Precautions
Bladder, ureter and renal pelvis cancers are known as urothelial cancers. Atezolizumab may sometimes be used to treat other cancers. It is best to read this information with our general information about the type of cancer you have.
What kind of cancer does atezolizumab treat?
In the United States, atezolizumab is indicated for the treatment of urothelial carcinoma, non-small cell lung cancer (NSCLC), triple-negative breast cancer (TNBC), small cell lung cancer (SCLC), hepatocellular carcinoma (HCC), and melanoma. The most common adverse effects in studies were fatigue, decreased appetite, nausea, and infections.
What are the possible adverse effects of atezolizumab?
History. In 2015, it was in clinical trials as an immunotherapy for several types of solid tumors. It was under investigation by Genentech / Roche. In April 2016, Roche announced that atezolizumab had been granted fast track status for lung cancer by the FDA. In May 2016, it was approved by the FDA for bladder cancer treatment,...
What is the history of atezolizumab?
You will be given atezolizumab at a day unit as an outpatient. Atezolizumab can be given on its own or with other cancer drugs. During treatment you usually see a cancer doctor, a specialist nurse, and a specialist pharmacist.
Where will I be given atezolizumab?
Can atezolizumab cure cancer?
Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving combination chemotherapy, bevacizumab, and atezolizumab may work better in treating patients with colorectal cancer.
What are the side effects of atezolizumab?
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Is atezolizumab chemotherapy or immunotherapy?
Atezolizumab (brand name: Tecentriq) is a type of immunotherapy drug called an “immune checkpoint inhibitor”.
How long do you take atezolizumab?
How atezolizumab is given depends on the type of cancer. You may have it once every 2, 3 or 4 weeks. You usually keep having it for as long as it is working, or for up to 2 years. Your doctor, nurse or pharmacist will discuss your treatment plan with you.
How good is atezolizumab?
Atezolizumab has an average rating of 7.0 out of 10 from a total of 4 ratings on Drugs.com. 67% of reviewers reported a positive experience, while 33% reported a negative experience.
How effective is atezolizumab?
Tecentriq effectiveness for small cell lung cancer Median overall survival for those who took the Tecentriq combination was 12.3 months, compared to 10.3 months among those who took the chemotherapy drugs and a placebo.
What type of treatment is atezolizumab?
Atezolizumab injection is used to treat urothelial carcinoma (a type of bladder cancer) that has spread throughout the body (metastatic) or cannot be removed by surgery (advanced).
What is the cost of atezolizumab?
Official answer. Tecentriq treatment costs around $14,540 per month depending on the dosage schedule. Tecentriq (atezolizumab) is a programmed death-ligand 1 (PD-L1) blocking antibody (or immune checkpoint inhibitor) used in the treatment of: urothelial carcinoma.
Is atezolizumab an immunosuppressant?
Atezolizumab is a monoclonal antibody targeting the immunosuppressive receptor PD-L1, and its effectiveness has been verified in numerous diseases, such as urothelial and renal cell carcinoma and non-small-cell lung cancer (15–17). Immunotherapy with anti-PD-1 or anti-PD-L1 antibodies target the PD-1-PD-L1 pathway.
What is atezolizumab made from?
*Atezolizumab is an Fc-engineered, humanised IgG1 anti-programmed death-ligand 1 (PD-L1) monoclonal antibody produced in Chinese hamster ovary cells by recombinant DNA technology.
Is atezolizumab better than pembrolizumab?
For overall patients, pembrolizumab had significantly superior OS (hazard ratio (HR) with 95% confidence interval, 0.67, 0.47–0.94; P = 0.02) and numerically better PFS (HR, 0.79, 0.60–1.04; P = 0.10) than atezolizumab, while they had similar ORR, all cause AE and grade 3–5 AE.
Does atezolizumab cause constipation?
Mild side effects that have been reported with Tecentriq include: constipation. cough. decreased appetite.
Is atezolizumab (Tecentriq) a chemotherapy or immunotherapy drug?
Atezolizumab (brand name: Tecentriq) is a type of immunotherapy drug called an “immune checkpoint inhibitor”. It helps to stimulate the body’s immu...
How effective is atezolizumab (Tecentriq)?
Atezolizumab (Tecentriq) is approved to treat several different types of cancer. Cancer treatment is always individualized for each patient. It’s e...
Does atezolizumab (Tecentriq) cause hair loss?
Hair loss (alopecia) is listed as a common side effect with atezolizumab (Tecentriq) when used with other cancer treatments for lung cancer or trip...
How is atezolizumab (Tecentriq) administered?
Atezolizumab (Tecentriq) is given by a slow intravenous (IV) infusion into your vein, usually once every 2, 3 or 4 weeks. Your initial infusion typ...
What is Atezolizumab used for?
Small cell lung cancer. Atezolizumab is used with carboplatin and etoposide as the first treatment in adults with extensive-stage cancer. Urothelial carcinoma (a type of bladder cancer) that has spread. Atezolizumab is used in: Adults whose cancer has the PD-L1 protein and cannot be treated with cisplatin .¹.
What is the name of the gene that is used to treat melanoma?
Melanoma that has a certain mutation in the BRAF gene. Atezolizumab is used with cobimetinib fumarate and vemurafenib in adults whose cancer is metastatic or cannot be removed by surgery. Non-small cell lung cancer that has metastasized. Atezolizumab is used:
Is atezolizumab a clinical benefit?
As a condition of approval, a confirmatory trial (s) must show that atezolizumab provides a clinical benefit in these patients. Atezolizumab is also being studied in the treatment of other types of cancer.
Does atezolizumab help with lung cancer?
For patients whose cancer has a mutation in the EGFR gene or ALK gene, atezolizumab is used if their cancer has gotten worse after treatment with FDA -approved therapy for these mutations. Small cell lung cancer.
What is Atezolizumab used for?
What Atezolizumab Is Used For: For the treatment of patients with locally advanced or metastatic urothelial carcinoma who: Have disease progression during or following platinum-containing chemotherapy. Have disease progression within 12 months of neoadjuvant or adjuvant treatment with platinum-containing chemotherapy.
How long does it take to get Atezolizumab?
How Atezolizumab Is Given: Atezolizumab is given as an intravenous injection through a vein (IV) over 60 minutes for the first infusion, and if no infusion reaction, over 30 minutes for each infusion thereafter.
What to know before starting atezolizumab?
Precautions: Before starting atezolizumab treatment, make sure you tell your doctor about any allergies, and other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.) and your complete past medical, surgical, family and social history.
What is monoclonal antibody?
Monoclonal antibodies are a relatively new type of "targeted" cancer therapy (against a specific "target"). Antibodies are an integral part of the body's immune system. Normally, the body creates antibodies in response to an antigen (such as a protein in a germ) that has entered the body.
What is Atezolizumab used for?
Atezolizumab is used to treat some types of advanced (meta static): non-small cell lung cancer. bladder cancer. ureter and renal pelvis cancer. Bladder, ureter and renal pelvis cancers are known as urothelial cancers. Atezolizumab may sometimes be used to treat other cancers.
How long does atezolizumab last?
You may have atezolizumab once every 3 weeks. You usually keep having it for as long as it is working, for a maximum of 2 years. Your doctor, nurse or pharmacist will discuss your treatment plan with you.
Is Atezolizumab a checkpoint inhibitor?
Atezolizumab is an immunotherapy drug. It may also be called a checkpoint inhibitor or monoclonal antibody.
What is the mechanism of action of Atezolizumab?
Mechanism of action. Non-small cell lung cancer (NSCLC) cells expressing programmed death-ligand 1 (PD-L1) could interact with programmed death receptor 1 (PD-1) expressed on the surface of T cells, and result in decreased tumor cell kill by the immune system. Atezolizumab is an anti PD-L1 monoclonal antibody.
How much does Atezolizumab cost?
Atezolizumab treatment costs on average US$13,200 per month in the United States, depending on the dosage schedule. Despite updated data showing 30% more people with extensive stage small cell lung cancer are alive at 24 months compared to those who received chemotherapy alone, Canadian regulator had rejected to fund atezolizumab for extensive stage small-cell lung cancer "as too costly" followed by United Kingdom also citing "drug's cost-effectiveness." However, U.K. reversed its previous decision and approved tecentriq for extensive stage small cell lung cancer after price re-think on May 27, 2020.
What is the objective response rate of atezolizumab?
A phase I trial reported a 19% objective response rate in metastatic triple-negative breast cancer. As of 2019, atezolizumab is in trial for several types of cancer, such as pancreatic cancer, gastric cancer and ovarian Cancer.
What is the target of ipilimumab?
Ipilimumab is a monoclonal antibody that targets Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) on the surface of T cells. Bevacizumab is a monoclonal antibody that targets Vascular Endothelial Growth Factor (VEGF) in the circulation and functions as an angiogenesis inhibitor.
Is Atezolizumab a combination drug?
Atezolizumab, in combination with bevacizumab, paclitaxel, and carboplatin, was approved in the United States in December 2018, for the first-line treatment of people with metastatic non-squamous, non-small cell lung cancer (NSq NSCLC) with no EGFR or ALK genomic tumor aberrations.
Is atezolizumab fast track?
In April 2016, Roche announced that atezolizumab had been granted fast track status for lung cancer by the U.S. Food and Drug Administration (FDA).
Does atezolizumab prolong lung cancer?
In September 2018, it was announced that atezolizumab prolongs survival in extensive stage small cell lung cancer treatment, according to study results presented at the 19th World Conference on Lung Cancer (WCLC) in Toronto, Canada.
What does it mean to have a cycle of Atezolizumab?
A cycle means that you have Atezolizumab on its own or in combination with other cancer drugs, and then have some time with no treatment to allow your body to recover. Your doctor or nurse will tell you more about this.
How long does it take for atezolizumab to go into your bloodstream?
You have atezolizumab as a drip into your bloodstream (intravenously). The first time you have atezolizumab, you have it over an hour. If you don’t have a reaction to it you have your next infusions over 30 minutes.
What is Tecentriq used for?
Atezolizumab (Tecentriq) Atezolizumab is a type of immunotherapy drug. This treatment is used for a number of different cancer types. Depending on your situation you may have atezolizumab on its own or you might have it in combination with other drugs.
What is atezolizumab (Tecentriq)?
Atezolizumab is used to treat certain cancers of the breast, skin, lung, liver, or bladder and urinary tract.
What are the possible side effects of atezolizumab (Tecentriq)?
Get emergency medical help if you have signs of an allergic reaction ( hives, difficult breathing, swelling in your face or throat) or a severe skin reaction ( fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
What is the most important information I should know about atezolizumab (Tecentriq)?
Atezolizumab affects your immune system and may cause it to attack normal healthy tissues or organs, leading to serious or life-threatening medical problems.
How is atezolizumab given (Tecentriq)?
Atezolizumab is given as an infusion into a vein, usually once every 2 to 4 weeks. A healthcare provider will give you this injection.
What happens if I miss a dose (Tecentriq)?
Call your doctor for instructions if you miss an appointment for your atezolizumab injection.
What happens if I overdose (Tecentriq)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while receiving atezolizumab (Tecentriq)?
Atezolizumab could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen ( SPF 30 or higher) when you are outdoors.
What is Tecentriq used for?
Tecentriq is a prescription medicine used to treat adults with: a type of bladder and urinary tract cancer called urothelial carcinoma. Tecentriq may be used when your bladder cancer has spread or cannot be removed by surgery, and if you have any one of the following conditions: you are not able to take chemotherapy that contains ...
Does platinum chemotherapy work?
you have tried chemotherapy that contains platinum, and it did not work or is no longer working. a type of lung cancer called non-small cell lung cancer (NSCLC). you have tried chemotherapy that contains platinum, and it did not work or is no longer working.
Is Tecentriq used for lung cancer?
is a type of lung cancer called “non-squamous NSCLC. your tumor does not have an abnormal “EGFR” or “ ALK ” gene. Tecentriq may be used alone when your lung cancer: has spread or grown, and. you have tried chemotherapy that contains platinum, and it did not work or is no longer working. if your tumor has an abnormal “EGFR” or “ALK” gene, ...
