Precautions
- a diuretic or "water pill";
- other blood pressure medications;
- lithium;
- celecoxib; or
- aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.
Is losartan a good blood pressure medication?
Your doctor may prescribe the lowest dose of losartan (25 mg) if you have certain health conditions, such as liver problems. You can take losartan in the morning, at night, or any time of day.
What is losartan 25 mg prescribed for?
Searching... Losartan is primarily prescribed for the treatment of hypertension with or without concurrent use of thiazide diuretics. It belongs to the angiotensin II receptor antagonists group of drugs. It prevents the blood vessels in your body from narrowing, thus lowering your blood pressure and improving the blood circulation.
What is losartan prescribed for primarily?
They all have the same mechanism of action and potentially inhibit the actions of angiotensin better than ACE inhibitors, such as lisinopril, because there are other enzymes than ACE that have the capability of producing angiotensin II. Losartan is a uricosuric.
Is losartan an ACE inhibitor?
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Is losartan an ACE inhibitor or a beta blocker?
Is losartan an ACE inhibitor or a beta blocker? Losartan is an angiotensin receptor blocker. It is not an ACE inhibitor or a beta blocker.
What drugs should not be taken with losartan?
Losartan may interact with other medicationsLithium. Taking losartan with lithium, a drug used to treat bipolar disorder, may increase the levels of lithium in your body. ... Blood pressure drugs. ... Nonsteroidal anti-inflammatory drugs (NSAIDs) ... Rifampin. ... Diuretics (water pills) ... Drugs or supplements that contain potassium.
Is losartan a good blood pressure medication?
Losartan (Cozaar) is a medication used to lower blood pressure. It can also help protect the kidneys, so it is a good first-line option for people with both hypertension and diabetes.
Is losartan a beta blocker?
Losartan is not a beta-blocker. Losartan belongs to a class of medications called angiotensin II receptor blockers, or ARBs, which are used to treat high blood pressure. These are different from beta-blockers, another type of prescription drug sometimes used to lower blood pressure.
Is it better to take losartan at night or morning?
Take losartan tablets once a day. Your doctor may suggest that you take your first dose before bedtime, because it can make you feel dizzy. After your first dose, you can take losartan at any time of day.
Does losartan affect sleep?
It has been reported that losartan, an angiotensin II receptor blocker, alters the circadian rhythm of melatonin secretion and significantly reduces melatonin production.
Why was losartan taken off the market?
Losartan was recalled due to impurities found while testing finished products. The impurity found in these batches is N-Methylnitrosobutyric acid (NMBA). This is the third type of impurity to cause recalls of these medications. The other two are N-Nitrosodimethylamine (NDMA) and N-Nitrosodiethylamine (NDEA).
What is the problem with losartan?
Since losartan is a medication used to lower blood pressure, sometimes it can lower blood pressure too much, which can cause dizziness or even fainting. In certain cases, it can reduce blood flow to the kidneys, causing kidney failure. In addition, it can cause high blood potassium (hyperkalemia) (UpToDate, n.d.).
What are the long term side effects of losartan?
Side effects of losartanFeeling dizzy. If losartan makes you feel dizzy when you stand up, try getting up very slowly or stay sitting down until you feel better. ... Headaches. Make sure you rest, and drink plenty of fluids. ... Feeling sick (nausea) ... Being sick (vomiting) ... Diarrhoea. ... Pain in your joints or muscles.
Does losartan make you gain weight?
Losartan causes weight fat loss by reducing blood cholesterol levels. More specifically, it lowers the amount of bad cholesterol and triglyceride circulating in the blood and fat deposits in the adipose tissue.
What is the safest blood pressure medicine?
Methyldopa, which works to lower blood pressure through the central nervous system, has the lowest risk of harming the mother and developing fetus. Other possible safe options include labetalol, beta-blockers, and diuretics.
Can you stop taking losartan cold turkey?
According to health specialists, Losartan users should not quit the drug cold turkey, as it can be dangerous. It can lead to a spike in blood pressure, and this increase can lead to things like confusion, feeling dizzy, heart attack, stroke, and nausea.
What pain relievers can I take with losartan?
These may also increase the risk of getting kidney problems. You should avoid taking this type of painkiller while you're taking losartan, unless it's recommended by your doctor. If you need a painkiller it's fine to take paracetamol with losartan.
Can I take Tylenol while on losartan?
Interactions between your drugs No interactions were found between losartan and Tylenol. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Can I drink coffee while taking losartan?
Also, drinking coffee can increase your blood pressure. And losartan is used to lower blood pressure. So if you drink coffee while taking losartan, the drug may not work as well for you.
Why was losartan taken off the market?
Losartan was recalled due to impurities found while testing finished products. The impurity found in these batches is N-Methylnitrosobutyric acid (NMBA). This is the third type of impurity to cause recalls of these medications. The other two are N-Nitrosodimethylamine (NDMA) and N-Nitrosodiethylamine (NDEA).
Before Taking This Medicine
You should not use losartan if you are allergic to it.If you have diabetes, do not use losartan together with any medication that contains aliskire...
How Should I Take Losartan?
Take losartan exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose...
What Happens If I Miss A Dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...
Losartan Dosing Information
Usual Adult Dose of Losartan for Diabetic Nephropathy:Initial dose: 50 mg orally once a day.Maintenance dose: 25 to 100 mg orally in 1 to 2 divided...
What Other Drugs Will Affect Losartan?
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with losartan, especially: 1. a diuretic or "...
What is the name of the drug that is used to treat high blood pressure?
Losartan (Cozaar) is a medication prescribed fro the treatment of high blood pressure. Losartan (Cozaar) belongs to a class of drugs referred to as ARBs (angiotensin receptor blockers). Side effects, drug interactions, warnings and precautions, and pregnancy and breastfeeding safety information should be reviewed prior to taking any medication.
What is Losartan used for?
What are the uses for losartan? Losartan is used for treating hypertension, reducing the risk of stroke in patients with hypertension, and left ventricular hypertrophy (over developed heart muscle), and treating people with type 2 diabetes, and hypertensive patients with diabetic nephropathy ( kidney disease ).
How to take losartan?
What is the dosage for losartan? How is it taken? 1 The starting dose of losartan for adults is 25-50 mg daily. 2 The maximum dose is 100 mg daily. The total daily dose of losartan may be divided and administered two doses daily. 3 The starting dose of losartan for pediatric patients 6 years of age or older is 0.7 mg/kg up to 50 mg once daily. Doses more than 1.4 mg/kg or 100 mg daily have not been 4 Losartan may be given with or without food.evaluated in pediatric patients.
What is the chemical that attaches to angiotensin receptors?
Angiotensin formed in the blood by the action of angiotensin converting enzyme (ACE) is a powerful chemical that attaches to angiotensin receptors found in many tissues but primarily on smooth muscle cells of blood vessels. Angiotensin's attachment to the receptors causes the muscle cells to contract and the blood vessels to narrow (vasoconstrict) ...
What causes an increase in blood pressure?
Angiotensin's attachment to the receptors causes the muscle cells to contract and the blood vessels to narrow (vasoconstrict) which leads to an increase in blood pressure ( hypertension ). Losartan (more specifically, the chemical formed when the liver converts the inactive losartan into its active form) blocks the angiotensin receptor.
How to report a drug problem to the FDA?
Report Problems to the Food and Drug Administration. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Can you take losartan with NSAIDs?
Combining losartan or other ARBs with nonsteroidal anti-inflammatory drugs ( NSAIDs) in patients who are elderly, fluid-depleted (including those on diuretic therapy), or with poor kidney function may result in reduced kidney function, including kidney failure. These effects usually are reversible.
How to use Losartan POTASSIUM
Read the Patient Information Leaflet if available from your pharmacist before you start taking losartan and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Are you currently using Losartan POTASSIUM?
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What is Losartan used for?
Losartan is an angiotensin II receptor blocker used in the therapy of hypertension and diabetic nephropathy. Losartan is associated with a low rate of transient serum aminotransferase elevations and has been linked to rare instances of acute liver injury.
What is losartan antihypertensive?
2005-03-25. Losartan is a non-peptide angiotensin II antagonist with antihypertensive activity. Upon administration, losartan and its active metabolite selectively and competitively blocks the binding of angiotensin II to the angiotensin I (AT1) receptor.
What is the BCF of 110?
An estimated BCF of 110 was calculated in fish for losartan (SRC), using an estimated log Kow of 4.01 (1) and a regression-derived equation (1) . According to a classification scheme (2), this BCF suggests the potential for bioconcentration in aquatic organisms is high (SRC).
What is the Henry's law constant for Losartan?
The Henry's Law constant for losartan is estimated as 3.3X10-16 atm-cu m/mole (SRC) using a fragment constant estimation method (1). This Henry's Law constant indicates that losartan is expected to be essentially nonvolatile from water and moist soil surfaces (2). Losartan is not expected to volatilize from dry soil surfaces (SRC) based upon an estimated vapor pressure of 5.4X10-18 mm Hg (SRC), determined from a fragment constant method (3).
What are the precautions for accidental release?
Accidental Release Measures. Personal precautions, protective equipment and emergency procedures: Avoid dust formation. Avoid breathing vapours, mist or gas. Environmental precautions: Do not let product enter drains. Methods and materials for containment and cleaning up: Sweep up and shovel. Keep in suitable, closed containers for disposal.
How to treat a contaminated eye?
Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/
What are anti-arrhythmia drugs?
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents .)
How long does losartan stay in your system?
The terminal elimination half lives of losartan and EXP3174 are about 1.5 to 2.5 hours and 3 to 9 hours, respectively.
How long does it take for losartan to peak?
Peak plasma concentrations of losartan and EXP3174 occur about one hour and three to four hours, respectively, after an oral dose. Both losartan and EXP3174 are more than 98% bound to plasma proteins. Losartan is excreted in the urine, and in the feces via bile, as unchanged drug and metabolites.
How is Losartan absorbed?
Losartan is well absorbed following oral administration and undergoes significant first-pass metabolism to produce the 5- carboxylic acid metabolite, designated as EXP3174. About 14% of an oral dosage is converted to this metabolite, which is long-acting (6 to 8 hr) and a noncompetitive antagonist at the AT 1 receptor, contributing to the pharmacological effects of losartan. EXP3174 is 10-40 times more potent in blocking AT 1 receptors than losartan. In addition, the binding to the target enzyme is pH-sensitive, and the negatively-charged tetrazole ring, which is similar in size to the negative carboxylic acid derivative, may contribute to the activity of the drug.
What is Losartan used for?
Losartan is used for hypertension, including in people with left ventricular hypertrophy (enlarged heart muscle), and kidney dysfunction among type II diabetics. It may also delay progression of diabetic nephropathy.
What companies are recalling losartan?
Between November 2018, and September 2019, the FDA announced multiple recalls of tablets containing losartan by Sandoz, Torrent Pharmaceuticals, Hetero Labs, Camber Pharmaceuticals, Legacy Pharmaceutical Packaging, Teva Pharmaceuticals, Vivimed Life Sciences, and Macleods Pharmaceutical Limited due to detection of one of the possible carcinogens N-nitrosodiethylamine, N-methylnitrosobutyric acid, or N-nitroso-N-methyl-4-aminobutyric acid in the active pharmaceutical ingredient (API).
What is the name of the medication that is used to treat high blood pressure?
Losartan. Losartan, sold under the trade name Cozaar among others, is a medication mainly used to treat high blood pressure. It is also used for diabetic kidney disease, heart failure, and left ventricular enlargement. It is taken by mouth. It may be used alone or in addition to other blood pressure medication.
Does Losartan decrease afterload?
Losartan administration results in a decrease in total peripher al resistance (afterload) and cardiac venous return (preload). All of the physiological effects of angiotensin II, including release of aldosterone, are antagonized in the presence of losartan.
What is Losartan used for?
Losartan is also used to decrease the risk of stroke in patients with high blood pressure and enlargement of the heart. It is also used to treat kidney problems in patients with type 2 diabetes and a history of hypertension. This medicine is available only with your doctor's prescription.
Does Losartan cause heart failure?
This can damage the blood vessels of the brain , heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood pressure may reduce the risk of strokes and heart attacks. Losartan is an angiotensin II receptor blocker (ARB).
Does Losartan help with blood pressure?
As a result, losartan relaxes the blood vessels. A lower blood pressure will increase the supply of the blood and oxygen to the heart. Losartan is also used to decrease the risk of stroke in patients with high blood pressure and enlargement of the heart.
How long does it take for losartan to work?
The time to peak effect after a dose is 1-2 hours for losartan and 3-4 hours for the metabolite. At its peak level, losartan inhibits 85% of the effects of angiotensin II, and 25 to 40% or this inhibition persists for 24 hours. It may take up to a week for significant blood pressure lowering or kidney effects are noted, with maximal effects occurring in 3 to 6 weeks. No rebound effect on withdrawal of losartan has been noted.
How does Losartan work?
Losartan works by blocking the effect of angiotensin II, a hormone that causes blood vessels to narrow (constrict) increasing blood pressure. Blocking angiotensin II widens (dilates) blood vessels which lowers blood pressure. Losartan also increases the excretion of certain salts from the kidney.
How long can you keep a Losartan suspension in the fridge?
Losartan suspension can be refrigerated for up to 4 weeks.
Does losartan affect the effects of dehydration?
The effects of losartan may be enhanced in people who are dehydrated. 7. Interactions. Medicines that interact with losartan may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with losartan.
Can you take Losartan with Aliskiren?
Losartan should never be administered with aliskiren. Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects.
Does Losartan increase potassium?
May increase potassium levels in the body. Generally, should not be prescribed with potassium supplements or other medicines that retain potassium. Potassium levels may require ongoing monitoring. Losartan may not have as good an effect in people of African-American descent.
Can Losartan be used for kidney disease?
May also be used to improve kidney outcomes in the general population (excluding African-American people) without kidney disease. May be the preferred treatment in people with more than one type of heart condition. Losartan tablets may be made into a suspension for people who have difficulty swallowing.
What is Losartan used for?
Losartan is used for three main purposes. It’s used to: reduce your risk of a stroke if you have high blood pressure and left ventricular hypertrophy (LVH), a condition that causes the walls in the heart’s left ventricle to thicken. treat diabetic nephropathy, which is kidney disease caused by diabetes.
How does Losartan work?
How losartan works. Losartan works by blocking the action of angiotensin II, a chemical in your body that causes your blood vessels to tighten and narrow. Losartan helps relax and widen your blood vessels. This lowers your blood pressure.
What are the conditions that losartan is used for?
These include: the type and severity of the condition you’re using losartan to treat. your age. your weight. other medical conditions you may have, such as liver damage. Typically, your doctor will start you on a low dosage and adjust it over time to reach the dosage that’s right for you.
What is the class of Losartan?
Losartan drug class. Losartan belongs to a class of drugs called angiotensin receptor blockers (ARBs). A class of drugs is a group of medications that work in a similar way. They’re often used to treat similar conditions. Other ARBs include olmesartan, valsartan, and telmisartan.
Does Losartan cause hyperkalemia?
Losartan can increase the levels of a substance called potassium in your blood. Taking losartan with drugs that contain potassium, potassium supplements, or salt substitutes with potassium, can increase your risk of hyperkalemia (high levels of potassium ).
Does losartan affect potassium levels?
Taking losartan with other drugs that work in the same way may increase your chance of low blood pressure, high potassium levels in your blood, and kidney damage. Examples of these drugs include: angiotensin receptor blockers (ARBs), such as: irbesartan. candesartan.
Can you take losartan while pregnant?
Losartan should be used during pregnancy only if the potential benefit justifies the potential risk. For women who are breastfeeding: It isn’t known if losartan passes into breast milk. If it does, it may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child.
