What does COMT stand for?
| Rank Abbr. | Meaning |
| COMT | College of Maritime Transport and Techno ... |
| COMT | Certified Ophthalmic Medical Technologis ... |
| COMT | Certification in Orthopedic Manual Thera ... |
| COMT | Conscientious Objectors to Military Taxa ... |
What is COMT and how does it work?
COMT helps the body get rid of excess Dopamine, Epinephrine, Norepinephrine and Estrogens. A homozygous mutation of the V158M allele is associated with a 40% reduction in COMT gene activity.
What is COMT certification in physical therapy?
Certification in Orthopedic Manual Physical Therapy The COMT program is for clinicians who wish to significantly enhance their manual therapy skills for soft tissue work, joint mobilization and joint manipulation, along with evidenced-based critical decision making to improve their clinical practice.
What is the function of the COMT gene?
The COMT gene provides instructions for making an enzyme called catechol-O-methyltransferase. Two versions of this enzyme are made from the gene. The longer form, called membrane-bound catechol-O-methyltransferase (MB-COMT), is chiefly produced by nerve cells in the brain.
What is COMT (catechol-O-methyltransferase)?
COMT (Catechol-O-Methyltransferase) breaks down estrogen, catecholamines and neurotransmitters including dopamine, epinephrine and norepinephrine. Shop Services Order DNA Kit and Report Improve Your Immunity How it Works About Nutrigenomics Testimonials Find a Practitioner Practitioners | Affiliates Practitioner Affiliates
What does the COMT gene do?
Normal Function. The COMT gene provides instructions for making an enzyme called catechol-O-methyltransferase. Two versions of this enzyme are made from the gene. The longer form, called membrane-bound catechol-O-methyltransferase (MB-COMT), is chiefly produced by nerve cells in the brain.
What is COMT medical?
COMT (catechol-O-methyltransferase) inhibitors are a class of drugs used along with carbidopa-levodopa therapy to treat the symptoms of Parkinson's disease (PD). Carbidopa-levodopa therapy is the most effective drug available to treat the motor symptoms of PD.
How do you treat COMT?
If you have the COMT Val/Val variant you may benefit from being treated with stimulants, and by including flavonoids (red wine, berries, apples), and Quercetin (red wine, berries, cherries, leafy veggies) in your diet.
Does COMT increase dopamine?
Increased COMT activity results in increased dopamine release capacity in the striatum. Changes in the level of TH and DAT protein would represent a major compensatory shift in the dopamine system.
What is COMT test?
COMT Genotyping & Anti-Depressant Medications Catechol-O-Methyltransferase (COMT) is an enzyme that allows our body to get rid of hormones like epinephrine, norepinephrine, and dopamine. These hormones are linked to heart rate, breathing rate, cognitive function, pain perception, mood, and memory.
What does slow COMT mean?
COMT Genes & Detoxification People with slow COMT should avoid things their body has to get rid of. Slow COMT genes means slow detoxification. This can show up in different ways – allergies, sensitivities, fatigue, etc.
What can I take for a slow COMT?
To support your slow COMT gene, you need supplementation that promotes the optimal way your gene should function. Hydrox-Adeno B12 and Folinic Acid provide bioavailable sources of vitamin B12 and folate in methyl-free versions, which might be easier to tolerate if you have a sensitive brain.
How do you eat slow COMT?
Eating magnesium-rich foods is a crucial nutrient for a slow COMT diet. Additional nutrients required for the production of SAMe include folate, vitamin B2 and vitamin B12. Eating foods high in B2 and folate is the best diet for the MTHFR gene which is involved in the production of SAMe.
Does quercetin slow COMT?
Quercetin has been reported to inhibit COMT activity through a combination of two mechanisms: one through the formation of S-adenosyl-L-homocysteine as a result of its own rapid O-methylation catalyzed by COMT, and the other as its direct competitive inhibition of the enzyme by serving as a substrate 23.
What are the symptoms of low dopamine?
Symptoms of dopamine deficiency (low dopamine levels) may include:You lack motivation, “the drive.”You're tired.You can't concentrate.You're moody or anxious.You don't feel pleasure from previously enjoyable experiences.You're depressed; you feel hopeless.You have a low sex drive.More items...•
Which drug is COMT resistant?
COMT InhibitorsDrugTargetTypeEntacaponeCytochrome P450 2D6enzymeQuercetinTyrosine-protein kinase HCKtargetQuercetinCytochrome P450 2C8enzymeQuercetinMultidrug resistance-associated protein 1transporter67 more rows
How does COMT break down dopamine?
COMT plays an important role in dopamine metabolism by modulating extracellular levels of dopamine. The functional Val/Met polymorphism of COMT has a measurable effect on COMT enzyme activity, with the Val allele degrading extracellular dopamine more quickly than the less enzymatically active Met allele.
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What is a comt?
What is COMT? COMT (Catechol-O-Methyltransferase) breaks down estrogen, catecholamines and neurotransmitters including dopamine, epinephrine and norepinephrine . Heterozygous or homozygous variants for the COMT V158M methionine allele slow down the COMT enzyme, affecting estrogen metabolism and the breakdown of dopamine and stress hormones.
Why is the COMT V158M called the Warrior?
The wild-type COMT V158M genotype has been called the warrior genotype because there is a higher threshold of pressure to perform due to a lower baseline of dopamine. Stress slows down COMT, increasing dopamine and adrenaline levels.
What is the downside of the COMT genotype?
The downside is that this genotype can overreact to stress and pressure, creating dopamine and adrenaline levels that are too high, shutting the brain down. You can read more about the Warrior or Worrier gene here, including where the heterozygous COMT V158M falls in this spectrum.
Does EGCG inhibit COMT?
For EGCG, there appear to be conflicting results for in vitro vs. in vivo. In vitro says that EGCG inhibits COMT. However, in vivo says it does not inhibit COMT and therefore should not pose any issue to COMT variants, even at higher doses.
Is CoMT working for heterozygous or homozygous?
Since COMT is working at a reduced rate for the heterozygous and homozygous variants, and it is potentially moving too fast for the wild-type variant, you want to avoid, minimize or increase certain lifestyle and diet factors based on the genotype.
What is COMT responsible for?
In addition, COMT is responsible for processing certain phytonutrients ( catechol-containing flavonoids ). It's key to avoid overconsumption of these phytonutrients so as not to overwhelm a slow COMT, while at the same time keeping antioxidant levels high to limit oxidative damage. For example, limit catechol-containing flavonoids ...
What is the COMT gene?
The COMT gene provides instructions for making an enzyme called catechol-O-methyltransferase. An estimated 20-30% of Caucasians of European ancestry have a COMT gene variation which limits the body's ability to remove catechols (a specific type of molecule that includes dopamine , norepinephrine, estrogen, etc.) by 3-4 times.
Why is it important to take B vitamins with COMT?
1. Because COMT is a methylation gene, it's essential to get adequate B vitamins to support COMT, especially B2, B6, B9, and B12 as well as magnesium. To support COMT methylation, others suggest people with COMT Met/Met also take SAMe. 2. Because COMT has a hard time removing catechols from the body , it can also be helpful to avoid foods ...
Does stress increase COMT?
Note. There are not many known ways to increase COMT activity, so avoiding anything that inhibits COMT activity is key to recovering from COMT-related issues. Other things to do.
Does COMT cause stress?
COMT is also associated with greater levels of cortisol and HPA axis dysfunction (which is largely responsible for the body's ability to calm itself and de-stress ). Because of the effects that COMT has on hormones, it directly affects stress reactivity, health, and well-being. Interestingly, those with this gene appear to experience both negative ...
What is the COMT gene?
COMT gene (Catechol-O-Methyltransferase) codes for the essential COMT enzyme involved in the inactivation of catecholamines such as dopamine, norepinephrine and catecholestrogens. COMT helps the body get rid of excess Dopamine, Epinephrine, Norepinephrine and Estrogens. A homozygous mutation of the V158M allele is associated with ...
What are the disorders associated with the COMT gene?
Polymorphisms in the COMT gene have been implicated in association with various mental health disorders due to the resulting changes in dopamine levels. 1,2,5,6 Disorders that may be associated with this gene variant in some populations include drug abuse, 7 alcohol abuse, 8 schizophrenic symptoms, 9,10 obsessive compulsive disorder, 11 panic disorder, 12 post-traumatic stress disorder, and 13 bipolar affective disorder.
What are the effects of a COMT mutation?
Individuals with a COMT gene mutation are generally volatile susceptible to depression, anxiety, mood disorders and toxicity symptoms.
Why is it harder to recover from a COMT mutation?
If you have a COMT gene mutation, your recovery from stressful events might be harder than for someone without this mutation or without impaired methylation because you don’t metabolize stress neurotransmitters , such dopamine, epinephrine, and norepinephrine as rapidly.
What is the role of the COMT gene in estrogen metabolism?
The COMT gene has also been demonstrated to play a role in estrogen metabolism through inactivation of the catecholestrogens. 14 This inactivation step lowers the cancer-causing potential of these metabolites, while simultaneously increasing the amount of 2-methoxyestradiol, a metabolite that has been shown to inhibit the growth of breast cancer cells. 4,15,16 Additionally, COMT gene polymorphisms have been shown to exert an effect on estradiol levels. Patients receiving estrogen therapy should pay attention to this gene especially if they have a family history of estrogen related cancers.
Does COMT cause pain?
COMT gene polymorphisms have also been linked to pain sensitivity. It has been suggested that a reduction in dopamine inactivation, such as is seen with the Met/Met genotype, results in higher levels of dopamine, leading to chronic stimulation of the dopamine receptors.
