What functional groups are in allopurinol?
Allopurinol is a bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring. It has a role as a radical scavenger, a gout suppressant, an antimetabolite and an EC 1.17. 3.2 (xanthine oxidase) inhibitor. It is an organic heterobicyclic compound and a nucleobase analogue.
Is allopurinol an anti-inflammatory drug?
These findings support that allopurinol contributes to a variety of beneficial effects beyond urate lowering. This manuscript reviews the analgesic and anti-inflammatory properties of allopurinol, which are rarely discussed.
What drug class is colchicine?
Colchicine is in a class of medications called anti-gout agents.
Is allopurinol an anticoagulant?
Allopurinol may also increase the effect of warfarin and other drugs that thin the blood. These are known as anticoagulants. If you're taking blood thinners, you may need your clotting time tested more frequently to check you're still on the right dose.
What are the long term side effects of allopurinol?
The more common side effects of allopurinol oral tablet can include:skin rash.diarrhea.nausea.changes in your liver function test results.gout flare-up (if you have gout)
What drugs should not be taken with allopurinol?
Serious Interactions of Allopurinol include:azathioprine.benazepril.captopril.didanosine.dyphylline.enalapril.perindopril.protamine.More items...
Which is better colchicine or allopurinol?
Zyloprim (allopurinol) works well to prevent gout attacks and is cheaper than some alternatives, but it takes a few weeks to start working. Prevents and treats gout. Colcrys (colchicine) is a second-choice treatment for gout attacks. Be careful how much you use since it can cause problems with your blood.
What is the safest gout medication?
Allopurinol is considered very safe to take for a long period of time. There are unlikely to be any long-term effects. What will happen if I stop taking it? If you stop allopurinol treatment suddenly, there is a high risk that gout may get worse or you will get serious side effects.
Why was colchicine taken off the market?
However, Colcrys (colchicine, Takeda Pharmaceuticals) — the first FDA-regulated product — entered the market in 2009 at $5 per pill and received exclusivity to treat gout for 3 years. This caused the other unapproved formulation of colchicine to be ordered off the market.
Does allopurinol raise blood pressure?
A meta-analysis of the effect of allopurinol on BP, combining data from 10 clinical studies with 738 participants, found a small reduction in BP in allopurinol-treated patients (3.3 mm Hg; 95% confidence interval [CI], −1.4 to −5.3 mm Hg) for systolic BP.
Is allopurinol an immunosuppressant?
Abstract. Allopurinol demonstrated to have an immunosuppressive action when given at the dose of 200 microgram daily to the mice receiving skin grafts. This effect was not as apparent in adult mongrel dogs receiving kidney allografts and immediate bilateral nephrectomy.
What are the 10 foods that trigger gout?
The top 10 foods and drinks that trigger gout are:Sugary drinks and sweets. ... High fructose corn syrup. ... Alcohol. ... Organ meats. ... Game meats. ... Certain seafood, including herring, scallops, mussels, codfish, tuna, trout and haddock.Red meats, including beef, lamb pork and bacon.Turkey.More items...•