Precautions
They do not treat viral infections (eg, the common cold). When AZACTAM is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed.
Can Azactam be used to treat viral infections?
Tell all of your health care providers that you take Azactam (aztreonam (systemic)). This includes your doctors, nurses, pharmacists, and dentists. Unsafe allergic effects may rarely happen. Do not use longer than you have been told. A second infection may happen. This medicine may affect certain lab tests.
What should I know before taking Azactam (aztreonam)?
Generic name: Aztreonam (Systemic) (AZ tree oh nam) Brand name: Azactam, Azactam in Dextrose Drug class: Miscellaneous antibiotics Medically reviewed by Drugs.com.
What is the generic name for Azactam?
DESCRIPTION. AZACTAM is a sterile, nonpyrogenic, sodium-free, white powder containing approximately 780 mg arginine per gram of aztreonam. Following constitution, the product is for intramuscular or intravenous use. Aqueous solutions of the product have a pH in the range of 4.5 to 7.5.
What is Azactam made of?
See more
What type of infection does Azactam treat?
Aztreonam, sold under the brand name Azactam among others, is an antibiotic used primarily to treat infections caused by gram-negative bacteria such as Pseudomonas aeruginosa. This may include bone infections, endometritis, intra abdominal infections, pneumonia, urinary tract infections, and sepsis.
When should I take Azactam?
Aztreonam injection is used to treat certain infections that are caused by bacteria, including respiratory tract (including pneumonia and bronchitis), urinary tract, blood, skin, gynecological, and abdominal (stomach area) infections, that are caused by bacteria.
Is Azactam a penicillin?
Aztreonam is a monobactam antibiotic that was approved in 1986 for the treatment of Gram-negative bacterial infections via intravenous or intramuscular injection (Azactam®) [20]. This drug was marketed to treat bacterial infections and is safe for patients with penicillin allergies [21].
What class of antibiotic is Azactam?
Azactam Injection belongs to a class of drugs called Monobactams.
Who should not take aztreonam?
Aztreonam is not approved for use by anyone younger than 9 months old.
What is the side effects of aztreonam?
Diarrhea, nausea, vomiting, dizziness, headache, blurred vision, or redness/discomfort/pain/swelling at the injection site may occur. If any of these effects last or get worse, notify your doctor or pharmacist promptly.
Is aztreonam a good antibiotic?
In comparisons with other antibiotics, aztreonam has been at least as effective or more effective than cefamandole in urinary tract infections and similar in efficacy to tobramycin or gentamicin.
How much is Azactam cost?
The price of Azactam depends on several factors. These include your insurance coverage, pharmacy location, dosage and quantity needed. Without insurance, the average price of Azactam is about $324.13 for a supply of 10, 1 g injectable powders for injection. With SingleCare, you can pay as little as $57.59 for Azactam.
What is the best injection for pneumonia?
PCV13 helps protect people from 13 of the most severe types of bacteria that cause pneumonia. PPSV23 protects against an additional 23 types of pneumonia bacteria. Neither can prevent every type of pneumonia, but they work against more than 30 common, severe types.
How effective is aztreonam?
The aztreonam group had a lower rate of appropriate empiric therapy (44.4%) compared with the BL group (66.1%, P=0.074) and signifi-cantly higher alteration of empiric therapy (61.1%) compared with the BL group (28.2%, P=0.005).
Does aztreonam cover UTI?
Aztreonam has been demonstrated to be a valuable tool in the therapy of many types of nosoconiial urinary tract infections. It has considerable potential as therapy for resistant infections and as a prophylactic agent against postoperative urinary tract infection.
Is aztreonam renal safe?
It was concluded that aztreonam is effective and safe for the treatment of gram-negative bacterial infections in patients with renal failure.
Can Azactam be given IM?
Intramuscular or intravenous injection, or intravenous infusion. Azactam is given by deep injection into a large muscle mass, such as the upper quadrant of the gluteus maximus or the lateral part of the thigh.
Is Azactam a broad spectrum antibiotic?
It has a broad spectrum of activity against gram-negative bacteria but has no activity against gram-positive or anaerobic bacteria. Aztreonam readily penetrates the outer membrane of gram-negative bacteria.
How do I give aztreonam?
Directions for administration For aztreonam For intravenous infusion (Azactam®), manufacturer advises give intermittently in Glucose 5% or Sodium chloride 0.9%. Dissolve initially in water for injections (1 g per 3 mL) then dilute to a concentration of less than 20 mg/mL; to be given over 20–60 minutes.
What is the generic name of Azactam?
GENERIC NAME: AZTREONAM - INJECTION (az-TREE-oh-nam)
What are some things I need to know or do while I take Azactam?
Tell all of your health care providers that you take Azactam (aztreonam (systemic)). This includes your doctors, nurses, pharmacists, and dentists.
How is this medicine (Azactam) best taken?
Use Azactam (aztreonam (systemic)) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
What do I need to tell my doctor BEFORE I take Azactam?
If you have an allergy to aztreonam or any other part of Azactam (aztreonam (systemic)).
How do I store and/or throw out Azactam?
If you need to store Azactam (aztreonam (systemic)) at home, talk with your doctor, nurse, or pharmacist about how to store it.
What are the side effects of Azactam?
Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes. Azactam side effects (more detail)
Can you take Azactam with a prescription?
You must check to make sure that it is safe for you to take Azactam (aztreonam (systemic)) with all of your drugs and health problems.
Can you take Azactam longer than you have been told?
Do not use longer than you have been told. A second infection may happen. This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take Azactam (aztreonam (systemic)). If you are 65 or older, use Azactam (aztreonam (systemic)) with care. You could have more side effects.
Why is Azactam used?
To reduce the development of drug-resistant bacteria and maintain the effectiveness of AZACTAM (aztreonam for injection, USP) and other antibacterial drugs, AZACTAM should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.
What is a azactam injection?
Azactam Injection is a prescription medicine used to treat the symptoms of bacterial infections of the blood, urinary tract, lungs, skin, stomach, or female reproductive organs and Cystic Fibrosis. Azactam Injection may be used alone or with other medications.
How long after aztreonam is it in saliva?
The concentration of aztreonam in saliva at 30 minutes after a single 1 g intravenous dose (9 patients) was 0.2 mcg/mL; in human milk at 2 hours after a single 1 g intravenous dose (6 patients), 0.2 mcg/mL, and at 6 hours after a single 1 g intramuscular dose (6 patients), 0.3 mcg/mL; in amniotic fluid at 6 to 8 hours after a single 1 g intravenous dose (5 patients), 2 mcg/mL. The concentration of aztreonam in peritoneal fluid obtained 1 to 6 hours after multiple 2 g intravenous doses ranged between 12 mcg/mL and 90 mcg/mL in 7 of 8 patients studied.
How is Azactam administered?
AZACTAM may be administered intravenously or by intramuscular injection. Dosage and route of administration should be determined by susceptibility of the causative organisms, severity and site of infection, and the condition of the patient.
How to clear aztreonam from the blood?
If necessary, aztreonam may be cleared from the serum by hemodialysis and/or peritoneal dialysis.
What class of drugs is azactam?
Azactam Injection belongs to a class of drugs called Monobactams.
Where does Aztreonam enter the fetal circulation?
In pregnant women, aztreonam crosses the placenta and enters the fetal circulation.
1. What Azactam is and what it is used for
Azactam is an antibiotic belonging to the group of beta-lactams. Azactam is used to treat severe infections caused by gram-negative bacteria (eg pneumonia, urinary tract infections, and urogenital infections ). Aztreonam contained in Azactam may also be approved for the treatment of other conditions not mentioned in this product information.
Do not use Azactam
if you are allergic to aztreonam or any of the other ingredients of this medicine (listed in section 6).
Children
There are limited data on safety and efficacy in newborns younger than one week. Use in this group must be carefully evaluated.
Other medicines and Azactam
Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.
Pregnancy and breastfeeding
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Driving and using machines
No studies on the ability to drive and use machines have been performed.
Azactam contains arginine
Studies in children with low birth weight have shown that the amino acid arginine contained in this medicine can increase the amount of arginine, insulin, and bilirubin in the blood. The consequences of exposure to arginine during the treatment of newborns have not been fully established.
What is the name of the first class of beta-lactam antibiotics?
Aztre onam. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Aztreonam (azthreonam; SQ 26,776) is the first member of a new class of beta-lactam antibiotics, the monobactams.
Is Aztreonam safe for a gram negative infection?
Therapeutic trials have shown aztreon am to be effective in Gram-negative infections including complicated infections of the urinary tract, in lower respiratory tract infections and in gynaecological and obstetric, intra-abdominal, joint and bone, skin and soft tissue infections, uncomplicated gonorrhoea and septicaemia.
Is aztreonam an aerobic antibiotic?
Azt reonam is selectively active against Gram-negative aerobic bacteria and inactive against Gram-positive bacteria. Thus, in vitro, aztreonam is inhibitory at low concentrations (MIC90 l …. Aztreonam (azthreonam; SQ 26,776) is the first member of a new class of beta-lactam antibiotics, the monobactams. Aztreonam is selectively active ...
How long does azactam stay in the refrigerator?
Intravenous infusion solution of Azactam for Injection prepared with 0.9% Sodium Chloride Injection BP or 5% Glucose Intravenous Infusion BP, in PVC or glass containers, to which clindamycin phosphate, gentamicin sulphate, tobramycin sulphate, or cephazolin sodium have been added at concentrations usually used clinically, are stable for up to 24 hours in a refrigerator (2-8°C). Ampicillin sodium admixtures with aztreonam in 0.9% sodium chloride injection BP are stable for 24 hours in a refrigerator (2-8°C); stability in 5% Glucose Intravenous Infusion BP is eight hours under refrigeration. Store the reconstituted solution at 2°C-8°C (under refrigeration) for not more than 24 hours. Discard any unused solution.
Can you take more Azactam than you should?
It is unlikely that you will receive more Azactam than you should as it will be administered by injection into a muscle or vein by a doctor, nurse or other suitably trained person. If this does happen you will be closely monitored.
