Does Cytoxan cause kidney damage?
Cytoxan (cyclophosphamide) is a cancer (chemotherapy) medication used alone to treat breast cancer, leukemia, ovarian cancer, and nephrotic syndrome (a disease of the kidneys) in children. Common side effects of Cytoxan include hair loss, nausea, vomiting, diarrhea, mouth sores, weight loss, stomach pain, rash, mouth sores, skin pigmentation, nail changes, sterility, and yellowing skin and ...
Can Cytoxan cause weight gain?
Weight increased is found among people who take Cytoxan, especially for people who are female, 40-49 old, have been taking the drug for 1 - 6 months. The phase IV clinical study analyzes which people take Cytoxan and have Weight increased.
What are side effects with Taxol and Herceptin?
The following side effects are experienced by around 1 in 10 people:
- a reaction to the medicine, such as chills, a high temperature, swelling of the face and lips, headache, hot flushes, feeling sick, wheezing and breathlessness
- tiredness and difficulty sleeping (insomnia)
- diarrhoea or constipation
- a low number of infection-fighting white blood cells, which increases your risk of infections
Can Cytoxan cause hair loss?
Do you lose your hair with cyclophosphamide? Chemotherapy Drugs Most Likely to Cause Hair Loss Chemotherapy medications which cause hair loss, or at least significant hair thinning in the majority of people include: Adriamycin (doxorubicin) Cytoxan or Neosar (cyclophosphamide)
What are the long term side effects of Cytoxan?
The long-term side effects of cyclophosphamide (Cytoxan) are damage to the bladder and the bone marrow. Bladder cancer is a well-known risk and continues to arise at least 10-15 years after the drug was given.
What type of cancer is Cytoxan used for?
Cyclophosphamide is used to treat cancer of the ovaries, breast, blood and lymph system, and nerves (mainly in children). Cyclophosphamide is also used for retinoblastoma (a type of eye cancer mainly in children), multiple myeloma (cancer in the bone marrow), and mycosis fungoides (tumors on the skin).
What should I watch when taking Cytoxan?
Check with your doctor immediately if you notice any unusual bleeding or bruising; black, tarry stools; blood in the urine or stools; or pinpoint red spots on your skin. Be careful when using a regular toothbrush, dental floss, or toothpick.
How do you feel after Cytoxan?
Common side effects of Cytoxan include:nausea or vomiting (may be severe),loss of appetite,stomach pain or upset,diarrhea,temporary hair loss,a wound that will not heal,missed menstrual periods,changes in skin color (darkening), or.More items...
Do you lose your hair with Cytoxan?
Cyclophosphamide may cause a temporary loss of hair in some people. After treatment has ended, normal hair growth should return, although the new hair may be a slightly different color or texture.
What instruction should be given to a patient taking Cytoxan?
Usually it is best to take cyclophosphamide first thing in the morning, to reduce the risk of bladder problems. However, your doctor may want you to take it with food in smaller doses over the day, to lessen stomach upset or help the medicine work better.
What kind of chemo is Cytoxan?
Drug Type: Cyclophosphamide is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. This medication is classified as an "alkylating agent." (For more detail, see "How Cyclophosphamide Works" section below).
Does Cytoxan cause fatigue?
This effect can cause anemia, decrease your body's ability to fight an infection, or cause easy bruising/bleeding. Tell your doctor right away if you develop any of the following symptoms: unusual tiredness, pale skin, signs of infection (such as sore throat that doesn't go away, fever, chills), easy bruising/bleeding.
How long can you take Cytoxan?
An oral dose of 2 mg per kg daily for 8 to 12 weeks (maximum cumulative dose 168 mg per kg) is recommended.
Does Cytoxan cause weight gain?
For example, unlike prednisone, cyclophosphamide is NOT associated with the weight gain, bone thinning, increased blood pressure, or a tendency to induce diabetes.
Does Cytoxan have a black box warning?
Black Box Warnings: The main toxic effect of cytarabine injection is BONE MARROW SUPPRESSION with leukopenia, thrombocytopenia, and anemia.
Does Cytoxan cause heart damage?
Cyclophosphamide is increasingly used to treat various types of cancers and autoimmune conditions. Higher doses of this drug may produce significant cardiac toxicity, including fatal hemorrhagic myocarditis.
What are the side effects of Cytoxan?
What Are Side Effects of Cytoxan? Common side effects of Cytoxan include: nausea or vomiting (may be severe), loss of appetite, stomach pain or upset, diarrhea, temporary hair loss, a wound that will not heal, missed menstrual periods,
What is cytoxan used for?
What Is Cytoxan? Cytoxan (cyclophosphamide) is a cancer ( chemotherapy) medication used to treat several types of cancer. Cytoxan is also used to treat certain cases of nephrotic syndrome (kidney disease) in children.
How long does it take to take Cytoxan?
In treatment of cancer, the initial course of Cytoxan is usually of 40 to 50 mg/kg given intravenously (IV) in divided doses over a period of 2 to 5 days. Other intravenous regimens include 10 to 15 mg/kg given every 7 to 10 days or 3 to 5 mg/kg twice weekly. Oral Cytoxan dosing is usually in the range of 1 to 5 mg/kg/day for both initial and maintenance dosing. For non- malignant disease an oral dose of 2.5 to 3 mg/kg daily for a period of 60 to 90 days is recommended.
What are the side effects of liver disease?
any wound that will not heal; heart problems --swelling, rapid weight gain, pounding heartbeats or fluttering in your chest; liver problems --loss of appetite, stomach pain (upper right side), bloating, dark urine, jaundice (yellowing of the skin or eyes);
Can Cytoxan cause bruising?
changes in skin color (darkening), or. changes in nails. Tell your doctor if you have unlikely but serious side effects of Cytoxan including: pink/bloody urine, unusual decrease in the amount of urine, mouth sores, unusual tiredness or weakness, joint pain, or. easy bruising or bleeding.
Can Cytoxan interact with Digoxin?
Cytoxan may interact with phenobarbital, allopurinol, digoxin, warfarin, thiazide diuretics (water pills), other chemotherapy medicines, or "live" vaccines. Tell your doctor all medications you use.
What are the side effects of Cytoxan?
Common side effects of Cytoxan include hair loss, nausea, vomiting, diarrhea, mouth sores, weight loss, stomach pain, rash, mouth sores, skin pigmentation, nail changes, sterility, and yellowing skin and eyes (jaundice). Use of Cytoxan during pregnancy may cause birth defects. Cytoxan is excreted in breast milk and could cause serious problems in breastfeeding infants.
Does cyclophosphamide cause graft versus host disease?
This interaction may result in an increased incidence of graft-versus-host disease.
Does cyclophosphamide cause side effects?
Along with its needed effects, cyclophosphamide (the active ingredient contained in Cytoxan Lyophilized) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Does cyclophosphamide go away?
These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
What is the trade name for Cytoxan?
Other Trade Name: Neosar ®. Cyclophosphamide is the generic name for the trade name drug Cytoxan or Neosar. In some cases, health care professionals may use the trade name Cytoxan or Neosar when referring to the generic drug name cyclophosphamide. Drug Type: Cyclophosphamide is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug.
What are the side effects of cyclophosphamide?
Discoloration of the skin or nails. The following are less common side effects (occurring in 10-29%) for patients receiving cyclophosphamide: Loss of fertility: Your ability to conceive or father a child may be affected by cyclophosphamide.
Why is chemotherapy given in cycles?
The scheduling of chemotherapy is set based on the type of cells, rate at which they divide, and the time at which a given drug is likely to be effective. This is why chemotherapy is typically given in cycles. Unfortunately, chemotherapy does not know the difference between the cancerous cells and the normal cells.
What is the term for a drug that affects cells only when they are dividing?
They also induce cell suicide (self-death or apoptosis). Chemotherapy drugs that affect cells only when they are dividing are called cell-cycle specific. Chemotherapy drugs that affect cells when they are at rest are called cell-cycle non-specific.
How is cyclophosphamide given?
It is usually given through a vein by injection or infusion (intravenous, IV) or by mouth in tablet form, depending upon diagnosis. Cyclophosphamide is also approved to be given by a shot into a muscle (IM), into the abdominal lining (intraperitoneal, IP), or into the lining of the lung (intrapleural).
How does chemotherapy work?
Usually, the drugs work by damaging the RNA or DNA that tells the cell how to copy itself in division.
Does chemo kill hair?
Chemotherapy will kill all cells that are rapidly dividing. The "normal" cells most commonly affected by chemotherapy are the blood cells, the cells in the mouth, stomach and bowel, are the hair follicles; resulting in low blood counts, mouth sores, nausea, diarrhea, and/or hair loss.
What are the side effects of Cytoxan?
Tell your doctor if you have unlikely but serious side effects of Cytoxan including: pink/bloody urine, unusual decrease in the amount of urine, mouth sores, unusual tiredness or weakness,
What happens when you transport cyclophosphamide vials?
During transport or storage of cyclophosphamide vials, temperature influences can lead to melting of the active ingredient, cyclophosphamide [see DOSAGE AND ADMINISTRATION ]. Cyclophosphamide Tablets, USP are white tablets with blue flecks containing 25 mg and 50 mg cyclophosphamide, respectively.
What is the chemical name for cyclophosphamide?
Cytoxan (cyclophosphamide) is a synthetic antineoplastic drug chemically related to the nitrogen mustards. The chemical name for cyclophosphamide is 2- [bis (2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide monohydrate, and has the following structural formula:
What is cyclophosphamide used for?
Cytoxan (cyclophosphamide) is a cancer ( chemotherapy) medication used to treat several types of cancer. Cytoxan is also used to treat certain cases of nephrotic syndrome (kidney disease) in children.
How long does it take to take cyclophosphamide?
When used as the only oncolytic drug therapy, the initial course of cyclophosphamide for patients with no hematologic deficiency usually consists of 40 mg per kg to 50 mg per kg given intravenously in divided doses over a period of 2 to 5 days.
Where is cyclophosphamide biotransformed?
Cyclophosphamide is biotransformed principally in the liver to active alkylating metabolites by a mixed function microsomal oxidase system. These metabolites interfere with the growth of susceptible rapidly proliferating malignant cells.
Can cyclophosphamide harm a fetus?
Cyclophosphamide can cause fetal harm when administered to a pregnant woman based on its mechanism of action and published reports of effects in pregnant patients or animals. Exposure to cyclophosphamide during pregnancy may cause fetal malformations, miscarriage, fetal growth retardation, and toxic effects in the newborn. Cyclophosphamide is teratogenic and embryo-fetal toxic in mice, rats, rabbits and monkeys. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, apprise the patient of the potential hazard to a fetus.
What are the side effects of a syringe injection?
Frequent urination. redness, swelling, or pain at the injection site. sores in the mouth and on the lips. sudden shortness of breath. unusual thirst. yellow eyes or skin. Some side effects may occur that usually do not need medical attention.
Can medicine cause side effects?
Side Effects. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur:
