Precautions
Endocrine side effects include at least one case of indapamide-induced hyperparathyroidism. In one study, indapamide significantly reduced parathyroid hormone levels in all patients. [ Ref] Hematologic side effects are rare, but have included at least one case of mild thrombocytopenia and mucosal bleeding from the tongue.
What are the endocrine and hematologic side effects of indapamide (indapamide)?
Withdrawal syndrome is found among people who take Indapamide, especially for people who are female, 60+ old also take medication Amlodipine, and have Lower respiratory tract infection. This study is created by eHealthMe based on reports of 11,530 people who have side effects when taking Indapamide from FDA, and is updated regularly.
Does indapamide cause withdrawal syndrome?
Overdose symptoms may include vomiting, weakness, dizziness, dry mouth, thirst, and muscle pain or weakness. What should I avoid while taking indapamide?
What happens if you overdose on indapamide?
As with other medicines for high blood pressure or heart failure, you will usually have to take indapamide for a long time, probably for the rest of your life. It's important to carry on taking your medicines even if you feel well.
How long do you have to take indapamide?
Can I stop indapamide suddenly?
If you stop taking the drug or don't take it at all: Don't stop taking indapamide without talking to your doctor. Stopping this drug suddenly may cause your blood pressure to spike. This may increase your risk of a heart attack or stroke.
How long does indapamide stay in the body?
A dose of indapamide lowers the blood pressure for 24 hours or more, so patients only need to take the medicine once a day. However, if adverse effects happen they can last for a long time.
Can I take indapamide every other day?
These results suggest that a low dose of indapamide given every day or every other day is effective in lowering BP and does not result in metabolic derangements.
What are the long term side effects of indapamide?
If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure.
What does indapamide do for the body?
Indapamide is a type of medicine called a diuretic. Diuretics are sometimes called "water tablets" because they make you pee more. This helps get rid of extra fluid in your body. Indapamide is used to treat high blood pressure (hypertension).
Does indapamide cause anxiety?
weakness, tiredness; back pain, muscle cramps; feeling anxious or agitated; headache; or.
What foods should be avoided when taking indapamide?
Grapefruit and juice: Don't eat or drink grapefruit or its juice when you are on indapamide as it can increase the side effects of this drug.
How long does it take for indapamide to reduce blood pressure?
As a rule, indapamide's blood pressure-reducing effect is rapid in onset (within 1 or 2 weeks) and by 1 month reaches 65% of its maximum, which occurs after 3 to 4 months of treatment. No tachyphylaxis has been observed during long-term treatment, nor has withdrawal syndrome at discontinuation of therapy.
Does indapamide cause fatigue?
Taking too much indapamide may make you feel or be sick (nausea or vomiting), cause low blood pressure, cramps, dizziness, drowsiness, confusion and changes in the amount of urine produced by the kidneys due to severe dehydration.
Does indapamide cause joint pain?
Gout: Indapamide may increase the level of uric acid in the body. If you develop painful, warm and swollen joints contact your doctor as soon as possible.
What is indapamide 1.25 mg used for?
Indapamide, a 'water pill,' is used to reduce the swelling and fluid retention caused by heart disease. It also is used to treat high blood pressure. It causes the kidneys to get rid of unneeded water and salt from the body into the urine.
Does indapamide cause weight loss?
The mean weight loss at one week was 2.5 kg for the three indapamide groups and 2.6 kg for the hydrochlorothiazide group; this loss was maintained for the 12 weeks of the study. The mean decreases in weight and pitting edema were clinically and statistically significant (P less than 0.05) for both medications.
Why is it important to take indapamide in the morning?
Indapamide is prescribed for high blood pressure (hypertension). It is best taken in the morning. Any side-effects are usually mild. The most common are a skin rash, feeling sick (nausea), and feeling dizzy....About indapamide.Type of medicineAn antihypertensiveUsed forHigh blood pressure2 more rows•May 24, 2021
How long does indapamide take to work?
It may take up to several weeks before you get the full benefit of this drug. If you also take certain drugs to lower your cholesterol (bile acid-binding resins such as cholestyramine or colestipol), take indapamide at least 4 hours before or at least 4 hours after these medications.
What are the side effects of indapamide 1.25 mg?
Side effects of indapamideMild skin rash. If you get a mild rash, speak to your doctor for advice as your treatment may need to be changed.Feeling or being sick (nausea or vomiting) Try taking indapamide after a meal. ... Feeling dizzy or faint. Try sitting or lying down until you feel better.
Does indapamide affect potassium levels?
Conclusions: Indapamide can cause both severe hypokalemia and hyponatremia. The predominant clinical features can be a result of severe hyponatremia.
How many people have side effects from Indapamide?
It is created by eHealthMe based on reports of 15,873 people who have side effects when taking Indapamide from the FDA, and is updated regularly. With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness.
What is phase IV in Indapamide?
The phase IV clinical study analyzes which people take Indapamide and have Withdrawal syndrome. It is created by eHealthMe based on reports of 15,873 people who have side effects when taking Indapamide from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
What is Withdrawal syndrome?
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance) is found to be associated with 1,615 drugs and 1,239 conditions by eHealthMe.
Can you stop a medication without a doctor?
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
How long does it take to increase indapamide?
Dosage increases: After 4 weeks, your doctor may increase your dosage to 2.5 mg taken once per day. After another 4 weeks, your doctor may increase your dosage to 5 mg taken once per day. If your blood pressure is still high, your doctor may give you another drug to take along with indapamide.
What is Indapamide used for?
Indapamide oral tablet is used for long-term treatment of high blood pressure. It’s used for short-term or long-term drug treatment of edema.
How to avoid interactions with medications?
To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.
Is indapamide a prescription drug?
Indapamide is a prescription drug. It comes as an oral tablet.
Can you take indapamide if you are allergic to sulfonamide?
Sulfa drugs warning: Don’t use indapamide if you’re allergic to sulfonamide-derived (sulfa) drugs.
What to do if you have serious side effects?
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:
Is Indapamide a category B drug?
For pregnant women: Indapamide is a category B pregnancy drug. That means two things:
Dosage and strength
Indapamide comes as 2.5mg standard tablets, and as 1.5mg slow release tablets.
How to take it
It's best to take indapamide in the morning. If you take indapamide too late in the day you may have to get up during the night to go to the toilet.
How long to take it for
As with other medicines for high blood pressure or heart failure, you will usually have to take indapamide for a long time, probably for the rest of your life.
If you forget to take it
If you forget to take your dose, take it as soon as you remember. However, if you usually take your dose in the morning and it is after 4pm, skip the missed dose and take your next dose at the usual time.
If you take too much
If you have taken more than your prescribed dose of indapamide, you may:
What are the side effects of taking indapamide?
Check with your doctor as soon as possible if any of the following side effects occur while taking indapamide: Signs and symptoms of an imbalance of water or potassium in the body. Dryness of mouth. increased thirst. irregular heartbeat. mood or mental changes.
How many people have rashes with indapamide?
Dermatologic reactions, such as rashes, occur in less than 5% of patients, and comprise up to 36% of all adverse drug reactions associated with indapamide. [ Ref]
Does indapamide affect lipids?
Unlike the thiazides, indapamide has little or no adverse effect on the lipid profile. Severe cases of hyponatremia, accompanied by hypokalemia have been reported with recommended doses of indapamide in elderly females.
What are the side effects of a syringe?
Less common or rare. Diarrhea. dizziness or lightheadedness, especially when getting up from a lying or sitting position. headache. loss of appetite. trouble in sleeping. stomach upset. Managing side effects (general information)
Does indapamide need medical attention?
Side effects not requiring immediate medical attention. Some side effects of indapamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Does indapamide cause hyperparathyroidism?
Endocrine side effects include at least one case of indapamide-induced hyperparathyroidism. In one study, indapamide significantly reduced parathyroid hormone levels in all patients. [ Ref]
Is indapamide a hepatitis?
A case of reversible hepatitis associated with inda pamide has been reported. [ Ref]
How much indapamide is in a tablet?
each tablet contains 1.5 m/g indapamide. i started taking them 3 months ago and since then I've had a cough that can last up to 2/3 hours all through the day and night I'm heaving and fill like my airways are shutting down it makes it hard to breath I've seen the doctor and they they said ive had
Does Gp prescribe indapamide?
Gp has now prescribed Indapamide 2.5mg. My BP appears to have stabilised for 6mths now. My main concern now is, for the pass 4 was I developed severe dry eyes syndrome. Can anyone tell me if they have experienced eye problems with indapamide. Thanks
Indapamide Hemihydrate
Indapamide Hemihydrate is a diuretic antihypertensive. It appears to cause vasodilation, probably by inhibiting the passage of calcium and other ions (sodium, potassium) across membranes. It has an extra-renal antihypertensive action resulting in a decrease in vascular hyperreactivity and a reduction in total peripheral and arteriolar resistance.
Uses
Indapamide Hemihydrate is used for the treatment of essential hypertension . It is effective in treating hypertension in patients with renal function impairment, although its diuretic effect is reduced. Indapamide Hemihydrate is also used for the treatment of salt and fluid retention associated with congestive heart failure.
How Indapamide Hemihydrate works
Indapamide Hemihydrate acts on the nephron, specifically at the proximal segment of the distal convoluted tubule where it inhibits the Na+/Cl- cotransporter, leading to reduced sodium reabsorption. As a result, sodium and water are retained in the lumen of the nephron for urinary excretion.
Indapamide Hemihydrate
amlodipine, lisinopril, metoprolol, losartan, furosemide, hydrochlorothiazide, spironolactone, Lasix, chlorthalidone, torsemide
Dosage
One tablet daily preferably in the morning. In more sever case Indapamide Hemihydrate can be combine with other categories of anti-hypertensive agent. The safety and effectiveness in pediatric patients have not been established
Side Effects
Side effects of Indapamide Hemihydrate include headache, anorexia, gastric irritation,nausea, vomiting, constipation, diarrhoea etc.
Toxicity
Indapamide Hemihydrate overdose symptoms may include but are not limited to nausea, vomiting, gastrointestinal disorders, electrolyte disturbances and weakness. Other signs of overdose include respiratory depression and severe hypotension. In cases of overdose, supportive care interventions may be necessary to manage symptoms.
How long does it take to stop taking indapamide?from nhs.uk
If you're ill with a fever (a high temperature above 38C), sweats and shaking, being sick (vomiting) or have severe diarrhoea, contact your doctor as you may need to stop taking indapamide for 1 to 2 days until you are better. You can start to take it again when you're eating and drinking normally.
What happens if you take too much indapamide?from nhs.uk
feel sleepy. have muscle cramps. If you take too much indapamide by accident, contact your doctor and have the packet with you. In serious cases you can have fits (seizures) and may need emergency treatment in hospital.
How does indapamide work?from healthline.com
A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. Indapamide makes your body get rid of extra water and salt through your urine.
Why is Indapamide called water?from nhs.uk
Diuretics are sometimes called "water pills/tablets" because they make you pee more. Indapamide is used to treat high blood pressure (hypertension). It's also sometimes used to treat heart failure. Indapamide is only available on prescription. It comes as tablets and slow-release ("modified-release") tablets.
How to take indapamide after eating?from nhs.uk
feeling or being sick - try taking indapamide after a meal. Try to stick to simple foods and avoid rich or spicy meals. Drink water or squash in small, frequent sips so you don't get dehydrated (ask your doctor how much fluid you can drink). Speak to your doctor if your symptoms continue for more than a week.
How do diuretics help you pee?from nhs.uk
Diuretics make your body get rid of extra fluid through your kidneys. This increases the amount of salts (such as sodium and potassium) and water you pee out .
How to dispose of unneeded medication?from medlineplus.gov
However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website ( http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
How does hormone replacement therapy work?
Menopausal HRT works by replacing your natural hormones that decrease with menopause. Menopausal HRT is either estrogen alone — or both estrogen and progesterone. You can take it as a pill, shot, implant, patch, or even vaginally. Your healthcare provider can help you understand your options and what type of MHT might be right for you.
How long does hormone replacement therapy last?
As with any medication, there are some risks with hormone replacement therapy. That’s why experts recommend using HRT at the lowest dose that works and for the shortest amount of time needed to improve symptoms. When the symptoms of menopause start to decrease, you can begin to lower your dose.
What are the side effects of hormone replacement therapy?
It’s possible you may experience side effects of menopausal HRT that make you think about decreasing your dose or stopping it completely. These side effects may include:
What side effects can you expect when you start reducing doses of HRT?
When you start to decrease your dose of menopausal HRT, you may notice some symptoms. The cause of these symptoms is usually a dropping level of estrogen. Symptoms may include:
How can I support my menopausal symptoms naturally?
As you think about lowering and stopping menopausal HRT, there may be some natural or over-the-counter treatments for menopausal symptoms. These include nutrition and dietary changes, certain supplements, and exercise.
The bottom line
Menopause is a natural part of life. But for some people, it comes with some bothersome side effects that can have a big impact on quality of life. Menopausal hormone replacement therapy is an effective way to improve those symptoms. But it isn’t for long-term use.
