Lutalyse Sterile: Product Information
- DESCRIPTION. LUTALYSE® Injection (5 mg dinoprost/mL) is a sterile solution containing the naturally occurring prostaglandin F2 alpha (dinoprost) as the tromethamine salt.
- INDICATIONS AND USAGE. LUTALYSE Injection is indicated as a luteolytic agent. ...
- DOSAGE AND ADMINISTRATION. ...
What is Lutalyse injection for veterinary use?
This page contains information on Lutalyse Injection for veterinary use. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. LUTALYSE ® Injection (5 mg dinoprost/mL) is a sterile solution containing the naturally occurring prostaglandin F 2 alpha (dinoprost) as the tromethamine salt.
Is Lutalyse legal in the US?
Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. LUTALYSE ® Injection (5 mg dinoprost/mL) is a sterile solution containing the naturally occurring prostaglandin F2 alpha (dinoprost) as the tromethamine salt.
How to use Lutalyse in cows?
LUTALYSE is used to control the timing of estrus and ovulation in estrous cycling cattle that have a corpus luteum. Inject a dose of 5 mL LUTALYSE (25 mg PGF2α) intramuscularly either once or twice at a 10 to 12 day interval. With the single injection, cattle should be bred at the usual time relative to estrus.
How do you administer Factrel and Lutalyse?
1 Administer the first dose of FACTREL Injection (2-4 mL) at Day 0 2 Administer LUTALYSE (25 mg dinoprost, as dinoprost tromethamine) Injection by intramuscular injection 6-8 days after the first dose of FACTREL Injection. 3 Administer a second dose of FACTREL Injection (2-4 mL) 30 to 72 hours after the LUTALYSE injection. More items...
What will Lutalyse do to humans?
Inhalation may cause difficulty breathing, chest tightness, and respiratory irritation with coughing, wheezing, and sputum generation. May cause eye irritation. Exposure may cause temporary irritation, redness, or discomfort. Prolonged skin contact may cause temporary irritation.
How much does a shot of Lutalyse cost?
SKUSizeSkuPrice- +30ml000735-30ml$25.99100ml026256-100ml$79.99
What happens if you get Lutalyse on your skin?
Dinoprost tromethamine is readily absorbed through the skin and can cause abortion and/or bronchiospasms. Accidental spillage on the skin should be washed off immediately with soap and water.
Does Lutalyse require prescription?
Each mL contains 5 mg of dinoprost tromethamine. Supplied as either a 30 mL or 100 mL bottle. Needles and syringes sold separately. This product requires a veterinarian's prescription for purchase.
How long is Lutalyse good for?
The response to treatment varies by individual animals with a mean interval from administration of 2 mL LUTALYSE Injection (10 mg dinoprost) to parturition of approximately 30 hours. This can be employed to control the time of farrowing in sows and gilts in late gestation.
How much Lutalyse does it take to abort a cow?
25 mgLUTALYSE is indicated for its abortifacient effect in feedlot and other non-lactating cattle during the first 100 days of gestation. Inject a dose of 25 mg intramuscularly. Cattle that abort will abort within 35 days of injection.
Where do you inject Lutalyse?
LUTALYSE HighCon Injection is used to control the timing of estrus and ovulation in estrous cycling cattle that have a corpus luteum. Inject a dose of 2 mL LUTALYSE HighCon Injection (25 mg dinoprost) intramuscularly or subcutaneously either once or twice at a 10 to 12 day interval.
Can Lutalyse cause miscarriage?
Prostaglandins such as Lutalyse, Prostamate and Estrumate can lead to the abortion of a sow's pregnancy if there is an accidental exposure; they can also cause abortion in pregnant women.
Can you give Lutalyse to a dog?
Prostaglandin use Prostaglandins are not really a true mismate drug for dogs but can beused before pregnancy is recognized. The prostaglandin product Lutalyse(Pharmacia Animal Health) is most commonly used in the dog.
How do you use Fertagyl?
Administer the first Fertagyl injection (2 mL) on Day 0. Administer 2 mL of Estrumate (500 mcg cloprostenol, as cloprostenol sodium) by intramuscular injection 6 to 8 days after the first Fertagyl injection. Administer the second Fertagyl injection (2 mL) 30 to 72 hours after the Estrumate injection.
What is Lutalyse used for in dogs?
LUTALYSE® Injection (dinoprost tromethamine injection) is the most "veterinarian recommended" and "producer used" prostaglandin in the market. Artificial insemination synchronization programs with LUTALYSE can improve breeding success.
How do you induce heat in a cow?
The standard treatment for cows with a corpus luteum (CL) is an injection of prostaglandin (PG) which will bring most cows into heat two to four days after injection. Combining the PG with heat detection focussed on the treated cow will result in cows getting pregnant more quickly.
Where do you inject Lutalyse?
LUTALYSE HighCon Injection is used to control the timing of estrus and ovulation in estrous cycling cattle that have a corpus luteum. Inject a dose of 2 mL LUTALYSE HighCon Injection (25 mg dinoprost) intramuscularly or subcutaneously either once or twice at a 10 to 12 day interval.
How much Lutalyse do you give a heifer?
5 mLInject a dose of 5 mL LUTALYSE Injection (25 mg dinoprost) intramuscularly either once or twice at a 10 to 12 day interval. With the single injection, cattle should be bred at the usual time relative to estrus.
Will Lutalyse bring a pig in heat?
It works the same way on a bred animal as an open animal. She will come into heat in 3-5 days from that.
How much Lutalyse should I give my horse?
Administer a single intramuscular injection of 1 mg per 100 lbs (45.5 kg) body weight which is usually 1 mL to 2 mL LUTALYSE Sterile Solution. 3. Observe for signs of estrus by means of daily teasing with a stallion, and evaluate follicular changes on the ovary by palpation of the ovary per rectum.
How long after estrus injection should cows breed?
For treatment of unobserved estrus, inject a 5 mL dose IM. If estrus has not been observed by 80 hours after injection, breed at 80 hours; if the cow returns to estrus, breed at the usual time relative to estrus.
What is Zoetis dairy?
Zoetis is the world leader in dairy reproduction research and support and its products are supported by industry-leading sales and technical services.
Is lutealyse safe for pregnant women?
Aseptic technique should be used to reduce the possibility of post-injection clostridial infections. Do not administer LUTALYSE in pregnant cattle unless cessation of pregnancy is desired. See full Prescribing Information.
What is a lutealyse?
LUTALYSE® Injection (5 mg dinoprost/mL) is a sterile solution containing the naturally occurring prostaglandin F2 alpha (dinoprost) as the tromethamine salt. Each mL contains dinoprost tromethamine equivalent to 5 mg dinoprost: also, benzyl alcohol, 16.5 mg added as preservative and water for injection.
When to inject lutealyse in cows?
LUTALYSE Injection is indicated for its abortifacient effect in beef cows, beef heifers and replacement dairy heifers during the first 100 days of gestation. Inject a dose of 25 mg dinoprost (5 mL) intramuscularly. Cattle that abort will abort within 35 days of injection.
How long after luteal injection can cattle be bred?
With the two injections cattle can be bred after the second injection either at the usual time relative to detected estrus or at about 80 hours after the second injection of LUTALYSE Injection. Estrus is expected to occur 1 to 5 days after injection if a corpus luteum was present.
How early can you administer lumalyse injection?
The product must be administered at a relatively specific time (treatment earlier than 3 days prior to normal predicted farrowing may result in increased piglet mortality). It is important that adequate records be maintained on (1) the average length of gestation period for the animals on a specific location, and (2) the breeding and projected farrowing dates for each animal. This information is essential to determine the appropriate time for administration of LUTALYSE Injection.
Is luteolytic injection effective in cattle?
Cattle. LUTALYSE Injection is indicated as a luteolytic agent. LUTALYSE Injection is effective only in those cattle having a corpus luteum, i.e., those which ovulated at least five days prior to treatment.
Can lutealyse be used for future reproductive performance?
Future reproductive performance of animals that are not cycling will be unaffected by injection of LUTALYSE Injection.
Can you use lutelyse injection on cattle?
A successful breeding program can employ LUTALYSE Injection effectively, but a poorly managed breeding program will continue to be poor when LUTALYSE Injection is employed unless other management deficiencies are remedied first. Cattle expressing estrus following LUTALYSE Injection are receptive to breeding by a bull. Using bulls to breed large numbers of cattle in heat following LUTALYSE Injection will require proper management of bulls and cattle.
What is a lutealyse injection?
LUTALYSE ® Injection ( dinoprost tromethamine injection) was one of the first estrus-synchronization products approved for swine more than 20 years ago, and it remains unsurpassed today. LUTALYSE is indicated for parturition induction in gilts and sows.
What is a lutealyse?
LUTALYSE ® is an estrus-synchronization product that induces parturition in gilts and sows.
When is lutalyse ineffective?
Lutalyse is ineffective when administered prior to the fifth day after ovulation.
What is lutelyse sterile solution?
Lutalyse Sterile Solution is a natural estrus-synchronization product approved for use in horses. Lutalyse contains a well characterized prostaglandin that occurs naturally in nearly all mammalian tissue.
Can you use Lutalyse on Mares?
Mares that have either acute or subacute disorders of the vascular system, gastrointestinal tract, respiratory system or reproductive tract should not be treated with Lutalyse.
Can you give lutalyse to pregnant animals?
Do not administer Lutalyse in pregnant animals unless cessation of pregnancy is desired. Do not use intravenous administration. Women of childbearing age and persons with respiratory problems should exercise extreme caution when handling Lutalyse.
What is lutealyse used for?
LUTALYSE is used to control the timing of estrus and ovulation in estrous cycling cattle that have a corpus luteum.
How effective is lutealyse?
LUTALYSE is effective only in those cattle having a corpus luteum , i.e., those which ovulated at least five days prior to treatment . Future reproductive performance of animals that are not cycling will be unaffected by injection of LUTALYSE.
How long does it take for cattle to recover from a lutealyse injection?
Most cattle that recovered in response to LUTALYSE recovered within 14 days after injection. After 14 days, recovery rate of treated cattle was no different than that of non-treated cattle. 4. For Intramuscular Use for Abortion of Feedlot and Other Non-Lactating Cattle.
How long after a second injection can cattle be bred?
With the two injections cattle can be bred after the second injection either at the usual time relative to detected estrus or at about 80 hours after the second injection of LUTALYSE.
When to use luteallyse solution for swine?
LUTALYSE Sterile Solution is indicated for parturition induction in swine when injected within 3 days of normal predicted farrowing.
Can you use pyometra in cattle?
For intramuscular use for estrus synchronization, treatment of unobserved (silent) estrus and pyometra ( chronic endometritis) in cattle; for abortion of feedlot and other non-lactating cattle; for parturition induction in swine;
Helpful Information
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How to Order Prescriptions from PBS Animal Health
We fulfill livestock, equine, and pet prescriptions through our Matthews Veterinary Pharmacy. To process your prescription order, we need a valid prescription on file. We can receive a prescription through the three methods below.
Why do doe have corpus luteum defects?
Corpus luteum defects result in fertility issues for a doe. Defects can be caused by stress, body mass index/nutrition, prolactin levels (hormones associated with milk production), thyroid disorders, including iodine deficiency, a short luteal phase, and polycystic ovarian syndrome (cysts).
Is lute a risk?
There are risks to using Lute and other drugs. We prefer to avoid intervention in our herd unless there is a clear, unmistakable risk not to intervene.
Can you use Lutalyse on goats?
An error in math or observed breeding can result in a heartbreaking outcome. Lutalyse is not labeled for use in goats in the United States, and as such, must be used under the advice of a veterinarian. It should be handled with caution as it is readily absorbed through the skin and may cause bronchospasms.
Does lute help with ovulation?
Since Lute does not directly cause ovulation, a gonadotropin hormone may also be needed to resolve cysts and trigger ovulation.
Can a doe get a lute injection?
In some circumstances, such as when a small breed is inadvertently bred to a large breed, or a doe is unintentionally bred, or there is a health risk to the doe if a pregnancy is carried to term, Lute injections can be given to trigger absorption of the embryo or abortion, depending on when it is administered.
Is Lutalyse good for goats?
Lutalyse is a valuable tool for many goat producers. It can save lives, and simplify management for some producers, but it can also result in unintended consequences and death. Is it overused? Craig Koopmann believes so. “I think people overuse a lot of drugs in goats. And the reason I think they do is because they want to control everything. And that just is not possible with any livestock.”
Lutalyse Injection Indications For Use
- Cattle:LUTALYSE Injection is indicated as a luteolytic agent. LUTALYSE Injection is effective only in those cattle having a corpus luteum, i.e., those which ovulated at least five days prior to treatment. Future reproductive performance of animals that are not cycling will be unaffected by …
Management Considerations
- Many factors contribute to success and failure of reproduction management, and these factors are important also when time of breeding is to be regulated with LUTALYSE Injection. Some of these factors are: a. Cattle must be ready to breed-they must have a corpus luteum and be healthy; b. Nutritional status must be adequate as this has a direct effect on conception and the initiation of …
Lutalyse Injection Dosage and Administration
- As with any multi-dose vial, practice aseptic techniques in withdrawing each dose to decrease the possibility of post-injection bacterial infections. Adequately clean and disinfect the vial stopper prior to entry with a sterile needle and syringe. Use only sterile needles, and use each needle only once. No vial stopper should be entered more than 20 times. For this reason, the 100 mL bottle …
Warnings and Precautions
- User Safety: Not for human use. Keep out of the reach of children. Women of childbearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. In the early stages, women may be unaware of their pregnancies. Dinoprost tromethamine is readily absorbed through the skin and can cause aborti…
Adverse Reactions
- Cattle:Limited salivation has been reported in some instances. Swine:The most frequently observed side effects were erythema and pruritus, slight incoordination, nesting behavior, itching, urination, defecation, abdominal muscle spasms, tail movements, hyperpnea or dyspnea, increased vocalization, salivation, and at the 100 mg (10x) dose only, possible vomiting. These s…
Contact Information
- For a copy of the Safety Data Sheet or to report adverse reactions, call Zoetis Inc. at 1-888-963-8471. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or www.fda.gov/reportanimalae.
Clinical Pharmacology
- General Biologic Activity: Prostaglandins occur in nearly all mammalian tissues. Prostaglandins, especially PGE’s and PGF’s, have been shown, in certain species, to 1) increase at time of parturition in amniotic fluid, maternal placenta, myometrium, and blood, 2) stimulate myometrial activity, and 3) to induce either abortion or parturition. Prostaglandins, especially PGF2α, have b…
Target Animal Safety
- Laboratory Animals:Dinoprost was non-teratogenic in rats when administered orally at 1.25, 3.2, 10.0 and 20.0 mg dinoprost/kg/day from day 6th-15th of gestation or when administered subcutaneously at 0.5 and 1.0 mg/kg/day on gestation days 6, 7 and 8 or 9, 10 and 11 or 12, 13 and 14. Dinoprost was non-teratogenic in the rabbit when administered either subcutaneously a…
Effectiveness
- Cattle: For Treatment of Pyometra (chronic endometritis) in Cattle:In studies conducted with LUTALYSE Injection, pyometra was defined as presence of a corpus luteum in the ovary and uterine horns containing fluid but not a conceptus based on palpation per rectum. Return to normal was defined as evacuation of fluid and return of the uterine horn size to 40mm or less ba…