Knowledge Builders

what causes phantom limb pain

by Prof. Jimmie Predovic Published 2 years ago Updated 2 years ago
image

Many experts believe phantom pain may be at least partially explained as a response to mixed signals from the brain. After an amputation, areas of the spinal cord and brain lose input from the missing limb and adjust to this detachment in unpredictable ways.Jun 11, 2021

Explore

Multiple factors including site of amputation or presence of preamputation pain have been found to have a positive correlation with the development of phantom limb pain. The paradigms of proposed mechanisms have shifted over the past years from the psychogenic theory to peripheral and central neural changes involving cortical reorganization.

What causes phantom limb pain in amputees?

Risk factors. Residual limb pain. People who have persistent pain in the remaining part of the limb usually have phantom pain, too. Residual limb pain can be caused by an abnormal growth on damaged nerve endings (neuroma) that often results in painful nerve activity.

What are the risk factors for phantom limb pain?

The phantom part refers to the location of the pain: the missing limb or part of the limb (such as fingers or toes). Phantom limb pain ranges from mild to severe and can last for seconds, hours, days or longer.

What is the Phantom part of pain?

Antiseizure medications. Beta blockers. Muscle relaxers. Treatments that send electrical impulses to the nerves, brain or spinal cord may help ease the pain. These include: Neurostimulation. Spinal cord stimulation. Transcutaneous electrical nerve stimulation (TENS). What is mirror therapy for phantom limb pain?

What is the best treatment for phantom limb pain?

image

What is phantom pain and why does it occur?

The main cause of phantom pain is still unknown. However, some experts tend to believe that phantom pain is psychological. Similarly, it is thought to arise due to mixed signals from your brain or spinal cord. This occurs when the nerves in the part of your spinal cord and brain lose signals due to the detachment.

How do I get rid of phantom pains?

Medications used in the treatment of phantom pain include:Over-the-counter (OTC) pain relievers. Acetaminophen (Tylenol, others), ibuprofen (Advil, Motrin IB, others) or naproxen sodium (Aleve) might relieve phantom pain. ... Antidepressants. ... Anticonvulsants. ... Narcotics. ... N-methyl-d-aspartate (NMDA) receptor antagonists.

Is phantom limb pain normal?

After you have part of your arm or leg amputated, there's a chance you could feel pain in the limb that's no longer there. This is known as phantom limb pain. It's most common in arms and legs, but some people will feel it when they have other body parts removed, such as a breast.

Can phantom pain be triggered?

Phantom phenomena are frequent following amputation, but how this often painful experience is modified or triggered by spontaneous events or sensations often puzzles amputees and clinicians alike.

Is phantom pain mental or physical?

Phantom pain is pain that feels like it's coming from a body part that's no longer there. Doctors once believed this post-amputation phenomenon was a psychological problem, but experts now recognize that these real sensations originate in the spinal cord and brain.

Will phantom pain ever go away?

Phantom pain does eventually go away with time. Many people find their pain has decreased by about 75 percent or more within two years after amputation surgery. If it does return, talk to your doctor. There may be an underlying problem — such as a neuroma (nerve overgrowth) — triggering the sensation.

Can stress cause phantom limbs?

Seventy-four per cent of subjects demonstrated some significant stress-pain relationship. The results lend support to the psychological theory underlying the use of psychophysiological interventions such as biofeedback and relaxation therapy in amputees with phantom limb pain.

Who is at risk of phantom limb pain?

Higher prevalence rates of PLP have been reported in people with lower limb amputations than in those with upper limb amputations [4, 11]. Lower limb(s) amputations are performed chiefly to treat complications of diabetes, and may be associated with risk factors for PLP such as pre-amputation pain and depression [12].

Where is phantom limb pain most common?

PLP is often described as tingling, throbbing, sharp, pins/needles in the limb that is no longer there. It occurs more commonly in upper extremity amputations than lower extremities and tends to be intermittent in frequency. Pain severity varies, and onset can be immediate or years afterward.

Does phantom pain hurt a lot?

Phantom limb pain ranges from mild to severe and can last for seconds, hours, days or longer. It may occur after a medical amputation (removing part of a limb with surgery).

Can phantom pain be caused by anxiety?

But unfortunately, just like pain can make you feel worse mentally, your mind can cause pain without a physical source, or make preexisting pain increase or linger. This phenomenon is called psychogenic pain, and it occurs when your pain is related to underlying psychological, emotional, or behavioral factors.

How long does phantom pain usually last?

The length of time this pain lasts differs from person to person. It can last from seconds to minutes, to hours, to days. For most people, PLP diminishes in both frequency and duration during the first six months, but many continue to experience some level of these sensations for years.

How common is phantom limb pain?

How common is phantom limb pain? An estimated 8 out of 10 people who lose a limb experience some degree of phantom pain.

How common is phantom pain in amputees?

The onset of this pain most often occurs soon after surgery. It can feel like a variety of things, such as burning, twisting, itching or pressure. It is often felt in fingers or toes. It is believed that nearly 80 percent of the amputee population worldwide has experienced this kind of pain.

Can you have phantom pain without amputation?

Amputees often suffer from a phenomenon known as phantom limb syndrome, but researchers now say that non-amputees can also be made to feel phantom limbs, and even pain, when knives are jabbed into nonexistent hands.

Is phantom limb pain rare?

More recently, approximately 60%–80% of amputees experience phantom limb sensations. The incidence of phantom limb pain has varied from 2% in earlier records to higher rates today.

Why do people have phantom pain?

Because the risk of developing phantom pain is higher for people who have experienced pain in the limb before amputation, some doctors recommend regional anesthesia (spinal or epidural) in the hours or days leading up to amputation. This may reduce pain immediately following surgery and reduce the risk of lasting phantom limb pain.

What is Phantom Pain?

Overview. Phantom pain is pain that feels like it's coming from a body part that's no longer there. Doctors once believed this post-amputation phenomenon was a psychological problem, but experts now recognize that these real sensations originate in the spinal cord and brain. Most people who've had a limb removed report that it sometimes feels ...

What is pain that comes and goes?

Pain that comes and goes or is continuous. Symptoms affecting the part of the limb farthest from the body, such as the foot of an amputated leg. Pain that may be described as shooting, stabbing, cramping, pins and needles, crushing, throbbing, or burning.

What is the name of the scan that shows the brain in pain?

During imaging scans — such as magnetic resonance imaging (MRI) or positron emission tomography (PET) — portions of the brain that had been neurologically connected to the nerves of the amputated limb show activity when the person feels phantom pain.

What happens to the brain after an amputation?

Studies also show that after an amputation the brain may remap that part of the body's sensory circuitry to another part of the body. In other words, because the amputated area is no longer able to receive sensory information, the information is referred elsewhere — from a missing hand to a still-present cheek, for example.

What happens when you touch your cheek?

Because this is yet another version of tangled sensory wires, the result can be pain.

Is it a phantom limb to have a limb removed?

Most people who've had a limb removed report that it sometimes feels as if the amputated limb is still there. This painless phenomenon, known as phantom limb sensation, isn't the same as phantom pain.

Where does phantom pain come from?

"Makin and co-workers have directly challenged the notion that phantom pain as a consequence of limb amputation derives from reorganization of body parts that are represented in the somatosensory cortex [a mental map of body parts ]," neuroscientist Elena Nava of the University of Hamburg, who was not involved in the study, told LiveScience.

What part of the brain is affected by phantom pain?

In addition, the phantom pain was linked to disrupted activity between different parts of the sensorimotor cortex, the part of the brain that processes touch and movement.

Is pain remapping correlated with pain?

The problem, Makin said, is the study shows that pain and remapping are correlated, but does not show that one causes the other.

Do amputees with phantom pain have the same brain activity as people with both hands?

The scans showed that amputees with phantom pain had the same pattern of brain activity as individuals with both hands. This was a huge surprise, Makin said. "If we take an individual who suffers from phantom pain, his brain would be indistinguishable from your brain."

What is phantom limb pain?

Phantom-limb pain is a common sequela of amputation, occurring in up to 80% of people who undergo the procedure . It must be differentiated from non-painful phantom phenomena, residual-limb pain, and non-painful residual-limb phenomena.

What are the determinants of phantom limb pain?

Central changes seem to be a major determinant of phantom-limb pain; however, peripheral and psychological factors may contribute to it. A comprehensive model of phantom-limb pain is presented that assigns major roles to pain occurring before the amputation and to central as well as peripheral changes related to it.

Why do my phantom limbs hurt?

Other possible causes of phantom limb pain include damaged nerve endings and scar tissue from the amputation surgery.

How to help with a phantom limb?

If your pain is a problem even when you use medicine and non-drug therapies, your doctor may suggest other medical procedures. Spinal cord stimulation: Your doctor will put tiny electrodes inside your body along your spinal cord and send a small electrical current through them.

What are some medications that help with nerve pain?

Anticonvulsants. These drugs treat seizures, but some can also help with nerve pain. Examples include carbamazepine ( Carbatrol, Epitol, Tegretol ), gabapentin (Gralise, Neurontin ), and pregabalin ( Lyrica ). Opioids. Drugs such as codeine and morphine may ease phantom limb pain for some people, but not everyone.

What does it feel like to have your arm amputated?

After you have part of your arm or leg amputated, there’s a chance you could feel pain in the limb that’s no longer there. This is known as phantom limb pain. It’s most common in arms and legs, but some people will feel it when they have other body parts removed, such as a breast.

What to do if you have nerve pain on your stump?

Revision surgery: If nerve pain is the root of the problem, surgery on your stump may help correct it.

How long does it take to feel pain after amputation?

It’s common among people who’ve lost a limb. Most people who have an amputation will have some feelings connected to their missing limb within 6 months of the surgery.

How to help a missing limb?

It tricks your brain into thinking you have both limbs as you do therapy exercises. Research shows this can help relieve pain in a missing limb. Acupuncture . A skilled practitioner will insert very thin needles into your skin at specific places. This can prompt your body to release pain-relieving chemicals. Your habits.

What is phantom limb pain?

Phantom limb pain is a complex condition that causes pain or discomfort in a limb or body part that no longer exists. For many years, scientists and researchers believed phantom limb pain was psychological, but a number of research studies have indicated the pain sensations from this condition originate in the spinal cord and brain. Nevertheless, the cause of phantom limb pain is generally unclear—the most common theory is nerves misfiring pain signals to the brain.

Does phantom limb pain get better over time?

Phantom limb pain could get better over time for some individuals, but many times the pain becomes chronic. Symptoms of phantom limb pain generally include:

What is phantom limb pain?

The concept of phantom limb pain (PLP) as being the pain perceived by the region of the body no longer present was first described by Ambrose Pare, a sixteenth century French military surgeon [1]. Silas Weir Mitchell, a famous Civil War surgeon in the nineteenth century, coined the term “phantom limb pain” and provided a comprehensive description of this condition [2]. It continues to remain a poorly understood and difficult to treat medical condition. A recent study estimated that there were about 1.6 million people with limb loss in the USA in 2005 and this number was projected to increase by more than double to 3.6 million by the year 2050 [3]. Vascular problems, trauma, cancer, and congenital limb deficiency are among the common causes of limb loss. The number of traumatic amputations has also increased since the beginning of conflict in Iraq and Afghanistan [4]. The incidence of PLP has been reported to range from 42.2 to 78.8% in patients requiring amputation [5–8].

What is the name of the drug used to treat amputee pain?

52. Robinson LR, Czerniecki JM, Ehde DM, et al. Trial of amitriptyline for relief of pain in amputees: results of a randomized controlled study. Archives of Physical Medicine and Rehabilitation. 2004;85(1):1–6. [PubMed] [Google Scholar]

Is phantom limb pain a neuropathic pain?

Phantom limb pain is considered a neuropathic pain, and most treatment recommendations are based on recommendations for neuropathic pain syndromes. Mirror therapy, a relatively recently proposed therapy for phantom limb pain, has mixed results in randomized controlled trials.

What is Phantom Limb Pain?

Phantom limb pain is pain in an area where there has been an amputation. The pain can be minor and go away on its own with the symptoms decreasing over time. However, phantom limb pain can be extremely debilitating and can lead to chronic pain.

What Causes Phantom Limb Pain?

The underlying root cause of phantom limb pain is not clear, but it originates in the spinal cord and brain. This is believed to be caused by a mixed signal in the brain. After amputation occurs, areas of the spinal cord and brain miss input sensations from where the limb should be. The body takes time to adjust.

Treatment Options

Treatment options vary depending on the severity of the pain sensations. Like many pain conditions, a combination of multiple treatment options is most effective in reducing pain. It can be difficult to treat phantom limb pain, but your doctor may begin with medication options and noninvasive treatments.

image

1.Phantom Limb Pain: What is It, Causes, Treatment

Url:https://my.clevelandclinic.org/health/diseases/12092-phantom-limb-pain

1 hours ago In addition, the phantom pain was linked to disrupted activity between different parts of the sensorimotor cortex, the part of the brain that processes touch and movement.

2.Phantom pain - Symptoms and causes - Mayo Clinic

Url:https://www.mayoclinic.org/diseases-conditions/phantom-pain/symptoms-causes/syc-20376272

1 hours ago Phantom-limb pain is a common sequela of amputation, occurring in up to 80% of people who undergo the procedure. It must be differentiated from non-painful phantom phenomena, …

3.What causes phantom limb pain? A new theory - NBC News

Url:https://www.nbcnews.com/healthmain/what-causes-phantom-limb-pain-new-theory-1C8704102

9 hours ago Researchers don’t know exactly what causes phantom limb pain. One possible explanation: Nerves in parts of your spinal cord and brain “rewire” when they lose signals from the missing …

4.Phantom-limb pain: characteristics, causes, and treatment

Url:https://pubmed.ncbi.nlm.nih.gov/12849487/

12 hours ago  · Other causes could include: Areas of the spinal cord and brain losing contact with the missing limb, only to trigger warning signals in the form of... Damaged nerves at the site …

5.Phantom Limb Pain After Amputation: Causes

Url:https://www.webmd.com/pain-management/guide/phantom-limb-pain

15 hours ago  · Peripheral mechanisms and central neural mechanisms are among the hypotheses that have gained consensus as proposed mechanisms over the recent years. …

6.Phantom Limb Pain Causes, Symptoms & Treatments

Url:https://www.southwestspineandpain.com/blog/phantom-limb-pain-causes-symptoms-treatments

9 hours ago Possible causes of phantom limb pain may include: The misfiring of signals within the spinal cord and brain, causing pain to areas surrounding the missing limb. Damaged nerves or scar tissue …

7.Phantom Limb Pain: Mechanisms and Treatment …

Url:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198614/

22 hours ago  · The underlying root cause of phantom limb pain is not clear, but it originates in the spinal cord and brain. This is believed to be caused by a mixed signal in the brain. After …

8.What is Phantom Limb Pain? - Southern Pain and …

Url:https://southernpainclinic.com/blog/what-is-phantom-limb-pain/

34 hours ago The underlying root cause of phantom limb pain is not clear, but it originates in the spinal cord and brain. This is believed to be caused by a mixed signal in the brain. After amputation occurs, …

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 1 2 3 4 5 6 7 8 9