what diabetes drugs cause weight gain

Weight gain from these diabetes medications occurs for several reasons, according to Johns Hopkins Medicine:

• Insulin may cause low blood sugar, or hypoglycemia, which stimulates your appetite.
• Sulfonylureas such as glimepiride (Amaryl®) and chlorpropamide (Diabinese®) can also induce hypoglycemia and stimulate your appetite.
• The thiazolidinedione class of drugs makes fat cells store more fatty acids from the blood and increase fluid retention.

Full Answer

What are the best diabetic medicines?

• insulin aspart (NovoLog, FlexPen, Fiasp)
• insulin glulisine (Apidra)
• insulin lispro (Humalog)

What medications are associated with weight gain?

• Selective serotonin reuptake inhibitors (SSRIs): Paxil, Zoloft, Celexa, Prozac
• Older anti-depressants: Amitriptyline, Imipramine, Nortriptyline, Trazodone, Monoamine oxidase inhibitors (MAOIs)
• Lithium
• Benzodiazepines

What drugs can help you gain weight?

• May reduce appetite and increase feeling of fullness
• May increase resting metabolism (how the body burns calories)
• Although it can help a person lose weight, it does not treat the genetic defects

What blood pressure medicine, that will not cause weight gain?

Wellbutin is an anti-depressant that is not within the SSRI group and does not trigger weight gain. The truth is weight loss has been reported. Newer medication like Celexia and Lexapro cause the least weight gain in this group.

Which oral diabetic meds cause weight gain?

Major therapeutic classes of medications used for Type 2 diabetes, such as insulin, sulfonylureas and thiazolidinediones (TZDs), have been associated with weight gain.

What diabetic drugs does not cause weight gain?

DPP-4 inhibitors do not tend to cause weight gain and tend to have a neutral or positive effect on cholesterol levels. Alogliptin (Nesina), linagliptin (Tradjenta), saxagliptin (Onglyza), and sitagliptin (Januvia) are the DPP-4 inhibitors currently on the market in the US.

Why does diabetes medication cause weight gain?

When a person takes insulin as a treatment for diabetes, they may gain weight. This is because their body begins absorbing glucose again and converting any excess into fat. If treatment does not manage diabetes well, and blood glucose levels are too high, this weight gain can occur.

Which diabetic agent causes weight gain?

A number of medications including sulfonylureas, thiazolidinediones, and insulin are associated with weight gain particularly when used in combination, whereas metformin and amylin analogs are weight neutral or associated with modest weight loss.

What is the best weight loss pill for diabetics?

There are several medications approved in the United States for aiding weight loss. They include Xenical (orlistat), Qsymia (phentermine-topiramate) and Contrave (naltrexone-bupropion). Liraglutide is sold under two brand-names: Saxenda, the weight loss drug, and Victoza, for type 2 diabetes.

Can metformin make you gain weight?

Metformin has two advantages over other diabetes drugs: There's less risk of your blood sugar level falling too low. It doesn't cause weight gain.

Can I take metformin to lose weight?

The percentage of weight loss was independent of age, sex or BMI. Conclusion: Metformin is an effective drug to reduce weight in a naturalistic outpatient setting in insulin sensitive and insulin resistant overweight and obese patients.

Does everyone gain weight on glipizide?

There aren't any recent studies on glipizide and weight gain, but older studies suggest it may cause more weight gain compared to other Type 2 diabetes medications.

Why do diabetics have big stomachs?

When we drink beverages sweetened with sucrose, fructose, or high fructose corn syrup, the liver stores this extra sugar as fat, increasing belly fat, Norwood says. The hormones produced by this extra belly fat play a role in insulin resistance, possibly leading to type 2 diabetes.

Does Januvia make you gain weight?

Unlike some other Type 2 diabetes medications, Januvia and other gliptins are not associated with weight gain as a side effect. Weight loss, unfortunately, is also not a side effect of Januvia. Instead, Januvia is considered weight-neutral.

Which is better for weight loss Trulicity or Ozempic?

Is Ozempic or Trulicity more effective? In a phase 3b clinical trial, called SUSTAIN 7, comparing Ozempic against Trulicity, Ozempic was found to be slightly better in terms of improving blood sugar control and resulting in weight loss, with a similar safety profile.

Does lantus cause weight gain?

Some people may experience weight gain during their Lantus treatment. In studies, this was one of the most common side effects seen in people using Lantus. Weight gain is common with many other types of insulin as well. This is due to the way that insulin works in your body to help you store blood sugar.

What are the different types of drugs used for diabetes?

Drugs used in diabetes treat diabetes mellitus by lowering glucose levels in the blood. With the exceptions of Insulin, exenatide, liraglutide and pramlintide, all are administered orally and are thus also called oral hypoglycemic agents or oral antihyperglycemic agents. There are different classes of anti-diabetic drugs, and their selection depends on the nature of the diabetes, age and situation of the person, as well as other factors. Diabetes mellitus type 1 is a disease caused by the lack of insulin. Insulin must be used in Type I, which must be injected. Diabetes mellitus type 2 is a disease of insulin resistance by cells. Type 2 diabetes mellitus is the most common type of diabetes. Treatments include (1) agents that increase the amount of insulin secreted by the pancreas, (2) agents that increase the sensitivity of target organs to insulin, and (3) agents that decrease the rate at which glucose is absorbed from the gastrointestinal tract. Several groups of drugs, mostly given by mouth, are effective in Type II, often in combination. The therapeutic combination in Type II may include insulin, not necessarily because oral agents have failed completely, but in search of a desired combination of effects. The great advantage of injected insulin in Type II is that a well-educated patient can adjust the dose, or even take additional doses, when blood glucose levels measured by the patient, usually with a simple meter, as needed by the measured amount of sugar in the blood. Insulin Main article: insulin (medication) Insulin is usually given subcutaneously, either by injections or by an insulin pump. Research of other routes of administration is underway. In acute-care settings, insulin may also be given intravenously. In general, there are three types of insulin, Continue reading >>

How does diabetes affect the body?

Diabetes is a metabolism disorder that affects nearly 24 million Americans. In healthy people, after eating, food breaks down , gets converted into blood sugar and is then transported to cells by a hormone called insulin. People with diabetes either do not make any insulin, or make an unreliable amount, resulting in cells not getting the energy needed to function properly. In most cases, medications used for treating this disease will either cause weight gain or promote some weight loss. Video of the Day Metformin is one of the most commonly prescribed medications used for treatment of Type 2 diabetes. It’s used to increase insulin sensitivity, control blood sugar levels and help the body absorb glucose from food and the liver. Recently, researchers have been studying use of metformin for obesity treatment. According to a 2011 article published by "Redbook" magazine, glucophage, the generic drug name, can help reduce appetite. In a 2001 study published in the journal “Heart Disease,” 80 percent of nondiabetic women who took metformin on a low-calorie, modified-carb diet lost 10 percent of their body weight in 12 months. Most were successful in keeping the weight off after four years. Byetta, known generically as exenatide, was approved by the Food and Drug Administration in 2005 for treatment of Type 2 diabetes. Exenatide is administered by injection and helps metabolize blood sugar levels. In studies conducted by the company that produces the brand-name drug, patients who used Byetta for more than 30 weeks along with other diabetes medications lost 4 lbs. Patients taking a 10 mcg dose of Byetta alone lost 6 lbs. over 24 weeks. According to MayoClinic.com, exenatide reduces the amount of food needed, because blood sugar gets processed more efficiently. As of 2011, Continue reading >>

Is it better to take diabetes medication or newer?

WHEN it comes to prescription drugs, newer is not necessarily better. And that’s especially true when treating diabetes. One in 10 Americans has Type 2 diabetes. If the trend continues, one in three will suffer from the disease by the year 2050, according to the federal Centers for Disease Control and Prevention. Most Type 2 diabetes patients take one or more drugs to control blood sugar. They spent an estimated $12.5 billion on medication in 2007, twice the amount spent in 2001, according to a study by the University of Chicago. (That figure does not including drugs that diabetics are often prescribed for related health conditions, like high blood pressure and high cholesterol.) Why the increase? More diagnosed patients, more drugs per patient and an onslaught of expensive new drugs, according to Dr. G. Caleb Alexander, assistant professor of medicine at the University of Chicago and lead author of the study. Since 1995, several new classes of diabetes medications have come on the market. Diabetes drugs are important to the pharmaceutical industry, more lucrative than drugs for many other chronic diseases, Dr. Alexander noted in an interview. Simply put, many of these drugs help the body produce less glucose or more insulin, the hormone that shuttles glucose into cells for use as energy, or they increase the body’s sensitivity to its own insulin. Patients and health care professionals have long hoped that as pharmaceutical companies found ways to help the body lower blood sugar, they would produce safer and more efficient alternatives to older medications. But a true breakthrough doesn’t seem to have happened yet. A report released in March by the federal Agency for Healthcare Research and Quality and conducted by researchers at Johns Hopkins University reviewed Continue reading >>

Can diabetes medication cause weight gain?

Did you know that some of the diabetes medications you take can cause you to gain weight or lose weight? Yes, this is been scientifically proven. This ‘weight effect’ is something we doctors consider when deciding which medications to prescribe to our patients. In this article, I’ll give you a quick introduction to type 2 diabetes medications, and point out which are the ones that can cause weight changes. For anyone who is living with diabetes, we are in relatively exciting times. Back about 10 – 15 years ago, there were only a small handful of medications for diabetes – insulin, metformin, sulphonylureas. Today, we have better understanding of the various mechanisms that lead to diabetes and this has resulted in an explosion of new medications – at least 10 different classes, each of them targeting a different mechanism of action and organ in our body that contributes to high blood glucose levels. With so many options of therapy available, there is no longer an excuse for a person with diabetes not to have their glycated haemoglobin (HbA1c) at acceptable levels. Here’s a short list of type 2 diabetes medications, in rough order of ‘newness’: SGLT-2 Inhibitors (Jardiance, Invokana) Bromocriptine DPP4 Inhibitors (Januvia) GLP-1 Receptor Agonists (Byetta, Victoza) Thiazolidinediones (Avandia) Meglitinides (Prandin) Metformin (Glucophage) Sulphonylureas (Glipizide, Glimepiride) Acarbose Insulins Many of these came to market just in the last 5 years. To be honest, even for doctors it’s not easy to keep up with the latest drug developments because things are moving so fast (not to mention, learning how to pronounce their names!) You do not have to understand the full details of each one of these medications (that’s what you’re paying your doctor or p Continue reading >>

What drugs cause weight gain?

Most of the commonly used drugs are reported to have a fat depositing effect. Major diabetic drugs causing weight gain include: Insulin. Sulfonylureas.

How to control diabetes?

Try to burn extra calories by exercising. Talk to your doctor to devise a comprehensive plan to prevent this problem. Taking diabetic drugs and losing weight are both essential for good diabetes control. Sources: ...

Does insulin help with weight gain?

Growth hormones help build different tissues including the fat cells. All of these affects culminate in increased weight gain owing to insulin and other diabetic drugs.

How to avoid weight gain with insulin?

To avoid weight gain when taking diabetes medications such as insulin, the Mayo Clinic recommends significantly cutting back on calories. Most people take in way more than the daily recommended amount of calories (and remember that about 80 to 90 percent of people with type 2 diabetes are overweight or obese). ...

Do you gain weight if you have diabetes?

But, in most cases, doctors recommend that you do not gain additional weight, especially if you have type 2 diabetes.

Can diabetes cause weight gain?

Diabetes Medications and Weight Gain. Last year a study revealed that weight gain can be a positive thing for people who have type 1 diabetes. Those who gained an average of 10 to 55 pounds lived longer compared to those who gained less weight.

Does thiazolidinedione cause weight gain?

The thiazolidinedione class of drugs makes fat cells store more fatty acids from the blood and increase fluid retention. It' s well-known that weight gain isn't healthy , but when you have diabetes the effects on your body are even worse.

Does obesity cause high fasting?

Being overweight or obese reduces insulin sensitivity, and causes high fasting and post-meal blood glucose levels. Also, the immune system plays a role in diabetes, creating imbalances in cytokines which create inflammation; weight gain also increases inflammation in the body.

Does insulin cause weight gain?

Weight gain from these diabetes medications occurs for several reasons, according to Johns Hopkins Medicine: Insulin may cause low blood sugar, or hypoglycemia, which stimulates your appetite. Sulfonylureas such as glimepiride (Amaryl®) and chlorpropamide (Diabinese®) can also induce hypoglycemia and stimulate your appetite.

Do you have to include drinks when you are gaining weight?

Don’t forget to include drinks especially if you enjoy creamy sugar and carb-laden flavored lattes, a regular alcoholic tipple or fruit juices all which can be calorie-laden and possibly adding to your weight gain.

Can diabetes cause weight gain?

Well, the answer is not a simple yes or no. There can be issues relating to your diabetes causing you to gain weight, or it could be that you are simply overeating and/or not exercising enough.

Does insulin cause weight gain?

For example, insulin medications like meglitinides, sulfonylureas, and thiazolidinediones are also associated with weight gain. Even so, weight gain on these medications is far from universal. Studies show that it affects some but not others.

Can diabetes cause thyroid problems?

A thyroid disorder – Studies show that thyroid disorders are more common in people with diabetes so make sure your doctor checks your thyroid hormone levels every year. If you already take medication for a thyroid condition, make sure your healthcare provider checks the amount you take regularly.

Why is it so hard to tell weight gain from drug gain?

It is often difficult to distinguish between weight gain from a drug and weight gain from other reasons, like diet or lack of exercise, because it can be a slow process. Some conditions, like depression, can lead to weight loss or weight gain, depending upon the individual.

What are some examples of insulin?

Examples of insulin are insulin isophane (Humulin), insulin lispro (Humalog), insulin aspart (Novolog), insulin glargine (Lantus) or insulin glulisine (Apidra). Drugs in class known as thiazolidinediones can lead to weight gain and an increase in fat.

What is a beta blocker?

Beta blockers are an older class of heart drug used to treat high blood pressure, chest pain (angina), and protect or prevent the heart from a heart attack. Beta blockers has long been known to lead to weight gain. Common examples of this class are propranolol, metoprolol (Lopressor) and atenolol (Tenormin).

Does antihistaminic medication increase appetite?

Antihistaminic activity can also boost appetite, as noted with several other drugs that cause weight gain. A study compared the use of antihistamines and the risk of obesity. Users of cetirizine (Zyrtec) and fexofenadine (Allegra) had significantly greater weight, BMI, waist circumference, and insulin levels. .

Can pain medication cause weight gain?

If you are taking a prescribed medication for a medical condition, and it's causing weight gain, that almost seems unfair. Diabetes drugs, antidepressants, antihistamines and even some pain medications can all increase weight.

Does Remeron affect appetite?

Mirtazapine ( Remeron) is an atypical antidepressant that boosts serotonin, like SSRIs, but also has an antihistamine effect that may boost appetite and also lead to significant weight gain.

Does insulin cause weight gain?

slowed metabolism. fatigue or weakness, which may lead to less activity, exercise, and calories burned. For many drugs, it is not known exactly what causes weight gain.

What are the causes of weight gain?

About 70% of people in the United States are overweight and, in a cruel catch-22, many of the drugs used to treat obesity-linked conditions such as diabetes, high blood pressure, and depression can themselves cause weight gain.

How long does it take for a person to gain weight on zyprexa?

A 2005 study found that 30% of people on Zyprexa gained 7% or more of their body weight within 18 months.

Is Remeron good for weight gain?

Yet the antihistamine activity of this drug may tip the scales toward weight gain. This side effect can be a good thing, however. Remeron is sometimes given to elderly people who are underweight to improve their appetite, Roerig says.

Do antihistamines cause weight gain?

The antihistamine activity in psychiatric drugs often is what causes weight gain, but it turns out that this property is not important for these drugs to be effective, Roerig says. Antihistamine activity, however, is crucial for the effectiveness of allergy drugs.

Does sulfonylurea cause weight loss?

Sulfonylurea drugs such as Diabinese and Insulase—and others such as Actos and Prandin—stimulate insulin production or activity, which lowers blood sugar and may increase appetite. Metformin, Byetta, and Januvia are more likely to cause weight loss, Dr. Aronne says. (Dr.

Does Prozac help with weight loss?

Although Prozac, an SSRI, is generally associated with weight loss, it can have the opposite effect in the long term. A 60-week study found that, although patients on Prozac shed more than the placebo group (up to 11 pounds in the first six months), they started to regain the weight about halfway through the study.

Does lithium cause weight gain?

The drug affects proteins involved in appetite and metabolism, although it's not clear why it appears to affect women more than men. Lithium, another mood stabilizer for treating bipolar disorder, is also associated with weight gain, albeit less than Depakote. RELATED: Bipolar vs. BPD: How to Tell the Difference.

What antidepressants can cause weight gain?

Medications include amitriptyline ( Elavil ), doxepin ( Silenor ), nortriptyline ( Pamelor ). “As a class, these drugs may increase appetite to stimulate weight gain,” says Jessica Nouhavandi, PharmD, the co-CEO and cofounder of Honeybee Health, in Culver City, California. If you’re on antidepressants, don’t stop taking them abruptly; discuss it first with your doctor and develop a plan that will best support your mental health, notes Harvard Women’s Health Watch. If weight gain is making you want to stop taking your medication, you can talk to your doctor about switching to another class of antidepressants. “ Bupropion ( Wellbutrin XL or SR) or duloxetine ( Cymbalta) are more associated with weight loss, while fluoxetine ( Prozac) is considered weight neutral,” says Dr. Nouhavandi.

Is weight gain dangerous?

One common risk on these lists: weight gain. While this effect may not be dangerous in itself, depending on your health goals , a higher number on the scale can be distressing. That’s why it’s important to be prepared, understand why weight gain can happen, and feel confident that it’s not something you have to deal with.

Can beta blockers cause weight gain?

Augustine, Florida. Some are more likely to cause weight gain, including atenolol ( Tenormin) and metoprolol ( Lopressor ), notes the Mayo Clinic. The reason behind an uptick on the scale isn’t clear, Dr. Emmel says, but beta-blockers can make you tired, especially as you first start taking the medication. “It slows down your heart rate and can decrease your exercise tolerance,” he says. The fatigue and discomfort during activity may make you more likely to stay sedentary, prompting weight gain. A study published in the journal Gastroenterology in May 2017 showed the drug may decrease metabolism, too. For that reason, the researchers suggest that individuals who are overweight or have obesity should not be prescribed beta-blockers as a first-line treatment. Instead, ACE inhibitors may be a better option, but talk to your doctor.

Does metformin help with weight loss?

There are diabetes medications, including metformin or SGLT2 inhibitors, that also promote weight loss or are weight neutral, says Howard. The type of drug that’s best for you depends on your medical history, current health status, and cost considerations, he adds. 10.

Does sulfonylurea cause weight gain?

Sulfonylureas. Another common class of diabetes medication, sulfonylureas, reduce blood sugar levels by 20 percent but also cause a weight gain of about four to five pounds on average, notes a study published August 2015 in the Archives of Medical Science.

Does sugar turn into fat?

That said, after sugar is absorbed from the bloodstream and pushed into cells, if it’s not used by your body for energy, it will be converted into fat. If you’re overeating, particularly high-sugar foods (candy, desserts), you’ll gain weight, he says. If you have type 1 diabetes, you will need to take insulin.

Can SSRIs cause weight gain?

Examples include escitalopram ( Lexapro ), paroxetine ( Paxil ), sertraline ( Zoloft ). These may cause weight gain by affecting your appetite; also, by alleviating symptoms of mood disorders, they may also affect eating or exercise habits, says Emmel. “If you experience weight gain, talk to your physician. Weight gain usually happens early, which signals that it can become a long-term problem for you,” he says.

Why is it so hard to distinguish between weight gain from a drug and weight gain from other reasons?

It is often difficult to distinguish between weight gain from a drug and weight gain from other reasons, like diet or lack of exercise, because it can be a slow process. Some conditions, like depression, Continue reading >>. Diabetes: New compounds may lower blood sugar but prevent weight gain.

Why do people gain weight with insulin?

For many people with type 1, weight gain is advisable due to the loss of lean body mass often accompanying the disease prior to diagnosis and treatment . However, for people with type 2, and increasingly people with type 1 who were overweight or obese before their diagnosis, seeing the numbers on the scale rise is counterproductive. Increasing weight leads to more insulin resistance, which in addition to making diabetes harder to control, escalates cardiovascular risk. There are a variety of reasons weight gain occurs when people start insulin. Some people with type 2 were in poor glycemic control prior to beginning insulin. These folks were seeing the energy from the food they ate end up in their urine stream instead of being stored as fat. As their control improves with insulin, the lost energy finds its way into the fat cells. Treatment for hypoglycemia, if it happens frequently, can also be a source of added pounds when insulin is initiated. Additionally, since an exact replacement for physiological insulin secretion is almost impossible to duplicate, patients may often be taking slightly more insulin than needed over a 24-hour period. Normal circadian rhythm for insulin secretion surges from 4 am to about 7 am then drops, increases a bit around dinner time through 10 pm and declines to its lowest level until the early morning hours. Injected insulin is unable to mirror this profile. Finally, injected insulin follows a slightly different pathway to the cells from insulin that comes from our bodies. Insulin from our bodies is directed first to the liver but insulin that is injected travels first through the blood circulation wher Continue reading >>

Does diabetes medication cause weight gain?

There is a growing concern that the weight gain induced by most diabetes medications diminishes their clinical benefits. On the other hand, there is a claim that treating diabetes with medications that are weight neutral or induces weight loss or less weight gain while minimizing those that increase body weight may emerge as the future direction for treating overweight and obese patients with diabetes. This review clarifies the weight effect of each of the currently available diabetes medications, and explains the mechanism of action behind this effect. Despite the great variability among reviewed clinical trials, the currently available evidence is quite sufficient to demonstrate the change in body weight in association with most of the currently available medications. This review also provides some guidelines on using diabetes medications during weight management programs. Continue reading >>

Is it better to take diabetes medication or newer?

WHEN it comes to prescription drugs, newer is not necessarily better. And that’s especially true when treating diabetes. One in 10 Americans has Type 2 diabetes. If the trend continues, one in three will suffer from the disease by the year 2050, according to the federal Centers for Disease Control and Prevention. Most Type 2 diabetes patients take one or more drugs to control blood sugar. They spent an estimated $12.5 billion on medication in 2007, twice the amount spent in 2001, according to a study by the University of Chicago. (That figure does not including drugs that diabetics are often prescribed for related health conditions, like high blood pressure and high cholesterol.) Why the increase? More diagnosed patients, more drugs per patient and an onslaught of expensive new drugs, according to Dr. G. Caleb Alexander, assistant professor of medicine at the University of Chicago and lead author of the study. Since 1995, several new classes of diabetes medications have come on the market. Diabetes drugs are important to the pharmaceutical industry, more lucrative than drugs for many other chronic diseases, Dr. Alexander noted in an interview. Simply put, many of these drugs help the body produce less glucose or more insulin, the hormone that shuttles glucose into cells for use as energy, or they increase the body’s sensitivity to its own insulin. Patients and health care professionals have long hoped that as pharmaceutical companies found ways to help the body lower blood sugar, they would produce safer and more efficient alternatives to older medications. But a true breakthrough doesn’t seem to have happened yet. A report released in March by the federal Agency for Healthcare Research and Quality and conducted by researchers at Johns Hopkins University reviewed Continue reading >>

Does weight reduction help with diabetes?

Abstract Obesity is a major risk factor for diabetes and cardiovascular disease, and most people with diabetes are overweight or obese. Weight reduction has been shown to improve glycemic control and reduce cardiovascular risk in the diabetic population. While physicians strive to achieve better glycemic control for their patients with diabetes, they are faced with the problem of weight gain that is commonly encountered with the use of antidiabetic agents, particularly insulin, insulin secretagogues, and thiazolidinediones. Weight gain in this population could offset the beneficial effects of good glycemic control and discourage patients from adhering to treatment. In this review, we discuss the effects of the various antidiabetic agents on body weight, highlighting the potential mechanisms and the implications of weight gain in this population. We also present the available therapeutic modalities that have the potential of achieving better glycemic control without adverse effects on body weight. Continue reading >>