Constella side effects
- severe or ongoing diarrhea;
- severe stomach pain; or
- black, bloody, or tarry stools.
How common are adverse reactions to Constella therapy?
Total exposure in the clinical development plan exceeded 1,500 patient-years. The most frequently reported adverse reaction associated with Constella therapy was diarrhoea, mainly mild to moderate in intensity, occurring in less than 20% of patients.
Is Constella safe to use?
Regarding safety, the CHMP concluded that the side effects with Constella, mainly diarrhoea, are manageable. The CHMP therefore decided that Constella’s benefits are greater than its risks and recommended that it be given marketing authorisation.
What should I do if I take too much Constella?
The most likely effect of taking too much Constella is diarrhea. Contact your doctor or pharmacist if you have used too much of this medicine. Do not take a double dose to make up for a forgotten dose. Take the next dose at the usual time and continue as usual. Preferably discuss with a doctor before ending treatment.
What is the recommended dose of Constella?
The recommended dose of Constella is one capsule once a day, taken at least 30 minutes before a meal. The doctor should periodically assess the need of continued treatment. If the patient has not experienced an improvement in symptoms after four weeks of treatment, the benefits and risks of continuing treatment should be reconsidered.
Can I take constella every day?
Take one capsule once daily. Take the capsule at least half an hour before food.
Can you take constella long term?
The CHMP noted that Constella has been shown to have clinically relevant, beneficial effects in patients with IBS with constipation in the long term (for up to six months). It has also been shown to have a beneficial impact on the quality of life of patients.
When do you stop taking constella?
Stop taking the medication and seek immediate medical attention if any of the following occur: new or worsening abdominal pain. severe diarrhea (persistent watery stools)
What happens if you take constella after eating?
Constella produces more frequent bowel movements and diarrhoea (looser stools) when it is taken with food than when it is taken on an empty stomach (see section 3).
Does constella cause fatigue?
Across all studies, diarrhea was the most common adverse reaction to Constella®. Other reported adverse effects included flatulence, abdominal pain, bloating, vomiting, and fatigue, but these were uncommon.
Does constella work right away?
This medication is typically used for the treatment of irritable bowel syndrome. It may also be used to ease constipation. It requires several days to take effect.
How long can you take linaclotide?
Overall, prolonged linaclotide treatment in responding patients should be maintained for between 6 and 12 months. Furthermore, stopping treatment can be considered with the patient's consent, taking into consideration the time needed to achieve a therapeutic effect.
What type of laxative is linaclotide?
Linaclotide is an oral medication for the treatment of constipation. It is the first in a new class of drugs called guanylate cyclase-C agonists. It is used for relieving symptoms of irritable bowel syndrome (IBS) with constipation and for treating chronic constipation of unknown cause (idiopathic constipation).
Can you take linaclotide at night?
Consuming Linzess (linaclotide) at night is not recommended. The best time to take Linzess is in the morning (on an empty stomach), half an hour before breakfast. Consumption of Linzess with food may lead to several gastrointestinal side effects, including gas, diarrhoea, and abdominal pain.
How long can you take linaclotide?
Overall, prolonged linaclotide treatment in responding patients should be maintained for between 6 and 12 months. Furthermore, stopping treatment can be considered with the patient's consent, taking into consideration the time needed to achieve a therapeutic effect.
Can Linzess lose its effectiveness?
Taking expired or improperly stored medication could result in the medication not working properly and may even cause unwanted side effects. Linzess should be stored at room temperature in a dry place in its original container.
Is linaclotide good for IBS?
Linaclotide is an efficacious, well-tolerated treatment option for adults with irritable bowel syndrome with constipation (IBS–C) and chronic idiopathic constipation (CIC). This medication improves both bowel symptoms and abdominal pain and discomfort.
Can Linzess cause bowel obstruction?
Linaclotide (applies to Linzess) gastrointestinal obstruction. Major Potential Hazard, High plausibility. The use of linaclotide is contraindicated in patients with known or suspected mechanical gastrointestinal obstruction. Because linaclotide accelerates gastrointestinal transit, it can exacerbate a blockage.
What side effects are possible with this medication?
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
Can a pharmacist advise on side effects?
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Can you crush a capsule?
Do not crush or chew the capsules. Swallow the capsules whole with some water. If you have trouble swallowing, the contents of the capsule may be sprinkled on applesauce or water. If you are using applesauce, sprinkle the contents of one capsule onto one teaspoon of applesauce and consume immediately.
Are there any other precautions or warnings for this medication?
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
What are the side effects of a syringe?
rapid breathing. shortness of breath. sunken eyes. thirst. tightness in the chest. unusual tiredness or weakness. wrinkled skin. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.
Can medicine cause side effects?
Side Effects. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur:
What happens if you take too much Constella?
The most likely effect of taking too much Constella is diarrhea. Contact your doctor or pharmacist if you have used too much of this medicine.
What is Constella used for?
What Constella is used for#N#Constella contains the active substance linaclotide and is used to treat the symptoms of moderate to severe irritable bowel syndrome (often called IBS) with constipation in adult patients.
How many capsules are in a pack of Constella?
Constella is available in packs containing 10, 28, or 90 capsules and in a multi-pack of 112 capsules divided into 4 cartons with 28 capsules in each. Not all pack sizes may be marketed.
How old do you have to be to take Constella?
Do not give this medicine to children and adolescents under 18 years of age, as the safety and efficacy of Constella for this age group have not been established.
Can Constella be discontinued?
Preferably discuss with a doctor before ending treatment. However, treatment with Constella can be safely discontinued at any time.
Does Constella affect your ability to drive?
Constella does not affect your ability to drive or use machines.
Where to report side effects?
You can also report side effects directly to the Medical Products Agency, www.lakemedelsverket.se. By reporting side effects, you can help increase drug safety information. Postal address
What are the side effects of a syringe?
The most commonly reported side effects included diarrhea, abdominal pain, flatulence, and headache. [ Ref]
What are the side effects of a sour stomach?
belching. indigestion. pain or tenderness around the eyes and cheekbones. pressure in the stomach. stomach discomfort or upset. swelling of the abdominal or stomach area. Managing side effects (general information)
Does linaclotide cause side effects?
Side effects requiring immediate medical attention. Along with its needed effects, linaclotide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Does linaclotide need medical attention?
Side effects not requiring immediate medical attention. Some side effects of linaclotide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
How Does This Medication Work? What Will It Do For Me?
What Form(S) Does This Medication Come in?
How Should I Use This medication?
Who Should Not Take This medication?
What Side Effects Are Possible with This medication?
Are There Any Other Precautions Or Warnings For This medication?
- Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication. Diarrhea:The most common side effect of th...
What Other Drugs Could Interact with This medication?