids relatively easily and the protein concentration of hepatic lymph is very high. The reflection coefficient for protein in the sinusoids is low. The reflection coefficient in the pulmonary capillaries is intermediate in value: about 0.5.
What are the four forces of Starling's theory?
The four Starling's forces are: hydrostatic pressure in the capillary (Pc) hydrostatic pressure in the interstitium (Pi) ...
What is the quote from Starling?
A quote from Starling (1896) "... there must be a balance between the hydrostatic pressure of the blood in the capillaries and the osmotic attraction of the blood for the surrounding fluids. ".
What is the net fluid flux?
The net fluid flux (due to filtration) across the capillary wall is proportional to the net driving pressure. The filtration coefficient (Kf) is the constant of proportionality in the flux equation which is known as the Starling's equation.
When was hydrostatic pressure first measured?
When first measured by Landis in 1930 in a capillary loop in a finger held at heart level, the hydrostatic pressures found were 32 mmHg at the arteriolar end and 12 mmHg at the venous end. The later discovery of negative values for interstitial hydrostatic pressure by Guyton did upset the status quo a bit.
How many unknowns are needed to use the Starling equation?
To actually use the Starling equation clinically requires measurement of six unknowns. This is simply not possible and this limits the usefulness of the equation in patient care. It can be used in a general way to explain observations (eg to explain generalised oedema as due to hypoalbuminaemia).
What is the reflection coefficient?
The reflection coefficient is used to correct the magnitude of the measured gradient to take account of the �effective oncotic pressure�. It can have a value from 0 to 1. For example, CSF & the glomerular filtrate have very low protein concentrations and the reflection coefficient for protein in these capillaries is close to 1. Proteins cross the walls of the hepatic sinusoids relatively easily and the protein concentration of hepatic lymph is very high. The reflection coefficient for protein in the sinusoids is low. The reflection coefficient in the pulmonary capillaries is intermediate in value: about 0.5.
What would a leaky capillary have?
A �leaky� capillary (eg due to histamine) would have a high filtration coefficient. The glomerular capillaries are naturally very leaky as this is necessary for their function; they have a high filtration coefficient.
What is the quote from Starling?
A quote from Starling (1896) "... there must be a balance between the hydrostatic pressure of the blood in the capillaries and the osmotic attraction of the blood for the surrounding fluids. ".
Which theory states that the fluid movement due to filtration across the wall of a capillary is dependent on the?
Starling�s hypothesis states that the fluid movement due to filtration across the wall of a capillary is dependent on the balance between the hydrostatic pressure gradient and the oncotic pressure gradient across the capillary . The four Starling�s forces are:
What is the net fluid flux?
The net fluid flux (due to filtration) across the capillary wall is proportional to the net driving pressure. The filtration coefficient (Kf) is the constant of proportionality in the flux equation which is known as the Starling�s equation.
When was hydrostatic pressure first measured?
When first measured by Landis in 1930 in a capillary loop in a finger held at heart level, the hydrostatic pressures found were 32 mmHg at the arteriolar end and 12 mmHg at the venous end. The later discovery of negative values for interstitial hydrostatic pressure by Guyton did upset the status quo a bit.
How many unknowns are needed to use the Starling equation?
To actually use the Starling equation clinically requires measurement of six unknowns. This is simply not possible and this limits the usefulness of the equation in patient care. It can be used in a general way to explain observations (eg to explain generalised oedema as due to hypoalbuminaemia).
What balances outward fluid filtration?
Outward fluid filtration on the arterial side of the microcirculation largely balances inward fluid filtration on the venous side of the microcirculation. When added together there is a minuscule net outward filtration of fluid from most capillary beds. When this outward filtration is summed across all tissue capillary beds there appears to be only a few milliliters of outward fluid filtration per minute throughout the entire body. Although small, this net outward fluid filtration must be ultimately returned to the circulation to avoid long-term increases in interstitial fluid volume and long-term declines in circulatory volume. Return of filtered fluid is ultimately achieved by lymphatic vessels as discussed in Lymphatic Physiology.
What is the oncotic pressure gradient?
Oncotic Pressure Gradient. Oncotic Pressure refers to the osmotic pressure generated by the presence of proteinacious solutes. Because plasma proteins cannot cross the capillary barrier, these osmotically-active solutes are at higher concentration in the plasma than in the interstitial fluid.
Why does oncotic pressure decrease?
Derangements of the oncotic pressure gradient usually occur due to reductions in plasma oncotic pressure from poor synthesis or excessive loss of plasma proteins, especially albumin. Reduced plasma oncotic pressure in turn reduces in the inward oncotic pressure gradient and thus allows for increased outward fluid filtration. Reduced plasma protein synthesis, especially that of albumin, can occur in a variety of pathologies including protein-energy malnutrition, cirrhosis, and nephrotic syndrome.
What determines the direction of water exchange between plasma and interstitial fluid?
The direction of water exchange between the plasma and interstitial fluid across the capillary wall is largely determined by a combination of the relative hydrostatic and oncotic pressures of these two compartments . The rate of exchange is governed by the permeability of the capillary wall itself.
Why does the P-C decrease in the venous side of the microcirculation?
Toward the venous side of the microcirculation, the capillary hydrostatic pressure (P c) has declined due to the resistance to blood flow generated by the capillary. Furthermore, progressive outward filtration of water as blood travels through the microcirculation causes plasma proteins to become concentrated within the circulation, thus raising the plasma oncotic pressure. Because the outward hydrostatic pressure gradient has declined and the inward oncotic pressure gradient has increased, there is now net fluid resorption.
What are the Starling forces?
Starling Forces govern the passive exchange of water between the capillary microcirculation and the interstitial fluid. These forces not only determine the directionality of net water movement between two different compartments but also determines the rate at which water exchange occurs.
What determines the permeability of a capillary?
The histological architecture of capillaries determine the permeability of capillaries to water and this can vary by over two orders of magnitude in different capillary beds. For example, the fenestrated architecture of the glomerular capillaries causes these vessels to display an extremely high permeability to water whereas the extremely tight architecture of the blood brain barrier results in an extremely low water permeability. It should be also pointed out that acute inflammation or certain types of damage to the capillary wall such as during burns can increase the water permeability of the microcirculation.
