what are the side effects of neupogen

Does Neupogen cause cancer?

Can Neupogen cause cancer? Normal individuals are at risk for developing cancer, including leukaemia, lymphoma or other blood diseases throughout their lifetime. Based on limited long-term data from healthy people who have received filgrastim, no long-term risks have been found so far.

When to stop Neupogen?

stop using neupogen and call your doctor at once if you have a serious side effect such as sudden or severe pain in your left upper stomach spreading up to your shoulder, rapid breathing or feeling short of breath, or signs of infection (fever, chills, sore throat, flu symptoms, easy bruising or bleeding, loss of appetite, nausea and vomiting, …

Does Neupogen cause bone pain?

What are the side effects of Neupogen ®? The most common side effect of Neupogen ® is mild to moderate bone pain. Other possible side effects of Neupogen ® include fever, diarrhea, skin rash and weakness. Enlargement and rupture of the spleen can rarely occur in patients who are receiving Neupogen ®.

Does Neupogen cause tiredness?

Stop using Neupogen and call your doctor at once if you have: rapid breathing, feeling short of breath, pain while breathing; capillary leak syndrome - sudden dizziness or light-headed feeling, tiredness, trouble breathing, swelling or puffiness and feeling full;

Before Taking This Medicine

You should not use Neupogen if you are allergic to filgrastim or pegfilgrastim, or to other medicines that contain the E. coli bacteria.To make sur...

How Should I Use Neupogen?

Neupogen is injected under the skin or as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properl...

What Happens If I Miss A Dose?

Use the missed dose as soon as you remember, but not within the 24-hour period before or after you receive chemotherapy treatment. Skip the missed...

What Should I Avoid While Using Neupogen?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

What Other Drugs Will Affect Neupogen?

Other drugs may interact with filgrastim, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your h...

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Sorry, we have no data available. Please contact your doctor or pharmacist.

Are you currently using Neupogen Syringe?

This survey is being conducted by the WebMD marketing sciences department.

What are the adverse reactions to neuogen?

Adverse reactions with ≥ 5% higher incidence in NEUPOGEN patients compared to patients receiving no NEUPOGEN included rash and hypersensitivity.

What is a neupogen?

What Is Neupogen? Neupogen ( filgrastim) is a man-made form of a protein that stimulates the growth of white blood cells in your body used to treat neutropenia, a lack of certain white blood cells caused by cancer, bone marrow transplant, receiving chemotherapy, or by other conditions.

How is Neupogen dose determined?

Dose of Neupogen is individualized, and is determined by the condition being treated and the patient's weight.

What are the signs of an allergic reaction?

Get emergency medical help if you have signs of an allergic reaction: hives, sweating; dizziness, fast heart rate; wheezing, difficult breathing; swelling of your face, lips, tongue, or throat.

Does Neupogen cause a headache?

Common side effects of Neupogen include: aching or pain in the bones and muscles, diarrhea, constipation, hair loss, headache, tired feeling, skin rash, nosebleeds, or.

What are the side effects of a syringe?

nosebleeds; bone pain, muscle or joint pain; diarrhea; headache; numbness; or. rash, thinning hair. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Is filgrastim immunogenic?

As with all therapeutic proteins, there is a potential for immunogenicity. The detection of antibody formation is highly dependent on the sensitivity and specificity of the assay, and the observed incidence of antibody (including neutralizing antibody) positivity in an assay may be influenced by several factors, including assay methodology, sample handling, timing of sample collection, concomitant medications, and underlying disease. For these reasons, comparison of the incidence of antibodies to filgrastim in the studies described below with the incidence of antibodies in other studies or to other products may be misleading.

What other drugs will affect Neupogen?

If you also receive chemotherapy or a bone marrow transplant: Do not use Neupogen within 24 hours before or 24 hours after you receive chemotherapy, or within 24 hours after a bone marrow transplant.

What is the function of neupogen?

Neupogen (filgrastim) is a man-made form of a protein that stimulates the growth of white blood cells in your body. White blood cells help your body fight against infection.

What should I avoid while using Neupogen?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

How is neupogen injected?

Neupogen is injected under the skin or as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

What are the side effects of a syringe?

nosebleeds; bone pain, muscle or joint pain; diarrhea; headache; numbness; or. rash, thinning hair. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Does Neupogen have filgrastim?

Neupogen vials and prefilled syringes do not contain the same concentrations of filgrastim. Do not give an injection unless you are trained in properly measuring your dose from either the vial or the prefilled syringe.

Does Neupogen harm babies?

It is not known whether Neupogen will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

What are the side effects of neupogen?

Common side effects of Neupogen include. nausea, vomiting, bone pain, fever, fatigue, hair loss, diarrhea,

What are the adverse reactions of Neupogen?

Adverse reactions with ≥ 5% higher incidence in Neupogen patients compared to patients receiving no Neupogen included rash and hypersensitivity.

How old was the median age for Neupogen?

The safety population included 518 patients randomized to receive either 5 mcg/kg/day Neupogen (n = 257) or placebo (n = 261). The median age was 54 (range 16 to 89) years and 54% were male.

How long before chemo should you give neupogen?

If you or your child are receiving Neupogen because you are also receiving chemotherapy, the last dose of Neupogen should be injected at least 24 hours before your next dose of chemotherapy. It is unknown if Neupogen will harm a fetus. There are no studies to determine if Neupogen is excreted into breast milk.

Does Neupogen have antibodies?

The incidence of antibody development in patients receiving Neupogen has not been adequately determined. While available data suggest that a small proportion of patients developed binding antibodies to filgrastim, the nature and specificity of these antibodies has not been adequately studied. In clinical studies using Neupogen, the incidence of antibodies binding to filgrastim was 3% (11/333). In these 11 patients, no evidence of a neutralizing response was observed using a cell based bioassay.

Does neupogen cause shortness of breath?

Common side effects of Neupogen include nausea, vomiting, bone pain, fever, fatigue, hair loss, diarrhea, headache, weight loss, shortness of breath, mouth sores, and rash. It is unknown if Neupogen will harm a fetus. There are no studies to determine if Neupogen is excre ted into breast milk.

How to report side effects of prescription drugs?

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

What are the side effects of Neupogen ®?

The most common side effect of Neupogen ® is mild to moderate bone pain.

How does Neupogen ® work?

Patients who receive very high doses of radiation will not be able to produce new white blood cells. This will lead to a drop in the number of white blood cells in circulation.

What is Neupogen ® (Filgrastim)?

Neupogen ® (filgrastim) is a drug that has been used successfully for cancer patients to stimulate the growth of the white blood cells , making patients less vulnerable to infections, it is expected to help patients who have bone marrow damage from very high doses of radiation in much the same way.

Where can I get Neupogen ®?

During a radiation emergency, doctors will provide Neupogen ® treatment as needed.

What happens if you get radiation?

A person who has received a very high dose of radiation may experience bone marrow destruction, possibly resulting in infection and uncontrolled bleeding. Since March 2015, Neupogen ® was also approved by the U.S. Food and Drug Administration (FDA) to treat those people who have received high doses of radiation.

Can pregnant women take neupogen?

Children and pregnant women should take Neupogen ® with caution.

Does Neupogen speed up the process of white blood cell creation?

Neupogen ® can speed up the process of white blood cell creation, reducing the time that the patient is vulnerable to infection.

What are the side effects of Neupogen (filgrastim)?

With any medication, there are risks and benefits. Even if the medication is working, you may experience some unwanted side effects.

Why do you start neupogen 24 hours after chemo?

Neupogen (filgrastim) and other similar medications are started 24 hours after chemotherapy to prevent interactions between the two medications, which can lead to toxic (dangerous) drug levels.

What is Neupogen (filgrastim)?

Neupogen (filgrastim) is a granulocyte colony-stimulating factor (G-CSF). It works like the naturally occurring G-CSF protein in your body to stimulate (trigger) bone marrow to make neutrophils, a type of white blood cell that helps your body fight infections.

How to prevent skin problems from injections?

Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. This will help prevent skin problems from the injections. Do not inject into skin areas that are tender, red, bruised, hard, or has scars or stretch marks.

Where to inject neupogen?

If Neupogen (filgrastim) is injected under the skin (subcutaneously), it can be injected into the outer area of your upper arm, belly (2 inches away from your belly button), thigh, or upper outer buttocks. It needs to be injected into your fatty tissue, not your muscle.

Does Neupogen cause pain?

Injection site pain was not reported during clinical trials of Neupogen (filgrastim), and it might depend on your personal pain tolerance. In general, subcutaneous (under the skin) injections are less painful than ones given in the muscle.

What are the ingredients in Neupogen?

Inactive ingredients: acetate, polysorbate 80, sodium, sorbitol, and water for Injection

How should I take Neupogen?

Neupogen injections can be given by a healthcare provider by intravenous (IV) infusion or under your skin (subcutaneous injection). Your healthcare provider may decide subcutaneous injections can be given at home by you or your caregiver. If Neupogen is given at home, see the detailed “Instructions for Use” that comes with your Neupogen for information on how to prepare and inject a dose of Neupogen.

What should I tell my healthcare provider before taking Neupogen?

Before you take Neupogen, tell your healthcare provider about all of your medical conditions, including if you:

How long after chemo can you take neupogen?

If you are receiving Neupogen because you are also receiving chemotherapy, your dose of Neupogen should be injected at least 24 hours before or 24 hours after your dose of chemotherapy. Your healthcare provider will do blood tests to monitor your white blood cell count, and if necessary, adjust your Neupogen dose.

How long can you leave Neupogen at room temperature?

Throw away (dispose of) any Neupogen that has been left at room temperature for longer than 24 hours.

What is the purpose of neupogen?

G-CSF is a substance produced by the body. It stimulates the growth of neutrophils, a type of white blood cell important in the body’s fight against infection. Acute Radiation Syndrome: The effectiveness of Neupogen for this use was only studied in animals, ...

What are the symptoms of chemotherapy?

Patients with cancer receiving chemotherapy: fever, pain, rash, cough, and shortness of breath. Patients with acute myeloid leukemia receiving chemotherapy: pain, nose bleed, and rash. Patients who are having their own blood cells collected: bone pain, fever, and headache.

Clinical Trials Experience

Adverse Reactions in Patients with Acute Myeloid Leukemia

Adverse Reactions in Patients with Cancer Undergoing Bone Marrow Transplantation

Adverse Reactions in Patients with Severe Chronic Neutropenia

Immunogenicity

• If experienced, these tend to have a Less Severe expression i
  1. itching 2. joint pain 3. muscle pain 4. bone pain 5. fever 6. low energy 7. pain 8. numbness 9. a skin rash 10. headache 11. cough 12. nausea 13. vomiting

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