Precautions
What does Pradaxa interact with? Pradaxa may interact with antibiotics, St. John's wort, antifungal medications, aspirin or other NSAIDs, heart or blood pressure medication, HIV/AIDS medicine, or medicines used to prevent organ transplant rejection. Click to see full answer.
Does Pradaxa interact with other medications?
Tell your doctor if you have serious side effects of Pradaxa including:
- severe heartburn,
- nausea, or
- vomiting.
What are the side effects of Pradaxa?
Pradaxa (dabigatran): Basics, Side Effects & Reviews. You can drink in moderation while taking Pradaxa (dabigatran). Large amounts of alcohol can cause you to bleed more. Try to limit alcohol to 1 drink equivalent per day (12 ounces of regular beer, 5 ounces of wine, or 1.5 oz of distilled spirits). More ›.
Can I drink alcoho while taking Pradaxa?
While taking Pradaxa, avoid aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) or naproxen (Aleve), and other medications that may thin the blood. If you need a medication like these -- for arthritis, for example -- talk to your doctor about how to safely proceed.
Can you take ibuprofen with Pradaxa?
What drugs should not be taken with Pradaxa?
You may have a higher risk of bleeding if you take PRADAXA and:aspirin or aspirin-containing products.long-term (chronic) use of non-steroidal anti-inflammatory drugs (NSAIDs)warfarin sodium.a medicine that contains heparin.clopidogrel bisulfate.prasugrel.More items...
Can you take vitamin D with Pradaxa?
Interactions between your drugs No interactions were found between Pradaxa and Vitamin D3.
Are there dietary restrictions with Pradaxa?
3. Does PRADAXA have any dietary restrictions? Unlike warfarin, PRADAXA has no dietary restrictions, so taking PRADAXA requires no change to your diet.
Can you take vitamin C with Pradaxa?
Interactions between your drugs No interactions were found between dabigatran and Vitamin C.
Does Pradaxa make you tired?
It's important to watch for symptoms of bleeding while you're taking Pradaxa. Tell your doctor if you have any of the following: fatigue (lack of energy)
What is the most common side effect of Pradaxa?
Bleeding is the most frequently reported Pradaxa side effect. The body usually stops itself from losing too much blood by forming clots, but Pradaxa reduces the body's ability to do so. As a result, people may notice they bruise more easily and it may take longer for bleeding to stop when they suffer a cut or injury.
Can you eat green vegetables while taking Pradaxa?
Pradaxa interacts with only a few other drugs and no foods. Unlike with warfarin, patients using Pradaxa can eat green, leafy vegetables and other vitamin K–enriched foods without worry. Also, the drug begins working rapidly and doesn't require longer hospital stays to reach therapeutic anticoagulant levels.
Does Pradaxa cause hair loss?
Medsafe is highlighting a possible risk of hair loss with the use of novel oral anticoagulants (NOACs). The NOACs available in New Zealand are rivaroxaban, dabigatran and apixaban....Products Affected.Product nameSponsorDabigatranPradaxaBoehringer IngelheimApixabanEliquisPfizer2 more rows•May 30, 2016
What pain reliever can be taken with Pradaxa?
You can take Tylenol (acetaminophen) instead but follow the directions on the box to make sure you don't take more than the recommended amount. 2. If you have a stomach ache, avoid taking Pepto Bismol, as it can make you more likely to bleed when you're on Pradaxa.
When is the best time to take Pradaxa?
The recommended dose of Pradaxa is 300 mg taken as 1 capsule of 150 mg in the morning and 1 capsule of 150 mg in the evening. Patients over 75 years should take a lower dose of 220 mg, taken as 1 capsule of 110 mg in the morning and 1 capsule of 110 mg in the evening.
How long can you take Pradaxa?
Treatment continues with two 110mg capsules taken once a day for 28 to 35 days after hip replacement and for 10 days after knee replacement. Treatment is delayed in patients who are still bleeding from the site of surgery. A lower dose is used in patients with moderate kidney problems.
Can you drink alcohol with Pradaxa?
What drugs and food should I avoid while taking Pradaxa (Dabigatran)? Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth. Avoid alcohol.
Before Taking This Medicine
You should not take Pradaxa if you are allergic to dabigatran, or if you have: 1. an artificial heart valve; or 2. any active bleeding from a surge...
How Should I Take Pradaxa?
Take Pradaxa exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller...
What Happens If I Miss A Dose?
If you miss a dose of Pradaxa, take it as soon as you remember. If your next dose is less than 6 hours away, skip the missed dose. Do not take two...
What Should I Avoid While Taking Pradaxa?
Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.Avoid d...
What Other Drugs Will Affect Pradaxa?
Before you take Pradaxa, tell your doctor if you also take rifampin (Rifater, Rifamate, Rimactane, Rifadin).Tell your doctor about all medicines yo...
What are the side effects of Pradaxa?
pink or brown urine; joint pain or swelling; or. heavy menstrual bleeding. Common Pradaxa side effects may include: stomach pain or discomfort; indigestion; or. nausea, diarrhea. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
What is Pradaxa?
Pradaxa ( dabigatran) is an anticoagulant (thrombin inhibitor) that helps prevent the formation of blood clots.
How should I take Pradaxa?
Take Pradaxa exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.
What medications can cause a stomach ulcer?
you have a stomach ulcer or bleeding in your stomach or intestines; you have kidney disease (especially if you also take dronedarone or ketoconazole ); you take certain other medicines that can increase bleeding risk, such as aspirin, clopidogrel ( Plavix ), heparin, prasugrel, warfarin ( Coumadin, Jantoven );
Why is Pradaxa used after hip replacement?
Pradaxa is also used after hip replacement surgery to prevent a type of blood clot called deep vein thrombosis ( DVT ), which can lead to blood clots in the lungs ( pulmonary embolism ).
What happens if you are allergic to Pradaxa?
Get emergency medical help if you have signs of an allergic reaction to Pradaxa: hives; pain or tight feeling in your chest, wheezing, difficult breathing; swelling of your face, lips, tongue, or throat.
Can you take Pradaxa if you are allergic to dabigatran?
You should not take Pradaxa if you are allergic to dabigatran, or if you have: an artificial heart valve; or. active bleeding from a surgery, injury, or other cause. Dabigatran can cause a very serious blood clot around your spinal cord if you undergo a spinal tap or receive spinal anesthesia (epidural).
How Does Pradaxa Work?
Pradaxa is known as a direct thrombin inhibitor. It blocks the blood’s central clotting agent, thrombin. This lowers the chance of blood clots forming.
Why do people with kidney problems take Pradaxa?
People with kidney problems may take lower doses of Pradaxa because the drug is eliminated through the kidneys. The FDA advises doctors to check a patient’s kidney function before prescribing Pradaxa and to reassess kidney function throughout treatment with the drug.
Why was Pradaxa recalled?
The company cited a potential packaging defect. It warned that a damaged bottle could allow moisture to get into the bottle. This could harm the quality of the drug.
What to do if you suspect a Pradaxa overdose?
If a person suspects a Pradaxa overdose, he or she should immediately contact a poison control center or seek emergency treatment.
Can Pradaxa cause bleeding?
Pradaxa can also cause drug interactions if taken at the same time as certain medications. Side effects of Pradaxa include serious and sometimes fatal bleeding. The FDA gave full approval to a Pradaxa bleeding antidote in April 2018. Boehringer Ingelheim makes Pradaxa.
Who makes Pradaxa?
Boehringer Ingelheim makes Pradaxa. The U.S. Food and Drug Administration first approved Pradaxa in 2010.
Does Pradaxa help with stroke?
Pradaxa reduces the risk of stroke by lowering the chance of a blood clot forming. The FDA also approved Pradaxa to treat deep vein thrombosis (DTV) and pulmonary embolism (PE) in patients who have been treated with injectable blood thinner for five to 10 days. DTV is a serious condition that occurs when a blood clot forms in the deep veins in ...
What foods should I avoid while taking Pradaxa?
Are There Foods to Avoid While Taking Pradaxa? Patients taking older anticoagulants, such as warfarin, were required to avoid eating foods that were high in vitamin K, such as cabbage, spring onions, broccoli, fermented soy products, Brussels sprouts, and kale and other leafy greens.
Does Pradaxa cause blood clots?
Pradaxa, on the other hand, impedes clotting using a completely different mechanism of action—it inhibits thrombin, an enzyme that enables platelets to stick together to form blood clots. Because Pradaxa's blood-thinning action isn't related to vitamin levels in the blood, people taking the drug aren't required to avoid certain types of foods.
Is Pradaxa safe for everyone?
Pradaxa isn't for everyone. The drug was approved for use in adult patients with abnormal heart rhythm or atrial fibrillation that wasn't caused by a problem with the heart valves, but its safety hasn't been studied in pediatric patients.
Is Pradaxa a blood thinner?
by Boehringer Ingelheim, Germany's second-largest drugmaker. While Pradaxa has fewer requirements and restrictions than other blood-thinners such as warfar in, there are still a few things that patients should know before taking their first dose.
Can you take Pradaxa while pregnant?
Women who are pregnant, plan to become pregnant or are nursing should n't take Pradaxa, as it has not been proven safe for unborn babies or infants, and it is unknown how much Pradaxa passes into the breast milk. Additionally, patients who have a mechanical prosthetic heart valve, active pathological bleeding, or kidney problems should avoid taking Pradaxa. The drug is also contraindicated for patients who have had bleeding problems, stomach ulcers, or an allergic reaction to Pradaxa's active ingredient, dabigatran.
Can you take Pradaxa with a heart valve?
Additionally, patients who have a mechanical prosthetic heart valve, active pathological bleeding, or kidney problems should avoid taking Pradaxa. The drug is also contraindicated for patients who have had bleeding problems, stomach ulcers, or an allergic reaction to Pradaxa's active ingredient, dabigatran.
Can you take Pradaxa with other medications?
When taken together, some common medications can interact with Pradaxa, changing the way drug works in the body . Depending on the medication, drug interactions may decrease Pradaxa's life-saving blood-thinning effects; or cause the drug to work too well, increasing the patient's risk of experiencing an uncontrollable bleeding event. This is why it's so important to tell your doctor about all the medications you're taking—including over-the-counter medications, other prescription drugs, and even vitamins and herbal supplements—before you take Pradaxa.
What other drugs could interact with this medication?
There may be an interaction between dabigatran and any of the following:
What side effects are possible with this medication?
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
How should I use this medication?
For knee replacement surgery, the usual dose of dabigatran is 110 mg (one capsule) taken by mouth between 1 and 4 hours after the surgery, followed by 220 mg (2 capsules) once daily for a total of 10 days. If treatment is not started on the day of surgery, then treatment should be started with a dose of 220 mg once daily. For people over the age of 75, the doctor may recommend a lower dose of 150 mg taken once daily.
What is the purpose of Dabigatran?
Dabigatran is used to prevent blood clots for people who have had total hip replacement or knee replacement surgery.
Can you take dabigatran with food?
Dabigatran may be taken with food or on an empty stomach, with a full glass of water. If you experience heartburn or upset stomach, take dabigatran with food. Swallow the capsules whole. Do not open, break, or chew the capsules.
When to stop taking dabigatran?
Surgery: Your doctor may want to stop dabigatran for a few days prior to any planned surgery to prevent any unnecessary bleeding, so it is important to tell all of your doctors that you are taking dabigatran.
Can a pharmacist advise on side effects?
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
What is Pradaxa used for?
Pradaxa has active ingredients of dabigatran etexilate mesylate. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 80,897 Pradaxa users for its effectiveness, alternative drugs and more.
What to do when serious adverse effects are detected in your trial?
When serious adverse effects are detected in your trial, your doctor will be notified to check them out promptly. What you need to do:#N#1. start your phase IV clinical trial#N#2. ask your doctor to join eHealthMe professional network
What is Pradaxa?
Pradaxa has active ingredients of dabigatran etexilate mesylate. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 82,282 Pradaxa users for its effectiveness, alternative drugs and more.
How many people take carvedilol and pradaxa together?
2,242 people who take Pradaxa and Carvedilol together, and have interactions are studied.
What to do when serious adverse effects are detected in your trial?
When serious adverse effects are detected in your trial, your doctor will be notified to check them out promptly. What you need to do:#N#1. start your phase IV clinical trial#N#2. ask your doctor to join eHealthMe professional network
Severe Interactions
These medications are not usually taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.
Serious Interactions
These medications may interact and cause very harmful effects. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.
Moderate Interactions
These medications may cause some risk when taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.
How does Pradaxa work?
Pradaxa works by blocking the action of thrombin, a protein that is necessary for the coagulation of blood that results in blood clots. Reducing the action of thrombin reduces the ability of blood to clot.
What are the factors that increase the exposure to dabigatran?
P-gp inhibition and impaired renal function are the major independent factors that result in increased exposure to dabigatran. Concomitant use of P-gp inhibitors in patients with renal impairment is expected to produce increased exposure of dabigatran compared to that seen with either factor alone.
How to report side effects of prescription drugs?
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
How to report a drug problem to the FDA?
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088 . Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.
Does Pradaxa cause major bleeding?
The risk of major bleeds was similar with Pradaxa 150 mg and warfarin across major subgroups defined by baseline characteristics (see Figure 1), with the exception of age, where there was a trend towards a higher incidence of major bleeding on Pradaxa (hazard ratio 1.2, 95% CI: 1.0 to 1.5) for patients ≥75 years of age.
Does dabigatran cause bleeding?
Dabigatran increases the risk of bleeding and can cause significant and, sometimes, fatal bleeding. All signs or symptoms of blood loss such as a drop in hemoglobin and/or hematocrit or low blood pressure should be evaluated and dabigatran should be discontinued in patients with active bleeding.
Can you take Pradaxa while pregnant?
Combining Pradaxa with P-gp inducers (for example, rifampin) reduces dabigatran blood levels and should generally be avoided. There are no adequate or well-controlled trials of Pradaxa use in pregnant women. It is unknown if Pradaxa is excreted into breast milk. Consult your doctor before breastfeeding.
