what are the side effects of simponi

What are the side effects of Simponi ARIA?

Common side effects of Simponi Aria include: infection. Other side effects include: malignant neoplasm. See below for a comprehensive list of adverse effects.

How long do the side effects of Simponi last?

Both Simponi and Simponi Aria can cause side effects, some of which are more common than others. These side effects may be temporary, lasting a few days to weeks. But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist.

Can Simponi ® cause liver problems?

Serious liver problems can happen in people using TNF blockers, including SIMPONI ®. Contact your doctor immediately if you develop symptoms such as feeling very tired, skin or eyes look yellow, poor appetite or vomiting, or pain on the right side of your stomach.

What are the symptoms of a Simponi allergy?

Simponi Consumer Information. Get emergency medical help if you have signs of an allergic reaction: hives, itching; nausea; chest pain, difficulty breathing; swelling of your face, lips, tongue, or throat. You may get infections more easily, even serious or fatal infections.

What infections can golimumab cause?

How common is rhinitis?

What are the side effects of Simponi?

Does Simponi cause side effects?

Does golimumab need medical attention?

Can a health care professional tell you about side effects?

See 3 more

About this website

Is weight gain a side effect of SIMPONI?

It's also important to note that methotrexate (Trexall, Otrexup), a medication sometimes prescribed with Simponi or Simponi Aria, can cause weight gain. Weight gain can also be related to symptoms of the conditions these drugs are prescribed to treat, such as rheumatoid arthritis.

Does Simponi Aria cause high blood pressure?

The most common side effects of SIMPONI ARIA® include: upper respiratory infection, abnormal liver tests, decreased blood cells that fight infection, viral infections, bronchitis, high blood pressure, and rash.

Does SIMPONI cause depression?

In clinical trials, serious depression including suicidality has been reported in patients treated with SIMPONI.

Does SIMPONI weaken immune system?

SIMPONI is a medicine that affects your immune system. SIMPONI can lower the ability of your immune system to fight infections. Some people have serious infections while taking SIMPONI, including tuberculosis (TB), and infections caused by bacteria, fungi, or viruses that spread throughout their body.

Can you drink alcohol on SIMPONI?

Alcohol. There's no known interaction between golimumab and alcohol, so it's fine to have a drink if you're taking this medication.

Why do you have to take methotrexate with SIMPONI?

Studies have found that when methotrexate is taken with some biologic treatments, like SIMPONI®, the 2 medicines together may help to control the symptoms of RA. Biologics may help relieve the joint pain, stiffness, and swelling caused by moderate to severe RA.

Is fatigue a side effect of Simponi Aria?

FDA expands Simponi Aria labeling to include fatigue in RA, PsA.

How long has SIMPONI been on the market?

Development timeline for SimponiDateArticleMay 15, 2013Approval FDA Approves Simponi to Treat Ulcerative ColitisApr 24, 2009Approval Simponi (golimumab) Receives FDA Approval as First Once-Monthly Anti-TNF for Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis1 more row•Jan 28, 2021

How long do you stay on biologics?

It should also be noted that treatment courses for each biologic agent varied, from 6 to 40 weeks of treatment. The treatment duration could have impacted the time to relapse, as many biologics are known to produce a sustained or improved response with longer treatment durations (Figure 3).

What's the cost of Simponi?

GOLIMUMABCode & PrescriberMedicinal Product Pack (Name, form & strength and pack size)General Patient Charge3426HGOLIMUMAB golimumab 50 mg/0.5 mL injection, 0.5 mL syringe (PI, CMI)$42.50Available brandsSimponi

Can Simponi cause lymphoma?

For children and adults taking TNF blockers, including SIMPONI®, the chances for getting lymphoma or other cancers may increase.

How long does SIMPONI take to work for RA?

Simponi can take about 2 weeks before patients start to feel its effects. Some patients notice a benefit shortly after their first dose, while in others it can take several weeks. It can take 4 to 12 weeks before patients feel a lot of benefit.

What is SIMPONI made from?

In the 100-mg strength, 1 mL of SIMPONI contains 100 mg of the golimumab antibody, 0.87 mg of L-histidine and L-histidine monohydrochloride monohydrate, 41.0 mg of sorbitol, 0.15 mg of polysorbate 80, and Water for Injection.

Can you take ibuprofen with SIMPONI?

Interactions between your drugs No interactions were found between ibuprofen and Simponi Aria.

What is the best alcohol to drink if you have rheumatoid arthritis?

Red wine has a compound in it called resveratrol, which has well-established anti-inflammatory effects. Some studies show wine consumption is associated with a reduced risk of knee OA, and moderate drinking is also associated with a reduced risk of RA.

Why should you not touch methotrexate?

Methotrexate and pregnancy Even touching or inhaling the dust from the tablet can allow the medicine to get into the body. Methotrexate goes into sperm, so it's important that a man taking it doesn't get his partner pregnant.

Does SIMPONI cause joint pain?

muscle or joint pain, butterfly-shaped rash on the nose and cheeks, symptoms of heart failure (including swelling ankles or feet, trouble breathing, unusual tiredness), signs of infection (such as fever/chills/cough/persistent sore throat, unusual sweating), or.

How do you permanently treat rheumatoid arthritis?

There is no cure for rheumatoid arthritis. But clinical studies indicate that remission of symptoms is more likely when treatment begins early with medications known as disease-modifying antirheumatic drugs (DMARDs).

What happens if I don't take methotrexate?

Patients who stopped taking methotrexate reported having substantially more gastrointestinal issues — including nausea, abdominal pain, and loss of appetite — from methotrexate than current users did. Just 26 percent of current MTX users reported nausea, compared with 40 percent of those who used it previously.

What is the latest treatment for rheumatoid arthritis?

Official answer. The newest drugs for the treatment of rheumatoid arthritis are the Janus kinase (JAK) inhibitors, which are FDA approved under the brand names Rinvoq, Olumiant, and Xeljanz.

What can cause a sudden increase in blood pressure?

Causes of Blood Pressure SpikesCaffeine. Even if you have normal blood pressure readings, caffeine consumption can cause a temporary but dramatic blood pressure spike. ... Certain Medications. ... Consumption of Foods Containing Tyramine. ... Smoking. ... Stress. ... Anxiety. ... Overactive Adrenal Gland. ... Drug Use.More items...

What drugs increase heart rate and blood pressure?

Stimulants. Stimulants, such as methylphenidate (Ritalin, Concerta, others), can cause your heart to beat faster or irregularly, raising your blood pressure.

What supplements to avoid if you have high blood pressure?

Caffeine and caffeine-like substances can increase the heart rate and, consequently, increase blood pressure. Research has shown that guarana and ephedra supplements, even when taken as directed, can increase blood pressure and heart rate.

What is the main cause of high blood pressure?

What causes high blood pressure? High blood pressure usually develops over time. It can happen because of unhealthy lifestyle choices, such as not getting enough regular physical activity. Certain health conditions, such as diabetes and having obesity, can also increase the risk for developing high blood pressure.

Common and Rare Side Effects for Simponi Syringe - WebMD

COMMON side effects If experienced, these tend to have a Severe expression i ; a systemic inflammatory response called sepsis due to an infection with bacteria

Side Effects of Simponi (Golimumab) - Verywell Health

Allergic reactions: Let your healthcare provider know if you are allergic to latex or rubber because the cover for the needle used for injection contains dry natural rubber.; Pregnancy: Tell your practitioner if you are pregnant, are planning on becoming pregnant, or breastfeeding. Infections: Let your medical provider know if you have an infection or if you're being treated for symptoms of ...

Simponi Aria Side Effects: Common, Severe, Long Term - Drugs.com

Simponi Aria Side Effects. Generic name: golimumab Medically reviewed by Drugs.com. Last updated on Apr 25, 2022. Consumer; Professional; FAQ; Note: This document contains side effect information about golimumab. Some of the dosage forms listed on this page may not apply to the brand name Simponi Aria.. Summary

Side Effects of Simponi Injection (Golimumab Injection ... - RxList

What Is Simponi? Simponi (golimumab injection) is a human IgG1k monoclonal antibody used to treat rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.Simponi is sometimes used with another medication called methotrexate (Rheumatrex, Trexall).Simponi works by blocking a protein (tumor necrosis factor or TNF) found in the body's immune system that causes joint swelling and damage.

SIMPONI® (golimumab) Side Effects & Safety

SIMPONI ® (golimumab) Other Important Considerations. SIMPONI ® can lower your ability to fight infections. Serious and sometimes fatal events may occur. There have been reports of serious infections including tuberculosis (TB) and infections caused by bacteria, fungi, or viruses that have spread throughout the body.

Simponi Injection: Uses, Dosage, Side Effects - Drugs.com

Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 1 Sep 2022), Cerner Multum™ (updated 21 Sep 2022), ASHP (updated 12 Sep 2022 ...

What infections can golimumab cause?

Serious Infections and MalignancySerious infections leading to hospitalization or death including tuberculosis (TB), bacterial sepsis, invasive fungal (such as histoplasmosis), and other opportunistic infections have occurred in patients receiving golimumab.Discontinue golimumab if a patient develops a serious infection or sepsis.Perform test for latent TB; if positive, start treatment for TB prior to starting golimumab.Monitor all patients for active TB during treatment, even if initial latent TB test is negative.Lymphoma and other malignancies, some fatal, have been reported in children and adolescent patients treated with TNF blockers, of which golimumab is a member.

What are the side effects of Simponi Aria?

Common side effects of Simponi Aria include: infection. Other side effects include: malignant neoplasm. See below for a comprehensive list of adverse effects.

What are the side effects of taking Golimumab?

Check with your doctor immediately if any of the following side effects occur while taking golimumab: More common. Body aches or pain. chills.

Can you discontinue golimumab?

Serious Infections and MalignancySerious infections leading to hospitalization or death including tuberculosis (TB), bacterial sepsis, invasive fungal (such as histoplasmosis), and other opportunistic infections have occurred in patients receiving golimumab.Discontinue golimumab if a patient develops a serious infection or sepsis.Perform test for latent TB; if positive, start treatment for TB prior to starting golimumab.Monitor all patients for active TB during treatment, even if initial latent TB test is negative.Lymphoma and other malignancies, some fatal, have been reported in children and adolescent patients treated with TNF blockers, of which golimumab is a member.

Does golimumab need medical attention?

Side effects not requiring immediate medical attention. Some side effects of golimumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.

Can a health care professional tell you about side effects?

Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Less common.

What is Simponi 2021?

Updated on March 03, 2021. Simponi (golimumab) is a tumor necrosis factor-alpha (TNF-alpha) inhibitor approved to treat ulcerative colitis, ankylosing spondylitis, psoriatic arthritis, and rheumatoid arthritis. The side effects of this medication vary and can include serious infections, bruising, a rash, and more.

What infections can you get from Simponi?

Some of the infections you may be at increased risk for while on Simponi include aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, histoplasmosis, legionellosis, listeriosis, pneumocystosis, and tuberculosis. 3

What is the black box warning for Simponi?

Simponi carries a black box warning from the U.S. Food and Drug Administration (FDA), which is the most serious warning issued by the agency. It alerts healthcare providers and patients to potentially serious side effects that can lead to injury and death.

Can you take Simponi while taking other biologics?

A higher rate of infections has also occurred in people who take other biologic drugs, like those commonly used for rheumatoid arthritis, while taking Simponi. Also, people taking Simponi should avoid getting live vaccines because they can cause infections if your immune system is suppressed.

What are the warnings for a syringe?

This medication comes with several important warnings: 1. Allergic reactions: Let your doctor know if you are allergic to latex or rubber because the cover for the needle used for injection contains dry natural rubber. Pregnancy: Tell your doctor if you are pregnant, are planning on becoming pregnant, or breastfeeding.

What are the symptoms of a swollen thigh?

Symptoms of liver damage, including dark urine, persistent nausea or vomiting, stomach or abdominal pain, or yellow eyes or skin. Weakness, numbness, or tingling of the arms or legs.

What are the symptoms of heart failure?

Hives and swollen eyes, lips, mouth, throat, or tongue. Symptoms of heart failure, including swelling in the ankles or feet, trouble breathing, unusual tiredness. Signs of infection, such as fever, chills, cough, persistent sore throat, unusual sweating.

What is SIMPONI used for?

SIMPONI® (golimumab) is a prescription medicine. SIMPONI® can lower your ability to fight infections. There are reports of serious infections caused by bacteria, fungi, or viruses that have spread throughout the body, including tuberculosis (TB) and histoplasmosis. Some of these infections have been fatal. Your doctor will test you for TB before starting SIMPONI® and will monitor you for signs of TB during treatment. Tell your doctor if you have been in close contact with people with TB. Tell your doctor if you have been in a region (such as the Ohio and Mississippi River Valleys and the Southwest) where certain fungal infections like histoplasmosis or coccidioidomycosis are common.

When to tell your doctor about simponia?

Tell your doctor if you are pregnant, planning to become pregnant or are breastfeeding or have a baby and were using SIMPONI ® during pregnancy. Tell your baby’s doctor before your baby receives any vaccine because of an increased risk of infection for up to 6 months after birth.

Can you die from taking Simponi?

HEART FAILURE. Heart failure can occur or get worse in people who use TNF blockers, including SIMPONI®. If you develop new or worsening heart failure with SIMPONI ®, you may need treatment in a hospital, and it may result in death. Your doctor will closely monitor you if you have heart failure.

What happens if you don't have enough blood cells?

If this occurs, your body may not make enough blood cells to help fight infections or help stop bleeding. Your doctor will check your blood counts before and during treatment. Tell your doctor if you have signs such as fever, bruising, bleeding easily, or paleness.

What are the symptoms of a rash on the cheeks?

Tell your doctor if you have any symptoms such as a rash on your cheeks or other parts of the body, sensitivity to the sun, new joint or muscle pain, becoming very tired, chest pain or shortness of breath, swelling of the feet, ankles, and/or legs.

Can TNF blockers cause cancer?

Unusual cancers have been reported in children and teenage patients taking TNF‑blocker medicines. For children and adults taking TNF blockers, including SIMPONI ®, the chances for getting lymphoma or other cancers may increase. Hepatosplenic T-cell lymphoma, a rare and fatal lymphoma, has occurred mostly in teenage or young adult males with Crohn’s disease or ulcerative colitis who were taking other TNF blockers with azathioprine or 6‑mercaptopurine. You should tell your doctor if you have had or develop lymphoma or other cancers.

What are the symptoms of TB?

shortness of breath. blood in phlegm. weight loss. warm, red, or painful skin or sores on your body. diarrhea or stomach pain. burning when you urinate or urinate more than normal. feel very tired. Your doctor will examine you for TB and perform a test to see if you have TB.

What is Simponi used for?

Simponi (golimumab injection) is a human IgG1k monoclonal antibody used to treat rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. Simponi is sometimes used with another medication called methotrexate ( Rheumatrex, Trexall ). Simponi works by blocking a protein ( tumor necrosis factor or TNF) found in the body's immune system that causes joint swelling and damage.

How often is Simponi given?

The Simponi dose regimen is 50 mg administered by subcutaneous ( SC) injection once a month.

What are the side effects of Simponi?

Common side effects of Simponi include: injection site reactions (redness, itching, pain, or swelling). Tell your doctor if you have serious side effects of Simponi including: symptoms of liver damage (including dark urine, persistent nausea/ vomiting / loss of appetite, stomach/abdominal pain, or yellow eyes or skin).

What is the most common adverse reaction in Phase 3?

Upper respiratory tract infection and nasopharyngitis were the most common adverse reactions reported in the combined Phase 3 RA, PsA and AS trials through Week 16, occurring in 7% and 6% of SIMPONI-treated patients as compared with 6% and 5% of control-treated patients, respectively.

How many patients were in the Phase 2/3 trial of SIMPONI?

In the Phase 2/3 trials in UC evaluating 1233 SIMPONI-treated patients, no new adverse drug reactions were identified and the frequency of adverse drug reactions was similar to the safety profile observed in patients with RA, PsA and AS.

What is the medical term for a skin disorder?

Skin and subcutaneous tissue disorders: Psoriasis (new onset or worsening, palmar/plantar and pustular), vasculitis (cutaneous)

What is the term for stiffness in the joints?

The term arthritis refers to stiffness in the joints. See Answer

Simponi and Simponi Aria basics

Simponi and Simponi Aria belong to a group of drugs called tumor necrosis factor (TNF) blockers.

Mild side effects

Here’s a short list of some of the mild side effects that Simponi and Simponi Aria can cause. To learn about other mild side effects, talk with your doctor or pharmacist, or read Simponi and Simponi Aria’s prescribing information.

Serious side effects

Serious side effects from Simponi and Simponi Aria can occur, but they aren’t common. If you have serious side effects from Simponi or Simponi Aria, call your doctor right away. But if you think you’re having a medical emergency, call 911 or your local emergency number.

Side effect focus

Learn more about some of the side effects Simponi and Simponi Aria may cause.

Accessible medication containers and labels

If it’s hard for you to read the label on your prescription, tell your doctor or pharmacist. Certain pharmacies may provide medication labels that:

Using Simponi and Simponi Aria with other drugs

Whether you are prescribed Simponi and Simponi Aria with other drugs will depend on the condition you’ve been prescribed the drugs to treat. Your doctor will tell you whether you’ll use Simponi and Simponi Aria with other drugs for your specific condition.

Questions about Simponi and Simponi Aria

See below for answers to some questions you may have about Simponi or Simponi Aria.

What infections can golimumab cause?

Serious Infections and MalignancySerious infections leading to hospitalization or death including tuberculosis (TB), bacterial sepsis, invasive fungal (such as histoplasmosis), and other opportunistic infections have occurred in patients receiving golimumab.Discontinue golimumab if a patient develops a serious infection or sepsis.Perform test for latent TB; if positive, start treatment for TB prior to starting golimumab.Monitor all patients for active TB during treatment, even if initial latent TB test is negative.Lymphoma and other malignancies, some fatal, have been reported in children and adolescent patients treated with TNF blockers, of which golimumab is a member.

How common is rhinitis?

Very common (10% or more): Upper respiratory tract infections (nasopharyngitis, pharyngitis, laryngitis, and rhinitis) (up to 16%)

What are the side effects of Simponi?

Common side effects of Simponi include: infection . Other side effects include: malignant neoplasm. See below for a comprehensive list of adverse effects.

Does Simponi cause side effects?

Side effects requiring immediate medical attention. Along with its needed effects, golimumab (the active ingredient contained in Simponi) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur ...

Does golimumab need medical attention?

Side effects not requiring immediate medical attention. Some side effects of golimumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.

Can a health care professional tell you about side effects?

Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Less common.

Common Side Effects

Serious Side Effects

Warnings

A Word from Verywell