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what is cyclamate used in

by Carolyn Bednar MD Published 2 years ago Updated 2 years ago
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Cyclamates have a very sweet taste, with about 30 times the sweetening power of sucrose. They are used as sweeteners in baked goods, confections, desserts, soft drinks, preserves, and salad dressings. They are often combined with saccharin to produce a synergistic sweetening effect.

Full Answer

What products use cyclamate?

Products containing cyclamate include jellies, baked goods, soft drinks, chocolate, candies, breakfast cereals, salad dressing and toothpaste.

Is cyclamate still used today?

As a result, the FDA (Food and Drug Administration) immediately banned cyclamates in food but not in medicines. One year later, in 1970, after an inquiry in congress, cyclamates were also banned in medicine. It is a ban that still stands today despite several attempts to adress it.

Why was cyclamate banned?

This controversial high-potency sweetener was used in the United States in diet foods until 1970, at which time it was banned because animal studies suggested that it caused cancer. (It is still permitted in Canada, Europe, and some other countries.)

What is sodium cyclamate used for?

According to information gathered by the Government, sodium cyclamate is mainly used in Canada as a table-top sweetener, and as a non-medicinal ingredient in drugs including natural health products.

What does cyclamate taste like?

Cyclamate is an odorless, white crystalline powder. The name usually denotes either calcium cyclamate or sodium cyclamate, both of which are salts of cyclohexylsulfamic acid. They have a very sweet taste, with about 30 times the sweetening power of sucrose.

What are the side effects of cyclamate?

Cancer Risk Early studies in the 1970s linked the use of artificial sweeteners containing a mix of cyclamate and saccharin to an increased risk of bladder cancer in lab animals. Other early studies showed that bacteria in the intestines may convert cyclamate to cyclohexamine, a carcinogen.

What is the sweetener in Coke Zero?

aspartameWe sweeten Coke Zero Sugar in our bottles and cans with a blend of aspartame and acesulfame potassium (or Ace-K). Together, they create a great taste with zero sugar and zero calories. Yes. Diet Coke in our bottles and cans is sweetened with aspartame.

Why is cyclamate no longer used in the US?

Cyclamates were banned by the FDA as a food ingredient in 1969 because the saccharin/cyclamate mixture was shown to cause cancer in experimental laboratory rats. The primary concern was that it could be toxic to some individuals who appear to metabolize cyclamate to cyclohexylamine.

What are the worst sweeteners?

The worst sweeteners include artificial sweeteners like sucralose, saccharin and aspartame, high fructose corn syrup, agave, and brown rice syrup. It's best to avoid these sweeteners, if possible.

What is the safest artificial sweetener to use?

Stevia — in packet, drops or plant form — is a dietitian favorite. Not only does it contain zero calories, but stevia-based sweeteners are herbal as opposed to artificial. Stevia blended with a sugar alcohol called erythritol (Truvia®) works well in low-carb baked desserts, too.

What is magic sugar made of?

"Magic sugar" is an artificial non-caloric sweetening agent which was discovered in 1937. It is chemically known as sodium cyclamate, cyclamic acid or calcium cyclamate. Despite the findings that it can cause urinary bladder tumors in laboratory rats, it was marketed in several countries, but not in the Philippines.

What sweeteners contain cyclamate?

It is often used with other artificial sweeteners, especially saccharin; the mixture of 10 parts cyclamate to 1 part saccharin is common and masks the off-tastes of both sweeteners. It is less expensive than most sweeteners, including sucralose, and is stable under heating....Cyclamate.NamesNFPA 704 (fire diamond)2 1 019 more rows

Why is cyclamate no longer used in the US?

Cyclamates were banned by the FDA as a food ingredient in 1969 because the saccharin/cyclamate mixture was shown to cause cancer in experimental laboratory rats. The primary concern was that it could be toxic to some individuals who appear to metabolize cyclamate to cyclohexylamine.

What happened cyclamate?

Cyclamate remains banned in the United States and South Korea.

What is the most common artificial sweetener used today?

AspartameAspartame Aspartame (also known as Equal) is one of the most popular artificial sweeteners, adding sweetness to diet sodas, desserts, cereals, and many other foods and beverages.

Is sodium cyclamate banned in US?

In the EU, this substance is present in a variety of products such as soft drinks, cakes and puddings, ice cream, desserts and canned fruit, while it has been banned in the United States since 1969.

What is cyclamate used for?

It is used like most zero-calorie sweeteners, is heat stable, and has a long shelf life. Food factories sometimes use this as a masking agent and sweetener enhancer. Cyclamate has zero glycemic index and zero calories, and is one of the cheapest artificial sweeteners in the world. In the 1960s, studies showed that cyclamate caused development of tumors in the bladders of rodents when fed large quantities. The U.S. banned cyclamate in 1969 due to the results of the study, however, the toxic ingredient is used in many other countries up until now. A common brand name of cyclamate is Sucaryl, manufactured by Merisant, and is sold in more than 90 countries worldwide.

What is cyclamate sold under?

Cyclamate is sold in many countries under the brand names Assugrin, Sweet’N Low, Sugar Twin, Sucaryl, and many more. It may be found in sodas, fruit juices, diabetic foods, desserts and chewing gum. It may also be found in table-top sweeteners, instant beverages, shakes, sports drinks, breakfast cereals, dairy products, biscuits, chocolate, dressings, cakes and baked goods, fruit preservatives, jams, marmalades, puddings, flans, jellies, and some pharmaceutical products.

Does cyclamate cause mental health problems?

Artificial sweeteners and probably cyclamate may cause problems with the cardiovascular system, decrease in mental health and gastrointestinal disorders or adverse reactions.

Can cyclamate cause high blood pressure?

Breakdown of cyclamate which results in cyclohexylamine (CHA) can cause high blood pressure and atrophy of the testicles in rats. Some studies show that it may also be toxic to embryos.

Is cyclamate a sugar?

It has been studied and approved of in more than 55 countries under the brand names Assugrin, Sweet’N Low and Sugar Twin. Cyclamate, however, is still restricted in some countries despite proof of its safety. The acceptable intake of cyclamate is 11 milligrams per kilogram of body weight.

Is cyclamate carcinogenic?

Another study, this time in 1969, claimed that cyclamate may increase the incidence of bladder cancer in rats. However, current evidence indicates that cyclamate is not carcinogenic.

Is cyclamate a sweetener?

Cyclamate is an artificial sweetener which may be harmful to human health.

What is cyclamate made of?

Cyclamate is the sodium or calcium salt of cyclamic acid (cyclohexanesulfamic acid), which itself is prepared by reacting freebase cyclohexylamine with either sulfamic acid or sulfur trioxide.

When was cyclamate discovered?

Funny Face drink mix packet from 1970–71 advertising "No Cyclamate - Just Add Sugar". Cyclamate was discovered in 1937 at the University of Illinois by graduate student Michael Sveda. Sveda was working in the lab on the synthesis of an antipyretic drug. He put his cigarette down on the lab bench, and, when he put it back in his mouth, ...

What is the name of the artificial sweetener that is 30 times sweeter than sucrose?

Sodium cyclamate (sweetener code 952) is an artificial sweetener. It is 30–50 times sweeter than sucrose (table sugar), making it the least potent of the commercially used artificial sweeteners.

Why did Abbott use cyclamate?

Abbott intended to use cyclamate to mask the bitterness of certain drugs such as antibiotics and pentobarbital. In 1958, it was designated GRAS ( Generally Recognized as Safe) by the United States Food and Drug Administration.

Does cyclamate cause bladder cancer?

In 1966, a study reported that some intestinal bacteria could desulfonate cyclamate to produce cyclohexylamine, a compound suspected to have some chronic toxicity in animals. Further research resulted in a 1969 study that found the common 10:1 cyclamate–saccharin mixture increased the incidence of bladder cancer in rats. The released study was showing that eight out of 240 rats fed a mixture of saccharin and cyclamates, at levels equivalent to humans ingesting 550 cans of diet soda per day, developed bladder tumors.

Is cyclamate a carcinogen?

Although the FDA has stated that a review of all available evidence does not implicate cyclamate as a carcinogen in mice or rats, cyclamate remains banned from food products in the United States. The petition is now held in abeyance, though not actively considered.

Is cyclamate a liquid or a tablet?

Cyclamate was marketed in tablet form for use by diabetics as an alternative tabletop sweetener, as well as in a liquid form. As cyclamate is stable to heat, it was and is marketed as suitable for use in cooking and baking.

What is the formula for cyclamate?

Cyclamate (chemical formula C 6 H 13 NO 3 S) is an artificially-made sweetener with approximately 30 times the sweetness of ordinary table sugar. It does not add any calories, in contrast to a sweetener like sugar, which has made it attractive to those who are striving to lose weight.

Why is cyclamate banned?

While still available in some countries, the sale of cyclamate and its use as a sweetener in processed foods has been banned since 1970, due to concerns of a link between ingestion of cyclamate and the development of cancer.

What is the name of the compound that is used to sweeten sugar?

By the mid-1960s, a combination of cyclamate and saccharin (another artificial sweetener) known as Sucaryl had become one of the most popular alternatives to sugar.

Why do you mix saccharin and cyclamate?

Another reason for combining saccharin with cyclamate is that the sweet taste of cyclamate develops slowly , although it lingers attractively on the tongue. On the other hand, saccharin has a bitter aftertaste that is much less noticeable in the mixture than when saccharin is used alone. Indeed, cyclamate is better than sugar at masking bitter flavors.

How long can you keep cyclamate?

Scientists have found no detectable change in Sucaryl tablets stored for seven years or more.

Is cyclamate carcinogenic?

As a result, the Cancer Assessment Committee of the FDA's Center for Food Safety and Applied Nutrition concluded in 1984 that, "the collective weight of the many experiments... indicates that cyclamate is not carcinogenic (not cancer causing)." The results of the 1969 study that led to banning of cyclamate, the committee says, "are... not repeatable and not explicable." The following year, the National Academy of Sciences added that, "the totality of the evidence from studies in animals does not indicate that cyclamate... is carcinogenic by itself." A joint committee of the World Health Organization (WHO) and the Food and Agriculture Organization (FAO) has similarly concluded that cyclamate is safe for human consumption. Unlike the two United States groups, the WHO/FAO panel addressed issues of genetic damage as well as cancer.

Does cyclamate cause cancer?

The idea that cyclamate may cause cancer rests on one study: When scientists fed 80 rats a cyclamate/saccharin mixture at a level equal to 5% of their diets, 12 of them developed bladder cancer within two years. Since then, there have been more than two dozen studies in which animals were fed similar levels of cyclamate for their entire lives; none has given any indication that the sweetener causes cancer.

What is Cyclamate?

Cyclamate is a synthetic artificial sweetener that is 30 to 50 times sweeter than sugar -- the least sweet of all artificial sweeteners. Cyclamate does leave an aftertaste, although less so than other artificial sweeteners such as saccharin. Cyclamate is stable under heating and is commonly used in baked goods where other artificial sweeteners cannot be used. Cyclamate is also combined with other sweeteners, particularly saccharin, to improve palatability.

How to reduce sodium cyclamate?

Go the natural route by sweetening your food with stevia, an intense sweetener that packs a sweetening punch much more powerful than sugar. Alternatively, a very modest amount of honey or maple syrup can sweeten your food with slightly more nutrients than typical table sugar.

Why was cyclamate banned?

Another petition of approval for cyclamate is currently pending with the FDA, although is not being actively considered. Cyclamate does not occur naturally, and foods that contain cyclamate are considered to be in violation of the FDA's tampering and alteration policy.

Is cyclamate a solid?

By Chris Daniels Updated December 07, 2018. Sodium cyclamate is the solid form of the artificial sweetener cyclamate. Because of potential health concerns, cyclamate is currently banned by the U.S. Food and Drug Administration for consumption by humans. However, cyclamate is currently being considered for reapproval due to its safe use in other ...

Does cyclamate cause testicular atrophy?

A study published in "Toxicological Sciences," found that cyclamate contributed to testicular atrophy and interrupted the maturation of sperm in a subset of monkeys fed cyclamate over a long period of time. However, the results were sporadic and do not demonstrate conclusive evidence of cyclamate's toxicity.

Does cyclamate cause cancer?

However, follow-up studies and use abroad has suggested that there is no evidence that cyclamate causes cancer or increases the risk of another substance causing cancer. Further research has demonstrated that cyclamate does not pose an increased risk of bladder cancer in humans, and that the mechanism appears to be distinct to rodents.

Is sodium cyclamate bad for you?

28 November, 2018. Sodium cyclamate is an artificial sweetener that's 30 times as sweet as sugar. The U.S. Food and Drug Administration banned it in 1969 due to concerns about its safety after an animal study showed a potential increased risk for cancer.

Does cyclamate affect fertility?

Although there's some concern about the risk of cyclamate affecting male fertility due to the results of certain animal studies, a study published in 2003 in Food Additives & Contaminants didn't find any effect of cyclamate on male fertility at the levels usually consumed by people in Spain, where this sweetener is legal. This concern came about after a study showed that cyclohexylamine, which is produced when cyclamate is metabolized, could cause testicular atrophy in rats.

Is cyclamate toxic to monkeys?

For example, a study published in Toxicological Sciences in 2000 found that high doses of cyclamate didn't increase cancer risk or have toxic effects in monkeys. The National Cancer Institute notes that the FDA's current concerns about this sweetener are not related to cancer.

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Overview

Cyclamate is an artificial sweetener. It is 30–50 times sweeter than sucrose (table sugar), making it the least potent of the commercially used artificial sweeteners. It is often used with other artificial sweeteners, especially saccharin; the mixture of 10 parts cyclamate to 1 part saccharin is common and masks the off-tastes of both sweeteners. It is less expensive than most sweeteners, including sucralose, and is stable under heating. Safety concerns led to it being banned in a few …

Chemistry

Cyclamate is the sodium or calcium salt of cyclamic acid (cyclohexanesulfamic acid), which itself is prepared by reacting freebase cyclohexylamine with either sulfamic acid or sulfur trioxide.
Prior to 1973, Abbott Laboratories produced sodium cyclamate (Sucaryl) by a mixture of ingredients including the addition of pure sodium (flakes or rods suspended in kerosene) with cyclohexylamine, chilled and filtered through a high speed centrifugal separator, dried, granulate…

History

Cyclamate was discovered in 1937 at the University of Illinois by graduate student Michael Sveda. Sveda was working in the lab on the synthesis of an antipyretic drug. He put his cigarette down on the lab bench, and when he put it back in his mouth, he discovered the sweet taste of cyclamate.
The patent for cyclamate was purchased by DuPont and later sold to Abbott Laboratories, which undertook the necessary studies and submitted a New Drug Application in 1950. Abbott intende…

Legal status

Cyclamate is approved as a sweetener in at least 130 countries. In the late 1960s, cyclamate was banned in the United Kingdom; however, it was approved after being re-evaluated by the European Union in 1996.
In the Philippines, cyclamate was banned until the Philippine Food and Drug Administration lifted the ban in 2013, declaring it safe for consumption. Cyclamate remains banned in the United Stat…

Brands

Sweeteners produced by Sweet'n Low and Sugar Twin for Canada contain cyclamate, though not those produced for the United States.
• Assugrin (Switzerland, Brazil)
• Cap Cangkir (Indonesia)
• Chuker (Argentina) – Merisant Company 2, SARL

External links

• European Commission Revised Opinion On Cyclamic Acid
• FDA Commissioner's Decision on Cyclamate, 45 FR 61474

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