What are examples of suspension drugs?
Examples of a few of the oral suspensions in which a specific and well defined particle size specification for the drug substance is important include phenytoin suspension, carbamazepine suspension, trimethoprim and sulfamethoxazole suspension, and hydrocortisone suspension.
How do you make a drug suspension?
0:328:17Pharmaceutics Making a Suspension (BTEC Pharmaceutical Science)YouTubeStart of suggested clipEnd of suggested clipUse here are some proprietary examples of pharmaceutical suspensions for external use when preparingMoreUse here are some proprietary examples of pharmaceutical suspensions for external use when preparing a diffusible suspension weigh all solid ingredients and check their solubility pre-measure any
What is an oral suspension drug?
Medical Definition of oral suspension : a suspension consisting of undissolved particles of one or more medicinal agents mixed with a liquid vehicle for oral administration nystatin powder for oral suspension.
Why we use suspension as a drug?
1. Suspensions are a useful drug delivery system for therapeutic agents that have a low solubility. Although low-solubility therapeutic agents may be solubilised and therefore administered as a solution, the volume of the solvent required to perform this may be large.
How do pharmacists make suspension?
Preparation of SuspensionsReduce drug powder to desired size.Add drug and wetting agent to solution.Prepare solution of suspending agent.Add other ingredients.Homogenize medium.Package.
How do you use suspension drugs?
Swallow the whole or split tablet without crushing or chewing. For effervescent tablets, dissolve the dose in the recommended amount of water, then drink. Pain medications work best if they are used as the first signs of pain occur. If you wait until the symptoms have worsened, the medication may not work as well.
How can you tell if a medication is a suspension?
In an elixir, the active ingredients are mixed with a liquid, usually a kind of syrup or alcohol, in which they can dissolve. In a suspension, the medicine is mixed with a liquid, usually water, in which it cannot dissolve and therefore remains intact in the form of small particles.
How do you know if a medicine is a solution or suspension?
In a solution, the solute is completely dissolved when the medication is administered. In a suspension, the solute is not completely dissolves. Thus, in a suspension there are particles which are unevenly distributed.
How do you give oral suspension?
Put the top back on the bottle. Put the tip of the oral syringe inside your child's mouth between the gums and the inside surface of their cheek. Gently push the plunger to squirt small amounts of medicine into the side of your child's mouth. Allow your child to swallow before you carry on pushing the plunger.
Is Oral Suspension a liquid?
Oral Suspension is an oral liquid that contains one or more active ingredients suspended in a suitable base. Suspended solids may separate a time period on keeping but are easily re-dispersed on shaking.
What is Paracetamol Oral Suspension?
1. What Paracetamol Oral Suspension is and what it is used for. Paracetamol belongs to a group of medicines called pain-killers or analgesics. n It is used for mild to moderate pain including headache, migraine, nerve pain, toothache, sore throat, period pains and general aches and pains.
What is a pharmaceutical suspension?
A pharmaceutical suspension is a coarse dispersion in which the internal phase (the active ingredient) is placed/distributed uniformly throughout the external phase/continuous phase.
What is a suspension in medical terms?
Suspensions are a class of dispersed systems (Heterogenous systems) in which a finely divided solid is dispersed uniformly in a liquid dispersion medium. or A pharmaceutical suspension may be defined as a coarse dispersion of biphasic liquid dosage form containing finely divided insoluble material suspended in a liquid medium.
What are the two groups of suspensions?
Suspensions can be divided into two groups as flocculated suspensions and deflocculated suspensions based on the electro-kinetic nature of solid particles that are suspended in the suspension.
What is flocculated suspension?
A flocculated suspension is a suspension in which particles of the suspension has undergone flocculation. A flocculated suspension is composed of large aggregates (flocks) and this type of suspension will lead to a rapid rate of sedimentation.
Why is suspension used in parentral application?
Suspension can be formulated for parentral application in order to control rate of drug absorption.E .g. penicillin procaine
What is the purpose of oxy tetracycline suspension?
To prevent degradation of drug or to improve stability of drug; E.g. Oxy tetracycline suspension
Where is suspension given?
Suspension dosage forms are given by the oral route, injected intramuscularly or subcutaneously, instilled intranasally, inhaled into the lungs, applied to the skin as topical preparations, or used for ophthalmic or otic purposes in the eye or ear, respectively.
What is a suspension in pharmaceuticals?
Pharmaceutical suspension is a liquid dosage form containing finely divided, undissolved drug particles dispersed throughout a liquid vehicle in which the drug exhibits a minimum degree of solubility. This dosage form is used for providing a liquid dosage form for insoluble drugs. In an ideal suspension, particles are uniformly dispersed ...
Which order is the drug in suspension?
Bioavailability is in following order, Solution > Suspension > Capsule > Compressed Tablet > Coated tablet.
Why is suspension so unstable?
Pharmaceutical suspensions are fundamentally unstable and for this reason, it requires formulation skill to ensure that the physical stability of the formulation is retained over the period of the shelf-life. 2. Aesthetic pharmaceutical suspension is difficult to formulate that is they lack elegance. 3.
Is aesthetic suspension difficult to formulate?
2. Aesthetic pharmaceutical suspension is difficult to formulate that is they lack elegance.
Do particles disperse after sedimentation?
In an ideal suspension, particles are uniformly dispersed and remain so even after prolonged periods of time. Even if sedimentation occurs, particles should readily redisperse upon mild agitation of the container.
Is suspension a ready to use medication?
Most suspensions are available in ready-to-use form from the manufacturer. In cases of physical or chemical incompatibility, they are marketed as reconstitutable medications in unit-dose sachet or multidose bottles. This article focuses on the advantages and disadvantages of pharmaceutical suspensions.
How fine are particles in a drug suspension?
As with topical products in which the drug is suspended, particles are usually very fine to micronized (less than 25 microns).
What are the problems with oral suspensions?
These include microbiological, potency and stability problems.
What are the specifications for a suspension?
Additional important specifications for suspensions include particle size of the suspended drug, viscosity, pH, and in some cases dissolution. Viscosity can be important from a processing aspect to minimize segregation. Additionally, viscosity has also been shown to be associated with bioequivalency. pH may also have some meaning regarding effectiveness of preservative systems and may even have an effect on the amount of drug in solution. With regard to dissolution, there are at least three products which have dissolution specifications. These products include phenytoin suspension, carbamazepine suspension, and sulfamethoxazole and trimethoprim suspension. Particle size is also important and at this point it would seem that any suspension should have some type of particle size specification. As with other dosage forms, the underlying data to support specifications should be reviewed.
What does it mean when a Pseudomonas sp. is present?
The presence of a specific Pseudomonas sp. may also indicate that other plant or raw material contaminants could survive the process. For example, the fact that a Pseudomonas putida contaminant is present could also indicate that Pseudomonas aeruginosa, a similar source organism, could also be present.
Why is there concern with uniformity in oral suspensions?
For oral suspensions, there is the additional concern with uniformity, particularly because of the potential for segregation during manufacture and storage of the bulk suspension, during transfer to the filling line and during filling. Review the firm's data that support storage times and transfer operations.
Which class of drugs are sensitive to oxygen?
There are also some oral liquids which are sensitive to oxygen and have been known to undergo degradation. This is particularly true of the phenothiazine class of drugs, such as perphenazine and chlorpromazine. The manufacture of such products might require the removal of oxygen such as by nitrogen purging.
Do suspension valves need to be flushed?
For the manufacture of suspensions, valves should be flush. Review and observe the batching equipment and transfer lines. With regard to transfer lines, they are generally hard piped and easily cleaned and sanitized. In some cases manufacturers have used flexible hoses to transfer product.