Chloroxylenol, also known as para-chloro-meta-xylenol (PCMX
Chloroxylenol
Chloroxylenol, also known as para-chloro-meta-xylenol, is an antiseptic and disinfectant which is used for skin disinfection and cleaning surgical instruments. It is also used within a number of household disinfectants and wound cleaners. It is less effective than some other available agents. I…
What is chloroxylenol?
Chloroxylenol, also known as para-chloro-meta-xylenol ( PCMX ), is an antiseptic and disinfectant which is used for skin disinfection, and together with alcohol for cleaning surgical instruments. It is also used within a number of household disinfectants and wound cleaners.
What is the KPA of chloroxylenol?
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Chloroxylenol, also known as para-chloro-meta-xylenol ( PCMX ), is an antiseptic and disinfectant which is used for skin disinfection, and together with alcohol for cleaning surgical instruments.
What is the brand name for chloroxylenol hydrocortisone?
chloroxylenol/hydrocortisone/pramoxine otic. Brand names: Oticin HC, Cortane-B, Otozone, Oto-End. Drug class(es): otic steroids with anti-infectives. Chloroxylenol/hydrocortisone/pramoxine otic is used in the treatment of: Acute Otitis Externa. Ear Conditions. Otitis Externa.
How long does it take for chloroxylenol to work?
Certain animal studies have shown that following dermal application of chloroxylenol, that the absorption was rapid with a Cmax = 1-2 hours, and that the administered substance was excreted via the kidney with almost complete elimination within 24 hours 7. The primary metabolites discovered in the excreted urine were glucuronides and sulfates 7.
Is chloroxylenol safe for skin?
The incidence of skin sensitization among 1752 dermatitis patients exposed to 1.0 percent Chloroxylenol was less than 1.0 percent. On the basis of the available information included in this report, it is concluded that Chloroxylenol is safe as a cosmetic ingredient in the present practices of use.
Is chloroxylenol safe for humans?
Chloroxylenol is generally slightly to moderately toxic to humans (but highly toxic for the eyes, causing severe eye irritation), is practically non-toxic to birds, and is moderately toxic to freshwater invertebrates.
Is chloroxylenol a good disinfectant?
Chloroxylenol is a substituted phenol which has been widely used for many years as an ingredient of antiseptic and disinfectant products intended for external use 9. It is known to be bactericidal in low concentration to a wide range of Gram positive and Gram negative bacteria 9.
Is chloroxylenol antifungal?
Salicyclic acid is widely used as a skin antiseptic, for example, in the treatment of acne and psoriasis, because of its antibacterial, antifungal, and keratinolytic activity.
What products contain chloroxylenol?
PRODUCT TYPEbar soap (1)brow liner (5)foundation (1)hand sanitizer (1)liquid hand soap (20)mascara (2)toners/astringents (1)
Can you bathe with Dettol?
For use as a gentle antiseptic on the skin. Also suitable as a household disinfectant. - To feel refreshed and really clean, 30ml of Dettol Liquid may be used safely in the bath.
Why is chloroxylenol used in Dettol?
Chloroxylenol is a substituted phenol which has been widely used for many years as an ingredient of antiseptic/disinfectant products intended for external use. It is known to be bactericidal in low concentration to a wide range of Gram positive and Gram negative bacteria.
What does Dettol do to your skin?
Contact dermatitis can be associated with pruritus, erythema, skin scaling, itching and stinging. Topical application of undiluted chloroxylenol can cause skin burning. Symptoms reported include corrosion of the oral mucosa, larynx, and the gastrointestinal tract, bradycardia, hypotension, and renal failure.
Is chloroxylenol safe for dogs?
The active ingredient is Chloroxylenol and is poisonous to dogs if ingested or comes into contact with your dog's skin or coat. It's hazardous to your dog's health.
What is the difference between chlorhexidine gluconate and chloroxylenol?
The key difference between chlorhexidine and chloroxylenol is that chlorhexidine has a high residual activity, whereas chloroxylenol has minimal residual activity. Moreover, chlorhexidine is suitable for skin disinfection, whereas chloroxylenol is not suitable for skin disinfection.
Is chloroxylenol an alcohol?
It does not contain alcohol but is formulated as an emulsion, requiring longer drying times, and provides less adhesion for the surgical occlusive drapes.
What happens if you mix Dettol and bleach?
And when mixed with bleach it can release toxic fumes that can cause watery eyes and breathing problems.
Is Dettol toxic to humans?
After ingestion, Dettol liquid (4.8% chloroxylenol, pine oil, isopropyl, alcohol), a common household disinfectant, can cause central nervous system depression and corrosion of the oral mucosa, larynx and the gastrointestinal tract.
Why is chloroxylenol used in Dettol?
Chloroxylenol is a substituted phenol which has been widely used for many years as an ingredient of antiseptic/disinfectant products intended for external use. It is known to be bactericidal in low concentration to a wide range of Gram positive and Gram negative bacteria.
What is the difference between chlorhexidine gluconate and chloroxylenol?
The key difference between chlorhexidine and chloroxylenol is that chlorhexidine has a high residual activity, whereas chloroxylenol has minimal residual activity. Moreover, chlorhexidine is suitable for skin disinfection, whereas chloroxylenol is not suitable for skin disinfection.
What are the side effects of Dettol?
Contact dermatitis can be associated with pruritus, erythema, skin scaling, itching and stinging. Topical application of undiluted chloroxylenol can cause skin burning. Symptoms reported include corrosion of the oral mucosa, larynx, and the gastrointestinal tract, bradycardia, hypotension, and renal failure.
What is chloroxylenol used for?
Chloroxylenol is an antimicrobial used to treat cuts, bites, stings, abrasions, and used as an antiseptic hand cleaner.
Where is chloroxylenol metabolized?
Any chloroxylenol absorbed into the body is likely extensively metabolized by the liver and rapidly excreted, mainly in the urine, as sulphate and glucuronide conjugates 9. Hover over products below to view reaction partners. Chloroxylenol. Glucuronic acid+ Sulfuric acid.
How long does it take for chloroxylenol to be excreted?
Certain animal studies have shown that following dermal application of chloroxylenol, that the absorption was rapid with a Cmax = 1-2 hours, and that the administered substance was excreted via the kidney with almost complete elimination within 24 hours 7. The primary metabolites discovered in the excreted urine were glucuronides and sulfates 7. Some chloroxylenol monographs liken its pharmacokinetic profile to that of another antiseptic - triclosan - which is rapidly excreted in the urine also as a glucuronide metabolite, as observed in the human model 7.
How much chloroxylenol is in the blood?
No chloroxylenol was detected in the blood following the dermal administration of 2 g of p-chloroxylenol in an ethanol/olive oil vehicle in human subjects 3. After a dose of 5 g, only traces were found, after 8 g, 1 mg % (1 mg/dL) was found in the blood after 3 hours, and 4 mg % (4 mg/dL) after 24 hours 3. After a dose of 20 g, 4 mg % (4 mg/dL) was measured after half an hour, and 1 mg % (1 mg/dL) was present at 72 hours 3.
What is PCMX in soap?
DB11121. Background. Chloroxylenol, or para-chloro-meta-xylenol (PCMX), is an antiseptic and disinfectant agent used for skin disinfection and surgical instruments. It is found in antibacterial soaps, wound-cleansing applications, and household antiseptics.
Which drug decreases the excretion rate of Indigotindisulfonic acid?
Indigotindisulfonic acid. Chloroxylenol may decrease the excretion rate of Indigotindisulfonic acid which could result in a higher serum level. Indomethacin. Indomethacin may decrease the excretion rate of Chloroxylenol which could result in a higher serum level.
What is the chemical taxonomy of meta cresols?
Chemical TaxonomyProvided by Classyfire. Description. This compound belongs to the class of organic compounds known as meta cresols. These are aromatic compounds containing a meta-cresol moiety, which consists of a benzene ring bearing a methyl group and a hydroxyl group at ring positions 1 and 3, respectively.
What are phenolics used for?
Phenol and phenolic derivatives are used as surface disinfectants and preservatives. These include biocides such as chlorophenol and o-phenylphenol, in which most disinfectant formulations usually contain two or more types of phenolics to provide a maximum range of antimicrobial activities. For this reason, products will vary considerably in activity but can include bactericidal, mycobactericidal, fungicidal, and both enveloped and nonenveloped virucidal activity. In general, only certain formulations have true activity against small, nonenveloped viruses (such as parvoviruses) and mycobacteria, highlighting the importance of formulation and the choice of phenolic derivatives used to optimize biocidal activity. Phenolics are not sporicidal, but they do inhibit spore germination and outgrowth. Formulations will also vary in toxicity, can be corrosive, and have a strong ‘institutional’ odor. Their associated strong odors and stability of the biocides on surfaces may be limiting in some applications. They are widely used as general surface disinfectants, including walls, floors, and equipment. A certain number of phenolics have also been particularly used as antiseptics such as the bisphenols (triclosan and hexachlorophene), chloroxylenol (PCMX), and salicyclic acid (the latter was previously considered as an acid). Triclosan, for example, is widely used in various antiseptics such as antimicrobial soaps and toothpastes because of its very low irritation index in comparison to other biocides. Triclosan has a rather narrow spectrum of biocidal activity, being a particular effective bacteristatic and fungistatic agent. It is rapidly bactericidal against Gram-positive bacteria and virucidal against enveloped viruses, although activity against other bacteria and fungi can be enhanced in combination with other formulation ingredients; therapeutic applications have been described against some protozoa, such as Plasmodium. Salicyclic acid is widely used as a skin antiseptic, for example, in the treatment of acne and psoriasis, because of its antibacterial, antifungal, and keratinolytic activity.
Is hydrogen peroxide a good antiseptic?
Hydrogen peroxide is used to clean severely contaminated wounds, but it is a poor antiseptic and is mainly effective against spores, and concentrations lower than 3% are damaging to tissues. 82 Chloroxylenol, or parachlorometaxylenol, a synthetic halogen-substituted phenol derivative, and triclosan, a diphenyl ether, do not appear to offer any advantages over the more commonly used antiseptics in veterinary medicine.37,65,83
Is dettol a household disinfectant?
There have been many cases of intoxication with oral Dettol liquid, a widespread household disinfectant that contains chloroxylenol 4.8%, pine oil, and isopropyl alcohol [4–8]. Dettol was involved in 10% of hospital admissions related to self-poisoning in Hong Kong. In a retrospective study of 67 cases, serious complications were relatively common (8%) and these included aspiration of Dettol with gastric contents, resulting in pneumonia, cardiopulmonary arrest, bronchospasm, adult respiratory distress syndrome, and severe laryngeal edema with upper airway obstruction. Of 89 patients, five developed minor hematemesis, in the form of coffee-colored or blood-stained vomitus [6]. One patient had a gastroscopy performed on the day after admission, which showed signs of chemical burns in the esophagus and stomach. Gastroscopy in another patient on day 11, done to rule out an esophageal stricture, showed no abnormality. All patients with hematemesis recovered completely. The authors suggest that upper gastrointestinal hemorrhage after Dettol ingestion tends to be mild and self-limiting. Gastroscopy, which may increase the risk of aspiration in patients with impaired consciousness, is not required unless other causes of gastrointestinal bleeding are suspected. Furthermore, Dettol poisoning can be associated with an increased risk of aspiration, possibly caused by the use of gastrointestinal lavage in 88% of the patients and vomiting in 62% [6, 7 ].
Is chlorhexidine a topical antiseptic?
Although most often used as a topical treatment due to possible toxicity concerns, the use of organic antiseptics incorporated into indwelling implant is increasingly becoming common ( Eltorai et al., 2016). Chlorhexidine is commonly used in combination with chloroxylenol and especially in combination with silver sulfadiazine. Chlorhexidine is a bisbiguanide and possesses broad-spectrum bactericidal and fungicidal properties (Russell and Path, 1986; Hiom et al., 1992). However, its activity is pH dependent and is reduced in the presence of organic matter such as serum. Although the mode of action is not completely defined, it is considered that initial cell membrane damage is induced by the cationic chlorhexidine interactions with the anionic phosphate groups in the bacterial lipid layer, allowing passive diffusion for the biocide to attack the cytoplasmic membrane (Table 1). This results in the leakage of low molecular weight cellular components and ultimately cell death (Sofiyanti et al., 2015 ).
Is chloroxylenol an emulsion?
It does not contain alcohol but is formulated as an emulsion, requiri ng longer drying times, and provides less adhesion for the surgical occlusive drapes. Properties of the surgical skin preparations are compared in Table 6.1.
Does chlorhexidine reduce SSI?
There is no scientific support that preoperative bathing with an antiseptic decreases the risk of SSI. Studies have demonstrated that preoperative showering with chlorhexidine decreases the number of organisms on the skin compared with povidone-iodine or soap and water. 10 However, various meta-analyses have been performed regarding the ability of a preoperative shower to reduce the incidence of SSI. Webster and Osborne evaluated 6 trials with 10,007 patients, all of which included evaluation of 4% chlorhexidine gluconate. 14 Chlorhexidine gluconate was compared with either bar soap or placebo or with no bathing. There was no evidence that chlorhexidine gluconate bathing decreased the risk of SSI. Another meta-analysis was performed by Chlebicki et al, which yielded similar results. 15 Their meta-analysis included 16 trials and 17,932 patients. Again, chlorhexidine gluconate was compared with various comparators. It was found that chlorhexidine gluconate did not significantly reduce SSI when compared with soap, placebo, or no shower or bath. Considering the results of these two large meta-analyses, there is no support for preoperative bathing with chlorhexidine gluconate.
What is PCMX used for?
Parachlorometaxylenol (PCMX, Fig. 3) has been used for many years in food service hand soaps and rinses. It is one of the phenolic derivatives most commonly used in household disinfectants and cosmetics, along with triclosan (2,4,4-trichlorohydroxyphenyl ether; Fig. 3), another representative of this group. Triclosan is a broad-spectrum, primarily bacteriostatic agent (at the concentrations commonly used), popular in consumer-level surface disinfectant and deodorizing formulations. Triclosan has a low level of toxicity to mammalian cells, and is a commodity chemical which is economically attractive for incorporation into many domestic and industrial use products.
How is cresol absorbed?
These are absorbed orally, through intact skin, by the GI tract, through inhalation by the respiratory tract, per rectum, and per vaginum. The toxicological actions of these compounds are similar to phenol but less severe. •. Cresol is a methyl phenol with meta, ortho, and para isomers.
Is chloroxylenol an emulsion?
It does not contain alcohol but is formulated as an emulsion, requiri ng longer drying times, and provides less adhesion for the surgical occlusive drapes. Properties of the surgical skin preparations are compared in Table 6.1.
Is dettol a household disinfectant?
There have been many cases of intoxication with oral Dettol liquid, a widespread household disinfectant that contains chloroxylenol 4.8%, pine oil, and isopropyl alcohol [4–8]. Dettol was involved in 10% of hospital admissions related to self-poisoning in Hong Kong. In a retrospective study of 67 cases, serious complications were relatively common ...
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Have you ever purchased Chloroxylenol Liquid?
This survey is being conducted by the WebMD marketing sciences department.
Available coupons
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.