what can you do for mthfr mutation

Eating a healthy MTHFR diet is a mainstay of treatment for the MTHFR mutation. People with an MTHFR mutation need to avoid folic acid to ensure proper methylation, as the body is not able to utilize this synthetic form of the vitamin folate

. Folic acid is found in vitamins and processed foods.

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How did you treat the MTHFR mutation?

MTHFR mutations do not require medical treatment. That said, making dietary and lifestyle changes can often help offset any resulting nutritional deficiencies. For example, people with high ...

Is MTHFR and Lupus the same thing?

The relationship between MTHFR (5, 10-methylene tetrahydrofolate reductase) gene polymorphisms and Systemic Lupus Erythematosus (SLE) has been wildly studied, but the results are still conflicting.

Is genetic testing necessary if you suspect MTHFR mutation?

The quick answer is no. You probably don’t need genetic testing for MTHFR even if you suspect there’s a problem, but you still might want it. If that isn’t enough information, then read on! Why Genetic Testing for MTHFR Might Not Be Necessary

What do you need to know about MTHFR and anesthesia?

MTHFR and Anesthesia. As I mention above, people with MTHFR cannot detox well. Thus, when given certain medication, vitamins and supplements, there can be adverse reactions. In many cases where anesthesia is used, the situation is immediate or an emergency and there isn’t much time to gather needed information on the spot.

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What is the treatment for MTHFR mutation?

MTHFR mutations do not require medical treatment. That said, making dietary and lifestyle changes can often help offset any resulting nutritional deficiencies. For example, people with high homocysteine levels due to folate or vitamin B12 deficiencies can take folic acid or vitamin B12, respectively.

What foods to avoid if you have MTHFR?

People with MTHFR mutations may want to avoid foods that contain the synthetic form of folate, folic acid — though it's unclear whether that's necessary or beneficial. Be sure to check labels, as this vitamin is added to many enriched grains, like pasta, cereals, breads, and commercially produced flours.

Is MTHFR mutation curable?

Even though adolescent/adult onset MTHFR deficiency is a rare disease, it is a treatable one, for which metabolic treatment comprising B9, B12 and betaine can prevent disease progression and promote improvement.

How serious is MTHFR mutation?

At least 40 mutations in the MTHFR gene have been identified in people with homocystinuria, a disorder in which the body is unable to process homocysteine and methionine properly. People with this condition often develop eye problems, abnormal blood clotting, skeletal abnormalities, and learning problems.

What is the best vitamin for MTHFR?

Methyl-B12, methyl-folate, TMG, N-acetylcysteine, riboflavin, curcumin, fish oil, Vitamins C, D, E, and probiotics are excellent supplements your body will love more so if you have an MTHFR mutation.

How do you treat MTHFR naturally?

Natural treatments for MTHFR mutation symptomsConsume more folate and vitamin B12. Consuming more folate in your diet may aid with methylation. ... Support detoxification. ... Minimize alcohol intake. ... Manage your stress with lifestyle changes. ... Check your supplements. ... Heal any underlying digestive issues.

What are the signs and symptoms of MTHFR?

MTHFR Mutation Symptoms:Depression.Bipolar disorder.Anxiety.Schizophrenia.Acute leukemia.Colon cancer.Cardiovascular and thromboembolic disorders.Chronic pain and fatigue.More items...

How do you detox with MTHFR?

MTHFR is a genetic variant or SNP (single nucleotide polymorphism) that can have significant consequences on health....Here are some strategies for detoxification that can be done at home:Epsom salt baths.Dry skin brushing.Castor oil packs.Exercise, especially exercise that produces a sweat.Sauna therapy.Coffee enemas.

What happens if you have MTHFR and take folic acid?

You might have read or heard that folic acid is not safe if you have one or two copies of the MTHFR C677T variant. This is not true. Even if you have one or two copies of the MTHFR C677T variant, your body can safely and effectively process all different types of folate, including folic acid.

What happens if you have MTHFR?

If you have an MTHFR mutation, your MTHFR gene may not work right. This may cause too much homocysteine to build up in the blood, leading to various health problems, including: Homocystinuria, a disorder that affects the eyes, joints, and cognitive abilities. It usually starts in early childhood.

Is MTHFR and autoimmune disorder?

Previous studies have provided evidence that a high prevalence of MTHFR gene polymorphisms is frequently detected in patients with autoimmune disease, suggesting a novel genetic association with autoimmune disorders.

Are you born with MTHFR mutation?

Nothing causes you to have a mutated MTHFR gene. It's simply passed onto you from your mother and father. You may be at risk if you've had: recurrent pregnancy losses.

What foods should you eat if you have MTHFR?

Load up on varieties such as arugula, kale, swiss chard, bok choy, spinach, collard greens, mustard greens, beet greens, and broccoli rabe for natural folate. Consuming ample amounts of these greens on a daily basis ensures that plenty of natural B9 is getting into the diet.

Can you eat dairy with MTHFR?

For people with MTHFR mutation, the consumption of dairy isn't the best idea. Dairy products could be bad for you because they may impair the way the body processes folate and transports it to your brain. Dairy, especially cow's milk, contains folate receptor A; the main receptor through which folate reaches the brain.

What deficiencies does MTHFR cause?

A mutation in your MTHFR gene may lead to low vitamin B-12 and folate levels and high homocysteine levels. This *might* increase your risk of experiencing blood clots, thyroid conditions, and developmental issues for a fetus.

What foods are high in Methylfolate?

The best sources of methyl-folate are spinach, asparagus, romaine lettuce, turnip greens, mustard greens, collard greens, cauliflower, broccoli, parsley, lentils and beets. Calf's liver is also a great source – but look for hormone and antibiotic-free animal sources that are naturally raised.

What are the MTHFR gene mutation symptoms?

Symptoms of the MTHFR gene mutation include neural tube defects, sugar bug vein, and chronic fatigue and pain.

What do you do if you have the MTHFR gene mutation?

If your MTHFR mutation test indicates that you have the mutation, you should take methylation supplements, follow a MTHFR detox protocol,

How do you know if you have the MTHFR gene mutation?

You should take a MTHFR mutation test. You should also look out for MTHFR gene mutation symptoms including sugar bug vein, chronic pain and fatigue...

Can the MTHFR gene mutation cause autoimmune disorders?

The MTHFR gene mutation can cause autoimmune disorders. Since the MTHFR gene mutation causes the body to be less able to methylate, it is hard for...

What Is The MTHFR Gene and What Does It do?

The MTHFR gene is responsible for the production of an enzyme called methylenetetrahydrofolate reductase, within our bodies. The role of that enzym...

What Are The Symptoms of A MTHFR Mutation?

The less efficiently your body can use folic acid, the more likely you are to experience health issues such as those listed above. That is because...

How Do I Find Out If I Have An MTHFR Mutation?

Traditional medical doctors do not generally test for MTHFR mutations, or are not yet trained to address the condition appropriately. Too often, pa...

How Can We Influence Our Genes?

Although this health condition is linked to a genetic mutation, it is important to remember that we can influence our genes.It used to be thought t...

How Can An MTHFR Mutation Be Treated?

Bear in mind, there is NO a one-size-fits-all approach for addressing an MTHFR mutation. Treatment is completely individualized based on your perso...

How Much Folate Should I take?

I never recommend a standard dose of folate, as it varies greatly from person to person. As mentioned, I first recommend my patients get a homocyst...

Who Should Test for MTHFR Mutations?

I firmly believe that is knowledge is power, and understanding your MTHFR mutation test status is an empowering tool to take back your health and eliminate MTHFR mutation symptoms!

How Does Detox Happen with an MTHFR Mutation?

In my clinic, when my patients and I uncovered one or more MTHFR mutations, I used a hypothetical example to demonstrate the impact these mutations have on the detoxification process. You can learn more about mercury overload in this article.

What is the MTHFR Gene and the MTHFR Mutation?

The MTHFR gene (not to be confused with the MTHFR enzyme) is one of the 20,000 genes in the human body. It is a ‘master instruction sheet’ for the production of the MTHFR enzyme.

What is MTHFR?

Methylenetetrahydrofolate reductase (MTHFR), is an enzyme that works as a catalyst for important biochemical reactions in your body. It converts vitamin B9 (folate) into methyl-folate which is essential for a process called methylation.

What Does MTHFR Produce?

One of the most important tasks methylation performs is turning homocysteine into methionine. Methionine builds proteins, repairs cells, detoxifies, supports your inflammatory response, and helps your liver process fats.

What is the homocysteine level in MTHFR?

An optimal homocysteine level is 6-9 umol/L.

Does MTHFR affect your health?

In addition to supplementing with Methylation Support®, we can work with our bodies to ensure the MTHFR gene mutation does not negatively impact our health. We used to think that our genes were static and there was nothing we could do about them — we now know that’s not true! An emerging science called epigenetics shows us that genes can be both turned on and turned off.

What is the MTHFR mutation?

The MTHFR gene mutation inhibits the way the body processes folic acid and other important B vitamins. Changing the supplementation of this nutrient is a potential focus in countering its effects. Folic acid is actually a man-made version of folate, a naturally occurring nutrient found in foods.

What is a confirmed MTHFR mutation?

a confirmed MTHFR mutation. vitamin deficiencies in folate, choline, or vitamins B-12, B-6, or riboflavin. In these cases, your doctor may suggest supplementation to address deficiencies along with medications or treatments to address the specific health condition.

What are the two variants of MTHFR?

There are two variants, or forms, of mutations that can occur on the MTHFR gene. Specific variants are: C677T. About 30 to 40 percent of the American population may have a mutation at gene position C677T. Roughly 25 percent of people of Hispanic descent, and 10 to 15 percent of Caucasian descent, are homozygous for this variant.

How long does it take to get a MTHFR test?

The test is performed by collecting DNA from the inside of your cheek with swabs. After shipping the specimen, results take one to two weeks.

What does it mean if you have a MTHFR?

Having an MTHFR variant doesn’t mean you need medical treatment. It could just mean you need to take a vitamin B supplement.

What percentage of women have multiple mutations?

It found that 59 percent of them had multiple homozygous gene mutations, including MTHFR, associated with blood clotting, versus only 10 percent of women in the control category. Speak with your doctor about testing if any of the following situations apply to you: You’ve experienced several unexplained miscarriages.

How to improve your overall health?

Continue to eat well, exercise, and practice other healthy lifestyle habits to support your overall well-being.

How Do I Find Out if I Have an MTHFR Mutation?

It has only been a little over a decade since geneticists mapped out the human genome. In that time, researchers have started linking specific genes to various health concerns and metabolic processes, but there is still so much more to learn and integrate into medical care.

What Are the Symptoms of a MTHFR Mutation?

That is because folate is used by the body to ensure healthy heart function, balanced neurotransmitter levels, energy production, liver detoxification, glutathione production, and new healthy cells such as when growing a baby – making this subject particularly important for women.

What Is the MTHFR Gene and What Does It Do?

The MTHFR gene is responsible for the production of an enzyme called methylenetetrahydrofolate reductase, within our bodies. The role of that enzyme is to turn folic acid into folate, which our bodies use in many ways, such as to make new cells (like red blood cells) and neurotransmitters, as well as in a process called methylation (our body’s way of controlling gene expression).

What is the process of methylation called?

Homocysteine comes together with folate and methyl-B12 to make something called SAM or S-adenosylmethionine (in supplements, it is called SAMe). This process is called “ methylation ,” because a methyl group is added to create SAM. SAM is the metabolic substance that goes out and does all kinds of good things in our bodies. Without enough SAM, our metabolic processes, including detoxification in the liver, breakdown of adrenaline, and energy production in the mitochondria, come to a standstill.

What is the clinical significance of MTHFR?

Two forms of MTHFR mutation are considered clinically significant in terms of our health: MTHFR A1298C and MTHFR C677T. If you have one SNP on either A1298C or C677T, your ability to turn folic acid into folate could be decreased by about 30%. If you have two SNPs on either 1298 or C677T, or one of each, then you may be up to 70% less able ...

Is MTHFR a curse word?

Patients often come to see me after they have learned, either from a doctor or through personal discovery, that they have an MTHFR mutation. MTHFR is not just a mouthful of letters that look like they could be a curse word. For many people, it is a long sought-after answer and the validation of health issues such as heart disease, heart attacks, ...

Is MTHFR a genetic mutation?

For many people, it is a long sought-after answer and the validation of health issues such as heart disease, heart attacks, strokes, headaches, migraines, anxiety, depression, fatigue, miscarriages, cervical dysplasia, cancer, and cognitive decline. Because MTHFR is a genetic mutation, it’s easy to think we can’t do anything for it.

How to check for MTHFR mutation?

Your doctor can also check for signs of MTHFR gene mutation by testing your homocysteine levels. This is often covered by insurance, but is not 100% conclusive.

How to change MTHFR gene?

6 Simple Changes to Support Your MTHFR Gene Mutation. 1. Look for methylated supplements – and avoid folic acid. Make sure that the supplements you buy are methylated, which means they need to either say “methyl-folate” or “folate” on the label. Folic acid, however, will be difficult for your body to assimilate, so avoid it.

What are indicators and symptoms that I have the MTHFR gene mutation?

While there are indicators and non-specific symptoms that can indicate having the MTHFR mutation, there isn’t a definitive list that will tell you if have it.

What is the best diet for MTHFR?

A diet rich in folate (not to be confused with the synthetic form called folic acid) would be beneficial for someone with the MTHFR gene mutation. Selective supplementation of high quality, practitioner-grade methylated B vitamins is also crucial for someone with this genetic mutation.

How many people are affected by MTHFR mutation?

But actually, the MTHFR gene mutation affects about 30-50% of people. Before you get freaked out by the word “mutation”, let me explain. If you don't care about the science, you can skip the next couple of paragraphs. However, I believe that when we understand the science, we can take more control over our health.

How to get folate into your diet?

If you tolerate legumes and lentils (preferably soaked and sprouted) are also a great way to get folate into your diet. 3. Treat your candida overgrowth. Again, it’s important to work with a practitioner to identify and treat a candida overgrowth.

Can you use stratagone to test for genetics?

Genetic snps are not easy to understand, and the average primary care physician won’t know what they mean (or even how to interpret your results!). Strategene not only tells you your genetic makeup (aka any gene mutations like MTHFR), but they give you personalized recommendations on optimizing your lifestyle to support your genetic mutations.

What happens during an MTHFR mutation test?

A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.

What is an MTHFR mutation test?

This test looks for mutations (changes) in a gene called MTHFR. Genes are the basic units of heredity passed down from your mother and father.

How to lower homocysteine levels?

You can reduce your homocysteine levels by taking folic acid or other B vitamins These can be taken as supplements or added through dietary changes. If you need to take folic acid or other B vitamins, your health care provider will recommend which option is best for you.

What are the variants of MTHFR?

There are different types of MTHFR mutations. An MTHFR test looks for two of these mutations, also known as variants. The MTHFR variants are called C677T and A1298C. The MTHFR gene helps your body break down a substance called homocysteine.

What happens if you have too much homocysteine?

This may cause too much homocysteine to build up in the blood, leading to various health problems, including: Homocystinuria, a disorder that affects the eyes, joints, and cognitive abilities. It usually starts in early childhood. An increased risk of heart disease, stroke, high blood pressure, and blood clots.

Does folic acid break down homocysteine?

Normally, folic acid and other B vitamins break down homocysteine and change it into other substances your body needs. There should then be very little homocysteine left in the bloodstream. If you have an MTHFR mutation, your MTHFR gene may not work right.

Is there anything else I need to know about an MTHFR mutation test?

Some health care providers choose to only test for homocysteine levels, rather than doing a MTHFR gene test. That is because treatment is often the same, whether or not high homocysteine levels are caused by a mutation.

What mutations are most common in MTHFR?

MTHFR C677T and A1298C gene mutations are the most common and the ones that are typically tested.

What is the function of MTHFR?

The MTHFR enzyme is critical for metabolizing one form of B vitamin, folate, into another. It is also part of the process that converts homocysteine into methionine, an important building block for many proteins. If someone has increased levels of homocysteine, that means the body is not processing it properly.

What is the effect of C677T on the MTHFR enzyme?

When a person has two copies of the MTHFR C677T gene mutation (homozygous) or one copy of MTHFR C677T and one copy of A1298C (compound heterozygous), decreased MTHFR enzyme activity slows down the homocysteine-to-methionine conversion process and can lead to a buildup of homocysteine in the blood.

What are the two variants of MTHFR?

The two MTHFR variants are called C677T and A1298C, and individuals can inherit one or both variants. These SNPs result in changes in the DNA (or mutations) that are associated with decreased MTHFR activity and increased homocysteine levels in the blood, which may increase the risk of premature cardiovascular disease (CVD), ...

What is the MTHFR gene?

The methylenetetrahydrofolate reductase ( MTHFR) gene contains the DNA code to produce the MTHFR enzyme. This test detects two of the most common mutations. When there are mutations or variations in the MTHFR gene, it can lead to serious genetic disorders such as homocystinuria, anencephaly, spina bifida, and others.

When to order MTHFR test?

The MTHFR mutation test may sometimes be ordered when a person has elevated homocysteine levels, especially when the person has a personal or family history of premature cardiovascular disease or thrombosis . It may sometimes be ordered when a close relative has MTHFR gene mutations, although it may not be useful if that relative has normal homocysteine levels, and some laboratories and organizations recommend against using it for thrombophilia screening.

Is homocysteine a risk marker?

Routine testing for homocysteine levels as a cardiac risk marker is not recommended by the American Heart Association. The College of American Pathologists and the American College of Medical Genetics recommend against testing for the C677T variant, citing limited utility for patients with blood clots.

What supplements are used to treat MTHFR?

Lifestyle modifications (healthy diet, no smoking, and keeping the body physically fit) Vitamin B supplements (such as folic acid) are most commonly prescribed by doctors to treat MTHFR mutation. Multivitamins.

What is the MTHFR mutation?

The term MTHFR stands for methylenetetrahydrofolate reductase. MTHFR is an enzyme that breaks down the amino acids' homocysteine and folate. Homocysteine is an amino acid that works to maintain the body’s cells. Folate is one of the B- vitamins needed to make red ...

What are the conditions associated with MTHFR?

Conditions associated with MTHFR include. Increased susceptibility to cardiovascular and thromboembolic diseases ( blood clots, stroke, embolism, and heart attacks) Depression. Anxiety.

Is MTHFR genetic testing discouraged?

Unless these symptoms are present, genetic testing is often discouraged. Healthcare professionals often recommend monitoring enzyme activity alongside other preventative measures. Treatment options are available for the MTHFR gene mutation. Patients with or without symptoms are advised to eat well and lead a healthy lifestyle filled with exercise , proper sleep, and other lifestyle habits that support wellbeing.

Does MedicineNet provide medical advice?

MedicineNet does not provide medical advice, diagnosis or treatment. See additional information.

Does MTHFR affect everyone?

The MTHFR mutation does not affect everyone in the same way. Yet those with the mutation may have higher-than-normal levels of homocysteine in their blood or urine, and symptoms due to such issues may arise. Unless these symptoms are present, genetic testing is often discouraged.

How to avoid MTHFR?

The body’s ability to detoxify chemicals, alcohol, pesticides and hormones in food is impaired with this mutation. Choose organic, non-GMO foods , avoid exposure to cigarette smoke and limit alcohol to a few drinks per week if at all. Avoid artificial sweeteners and limit sugar in the MTHFR diet. Avoid bottled water and food packaged with plastics due to BPA. Filter your water and drink half of your body weight in ounces each day. For example, if you weigh 150 pounds drink 75 ounces of water, organic green or black tea or organic coffee per day. Limit caffeine to two servings per day.

What is the best diet for MTHFR?

Eating a healthy MTHFR diet is a mainstay of treatment for the MTHFR mutation. People with an MTHFR mutation need to avoid folic acid to ensure proper methylation, as the body is not able to utilize this synthetic form of the vitamin folate. Folic acid is found in vitamins and processed foods. One of the main sources for folic acid in the U.S. diet is enriched grains, including bread, cereals, crackers, pasta and other processed carbohydrates.

What vitamins are needed for methylation?

Other B vitamins including thiamin, niacin, riboflavin, vitamin B-6, vitamin B-12, pantothenic acid and biotin may be needed in higher amounts for proper methylation and related biochemical reactions. The active forms of some of the B vitamins can be found in supplements only, and until the body has optimal methylation and other biochemical processes occurring, supplements may be needed. The breakdown of homocysteine, to methionine can be impaired with the MTHFR mutation, and this results in a higher need for methylfolate or folinic acid, and the active forms of vitamins B-12 and B-6. Consult with your MTHFR healthcare practitioner regarding appropriate use of supplements. You may order a home test kit for MTHFR here. An excellent option of a MTHFR supplement for those with MTHFR mutations is MTHFRdoctors.com Methylation Support.

How to get folate?

How do you get folate in the diet? Folate is easily obtained in fruits, green leafy vegetables, legumes, lentils, citrus, asparagus, beef liver and avocado. When you eat green veggies and leafy greens (ie. spinach, broccoli, bok choy, kale, greens) make sure to eat them raw or steamed so the folate stays intact. Boiling veggies will wash away much of the folate. Adult women and men need 400 mcg of folate per day, while pregnant women need 600 mcg and breast feeding women need 500 mcg per day. Women who are pregnant or breast feeding should take a pre-natal vitamin that contains methylfolate ( 5-MTHF) or folinic acid to ensure they are receiving all of the micronutrients for a healthy pregnancy.

Is gluten free bread good for MTHFR?

It is important to read the labels of all the foods you are consuming, so you can eliminate those containing folic acid. Gluten free grains are an alternative to enriched grains, but these foods (ie. gluten free breads, pasta, crackers, cereals etc.) are best limited in the MTHFR diet as they are high glycemic and can cause blood sugar spikes. Many people with the MTHFR mutation have gut issues that require them to eliminate gluten in their diet, so please consult with your health professional about how this issue impacts you specifically.