Precautions
Generic Name: phenylephrine hydrochloride ophthalmic solution; Brand Name: Neo-Synephrine
What is the generic name for Neo-Synephrine?
Last updated on Jun 10, 2022. It is used to treat low blood pressure . What do I need to tell my doctor BEFORE I take Neo-Synephrine? If you are allergic to Neo-Synephrine ( phenylephrine injection); any part of Neo-Synephrine ( phenylephrine injection); or any other drugs, foods, or substances.
What is neo-synephrine (phenylephrine) used to treat?
Anesthesia General. Neo-Synephrine. Neo-Synephrine is the trade name for phenylephrine. It is a pure alpha receptor agonist and has both venous and arterial constrictive effects. Because Alpha1 receptors have been discovered in the myocardium, it is also possible that it has positive inotropic effects.
Is Neo-Synephrine a venous agonist?
Pediatric Use: NEO-SYNEPHRINE (phenylephrine hydrochloride ophthalmic solution) hydrochloride 10 percent ophthalmic solutions are contraindicated in infants. (See CONTRAINDICATIONS.) For use in older children see DOSAGE AND ADMINISTRATION.
Is Neo Synephrine safe for babies?
What is the generic name for NEO-SYNEPHRINE?
Phenylephrine Nasal is an over-the-counter (OTC) product used to treat nasal congestion. Phenylephrine Nasal is available under the following different brand names: NeoSynephrine Nasal and Neo-Synephrine Cold & Sinus Mild Strength Spray.
What drug class is NEO-SYNEPHRINE?
It belongs to a class of drugs known as decongestants. Phenylephrine works by narrowing blood vessels.
Are NEO-SYNEPHRINE and phenylephrine the same?
NEO-SYNEPHRINE hydrochloride, brand of phenylephrine hydrochloride injectino, is a vasoconstrictor and pressor drug chemically related to epinephrine and ephedrine.
What are other names for phenylephrine?
Description and Brand NamesNeo-Synephrine.Nostril.Pretz-D.Rhinall.Tur-Bi-Cal.Vicks Sinex.
Does CVS have NEO-SYNEPHRINE?
Neo-Synephrine Regular Strength Nasal Spray - CVS Pharmacy.
Is NEO-SYNEPHRINE addictive?
THERE IS ONE TYPE OF NASAL SPRAY THAT IS “ADDICTIVE” These are nasal decongestant sprays such as OXYMETAZOLINE (AFRIN®, SINEX, SUDAFED NASAL SPRAY) or NEOSYNEPHRINE!
Do they still make NEO-SYNEPHRINE?
Medically reviewed by Drugs.com on May 13, 2022. Written by Cerner Multum. The Neo-Synephrine 12 Hour brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.
What does phenylephrine do to the heart?
Phenylephrine is an α-receptor agonist without β-agonist activity. Its administration causes vasoconstriction and an increase in arterial blood pressure, and a decrease in heart rate. Cardiac output may decrease13,27,28 or increase.
What happens if you use too much NEO-SYNEPHRINE?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include severe dizziness or drowsiness, slow heart rate, and fainting.
What OTC drugs contain phenylephrine?
Common brands containing phenylephrine:4 Way. ®Advil. ®Dimetapp. ®Little Noses. ®Neo-synephrine. ®Robitussin. ®Sudafed. ®Theraflu. ®More items...
Is pseudoephedrine same as phenylephrine?
The most important difference between phenylephrine (PE) and pseudoephedrine (PDE) is that the efficacy as PE as a decongestant is unproven, whereas there is some evidence that oral PDE is effective.
What is Neosynephrine used for?
This medication is used for temporary relief of congestion in the nose caused by various conditions including the common cold, sinusitis, hay fever, and allergies. It works by narrowing the blood vessels in the nose area, reducing swelling and congestion.
What is neo synephrine used for?
This medication is used for temporary relief of congestion in the nose caused by various conditions including the common cold, sinusitis, hay fever, and allergies. It works by narrowing the blood vessels in the nose area, reducing swelling and congestion.
What are the side effects of neo synephrine?
Common side effects of Neo-Synephrine include:burning,stinging,pain,increased redness of the eye,tearing or blurred vision,headache,tremor,nausea,More items...
What is phenylephrine used for?
Other uses for phenylephrine or Neo-Synephrine include reversing right-to-left shunt flow in patients with tetralogy of Fallot and terminating supraventricular tachycardias (SVTs) as it can cause reflex vagal stimulation in response to elevated blood pressure.
What is the term for a drug that is used in the ICU?
For example, the term neo is often used in the operating room and intensive care unit (ICU) to refer to the drug Neo-Synephrine; however, it could also reasonably be interpreted as neostigmine, another commonly used drug in the operating room and ICU.
How much neostigmine is needed to reverse neuromuscular blockade?
For example, 40 to 50 mcg/kg of neostigmine is required to reverse a 90% block produced by pancuronium or d-tubocurarine, whereas 20 to 30 mcg/kg is needed for atracurium, vecuronium, ...
How much phenylephrine is given in a bolus?
Phenylephrine or Neo-Synephrine is given as either an intravenous (IV) bolus or infusion; bolus doses are 1 to 10 mcg/kg, or in 50- to 100-mcg boluses in adults. As an Neo-Synephrine IV infusion, it is usually mixed as 10 to 15 mg in 250 mL and dosed as 0.15 to 0.75 mcg/kg/min.
What is the dose of neostigmine?
For use in pediatric patients with tetralogy of Fallot, IV bolus doses are 5 to 50 mcg/kg. Neostigmine. Neostigmine (marketed under the trade name Prostigmin) is a reversible acetylcholinesterase inhibitor. It is used clinically in the treatment of myasthenia gravis, glaucoma, and atony of the gastrointestinal and urinary tracts.
What is a syringe used for?
It is used clinically in the treatment of myasthenia gravis, glaucoma, and atony of the gastrointestinal and urinary tracts. In the operating room and ICU settings, it is commonly used to reverse nondepolarizing neuromuscular blockade.
Does phenylephrine affect cardiac output?
Acutely, phenylephrine causes an increase in venous return (preload) due to its venous constrictive effects; it increases after load as well. In normal individuals, it does not affect cardiac output. However, in patients with ischemic heart disease, it can decrease cardiac output.
What is a Neo Synephrine?
NEO-SYNEPHRINE (phenylephrine hydrochloride ophthalmic solution) hydrochloride is recommended for use as a decongestant and vasoconstrictor and for pupil dilatation in uveitis ( posterior synechiae), wide angle glaucoma, prior to surgery, refraction, ophthalmoscopic examination, and diagnostic procedures.
How to free posterior synechiae?
To free recently formed posterior synechiae, 1 drop of the 10 percent ophthalmic solutions may be applied to the upper surface of the cornea. On the following day, treatment may be continued if necessary. In the interim, hot compresses should be applied for five or ten minutes three times a day, with 1 drop of a 1 or 2 percent solution of atropine sulfate before and after each series of compresses.
What is the name of the sterile solution used as a vasoconstrictor and mydr?
NEO-SYNEPHRINE hydrochloride , brand of phenylephrine hydrochloride ophthalmic solution, is a sterile solution used as a vasoconstrictor and mydriatic for use in ophthalmology. NEO-SYNEPHRINE (phenylephrine hydrochloride ophthalmic solution) hydrochloride is a synthetic sympathomimetic compound structurally similar to epinephrine and ephedrine.
Can neosynephrine be used with miotics?
NEO-SYNEPHRINE (phenylephrine hydrochloride ophthalmic solution) hydrochloride may be used with miotics in patients with wide angle glaucoma. It reduces the difficulties experienced by the patient because of the small field produced by miosis, and still it permits and often supports the effect of the miotic in lowering the intraocular pressure. Hence, there may be marked improvement in visual acuity after using NEO-SYNEPHRINE (phenylephrine hydrochloride ophthalmic solution) hydrochloride in conjunction with miotic drugs.
Is phenylephrine a vasoconstrictor?
In the eye, phenylephrine acts locally as a potent vasoconstrictor and mydriatic, by constricting ophthalmic blood vessels and the radial muscle of the iris.
Does phenylephrine cause bradycardia?
Although rare, systemic absorption of sufficient quantities of phenylephrine may lead to systemic α-adrenergic effects, such as rise in blood pressure which may be accompanied by a reflex atropine-sensitive bradycardia.
Is Neo Synephrine a phenylephrine?
There have been rare reports associating the use of NEO-SYNEPHRINE (phenyleph rine hydrochloride ophthalmic solution) 10 percent ophthalmic solutions with the development of serious cardiovascular reactions, including ventricular arrhythmias and myocardial infarctions. These episodes, some ending fatally, have usually occurred in elderly patients with preexisting cardiovascular diseases.
What is the biological name for synephrine?
There has been some confusion about the biological effects of synephrine because of the similarity of this un-prefixed name to the names m-synephrine, Meta-syneph rine and Neosynephrine, all of which refer to a related drug and naturally-occurring amine more commonly known as phenylephrine.
What is the synephrine in a supplement?
Usually, the synephrine is present as a natural component of Citrus aurantium ("bitter orange"), bound up in the plant matrix, but could also be of synthetic origin, or a purified phytochemical (i.e. extracted from a plant source and purified to chemical homogeneity). The concentration range found by Santana and co-workers in five different supplements purchased in the US was about 5–14 mg/g.
What is the pathway that converts octopamine to synephrine?
This pathway differs from that thought to occur in animals, involving octopamine: tyramine → octopamine → synephrine, where the conversion of tyramine to octopamine is mediated by dopamine-β-hydroxylase, and the conversion of octopamine to synephrine by phenylethanolamine N -methyltransferase.
What is the concentration of synephrine in citrus?
Extracts of unripe fruit from Asian cultivars of Citrus aurantium (commonly known as "bitter" orange), collected in China, were reported to contain synephrine levels of about 0.1–0.3%, or ~1–3 mg/g; Analysis of dried fruit of C. aurantium grown in Italy showed a concentration of synephrine of ~1 mg/g, with peel containing over three times more than the pulp.
How much synephrine is used for colds?
The third edition (1965) of Drill's Pharmacology in Medicine stated, with reservations, that synephrine was "advertised as an antihistaminic to be used in the treatment of the common cold...", under the trade name of "Synephrin Tartrate", and indicated that the dose was 100 mg, given intramuscularly, or subcutaneously.
What temperature is p-synephrine?
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Synephrine, or, more specifically, p-synephrine, is an alkaloid, occurring naturally in some plants ...
Which neurotransmitter is produced by addition of another phenolic OH group to the 3-position of the?
Addition of another phenolic –OH group to the 3-position of the benzene ring produces the neurotransmitter epinephrine; addition of a methyl group to the α-position in the side-chain of synephrine gives oxilofrine (methylsynephrine). Four stereoisomers (two pairs of enantiomers) are possible for this substance.
What is Neo-Synephrine 12 Hour?
Oxymetazoline is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).
What is the name of the antidepressant?
an antidepressant-- amitriptyline, clomipramine, desipramine, doxepin, imipramine, nortriptyline; an MAO inhibitor -- isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, tranylcypromine. This list is not complete and other drugs may interact with Neo-Synephrine 12 Hour. Tell your doctor about all medications you use.
What is neosynephrine used for?
Neo-Synephrine is a nasal spray used in temporarily relieving stuffiness and congestion in the nose , which are usually caused by allergic rhinitis, hay fever, sinus trouble, or common colds.
How long does it take for phenylephrine to work?
Briskly sniff in the medicine as you squeeze the bottle. You may use 1-2 sprays in each nostril, wait for about 5 minutes for the drug to work, and then blow your nose thoroughly but gently. Rinse spray bottle with warm water, careful not to get water inside it. Dry the spray bottle using a clean tissue.
Does phenylephrine work in elderly?
Geriatric: There are no specific studies done in the elderly patients, hence, it is not known if phenylephrine nasal spray will work differently in the elderly as it works in younger adults.
How is this medicine (Neo-Synephrine 12 Hour Spray) best taken?
Use Neo-Synephrine 12 Hour Spray (oxymetazoline (nasal)) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
What are some things I need to know or do while I take Neo-Synephrine 12 Hour Spray?
Tell all of your health care providers that you take Neo-Synephrine 12 Hour Spray (oxymetazoline (nasal)). This includes your doctors, nurses, pharmacists, and dentists.
Overview
Phenylephrine is used for the temporary relief of stuffy nose, sinus, and ear symptoms caused by the common cold, flu, allergies, or other breathing illnesses (such as sinusitis, bronchitis).
May Treat: Acute hypotension · Eustachian tube congestion · Hemorrhoids · Mydriasis · Nasal congestion and more
Alternate Brand Names: Sudafed PE · Sudogest PE
Drug Class: Anorectal - Hemorrhoidal Single Agents Other · Cardiovascular Sympathomimetics · Nasal Sympathomimetic Decongestants (Intranasal) · Ophthalmic - Decongestants · Systemic Sympathomimetic Decongestants
Availability: Prescription sometimes needed
Pregnancy: Consult a doctor before using
May Treat: Acute hypotension · Eustachian tube congestion · Hemorrhoids · Mydriasis · Nasal congestion and more
Alternate Brand Names: Sudafed PE · Sudogest PE
Drug Class: Anorectal - Hemorrhoidal Single Agents Other · Cardiovascular Sympathomimetics · Nasal Sympathomimetic Decongestants (Intranasal) · Ophthalmic - Decongestants · Systemic Sympathomimetic Decongestants
Availability: Prescription sometimes needed
Pregnancy: Consult a doctor before using
Lactation: Consult a doctor before using
Alcohol: Avoid intake while taking this medication
Driving: May cause drowsiness or dizziness. Use caution
- Do not touch applicator tip
- For aerosol, mist products : Read directions carefully before start of therapy. Blow nose gently before dose. Prevent contamination. Keep away from eyes. Do not use for more than 3 days. Do not take more than package label recommends. Keep away from children.
- For drops products : For the eye. Measure dose using a dosing spoon/cup/syringe. Wash hands before and after using. May wear contact lenses 15 min. after using drug. Do not touch tip of open eye drop bottle. Wait 10 minutes before other eye medications. May sting or burn after applying. Call doctor if you are not better in 3 days. May blur vision. Use caution when driving. Call doctor if you are not getting better.
- Do not touch applicator tip
- For aerosol, mist products : Read directions carefully before start of therapy. Blow nose gently before dose. Prevent contamination. Keep away from eyes. Do not use for more than 3 days. Do not take more than package label recommends. Keep away from children.
- For drops products : For the eye. Measure dose using a dosing spoon/cup/syringe. Wash hands before and after using. May wear contact lenses 15 min. after using drug. Do not touch tip of open eye drop bottle. Wait 10 minutes before other eye medications. May sting or burn after applying. Call doctor if you are not better in 3 days. May blur vision. Use caution when driving. Call doctor if you are not getting better.
- For strip products : Dissolve on tongue.
- For suppository, rectal products : Empty bowel before insert -ing the suppository. Unwrap and insert suppository in rectum. Do not use in children under 12 years. Tell doctor your complete medical history. Review all drugs you are taking with your doctor. Follow directions on best place to keep drug supply.
- For suspension, oral products : Shake well & measure with dosing spoon/cup/syringe. Take hours before bedtime to avoid sleeplessness.
- For tablet, chewable products : Unless MD directs, do not use in kids less than 6. Chew medicine completely before swallowing. Do not take more drug than directed. Before using tell Dr. if you have phenylketonuria. May make you dizzy. Use caution when driving. May worsen high blood pressure. Inform doctor about all the medicines you use. Avoid other medicines containing the same drug.
Natural occurrences
Presence in nutritional/dietary supplements
Pharmaceutical use
Names
Synephrine, or, more specifically, p-synephrine, is an alkaloid, occurring naturally in some plants and animals, and also in approved drugs products as its m-substituted analog known as neo-synephrine. p-Synephrine (or formerly Sympatol and oxedrine [BAN]) and m-synephrine are known for their longer acting adrenergic effects compared to epinephrine and norepinephrine. This su…
Chemistry
Synephrine, although already known as a synthetic organic compound, was first isolated as a natural product from the leaves of various Citrus trees, and its presence noted in different Citrus juices, by Stewart and co-workers in the early 1960s. A survey of the distribution of synephrine amongst the higher plants was published in 1970 by Wheaton and Stewart. It has subsequently been detected in Evodia and Zanthoxylum species, all plants of the family Rutaceae.
Pharmacology
Some dietary supplements, sold for the purposes of promoting weight-loss or providing energy, contain synephrine as one of several constituents. Usually, the synephrine is present as a natural component of Citrus aurantium ("bitter orange"), bound up in the plant matrix, but could also be of synthetic origin, or a purified phytochemical (i.e. extracted from a plant source and purified to chemical homogeneity). The concentration range found by Santana and co-workers in five differ…
Pharmacokinetics
As a synthetic drug, synephrine first appeared in Europe in the late 1920s, under the name of Sympatol. One of the earliest papers describing its pharmacological and toxicological properties was written by Lasch, who obtained it from the Viennese company Syngala. By 1930, Sympatol was referred to as a Boehringer product, while one of the first US Patents describing its preparation and use was assigned to Frederick Stearns & Co. in 1933. Despite the date of this pa…