What is Tecentriq?
What is TECENTRIQ? TECENTRIQ is a prescription medicine used to treat adults with: TECENTRIQ is not for use with the medicine paclitaxel (a different medicine than paclitaxel protein-bound) in TNBC when your breast cancer has spread or cannot be removed by surgery. a type of bladder and urinary tract cancer called urothelial carcinoma.
What is the dosage of Tecentriq for chemotherapy?
The recommended dosage of TECENTRIQ is 1200 mg intravenously over 60 minutes followed by bevacizumab, paclitaxel, and carboplatin, on Day 1 of each 21-day cycle for a maximum of 4 to 6 cycles of chemotherapy.
What are the side effects of Tecentriq?
Tecentriq side effects Get emergency medical help if you have signs of an allergic reaction to Tecentriq (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Some side effects may occur during the injection.
What is Tecentriq (atezolizumab)?
Tecentriq (atezolizumab) is a prescription brand-name medication. It’s approved by the Food and Drug Administration (FDA) to treat certain types of the following cancers in adults: Tecentriq may be used short term or long term for treating these cancers.
What type of drug is TECENTRIQ?
TECENTRIQ is a prescription medicine used to treat adults with: A type of bladder and urinary tract cancer called urothelial carcinoma.
Is TECENTRIQ a chemotherapy drug?
Tecentriq alone. a chemotherapy drug called gemcitabine, used in combination with a placebo and chemotherapy that's made with platinum (either carboplatin or cisplatin) Tecentriq in combination with gemcitabine and one other chemotherapy drug that's made with platinum (either cisplatin or carboplatin)
What type of immunotherapy is TECENTRIQ?
Tecentriq is a type of immunotherapy called an “immune checkpoint inhibitor.” Immune checkpoints are proteins in your body that help your immune system tell the difference between your own cells and foreign invaders, such as harmful bacteria.
Is TECENTRIQ chemotherapy or immunotherapy?
Atezolizumab (brand name: Tecentriq) is a type of immunotherapy drug called an “immune checkpoint inhibitor”. It helps to stimulate the body's immune system to fight cancer.
Is Tecentriq a biologic?
Tecentriq basics Atezolizumab is a biologic drug, which means it's made from parts of living cells. It's only available as the brand-name drug Tecentriq. It's not available in a biosimilar form. (Biosimilars are like generic drugs.
Is Tecentriq a targeted therapy?
Atezolizumab is classified as a monoclonal antibody. Monoclonal antibodies are a relatively new type of "targeted" cancer therapy (against a specific "target").
What is the difference between Keytruda and Tecentriq?
In Keynote-189, Keytruda reduced the risk of death by 44%, compared with the 20% reduction for Tecentriq in IMpower 130. The other two drugs approved in lung cancer in this class of drugs, called PD-1/L1 blockers, are Bristol-Myers Squibb's Opdivo (nivolumab) and AstraZeneca's Imfinzi (durvalumab).
Is atezolizumab an immunotherapy?
Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving chemoradiation with or without atezolizumab may work better in treating patients with limited stage small cell lung cancer.
How long does Tecentriq stay in your system?
Both Imfinzi and Tecentriq stay in your system for months after your last dose. During this time, your body slowly breaks down the drug. After receiving a dose of Imfinzi, the drug stays in your system for about 3 months. A dose of Tecentriq stays in your system longer, about 5 months.
Is atezolizumab an immunosuppressant?
Atezolizumab is a monoclonal antibody targeting the immunosuppressive receptor PD-L1, and its effectiveness has been verified in numerous diseases, such as urothelial and renal cell carcinoma and non-small-cell lung cancer (15–17). Immunotherapy with anti-PD-1 or anti-PD-L1 antibodies target the PD-1-PD-L1 pathway.
Does Tecentriq cause hair loss?
Some people have reported hair loss while using Tecentriq in clinical trials. Hair loss was more common in people using Tecentriq with: other cancer medications to treat small cell and non-small cell lung cancer. the cancer drug paclitaxel protein-bound (Abraxane) to treat triple-negative breast cancer.
Is Avastin an immunotherapy?
Avastin is an immunotherapy drug. Immunotherapy is a treatment that works with your immune system to fight cancer. Avastin works* with your immune system to block a specific protein called vascular endothelial growth factor (VEGF). VEGF is found naturally in many cells throughout your body.
Is atezolizumab (Tecentriq) a chemotherapy or immunotherapy drug?
Atezolizumab (brand name: Tecentriq) is a type of immunotherapy drug called an “immune checkpoint inhibitor”. It helps to stimulate the body’s immu...
How effective is atezolizumab (Tecentriq)?
Atezolizumab (Tecentriq) is approved to treat several different types of cancer. Cancer treatment is always individualized for each patient. It’s e...
Does atezolizumab (Tecentriq) cause hair loss?
Hair loss (alopecia) is listed as a common side effect with atezolizumab (Tecentriq) when used with other cancer treatments for lung cancer or trip...
How is atezolizumab (Tecentriq) administered?
Atezolizumab (Tecentriq) is given by a slow intravenous (IV) infusion into your vein, usually once every 2, 3 or 4 weeks. Your initial infusion typ...
What Atezolizumab Is Used For
For the treatment of patients with locally advanced or metastatic urothelial carcinoma who:
How Atezolizumab Is Given
Atezolizumab is given as an intravenous injection through a vein (IV) over 60 minutes for the first infusion, and if no infusion reaction, over 30 minutes for each infusion thereafter.
When To Contact Your Doctor Or Health Care Provider
Contact your health care provider immediately, day or night, if you should experience any of the following symptoms (may NOT be related to atezolizumab):
Precautions
Before starting atezolizumab treatment, make sure you tell your doctor about any allergies, and other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.) and your complete past medical, surgical, family and social history
Self-Care Tips (both general and related to atezolizumab)
Drink at least two to three quarts of fluid every 24 hours, unless you are instructed otherwise.
Monitoring and Testing While Taking Atezolizumab
You will be checked regularly by your health care professional while you are taking atezolizumab, to monitor side effects and check your response to therapy.
How Atezolizumab Works
Atezolizumab is classified as a monoclonal antibody. Monoclonal antibodies are a relatively new type of "targeted" cancer therapy (against a specific "target").
What is Tecentriq used for?
Tecentriq is a prescription medicine used to treat adults with: a type of bladder and urinary tract cancer called urothelial carcinoma. Tecentriq may be used when your bladder cancer has spread or cannot be removed by surgery, and if you have any one of the following conditions:
How many ml of tecentriq?
TECENTRIQ injection is a sterile, preservative-free, and colorless to slightly yellow solution for intravenous infusion supplied as a carton containing one 840 mg/14 mL single-dose vial ( NDC 50242-918-01) or 1,200 mg/20 mL single-dose vial ( NDC 50242-917-01).
What is the molecular mass of tecentriq?
Atezolizumab is an Fc-engineered, humanized, non-glycosylated IgG1 kappa immunoglobulin that has a calculated molecular mass of 145 kDa. TECENTRIQ Injection for intravenous use is a sterile, preservative-free, colorless to slightly yellow solution in single-dose vials.
What is a TNBC?
a type of breast cancer called triple-negative breast cancer (TNBC). TECENTRIQ may be used with the medicine paclitaxel protein-bound when your breast cancer: has spread or cannot be removed by surgery, and. your cancer tests positive for “PD-L1”. a type of lung cancer called small cell lung cancer (SCLC).
Can tecentriq cause fetal death?
Based on its mechanism of action, TECENTRIQ can cause fetal harm when administered to a pregnant woman. There are no available data on the use of TECENTRIQ in pregnant women. Animal studies have demonstrated that inhibition of the PD-L1/PD-1 pathway can lead to increased risk of immune-related rejection of the developing fetus resulting in fetal death.
Can tecentriq cause infusion reactions?
TECENTRIQ can cause severe or life-threatening infusion-related reactions. Monitor for signs and symptoms of infusion-related reactions. Interrupt, slow the rate of, or permanently discontinue TECENTRIQ based on the severity [see DOSAGE AND ADMINISTRATION ]. For Grade 1 or 2 infusion-related reactions, consider using pre-medications with subsequent doses.
Can you use Tecentriq with chemotherapy?
a type of lung cancer called non-small cell lung cancer (NSCLC). Tecentriq may be used with chemotherapy and other anti-cancer medicines as your first treatment whenyour lung cancer: has spread or grown, and.
Uses for Tecentriq
Atezolizumab injection is used to treat urothelial carcinoma (a type of bladder cancer) that has spread throughout the body (metastatic) or cannot be removed by surgery (advanced).
Before using Tecentriq
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Proper use of Tecentriq
Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
Precautions while using Tecentriq
It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.
Tecentriq side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
What is the class of Tecentriq?
Drug class: immunotherapy. Drug form: liquid solution for intravenous (IV) infusion. As with other drugs, Tecentriq can cause side effects. Read on to learn about potential common, mild, and serious side effects. For a general overview of Tecentriq, including details about its uses, see this article.
What are the side effects of Tecentriq?
More common side effects in people using Tecentriq by itself include: weakness or fatigue (lack of energy) nausea. cough.
How long does it take for Tecentriq to go away?
Some side effects of Tecentriq, such as nausea, may not last long. Mild side effects of the drug may go away on their own after a few hours or days. Other side effects, such as liver problems, may not be reversible. So it’s possible they won’t go away.
Why did I stop taking Tecentriq?
In these trials, some people stopped using Tecentriq due to a side effect. Fatigue was one of the most common reasons for stopping treatment with the medication.
Does Tecentriq affect liver?
Liver, lung, or other organ problems. Tecentriq may cause immune reactions that can affect nearly any organ in your body, including your liver and lungs. If you already have a problem that affects these organs, you may be at a higher risk for these side effects.
Does Tecentriq cause nausea?
Nausea was another common but mild side effect reported by people who used Tecentriq in clinical trials. People who used Tecentriq with the drug bevacizumab ( Avastin) to treat liver cancer didn’t report nausea as a common side effect. But nausea was common with the other conditions Tecentriq is used to treat.
Is Tecentriq a serious drug?
Tecentriq may cause serious side effects. The list below may not include all possible serious side effects of the drug. For more information, you can refer to Tecentriq’s medication guide.
When to administer TecentrIQ?
Administer TECENTRIQ prior to paclitaxel protein-bound when given on the same day. For each 28 day cycle, paclitaxel protein-bound is administered at 100 mg/m 2 on days 1, 8, and 15 until disease progression or unacceptable toxicity.
Can you reduce tecentriq?
No dose reduction for TECENTRIQ is recommended. In general, withhold TECENTRIQ for severe (Grade 3) immune-mediated adverse reactions. Permanently discontinue TECENTRIQ for life-threatening (Grade 4) immune-mediated adverse reactions, recurrent severe (Grade 3) immune-mediated reactions that require systemic immunosuppressive treatment, or an inability to reduce corticosteroid dose to 10 mg or less of prednisone or equivalent per day within 12 weeks of initiating steroids.
What is Tecentriq used for?
The U.S. Food and Drug Administration today approved Tecentriq (atezolizumab) to treat the most common type of bladder cancer, called urothelial carcinoma. This is the first product in its class (PD-1/PD-L1 inhibitors) approved to treat this type of cancer.
Is Tecentriq approved for urothelial carcinoma?
Tecentriq is approved for the treatment of patients with locally advanced or metastatic urotheli al carcinoma whose disease has worsened during or following platinum-containing chemotherapy, or within 12 months of receiving platinum-containing chemotherapy, either before (neoadjuvant) or after (adjuvant) surgical treatment. ...
Does Tecentriq help the immune system?
By blocking these interactions, Tecentriq may help the body’s immune system fight cancer cells. Tecentriq is the first FDA-approved PD-L1 inhibitor and the latest in the broader class of PD-1/PD-L1 targeted biologics approved by the FDA in the last two years. Tecentriq is approved for the treatment of patients with locally advanced ...
Does Tecentriq cause nausea?
The most common side effects of treatment with Tecentriq were fatigue, decreased appetite, nausea, urinary tract infection, fever (pyrexia) and constipation. Tecentriq also has the potential to cause infection and serious side effects that result from the immune system effect of Tecentriq (known as “immune-mediated side effects”).
Tecentriq Prices
The cost for Tecentriq intravenous solution (840 mg/14 mL) is around $7,207 for a supply of 14 milliliters, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
Drugs.com Printable Discount Card
The free Drugs.com Discount Card works like a coupon and can save you up to 80% or more off the cost of prescription medicines, over-the-counter drugs and pet prescriptions.
Tecentriq Coupons and Rebates
Tecentriq offers may be in the form of a printable coupon, rebate, savings card, trial offer, or free samples. Some offers may be printed right from a website, others require registration, completing a questionnaire, or obtaining a sample from the doctor's office.
Patient Assistance Programs for Tecentriq
Patient assistance programs (PAPs) are usually sponsored by pharmaceutical companies and provide free or discounted medicines to low income or uninsured and under-insured people who meet specific guidelines. Eligibility requirements vary for each program.
In Summary
Common side effects of Tecentriq include: herpes simplex encephalitis, infection, mycobacterium infection, retroperitoneal hemorrhage, sepsis, severe infection, urinary tract infection, colitis, diarrhea, and increased thyroid stimulating hormone level. See below for a comprehensive list of adverse effects.
For the Consumer
Along with its needed effects, atezolizumab (the active ingredient contained in Tecentriq) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
