You should push Zofran IV over a few minutes because it apparently causes severe headaches if given to fast. Click to expand... It also causes a tachycardia if pushed too fast.
How long should I push Zofran?
You should really push Zofran over at least 5 minutes. If you don't, you can give your patients a massive headache. I speak from experience because with my last pregnancy, I had severe hyperemesis gravidarum and could only take Zofran for the vomiting.
What should I know about Zofran before taking it?
Consider laxatives to relieve or prevent constipation associated with Zofran. Monitor for serotonin syndrome (symptoms include mental status changes [such as agitation, hallucinations, coma, delirium]), fast heart rate, dizziness, flushing, muscle tremor or rigidity and stomach symptoms [including nausea, vomiting, diarrhea]).
Can I push Zofran through IVF?
I've never had a problem with Zofran - whether it be pushing it quickly, or slowly; pushing it through IVF, or just giving the med alone. However, the only med that I push "fast" is adenosine.
What are the side effects of Zofran during pregnancy?
Some cases have been fatal. Symptoms include mental status changes such as agitation, hallucinations, coma, or delirium; a fast heart rate; dizziness; flushing; muscle tremor or rigidity; and stomach symptoms (including nausea, vomiting, and diarrhea). There is not enough data to give a recommendation on the use of Zofran during pregnancy.
How fast can you push Zofran IV?
For prevention of PONV in paediatric patients having surgery performed under general anaesthesia, a single dose of Zofran may be administered by slow intravenous injection (not less than 30 seconds) at a dose of 0.1 mg/kg up to a maximum of 4 mg either prior to, at or after induction of anaesthesia.
Why do you push IV Zofran slow?
Perhaps slow administration of ondansetron as recommended over 2-5 min would decrease the incidence of potentially life-threatening adverse effects associated with ondansetron.
Can you give Zofran IV push?
Emetogenic chemotherapy and radiotherapy: Ondansetron can be given either by rectal, oral (tablets or syrup), intravenous or intramuscular administration.
How long do you push IV Zofran over?
The first dose is to be administered 30 minutes before the start of moderately to highly emetogenic chemotherapy. Subsequent doses (0.15 mg/kg up to a maximum of 16 mg per dose) are administered 4 and 8 hours after the first dose of ZOFRAN. The drug should be infused intravenously over 15 minutes.
Is Zofran compatible with normal saline?
Interactions between your drugs No interactions were found between Normal Saline Flush and ondansetron.
When is Zofran contraindicated?
ZOFRAN is contraindicated in patients: known to have hypersensitivity (e.g., anaphylaxis) to ondansetron or any of the components of the formulation [see ADVERSE REACTIONS] receiving concomitant apomorphine due to the risk of profound hypotension and loss of consciousness.
What are the side effects of Zofran?
Headache, lightheadedness, dizziness, drowsiness, tiredness, or constipation may occur. If these effects persist or worsen, notify your doctor promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects.
How does Zofran cause serotonin syndrome?
These drugs block serotonin, a chemical in the brain that passes signals between nerves. By blocking serotonin, ondansetron shuts down the “chemoreceptor trigger zone,” the area of the brain responsible for the nausea reflex. Zofran is a widely-used drug, but it may not be right for everyone.
How long does it take for dissolving Zofran to work?
Zuplenz (ondansetron) is a brand of ondansetron that comes as an oral film that dissolves on the tongue in 4 to 20 seconds.
How fast does Zofran work?
Ondansetron is an anti-sickness medicine. It will start to work within 1-2 hours. The most common side-effects are a headache, constipation, and feeling flushed.
Does Zofran stop gag reflex?
Conclusion: The results of the present study showed the efficacy of ondansetron in reducing the severity of gag reflex in both the soft palate and tonsil areas; therefore, its administration can be considered in clinical procedures in those areas.
Is Zofran safe for elderly?
IMO, zofran is one of the safest medications out there. Safe for elderly patients and patients with kidney disease, and no dose adjustment required. Its also safe in patients with liver failure (although dose should not exceed 8mg/day). Safe for peds with dose adjustment. Safe for bowel obstruction (unlike reglan). Not irritating to tissues (unlike phenergan). Relatively non-sedating (unlike compazine). No hyperactivity/anxiety/panic attacks (unlike reglan). I've never had a patient experience any side-effects from zofran (except for the cessation of N/V!!!). I love the stuff and I advocate for it to be given to all my patients with N/V since it works so well and is well-tolerated.
Does Zofran affect QT interval?
Zofran can have a proarrythmic affect related to lengethening of the QT interval.
Does Phenergan burn?
Phenergan on the other hand burns even diluted with fluids running.
How much Zofran should I dilute?
Recommended dilution for Zofran is 1:2. 50ml bag seems excessive. I work in pediatric oncology/BMT where you can't afford to use large amounts of fluid. So we usually dilute it in a 10ml syringe. Zofran can be pushed. However if its given around the clock, we run it over 15min which is the intermittent infusion recommendation.
How much Zofran should I inject into a bag?
I was taught by my experienced preceptor that any amount equal to or over 8mg of Zofran needs to be injected into a 50ml bag (D5 preferred but NS OK if pt is diabetic) and hung as a piggy back; however, after working on the unit for awhile I've come to realize that every nurse does it differently.
Can you dilute Phenergan IV?
Extravasation of the periphery is a nasty thing!! I advise ALWAYS diluting Phenergan yes, even 12.5mg unless you're utilizing a central line.
Can Zofran be put in a 50NS bag?
If the oncologist orders it as a premed for chemo, the pharmacy at my hospital puts the Zofran 8mg in a 50NS bag. I feel better to have it this way because if I am in a hurry I would hate to wait 2-5 minutes to push something...
How long does it take to dilution Zofran?
Infuse intravenously over 15 minutes beginning 30 minutes before the start of emetogenic chemotherapy and then repeat 4 and 8 hours after the first dose.
What is Zofran injection?
ZOFRAN ® Injection is indicated for the prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including high-dose cisplatin.
How long before chemo can you take Ondansetron?
In patients with severe hepatic impairment (Child-Pugh score of 10 or greater), a single maximal daily dose of 8 mg infused over 15 minutes beginning 30 minutes before the start of the emetogenic chemotherapy is recommended. There is no experience beyond first-day administration of ondansetron in these patients [see Use in Specific Populations (8.6)].
How much sodium chloride is in Zofran?
Dilution of Zofran Injection in 50 mL of 5% Dextrose Injection or 0.9% Sodium Chloride Injection is required before administration to adult and pediatric patients for the prevention of nausea and vomiting associated with emetogenic chemotherapy.
Is Zofran injection better than placebo?
In a double-blind, placebo-controlled trial of Zofran Injection (three 0.15-mg/kg doses) in 20 patients receiving cyclophosphamide (500 to 600 mg/m2) chemotherapy, Zofran Injection was significantly more effective than placebo in prevent ing nausea and vomiting . The results are summarized in Table 9.
Is Zofran more effective than placebo?
In a double-blind trial in 28 patients, Zofran Injection (three 0.15-mg/kg doses) was significantly more effective than placebo in preventing nausea and vomiting induced by cisplatin-based chemotherapy. Therapeutic response was as shown in Table 7.
Is Zofran contraindicated for hypersensitivity?
Zofran Injection is contraindicated for patients known to have hypersensitivity (e.g., ana phylaxis) to this product or any of its components. Anaphylactic reactions have been reported in patients taking ondansetron [see Adverse Reactions (6.2)].
What to know before taking Ondansetron?
Before using ondansetron, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems ( heart failure, slow heartbeat, QT prolongation in the EKG ), family history of certain heart problems ( QT prolongation in the EKG, sudden cardiac death).
How to take Ondansetron?
To prevent nausea from chemotherapy, ondansetron is mixed in a solution and given by injection into a vein as directed by your doctor, usually over 15 minutes. This drug is usually started 30 minutes before your chemotherapy treatment begins. Do not give this medication any faster than recommended or take more than the recommended dose because this may increase the chance of serious side effects such as blurred vision or slowed/irregular heartbeat. The usual maximum single dose is 16 milligrams. Older adults are usually prescribed a lower dose to decrease the risk of side effects. Depending on the type of chemotherapy treatment you are receiving, a second and third dose may be given 4 and 8 hours after your first dose. You may also be switched to a medication you can take by mouth.
How long after first chemo dose can you take a second?
Depending on the type of chemotherapy treatment you are receiving, a second and third dose may be given 4 and 8 hours after your first dose. You may also be switched to a medication you can take by mouth.
What drugs increase serotonin?
The risk of serotonin syndrome /toxicity increases if you are also taking other drugs that increase serotonin. Examples include street drugs such as MDMA/"ecstasy," St. John's wort, certain antidepressants (including SSRIs such as fluoxetine /paroxetine, SNRIs such as duloxetine / venlafaxine ), among others.
How long after chemo can you take a chemo pill?
Your doctor may direct you to continue this medication for 1 or 2 days after your chemotherapy treatment. If you are using this medication on a prescribed schedule, use it regularly to get the most benefit from it. To help you remember, use it at the same times each day. Use this medication exactly as directed.
How does a syringe work?
It is also used to prevent and treat nausea and vomiting after surgery. It works by blocking one of the body's natural substances (serotonin) that causes vomiting.
What are the side effects of a syringe?
Side Effects. Headache, fever, lightheadedness, dizziness, drowsiness, tiredness, constipation, or redness/pain/burning at the injection site may occur.
What to do if Zofran makes you dizzy?
If Zofran makes you dizzy or drowsy, do not drive or operate machinery while affected and avoid alcohol. Tell your doctor or other health care provider about all the medicines you take, including prescription and over-the-counter (OTC) medicines, vitamins, and herbal supplements.
How long does it take for Zofran to work?
The peak effect of Zofran is reached within 1.5-2 hours. The onset of effect is faster with the orally disintegrating or liquid form.
How long after chemo do you give 8mg?
For moderately emetogenic chemotherapy, an 8mg dose administered 30 minutes before the start of chemotherapy with a subsequent 8mg dose administered 8 hours after the first dose. Then administer twice a day for 1 to 2 days after completion of the chemotherapy. May be given to children aged 4 and older.
What is Zofran used for?
Zofran is a brand (trade) name for ondansetron which may be used to treat or prevent nausea and vomiting. Experts aren't sure exactly how Zofran (ondansetron) works and if its antiemetic action is mediated by a direct effect on the CTZ (the area of the brain associated with vomiting), the vagus nerve, or both.
When to take Zofran before surgery?
When used to prevent nausea associated with surgery, Zofran is usually taken one hour before anesthesia. The dose of Zofran orally disintegrating tablets is the same as Zofran solution. When taking the orally disintegrating tablets, peel back the foil (do not attempt to push the tablet through the foil).
What to take for Zofran constipation?
Consider laxatives to relieve or prevent constipation associated with Zofran.
What medications affect serotonin?
other medications that affect serotonin, such as amphetamines, fentanyl, tramadol, triptans ( eg, almotriptan, eletriptan, or sumatriptan), or St. John's Wort . Note that this list is not all-inclusive and includes only common medications that may interact with Zofran.
Indications and Usage For Zofran Injection
Zofran Injection Dosage and Administration
Dosage Forms and Strengths
Contraindications
Warnings and Precautions
- Hypersensitivity Reactions
Hypersensitivity reactions, including anaphylaxis and bronchospasm, have been reported in patients who have exhibited hypersensitivity to other selective 5-HT3receptor antagonists. - QT Prolongation
Ondansetron prolongs the QT interval in a dose-dependent manner [see Clinical Pharmacology (12.2)]. In addition, postmarketing cases of Torsade de Pointes have been reported in patients using ondansetron. Avoid ZOFRAN in patients with congenital long QT syndrome. ECG monitori…
Adverse Reactions
Drug Interactions
Use in Specific Populations
Drug Abuse and Dependence
Overdosage