what class of drug is imdur

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What class drug is Imdur?

This medication belongs to a class of drugs known as nitrates. It works by relaxing and widening blood vessels so blood can flow more easily to the heart.

What is isosorbide mononitrate drug class?

Isosorbide mononitrate belongs to the group of medicines called nitrates. It works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload.

Is Imdur a nitroglycerin?

Are Imdur and Nitrolingual the Same Thing? Imdur (isosorbide mononitrate) Extended Release and Nitrolingual Pumpspray (nitroglycerin lingual spray) are vasodilators indicated for the prevention of angina pectoris. Side effects of Imdur and Nitrolingual that are similar include dizziness.

What drugs should not be taken with Imdur?

You should not take erectile dysfunction medicine (Viagra, Cialis, Levitra, Stendra, Staxyn, sildenafil, avanafil, tadalafil, vardenafil) while you are taking Imdur. Taking these medicines together can cause a sudden and serious decrease in blood pressure.

What drugs should not be taken with isosorbide?

You should not take erectile dysfunction medicine (Viagra, Cialis, Levitra, Stendra, Staxyn, sildenafil, avanafil, tadalafil, vardenafil) while you are taking isosorbide mononitrate. Taking these medicines together can cause a sudden and serious decrease in blood pressure.

Is isosorbide the same as metoprolol?

Metoprolol Succinate is a nitrate which relaxes the blood vessels and decreases the oxygen demand of the heart. Isosorbide Mononitrate is a long-acting beta blocker that works specifically on the heart. It works by slowing down the heart rate and makes the heart more efficient at pumping blood throughout the body.

What drug must not be prescribed when a patient is on isosorbide mononitrate?

You must not stop taking Isosorbide Mononitrate Tablets to take sildenafil, tadalafil or vardenafil as this will increase your chances of having an angina attack. Noradrenalin (norepinephrine) to treat sharp and severe drop in blood pressure.

Which is better nitroglycerin or isosorbide?

Isosorbide dinitrate is good for chest pain, but you have to be able to stick to your dosing schedule or it won't work as well. Relieves chest pain. Nitroglycerin is the fastest-working medicine to relieve chest pain, but make sure to sit down before taking it.

When should you not take Imdur?

Who should not take Imdur Oral?significant anemia.methemoglobinemia, a type of blood disorder.a heart attack.hypertrophic cardiomyopathy.a hemorrhage in the brain.low blood pressure.abnormal absorption of food nutrients in the gastrointestinal tract.high pressure within the skull.

What is the best time of day to take Imdur?

You should take this medicine first thing in the morning and follow the same schedule each day. This medicine works best if you have a "drug-free" period of time every day when you do not take it. Your doctor will schedule your doses during the day to allow for a drug-free time.

Can you take isosorbide long term?

Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This form of nitrate is used to reduce the number of angina attacks over a long time. It will not relieve an attack that has already started because it works too slowly.

Does Imdur cause fatigue?

Body as a Whole: Asthenia, back pain, chest pain, edema, fatigue, fever, flu-like symptoms, malaise, rigors.

Is isosorbide an ACE inhibitor?

Is BiDil ( isosorbide dinitrate / hydralazine) an ACE inhibitor? ACE inhibitors are medications that end in "-pril" like lisinopril or benazepril. BiDil ( isosorbide dinitrate / hydralazine) and ACE inhibitors work differently, but they both relax blood vessels and help treat heart failure.

What is the difference between nitroglycerin and isosorbide?

Isosorbide dinitrate is good for chest pain, but you have to be able to stick to your dosing schedule or it won't work as well. Relieves chest pain. Nitroglycerin is the fastest-working medicine to relieve chest pain, but make sure to sit down before taking it.

Is isosorbide the same as nitroglycerin?

While both isosorbide mononitrate (Monoket) and nitroglycerin (Nitrostat) are both nitrate vasodilators, they are not the same medication. Isosorbide mononitrate (Monoket) works slowly to help prevent chest pain.

Is isosorbide same as amlodipine?

Are Imdur and Norvasc the Same Thing? Imdur (isosorbide mononitrate) Extended Release and Norvasc (amlodipine) are indicated for the prevention of angina pectoris. Norvasc is also prescribed for the treatment of high blood pressure. Imdur and Norvasc belong to different drug classes.

Before Taking This Medicine

You should not use Imdur if: 1. you are allergic to isosorbide mononitrate, isosorbide dinitrate, or nitroglycerin; or 2. you have early signs of a...

What Happens If I Miss A Dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...

What Happens If I Overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of isosorbide mononitrate can be fatal.Overdose sympto...

What Should I Avoid While Taking Imdur?

This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fas...

What Other Drugs Will Affect Imdur?

Taking Imdur with certain other medicines can cause severely low blood pressure. This includes medicine to treat erectile dysfunction or pulmonary...

What to do if you take Imdur for a long time?

Precautions while using Imdur. If you will be taking this medicine for a long time, it is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.

What is isosorbide mononitrate used for?

Isosorbide mononitrate is used to prevent angina (chest pain) caused by coronary artery disease (heart disease). It does not work fast enough to relieve the pain of an angina attack that has already started. Isosorbide mononitrate belongs to the group of medicines called nitrates.

Is Imdur discontinued?

Medically reviewed by Drugs.com. Last updated on Aug 7, 2020. The Imdur brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.

Is isosorbide mononitrate safe for children?

Appropriate studies have not been performed on the relationship of age to the effects of isosorbide mononitrate in the pediatric population. Safety and efficacy have not been established.

What is Imdur used for?

Imdur is a prescription medicine used to treat the symptoms of Chest Pain (Angina Pectoris). Imdur may be used alone or with other medications. Imdur belongs to a class of drugs called Nitrates, Angina. It is not known if Imdur is safe and effective in children.

What are the side effects of Imdur?

Get medical help right away, if you have any of the symptoms listed above. The most common side effects of Imdur include: headache, dizziness, lightheadedness, and. nausea.

How long does it take for IMDUR to increase tolerance?

Pooled data from two other trials, comparing IMDUR Tablets 60 mg once daily, ISDN 30 mg QID, and placebo QID in patients with chronic stable angina using a randomized, double-blind, three-way crossover design found statistically significant increases in exercise tolerance times for IMDUR Tablets compared to placebo at hours 4, 8 and 12 and to ISDN at hour 4. The increases in exercise tolerance on day 14, although statistically significant compared to placebo, were about half of that seen on day 1 of the trial.

What is isosorbide mononitrate?

Isosorbide mononitrate (ISMN), an organic nitrate and the major biologically active metabolite of isosorbide dinitrate (ISDN), is a vasodilator with effects on both arteries and veins. IMDUR ® Tablets, for oral administration, contain either 30 mg, 60 mg or 120 mg of isosorbide mononitrate in an extended-release formulation.

What is the molecular formula of ISMN?

The molecular formula of ISMN is C 6 H 9 NO 6 and the molecular weight is 191.14. The chemical name for ISMN is 1,4:3,6-dianhydro-,D-glucitol 5-nitrate; the compound has the following structural formula:

Does isosorbide mononitrate cause methemoglobinemia?

Methemoglobinemia has been reported in patients receiving other organic nitrates, and it probably could also occur as a side effect of isosorbide mononitrate. Certainly nitrate ions liberated during metabolism of isosorbide mononitrate can oxidize hemoglobin into methemoglobin. Even in patients totally without cytochrome b reductase activity, however, and even assuming that the nitrate moiety of isosorbide mononitrate is quantitatively applied to oxidation of hemoglobin, about 2 mg/kg of isosorbide mononitrate should be required before any of these patients manifest clinically significant (≥10%) methemoglobinemia. In patients with normal reductase function, significant production of methemoglobin should require even larger doses of isosorbide mononitrate. In one study in which 36 patients received 2-4 weeks of continuous nitroglycerin therapy at 3.1 to 4.4 mg/hr (equivalent, in total administered dose of nitrate ions, to 7.8-11.1 mg of isosorbide mononitrate per hour), the average methemoglobin level measured was 0.2%; this was comparable to that observed in parallel patients who received placebo.

Is ISMN safe for congestive heart failure?

The benefits of ISMN in patients with acute myocardial infarction or congestive heart failure have not been established; because the effects of isosorbide mononitrate are difficult to terminate rapidly, this drug is not recommended in these settings.

What is isosorbide mononitrate used for?

Isosorbide mononitrate is used to prevent chest pain ( angina) in patients with a certain heart condition ( coronary artery disease ). This medication belongs to a class of drugs known as nitrates. It works by relaxing and widening blood vessels so blood can flow more easily to the heart .This medication will not relieve chest pain once it occurs. Also, it is not intended to be taken just before physical activities (such as exercise or sexual intercourse) to prevent chest pain. Other medications may be prescribed by your doctor for these conditions. Consult your doctor for more details.

Can you take isosorbide if you are allergic to it?

Precautions. Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or to similar drugs (such as isosorbide dinitrate, nitroglycerin ); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.

What is the Imdur product?

The Imdur product is an oral extended-release formulation of ISMN, the major active metabolite of isosorbide dinitrate; most of the clinical activity of the dinitrate is attributable to the mononitrate.

What is Imdur used for?

Imdur Tablets are indicated for the prevention of angina pectoris due to coronary artery disease. The onset of action of oral isosorbide mononitrate is not sufficiently rapid for this product to be useful in aborting an acute anginal episode.

How long does it take for Imdur to increase tolerance?

Pooled data from two other trials, comparing Imdur Tablets 60 mg once daily, ISDN 30 mg QID, and placebo QID in patients with chronic stable angina using a randomized, double-blind, three-way crossover design found statistically significant increases in exercise tolerance times for Imdur Tablets compared to placebo at hours 4, 8 and 12 and to ISDN at hour 4. The increases in exercise tolerance on day 14, although statistically significant compared to placebo, were about half of that seen on day 1 of the trial.

How long does it take for Imdur to work?

Imdur Tablets, during long-term use over 42 days dosed at 120 mg once daily, continued to improve exercise performance at 4 hours and at 12 hours after dosing but its effects (although better than placebo) are less than or at best equal to the effects of the first dose of 60 mg.

What is isosorbide mononitrate?

Isosorbide mononitrate (ISMN), an organic nitrate and the major biologically active metabolite of isosorbide dinitrate (ISDN), is a vasodilator with effects on both arteries and veins.

How to maintain the efficacy of Imdur?

Patients should be told that the antianginal efficacy of Imdur Tablets can be maintained by carefully following the prescribed schedule of dosing. For most patients, this can be accomplished by taking the dose on arising.

What is the effect of ISMN on the heart?

The principal pharmacological action of ISMN and all organic nitrates in general is relaxation of vascular smooth muscle, producing dilatation of peripheral arteries and veins , especially the latter. Dilatation of the veins promotes peripheral pooling of blood, decreases venous return to the heart, thereby reducing left ventricular end-diastolic pressure and pulmonary capillary wedge pressure (preload). Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure and mean arterial pressure (afterload). Dilatation of the coronary arteries also occurs. The relative importance of preload reduction, afterload reduction, and coronary dilatation remains undefined.

What to do if you take Imdur ER for a long time?

Precautions while using Imdur ER. If you will be taking this medicine for a long time, it is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.

What is isosorbide mononitrate used for?

Isosorbide mononitrate is used to prevent angina (chest pain) caused by coronary artery disease (heart disease). It does not work fast enough to relieve the pain of an angina attack that has already started. Isosorbide mononitrate belongs to the group of medicines called nitrates.

Is isosorbide mononitrate safe for children?

Appropriate studies have not been performed on the relationship of age to the effects of isosorbide mononitrate in the pediatric population. Safety and efficacy have not been established.

What are the side effects of isosorbide mononitrate?

Check with your doctor immediately if any of the following side effects occur while taking isosorbide mononitrate: Less common. Abnormal heart sound. absence of or decrease in body movement. arm, back, or jaw pain. black, tarry stools. bladder pain.

Does isosorbide mononitrate need medical attention?

Side effects not requiring immediate medical attention. Some side effects of isosorbide mono nitrate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.

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Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

How is Imdur best taken?

Use Imdur as ordered by your doctor. Read all information given to you. Follow all instructions closely.

What are the side effects of Imdur that I need to call my doctor about immediately?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

What are some things I need to know or do while I take Imdur?

Tell all of your health care providers that you take Imdur. This includes your doctors, nurses, pharmacists, and dentists.

How old do you have to be to take Imdur?

If you are 65 or older , use Imdur with care. You could have more side effects.

Does Imdur affect lab results?

This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take Imdur.

Who to talk to about Imdur?

Check with your pharmacist. If you have any questions about Imdur, please talk with your doctor, nurse, pharmacist, or other health care provider.

Can Imdur be given to you?

Imdur may be given to you for other reasons. Talk to your doctor.

What are the side effects of isosorbide mononitrate?

Headaches are the most common side effect of isosorbide mononitrate and usually are dose related (increase with higher doses). Flushing may occur because isosorbide mononitrate dilates (enlarges) blood vessels. Isosorbide mononitrate may cause a severe drop in blood pressure when rising from a sitting position, causing:

What is isosorbide mononitrate, and how does it work (mechanism of action)?

Isosorbide mononitrate is in the class of drugs called nitrates that are used for treating and preventing angina. Other nitrates include nitroglycerin ( Nitrostat, NitroQuick, Nitrolingual, Nitro-Dur and others) and isosorbide dinitrate ( Isordil Titradose, Dilatrate-SR, Isochron ). Nitrates are vasodilators (dilators of blood vessels). Blood returning from the body in the veins must be pumped by the heart through the lungs and into the body's arteries against the high pressure in the arteries. In order to accomplish this work, the heart's muscle must produce and use energy ("fuel") which requires oxygen brought to the heart by the blood. The FDA approved isosorbide mononitrate in December 1991.

Why does isosorbide cause flushing?

Flushing may occur because isosorbide mononitrate dilates (enlarges) blood vessels. Isosorbide mononitrate may cause a severe drop in blood pressure when rising from a sitting position, causing: dizziness, palpitations, and. weakness. To reduce the risk of low blood pressure, patients should rise slowly from a sitting position.

When was isosorbide mononitrate approved?

The FDA approved isosorbide mononitrate in December 1991. Angina pectoris (angina) or "heart pain " is due to an inadequate flow of blood (and oxygen) to the muscle of the heart. Nitrates, including isosorbide mononitrate, correct the imbalance between the flow of blood and oxygen to the heart and the work that the heart must do by dilating ...

Is isosorbide mononitrate excreted in breast milk?

It is not known if isosorbide mononitrate is excreted in human breast-milk

Is isosorbide mononitrate safe to take if I'm pregnant or breastfeeding?

There are no adequate studies of isosorbide mononitrate in pregnant women..

Imdur Description

Imdur - Clinical Pharmacology

Indications and Usage For Imdur

Contraindications

Warnings

Precautions

• Mechanism of Action
  The Imdur product is an oral extended-release formulation of ISMN, the major active metabolite of isosorbide dinitrate; most of the clinical activity of the dinitrate is attributable to the mononitrate. The principal pharmacological action of ISMN and all organic nitrates in general is relaxation of …
• Pharmacodynamics
  Dosing regimens for most chronically used drugs are designed to provide plasma concentrations that are continuously greater than a minimally effective concentration. This strategy is inappropriate for organic nitrates. Several well-controlled clinical trials have used exercise testin…

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Imdur Dosage and Administration

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