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what happens if spermatogenesis occurs in cryptorchid testes

by Bradly Kassulke Published 2 years ago Updated 2 years ago

What happens if spermatogenesis occurs in cryptorchid testes? In some studies, patients with unilateral cryptorchidism had normal spermatogenesis, suggesting that additive detrimental factors may be responsible for impaired fertility. It is known that undescended testes, if untreated, lead to an increased risk of TC, usually seminomas (10), arising from mutant germ cells.

Full Answer

Is cryptorchidism associated with testicular function in early adulthood?

A history of cryptorchidism is associated with impaired testicular function in early adulthood: a cross-sectional study of 6376 men from the general population. Hum Reprod.

What is the pathophysiology of cryptorchidism?

Cryptorchidism: absence of one or both testes in the scrotum most commonly due to failure of descent into the scrotum during fetal development May occur with gonadal dysgenesis or following testicular ascent later in life Anorchia or vanishing testis syndrome: absence of one or both testes

What happens to the mitochondria during spermiogenesis?

During spermiogenesis, the nucleus will condense, the acrosome (sperm cap) will be formed, and the tail (of the sperm) will be formed. The mitochondria will also be concentrated in the middle piece of the sperm as it will help for its motility. It is important to note that during spermiogenesis,...

What happens to the shape of cells during spermatocytogenesis?

While the cells during the stage of spermatocytogenesis are typically rounded in appearance, they will dramatically change this configuration when they enter spermiogenesis, where they will have to be adapted for fertilization.

How does cryptorchidism affect spermatogenesis?

The inhibition of this process in undescended testis leads to a deficient pool of stem cells for post pubertal spermatogenesis and infertility. Moreover, in undescended testes, germ cells loss starts at 6 months of age.

How does cryptorchidism affect reproduction?

An undescended testicle stays up in the body, so it has a higher temperature. That causes a lower sperm count and quality, decreasing a man's chances of being able to fertilize a woman's egg and father a child.

What will happen to the male individual if he suffers from cryptorchidism?

Men who've had an undescended testicle have an increased risk of testicular cancer. The risk is greater for undescended testicles located in the abdomen than in the groin, and when both testicles are affected.

Does undescended testicle affect sperm?

Having two undescended testicles at birth is much more likely to result in lower sperm counts and fertility issues as an adult than having just one undescended testicle. You can check whether your fertility has been affected with a semen analysis.

Can cryptorchidism cause sterility?

Cryptorchidism is associated with impairment of germ cell maturation and subsequent infertility in adulthood.

How can cryptorchidism lead to male sterility?

The main reasons for infertility in men with a history of cryptorchidism treated by orchidopexy are maldevelopment of the testes and an improper environment for the normal development of the testes, hyperthermia, and antisperm antibodies.

Why is male cryptorchidism important?

Undescended testicles are associated with decreased fertility (bilateral cases), increased testicular germ cell tumors (overall risk under 1%), testicular torsion, inguinal hernias, and psychological problems. Without surgical correction, an undescended testicle may descend during the first three months of life.

What is the significance of cryptorchidism?

Undescended testicles are also linked to a higher risk of: Testicular cancer in adulthood (though the risk is still less than 1 in 100) Testicular torsion (twisting of the chord that brings blood to the scrotum) Developing a hernia near the groin.

Why is cryptorchidism a problem?

Cryptorchidism also increases the risk of testicular torsion. This occurs when the spermatic cord becomes twisted. The spermatic cord contains nerves, blood vessels, and tubes that carry semen between each testicle and the penis. If a person does not receive quick treatment, they could lose the twisted testicle.

Can a man with one testis pregnant a woman?

Yes, in most cases, people with one testicle can get someone pregnant. Remember, one testicle can provide enough testosterone for you to get an erection and ejaculate. This is also enough to produce adequate sperm for fertilization.

Can cryptorchidism affect erection?

Abieyuwa Emokpae, has warned that babies born with undescended testicles stand high risk of developing testicular cancer, infertility and erectile dysfunction later in life if the anomaly is not corrected on time. He said the condition, known as cryptorchidism, is a congenital disorder and is usually detected at birth.

Which of the following may be a consequence of undescended testes in a male?

If the testicles don't drop into the scrotum, they may not function normally and produce healthy sperm. This can lead to infertility later in life. Males born with undescended testicles also have a higher risk of testicular cancer in adulthood.

Why do sperm drop in the scrotum?

This is because sperm can't grow at body temperature. During childhood, sperm in the testicles go through a process that results in mature sperm at puberty. Normal testicles form early in a baby boy's growth. They form in the lower belly (abdomen), but descend, or "drop," into the scrotum toward the end of pregnancy.

Why are my testicles not attached to my baby?

Or it may be that the baby's hormones can't stimulate the testicles normally. No studies have shown that the problem is caused by something the mother did or ate during pregnancy. Sometimes the testicles drop but don't attach in the scrotum. Then, when the boy grows, it becomes clear that the testicles aren't attached.

How long does it take for testicles to drop?

Luckily, about half of these testicles will drop on their own during the first 3 months of life. But testicles won't drop on their own after 3 months of age. Thus, about 1 or 2 out of 100 boys with undescended testicles will need treatment.

What is an undescended testicle?

An undescended testicle (or " testis") is when it fails to drop into the normal place in the scrotum. Your child's health care provider can find this during a routine exam. This issue is found in about 3 or 4 out of 100 newborns (and up to 21 out of 100 premature newborns). Luckily, about half of these testicles will drop on their own during ...

Why do my testicles not drop?

In most children with this health issue, it's not known why the testicles fail to drop. It may be because the testicles aren't normal to start with. In other cases, there's a mechanical problem. The testicles drop but miss the scrotum, ending up next to the scrotum instead. These are called "ectopic testicles.".

When do testicles get pulled up?

It's important not to confuse undescended testicles with "retractile" testicles. After 6 months of age, a male child has a reflex that temporarily pulls the testicles up to protect them when he's cold or frightened. These testicles are in the scrotum at other times and don't need treatment.

Where do testicles form?

They form in the lower belly (abdomen), but descend, or "drop," into the scrotum toward the end of pregnancy. Normal testicles attach themselves with stretchable tissue in the bottom of the scrotum. This is controlled by the baby's normal hormones.

What is the difference between spermatocytogenesis and spermiogenesis?

On the other hand, spermiogenesis is the stage where spermatids differentiate. While the cells during the stage of spermatocytogenesis are typically rounded in appearance, they will dramatically change this configuration when they enter spermiogenesis, where they will have to be adapted for fertilization .

What is the function of spermatogenesis?

Physiology of Spermatogenesis. The maturation of the male reproductive system happens under the influence of the hormone testosterone which primarily removes unnecessary cytoplasm and organelles. These unnecessary cytoplasms are known as residual bodies and are engulfed by the Sertoli cells found in the testes.

What hormone is released into the testes to help spermatids mature?

The release of the follicle stimulating hormone (FSH) into the testes will help in the development of the Sertoli cells and will help these spermatids mature as they undergo spermiogenesis. 2. Spermiogenesis. On the other hand, spermiogenesis is the stage where spermatids differentiate.

What are the cells that support and nourish sperm cells?

Within the walls, there are cells called the Sertoli cells that support and nourish the sperm cells by supplying blood products and nutrients. As they grow, the Sertoli cells aid them to be transported up to the central channel of the tubule.

What is the process of mitosis?

During this phase of spermatocytogenesis , the spermatogonia (primitive cells) increase their number through mitosis.

Where does sperm come from?

Spermatogenesis is the production of sperm from the primordial germ cells within the male reproductive organs, the testes. The process of spermatogenesis occurs in the epithelium of the seminiferous tubules, with the spermatogonia and the spermatozoa at the lumen of the border of the tubule. Within the walls, there are cells called ...

What temperature should spermatogenesis be?

Surprisingly, the optimal temperature in the testes is maintained at about 34-35 degrees Celsius in human males. In addition to temperature, deficiencies in dietary nutrients like vitamins and minerals, infectious diseases, and alcohol can affect spermatogenesis.

1.Spermatogenesis and cryptorchidism - PubMed

Url:https://pubmed.ncbi.nlm.nih.gov/24829558/

23 hours ago What happens if spermatogenesis occurs in cryptorchid testes? In some studies, patients with unilateral cryptorchidism had normal spermatogenesis, suggesting that additive detrimental factors may be responsible for impaired fertility. It is known that undescended testes, if untreated, lead to an increased risk of TC, usually seminomas (10), arising from mutant germ …

2.Defective Spermatogenesis in Cryptorchid Testes: Cause …

Url:https://ehp.niehs.nih.gov/doi/10.1289/ehp.11489

21 hours ago It is also known that undescended testes, if untreated, lead to an increased risk of testicular tumors, usually seminomas, arising from mutant germ cells. In normal testes, germ cell development is an active process starting in the first months of life when the neonatal gonocytes transform into adult dark (AD) spermatogonia.

3.Defective Spermatogenesis in Cryptorchid Testes: Cause …

Url:https://www.researchgate.net/publication/23176530_Defective_Spermatogenesis_in_Cryptorchid_Testes_Cause_or_Effect

7 hours ago  · Maldescended testes is commonly cited as an important cause for defective spermatogenesis (Tomomasa et al. 2002). In contrast, testicular ascent (acquired cryptorchidism) could also be a risk factor for spermatogenesis in infertile men without any history of maldescended testes (Mieusset et al. 1997). However, it remains controversial …

4.Spermatogenesis in the unilateral cryptorchid testis after …

Url:https://pubmed.ncbi.nlm.nih.gov/6132013/

24 hours ago  · An ascending testis was encountered more frequently in previously cryptorchid (30.4%) than in non-cryptorchid infertile men without any history of cryptorchism (18.3%) or in fertile men (11.8%).

5.the process of spermatogenesis in the testes Flashcards

Url:https://quizlet.com/137517122/the-process-of-spermatogenesis-in-the-testes-flash-cards/

1 hours ago We herein examine the role of orchiopexy in the child with unilateral cryptorchidism and specifically discuss whether this operation produces a testis capable of good sperm production. Contralateral vasectomy was performed in subjects who …

6.Cryptorchidism - StatPearls - NCBI Bookshelf

Url:https://www.ncbi.nlm.nih.gov/books/NBK470270/

13 hours ago -no cell division occurs; each spermatid becomes a single sperm cell.-spherical spermatids transform into elongated, slender sperm.-sperm are released from their connections to Sertoli cells (spermiation).-Sperm then enter lumen of seminiferous tubule.-fluid from sertoli cells pushes sperm along their way toward the duct of the testes.

7.Cryptorchidism: Symptoms, Diagnosis & Treatment

Url:https://www.urologyhealth.org/urology-a-z/c/cryptorchidism

36 hours ago  · Cryptorchidism may occur on one or both sides but more commonly affects the right testicle. The testicle may be anywhere along the "path of descent," such as: Located high in the retroperitoneal abdomen to the inguinal ring; In the inguinal canal; ectopic from the path of descent; hypoplastic; dysgenetic; missing or absent; unilateral (two-thirds).

8.Spermatogenesis: The Generation of Sperm Cells - Bio …

Url:https://www.bioexplorer.net/spermatogenesis.html/

20 hours ago This happens because the testicle doesn't "fix" itself in the scrotum, and is noticed as the child grows. Often these boys are known to have a retractile testicle before they are diagnosed with an ascending testicle. These testicles need surgery to move them into the scrotum. Sperm won't mature if the testicle stays undescended.

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