Fibric acid derivatives are cholesterol medications whose exact mechanism of action is unknown. They are thought to reduce the formation and increase the breakdown of cholesterol and triglycerides. The most common side effects of this class of drugs are heartburn and stomach pain.
- headache.
- back pain.
- nausea.
- indigestion.
- stuffy or runny nose.
- stomach pain.
What are the side effects of fenofibrate?
Print Share. Commonly reported side effects of fenofibrate include: increased serum aspartate aminotransferase and increased serum alanine aminotransferase. Other side effects include: abnormal hepatic function tests, increased creatine phosphokinase in blood specimen, and increased serum transaminases.
What are the side effects of fenofibric acid?
Along with its needed effects, fenofibric acid may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking fenofibric acid: More common. Body aches or pain. chills.
What are the adverse effects of fibric acids?
Adverse effects of fibric acids vary depending on the particular agent selected for the patient. Some of the most common adverse effects include a headache, dizziness, back pain, diarrhea, dyspepsia, nasopharyngitis, sinusitis, and abnormal liver function tests.
What is fenofibrate used for?
Fenofibrate is a fibric acid derivative used in the therapy of hypertriglyceridemia and dyslipidemia. Fenofibrate therapy is associated with mild and transient serum aminotransferase elevations and with rare instances of acute liver injury, which can be severe and prolonged and lead to significant hepatic fibrosis. NCBI
Is fenofibrate a fibric acid derivative?
The fibric acid derivatives (gemfibrozil, fenofibrate, bezafibrate) are lipid-lowering agents that act by a number of mechanisms, including reduced secretion of very-low-density lipoproteins by the liver.
Are there any side effects to fenofibrate?
Pancreatitis may occur while you are using this medicine. Tell your doctor right away if you have bloating, sudden and severe stomach pain, chills, diarrhea, fast heartbeat, fever, indigestion. loss of appetite, nausea, pains in stomach, side, or abdomen, possibly radiating to the back, vomiting.
What does fenofibrate do for your body?
Fenofibrate is used together with a proper diet to reduce and treat high cholesterol and triglyceride (fat-like substances) levels in the blood. This may help prevent the development of pancreatitis (inflammation or swelling of the pancreas) caused by high levels of triglycerides in the blood.
What drugs should not be taken with fenofibrate?
Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first. Severe interactions of fenofibrate include: None....Serious Interactions of fenofibrate include:atorvastatin.colchicine.fluvastatin.idelalisib.ivacaftor.lovastatin.pitavastatin.pravastatin.More items...
What can replace fenofibrate?
Fenofibrate Alternatives ComparedVascepa.TriCor.Omega-3 polyunsaturated fatty acids.Trilipix.Lipofen.Rosuvastatin.
How safe is fenofibrate?
In general, fenofibrate can be considered a safe and well-tolerated lipid-lowering drug that has been scrutinized extensively for safety in clinical research and during an already long marketing period in Europe.
Will fenofibrate make you gain weight?
Fenofibrate prevents and reduces body weight gain and adiposity in diet-induced obese rats. FEBS Lett.
Does fenofibrate reduce belly fat?
Fenofibrate lowers abdominal and skeletal adiposity and improves insulin sensitivity in OLETF rats. Biochem Biophys Res Commun.
Can fenofibrate hurt your kidneys?
Adverse events reported with the use of fenofibrate include mild reversible increases in serum creatinine and blood urea nitrogen levels in subjects with normal kidney function or mild to moderate decreased kidney function, as well as those with end-stage kidney disease requiring transplantation.
Can fenofibrate damage your liver?
Fenofibrate therapy is associated with mild and transient serum aminotransferase elevations and with rare instances of acute liver injury, which can be severe and prolonged and lead to significant hepatic fibrosis.
How long fenofibrate can be taken?
Monitoring of cholesterol/triglyceride levels every four to eight weeks is important to establish the effectiveness of fenofibrate therapy. Your doctor should consider discontinuing therapy if you have not had an adequate response after two months of treatment.
Can fenofibrate cause memory loss?
A study including 6,830 community-dwelling residents in France (≥65 years old) found that fibrate use was associated with an increased risk of decline in visual memory over 7 years in women (Hazard ratio [HR]:1.29, 95%CI 1.09 to 1.54, p=0.004), though there was no significant effect on incident dementia risk Page 3 3 ...
What are the side effects of taking fenofibric acid?
Check with your doctor immediately if any of the following side effects occur while taking fenofibric acid: More common. Body aches or pain. chills. cough. difficulty with breathing. ear congestion. fever. headache.
What are the side effects of a syringe?
Side effects not requiring immediate medical attention 1 Acid or sour stomach 2 belching 3 difficulty having a bowel movement (stool) 4 heartburn 5 indigestion 6 pain or tenderness around the eyes and cheekbones 7 stomach discomfort, upset, or pain
Does fenofibric acid need medical attention?
Side effects not requiring immediate medical attention. Some side effects of fenofibric acid may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.
What are the adverse reactions of fenofibrate?
Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure: myalgia, rhabdomyolysis, pancreatitis, muscle spasm, acute renal failure, hepatitis, cirrhosis, anemia, headache, arthralgia, decreases in hemoglobin, decreases in hematocrit, white blood cell decreases, asthenia, severely depressed HDL-cholesterol levels, and interstitial lung disease. Photosensitivity reactions have occurred days to months after initiation; in some of these cases, patients reported a prior photosensitivity reaction to ketoprofen.
What is fenofibric acid?
Fibricor (fenofibric acid) is a lipid -regulating agent indicated as an adjunctive therapy to diet for treatment of severe hypertriglyceridemia and in patients with primary hypercholesterolemia or mixed dyslipidemia.
What are the side effects of a syringe?
chest pain, sudden co ugh, wheezing, rapid breathing, coughing up blood; or. swelling, warmth, or redness in an arm or leg. Common side effects may include: runny nose, sneezing; or. abnormal laboratory tests. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
How long after taking Fibricor should I take it?
Since bile-acid binding resins may bind other drugs given concurrently, patients should take FIBRICOR at least 1 hour before or 4 to 6 hours after taking a bile-acid binding resin to avoid impeding its absorption.
What is the recommended dose of fibrocor?
What Drugs, Substances, or Supplements Interact with Fibricor? Fibricor may be taken with or without meals. Fibricor is available in two strengths: 35 mg and 105 mg. For severe hypertriglyceridemia the recommended dose is 35 to 105 mg/day, though the dose should be adjusted according to patient response.
How much Fibricor should I take for hyperlipidemia?
Fibricor is available in two strengths: 35 mg and 105 mg. For severe hypertriglyceridemia the recommended dose is 35 to 105 mg/day, though the dose should be adjusted according to patient response. Patients with primary hyperlipidemia or mixed dyslipidemia should receive 105 mg/day.
What are the symptoms of a syringe?
Also call your doctor at once if you have: 1 sharp stomach pain spreading to your back or shoulder blade; 2 loss of appetite, stomach pain just after eating a meal; 3 jaundice (yellowing of the skin or eyes); 4 fever, chills, weakness, sore throat, mouth sores, unusual bruising or bleeding; 5 chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or 6 swelling, warmth, or redness in an arm or leg.
How long after fenofibric acid sequestrant?
Management: Separate doses by at least 2 hours to minimize this interaction; fenofibric acid labeling recommends administration one hour prior to or 4-6 hours after a bile acid sequestrant. Exceptions: Colesevelam.
What are the side effects of a syringe?
Other side effects of this drug: Talk with your doctor right away if you have any of these signs of: Liver problems like dark urine, fatigue, lack of appetite, nausea, abdominal pain, light-colored stools, vomiting, or yellow skin. Pancreatitis like severe abdominal pain, severe back pain, severe nausea, or vomiting.
Is fenofibrate a first line drug?
Note: While FDA-approved for hypercholesterolemia, fenofibrate is not a first- or second- line choice; other agents may be more suitable (ACC/AHA [Stone 2013]). In addition, use is not recommended to lower LDL-C or raise HDL-C in the absence of hypertriglyceridemia.
Does fenofibrate increase creatinine?
Fenofibrate has been shown to increase creatinine production (unknown mechanism) resulting in an equal increase of creatinuria thereby demonstrating that the increase does not reflect a reduction in creatinine clearance (Hottelart 2002).
Is fenofibrate safer than gemfibrozil?
In combination with HMG-CoA reductase inhibitors, fenofibrate is generally regarded as safer than gemfibrozil due to limited pharmacokinetic interaction with statins.
What are the side effects of fibric acid?
Some of the most common adverse effects include headache, dizziness, back pain, diarrhea, dyspepsia, nasopharyngitis, sinusitis, and abnormal liver function tests.
What are the contraindications for fibric acid?
Contraindications for the use of fibric acids include a history of hypersensitivity to the drugs in the class, patients with active liver disease, severe renal dysfunction, and preexisting gallbladder disease.
What are the different types of fibric acid?
In the fibric acids drug class, there are three agents of choice: fenofibric acid, fenofibrate, and gemfibrozil. All of these agents are administered orally as either tablets or capsules. Fenofibric acid and fenofibrate are each marketed under several different trade names and available in various strengths.
What are the symptoms of fibric acid overdose?
Signs and symptoms of overdose may include increased CPK, abnormal liver function tests, abdominal pain, diarrhea, joint and muscle pain, nausea, and vomiting. Fibric acids are highly protein-bound, which rules out the use of hemodialysis.
When to use fibric acid?
Fibric acids should be used in conjunction with a restriction of cholesterol and fat intake and exercise if the response to diet and nonpharmacological interventions alone has been inadequate. The clinician should rule out secondary causes of hyperlipidemia before initiating therapy with a fibric acid.
Can you use fenofibric acid while pregnant?
However, fibric acids should only be considered in pregnancy if the benefit outweighs the risk of potential toxicity to the fetus; there is a lack of safety and efficacy data in the pediatric population; fenofibric acids are not recommended for use in pediatric patients with lipid disorders. [5] .
Is fibric acid contraindicated for breastfeeding?
Therefore, fibric acids are contraindicated in women who are breastfeeding. Fibric acids, as a class, are pregnancy category C. There is a documented case of a 30-year-old female who received fenofibrate for the treatment of hypertriglyceridemia. The patient was on fenofibrate therapy for one year.
