what is dexdomitor used for in dogs

Full Answer

Can You sedate a dog with Dexdomitor?

Most veterinarians will make clients aware of these risks before their dogs are placed under sedation. Dexdomitor for dogs (dexmedetomidine hydrochloride) is an alpha 2 adrenergic agonist drug that is used as a sedative and analgesic (pain reliever, although not strong enough for any surgical procedure).

What is dexmedetomidine used for in dogs and cats?

The use of dexmedetomidine as a preanesthetic in dogs and cats significantly reduces the amount of induction and maintenance anesthetic requirements. Careful patient monitoring during anesthetic induction and maintenance is necessary to avoid anesthetic overdose.

What class of drug is Dexdomitor?

Dexdomitor contains the active substance dexmedetomidine, which belongs to a class of medicines having a psycholeptic (sedative) action. It is a solution for injection (0.1 mg/ml and 0.5 mg/ml). What is Dexdomitor used for?

Can you give Dexdomitor to dogs with liver disease?

Do not use DEXDOMITOR in dogs or cats with cardiovascular disease, respiratory disorders, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue.

What is the best medication for dogs to reverse dexmedetomidine?

How old is a dog when it is given dexmedetomidine?

How long after IV dexmedetomidine can you get a bddacardia?

How long does it take for a dog to recover from barbiturate?

How much does dexmedetomidine IM reduce induction drug requirements?

What are the symptoms of dexmedetomidine in dogs?

How long does it take for dexmedetomidine to be absorbed?

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What does Dexdomitor do for dogs?

PROVIDES SEDATION AND ANALGESIA, AND WORKS AS A PREANESTHETIC, FOR DOGS AND CATS. DEXDOMITOR is indicated for use as a sedative and analgesic in dogs and cats to facilitate clinical examinations, clinical procedures, minor surgical procedures and minor dental procedures.

What are the side effects of Dexdomitor?

The adverse effects of dexmedetomidine include hypotension, hypertension, nausea, bradycardia, atrial fibrillation, and hypoxia (22, 28) (Figure ​4). Overdose may cause first-degree or second-degree atrioventricular block.

What type of drug is Dexdomitor?

Dexmedetomidine is a new generation highly selective α2-adrenergic receptor (α2-AR) agonist that is associated with sedative and analgesic sparing effects, reduced delirium and agitation, perioperative sympatholysis, cardiovascular stabilizing effects, and preservation of respiratory function.

How do you administer a Dexdomitor?

Dexmedetomidine oral gel is administered in the dog's cheek pouch rather than the mouth. You should wear gloves when handling the syringe. Medication is ideally given 30 to 60 minutes before the noise is expected. Additional doses may be given if necessary but it is important to wait at least two hours between doses.

How long does it take for Dexdomitor to wear off?

The peak sedative and analgesic effects are reached within 30 minutes after administration. Sedation lasts for at least 120 minutes post administration and analgesia lasts for at least 90 minutes. Spontaneous recovery occurs within 3 hours.

How long does dog dexmedetomidine last?

Dexmedetomidine has a relatively short duration of action, with sedation lasting from 1-3 hours in dogs and cats at the recommended doses, making it ideal for short procedures or when a patient needs to be discharged on the same day as the procedure.

Does dexmedetomidine treat pain?

A large number of clinical studies have shown that intraoperative dexmedetomidine can significantly reduce postoperative pain intensity and opioid use, and the incidence of opioid-related adverse events.

Is dexmedetomidine a sedative?

Dexmedetomidine produces sedation while maintaining a degree of arousability and may reduce the duration of mechanical ventilation and delirium among patients in the intensive care unit (ICU).

Is dexmedetomidine a muscle relaxant?

It appears that dexmedetomidine is a safe and effective option for these patients. Its administration did not fully control the muscle spasms but decreased their frequency and severity, and reduced the use of sedative, analgesic, and muscle relaxant drugs to control muscle spasms and cardiovascular instability.

Can Dexdomitor be given orally?

Dexmedetomidine oral gel is administered in the cheek pouch of the dog, rather than into the mouth. The person administering the medication should wear gloves when handling the syringe and medication is ideally given 30-60 minutes before the noise or stressful event is expected.

Does Sileo make dogs drowsy?

Very few adverse events have been reported with the use of SILEO. Vomiting, sedation and/or drowsiness were infrequently reported. Why should pet owners avoid feeding or giving treats to their dog within 15 minutes after dosing SILEO?

Is Dexdomitor controlled?

Dexmedetomidine injection should be administered using a controlled infusion device.

What are the long term effects of Dexamphetamine?

These include arousal, hyperactivity, stereotypic perseverative movements, psychomotor depression, cognitive impairment, hallucinatory-like behaviors, and chronic self-administration.

How long do Dexamphetamine side effects last?

The half-life of Dexedrine is around 12 hours. While the duration of the effects of Dexedrine can be anywhere from 8 to 10 hours, it takes 12 hours for just half the amount of the drug to be eliminated from the body. It can take around five half-lives for a drug to be fully eliminated.

What happens when you take too much Dexamphetamine?

An overdose of dextroamphetamine can be fatal. Overdose symptoms may include restlessness, tremor, muscle twitches, rapid breathing, confusion, hallucinations, panic, aggressiveness, muscle pain or weakness, and dark colored urine. These symptoms may be followed by depression and tiredness.

What happens when you take dextroamphetamine?

Dextroamphetamine may cause sudden death in children and teenagers, especially children and teenagers who have heart defects or serious heart problems. This medication also may cause sudden death, heart attack or stroke in adults, especially adults who have heart defects or serious heart problems.

Feline Dosing Chart DEXDOMITOR (dexmedetomidine) - 0.5 mg/mL - Zoetis US

Package Insert NADA 141-267, Approved by FDA. caUtIOn: Federal law restricts this drug to use by or on the order of a licensed veterinarian. DescrIPtIOn: DEXDOMITOR (dexmedetomidine hydrochloride) is a synthetic alpha 2-adrenoreceptor agonist with sedative and analgesic properties.

Dexmedetomidine Uses, Side Effects & Warnings - Drugs.com

Dexmedetomidine side effects. Get emergency medical help if the patient has signs of an allergic reaction: hives; difficult breathing; swelling of the face, lips, tongue, or throat.. Tell the medical caregivers right away if the person receiving dexmedetomidine has:

Dexmedetomidine Dosage Guide + Max Dose, Adjustments - Drugs.com

Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 1 Sep 2022), Cerner Multum™ (updated 21 Sep 2022), ASHP (updated 12 Sep 2022 ...

DEXDOMITOR 0.5 mg/mL - Zoetis US

r p r AR rp r ppr ppr rr r: T: TEXT SIZE The BODY text on this A/W is at: Dimensions r r 09 Apr 2015 15:26 01 Leaflet 20 PA201500225 r 122691-6 25161 DEXDOMITOR N/A

Medetomidine (Domitor®) for Cats and Dogs - PetPlace

Overview of Medetomidine (Domitor®) for Cats and Dogs; Medetomidine, commonly known by the brand name Dormitor, is an injectable drug used for sedation in dogs and cats.

How old is a dog when given dexdomitor?

According to a study involving 106 dogs ranging in age from 16 weeks and 16 years, the administration of dexdomitor for sedation/analgesia purposes resulted is the several adverse reactions.

How long does it take for dexdomitor to work on dogs?

Three dogs were basically standing throughout the study. The drug had a slow onset of sedation in one dog out of 106 with the drug taking over 30 minutes to take effect. Finally, during recovery, one dog out of 106 sustained prolonged recovery times.

How much dexdomitor is given?

According to the drug's information leaflet, dexdomitor is administered at a dose of 500 mcg/m2 intramuscularly (IM) or 375 mcg/m2 intravenously (IV) for the purpose of sedation and analgesia and at a dose of 125 or 375 mcg/m2 intramuscularly as preanesthetic . Dosages as a preanesthetic tend to vary based on the duration and severity of the procedure as outlined below.

How long should dogs be fasted before taking Dexdomitor?

It is recommended that dogs are fasted for 12 hours before the use of Dexdomitor. Upon injected with dexdomitor, the sedation and analgesia effect tend to take place within 5 (when administered intravenously ) to 15 minutes (when administered intramuscularly), with peak effects at 15 to 30 minutes respectively.

Is a miniature schnauzer hyper?

To better understand whether miniature schnauzers are hyper it helps to take a closer look into this breed's history and purpose. Of course, as with all dogs, no general rules are written in stone when it come to temperament. You may find some specimens who are more energetic and others who are more on the mellow side.

Can you monitor a dog after a dog is released?

Once the dog is released to the owner's care, dog owners may wish to monitor their dogs for possible side effects taking place during the recovery time.

Can antisedan cause diarrhea in dogs?

Adverse reactions are more likely in dogs who are debilitated, geriatric and ill especially those with a compromised cardiovascular system. Side effects of antisedan include occasional vomiting, excitement or apprehensiveness, increased salivation diarrhea, and tremors. [otw_is sidebar="otw-sidebar-2"]

What is dexdomitor 0.5 mg/ml?

It is a solution for injection (0.5 mg/ml).

How is dexdomitors given?

In dogs, DEXDOMITOR is given by intravenous (into a vein) or intramuscular (into a muscle) injection. In cats, it is given by intramuscular injection. The duration and depth of sedation and analgesia depend on the dose that is used.

How long does it take for a dog to vomit after a dexdomitor injection?

In some dogs and cats, there may be a decrease in breathing rate and the mucous membranes may appear pale or with a blue tinge. Vomiting may occur five to 10 minutes after injection or at the time of recovery.

What is the active substance in Dexdomitor?

The active substance in Dexdomitor, dexmedetomidine , is an alpha2-adrenoceptor agonist. It works by preventing the release of the neurotransmitter noradrenaline from nerve cells in the body. Neurotransmitters are chemicals that allow nerve cells to communicate with each other. Since noradrenaline is involved in maintaining alertness and arousal, reducing its release decreases the level of consciousness, including the sensation of pain. Dexmedetomidine is closely related to another substance used to sedate animals, medetomidine, that has been used in veterinary medicines for many years.

When to use ketamine in cats?

before inducing general anaesthesia. When used in cats, ketamine should be used as the anaesthetic agent,

Is Dexdomitor a premedication?

Dexdomitor also showed adequate effectiveness for deep sedation of dogs in combination with butorphanol, and as a premedication in dogs and cats before induction of general anaesthetic, reducing the amount of anaesthetic that the dogs and cats needed.

Is Dexdomitor good for dogs?

The studies showed that Dexdomitor had an equivalent level of effectiveness as medetomidine in inducing sedation and analgesia in dogs and cats. As for medetomidine, ‘good’ or ‘excellent’ analgesia was reached in about 40 to 50% of the animals, supporting its use in non-invasive mildly to moderately painful procedures.

How old is a dog when it is given dexmedetomidine?

Dexmedetomidine has not been evaluated in dogs younger than 16 weeks of age, in cats younger than 12 weeks of age, or in geriatric dogs and cats. Dexmedetomidine has not been evaluated for use in breeding, pregnant, or lactating dogs or cats.

What are the symptoms of dexmedetomidine in dogs?

Other clinical signs observed in dogs treated with dexmedetomidine include decreased respiratory rate and hypothermia.

How many times can you give dexmedetomidine to a dog?

Canine safety study: In the multiple dose safety study, dexmedetomidine was administered at 0, 1, 3 or 5 times (X) the recommended IV and IM doses on 3 consecutive days to a total of 36 healthy, young beagles. Two additional groups were given a 3X dose of dexmedetomidine (IV or IM) followed by three 1X doses of the reversal agent, atipamezole (ANTISEDAN), every 30 minutes. This was repeated for a total of 3 days. No deaths occurred during the study.

How long after IV dexmedetomidine can you get a bddacardia?

Cardiac rhythms were evaluated by auscultation. Bradycardia occurred within 5 to 15 minutes after IV dexmedetomidine or medetomidine, and within 15 to 30 minutes after either drug given IM. Sixty-four dexmedetomidine-treated dogs and 50 medetomidine-treated dogs were observed with bradycardia.

How long does it take for dexmedetomidine to be absorbed?

In case of accidental eye exposure, flush with water for 15 minutes. In case of accidental skin exposure, wash with soap and water. Remove contaminated clothing.

Can dexmedetomidine cause apnea in dogs?

Apnea may occur with dexmedetomidine use. In the event of apnea, additional oxygen should be supplied. Administration of ANTISEDAN (atipamezole) to dogs is warranted when apnea is accompanied by bradycardia and cyanotic mucous membranes.

Does dexmedetomidine reduce intubation?

The use of dexmedetomidine as a preanesthetic markedly reduces anesthetic requirements in dogs. Injectable induction drug requirements for intubation will be reduced between 30% and 60%, depending on the choice of anesthetic and the dexmedetomidine preanesthetic dose.

How old is a dog when taking dexdomitors?

DEXDOMITOR is approved for use in dogs as young as 16 weeks of age and cats as young as 12 weeks of age.

Who makes dexdomitors?

DEXDOMITOR, DEXDOMITOR 0.1 and ANTISEDAN are trademarks owned by Orion Corporation Orion Pharma Animal Health. They are manufactured by Orion Corporation and distributed by Zoetis under license from Orion Corporation Orion Pharma Animal Health.

Is dexdomitors a sedative?

DEXDOMITOR is indicated for use as a sedative and anal gesic in dogs and cats to facilitate clinical examinations, clinical procedures, minor surgical procedures and minor dental procedures.

What is a dexdomitol?

DESCRIPTION: DEXDOMITOR (dexmedetomidine hydrochloride) is a synthetic alpha 2 -adrenoreceptor agonist with sedative and analgesic properties.

How old is a dog when they take dexmedetomidine?

Dexmedetomidine has not been evaluated in dogs younger than 16 weeks of age, in cats younger than 12 weeks of age, or in geriatric dogs and cats.

How long after IV dexmedetomidine can you get a bddacardia?

Cardiac rhythms were evaluated by auscultation. Bradycardia occurred within 5 to 15 minutes after IV dexmedetomidine or medetomidine, and within 15 to 30 minutes after either drug given IM. Sixty-four dexmedetomidine-treated dogs and 50 medetomidine-treated dogs were observed with bradycardia.

What is dexmedetomidine used for?

CLINICAL PHARMACOLOGY: Dexmedetomidine is a potent non-narcotic alpha 2 -adrenoceptor agonist which produces sedation and analgesia. These effects are dose dependent in depth and duration. Blood pressure is initially increased due to peripheral vasoconstriction, subsequently dropping to normal or slightly below normal levels. Vasoconstriction may cause mucous membranes to appear pale or mildly cyanotic. This initial vasopressor response is accompanied by a compensatory marked decrease in heart rate mediated by a vagal baroreceptor. The peripheral pulse may feel weak and a transient change in the conductivity of the cardiac muscle may occur, as evidenced by first and second degree atrioventricular blocks. Other arrhythmias may occur. Dexmedetomidine also decreases the respiratory rate and decreases body temperature. The magnitude and duration of the decrease in body temperature is dose dependent. Dexmedetomidine causes depression of gastrointestinal motility due to decrease in smooth muscle activity, increases in blood glucose levels due to inhibition of insulin release, and increases in production of urine. Spontaneous muscle contractions (twitching) can be expected in some dogs sedated with dexmedetomidine. Vomiting in cats has been associated with alpha 2 -adrenergic agonist central stimulation of the brain 4.

How long does it take for dexmedetomidine to sooth?

Sedation and analgesia occurred within 5 minutes after IV dexmedetomidine, and within 15 minutes after IM dexmedetomidine, with peak effects approximately at 15 or 30 minutes, respectively. Effects waned by approximately two hours after IV administration, and by three hours using the IM route. Dexmedetomidine and medetomidine showed comparable clinical effects.

What are the side effects of dexmedetomidine on cats?

The most frequently observed adverse reaction was vomiting in both fasted and fed cats. Other infrequent clinical signs observed in cats treated with dexmedetomidine included fatigue, anorexia, cystitis, and peripheral vascular disorder.

What are the symptoms of dexmedetomidine in dogs?

Other clinical signs observed in dogs treated with dexmedetomidine include decreased respiratory rate and hypothermia.

Why do veterinarians give dogs ivermectin?from coxwellvet.com

The majority of farm dogs are herding breeds, and veterinarians used to give them high doses of injectable Ivermectin as a dewormer because they were highly susceptible to getting worms by being around livestock.

What test is used to determine if a dog has MDR1?from vcahospitals.com

There is a commercially-available test that assesses blood samples or a cheek swab for the presence of the MDR1 mutation. Ask your veterinarian about this test if your dog is a herding breed, or if you otherwise suspect the possibility of MDR1 mutation. Contributors: Catherine Barnette, DVM.

What Is The Canine MDR1 Gene?from canna-pet.com

Unlike some genetic issues, it’s possible for even the most loving and doting dog owner to be completely unaware their dog carries the MDR1 gene until trouble arises. MDR1, which stands for “Multi-Drug Resistance 1”, occurs in a relatively short list of breeds and affects the way a dog’s body processes – or, more accurately, doesn’t process – a variety of canine-targeted medications such as ivermectin, the main ingredient in worming pills. As worming pills are routinely prescribed by vets to treat young dogs and puppies, MDR1 poses a significant health threat to the dog if the owner is unaware their new puppy is a carrier. Like most genetic issues, the most severe reactions will come from a dog that inherited the gene from both of his parents, while a single gene passing on is less worrisome, but still cause for concern.

What is the likelihood that my dog is affected by the MDR1 mutation?from vcahospitals.com

The effects of the mutation vary in severity, depending on whether the dog carries one or two copies of the mutation.

What breeds of dogs have MDR1?from vcahospitals.com

Other herding breeds, including Border Collies, English Shepherds, German Shepherds, and Old English Sheepdogs, have a less than 5% chance of carrying a defective copy of the MDR1 gene.

What happens if a dog has a buildup of toxins in his brain?from coxwellvet.com

When there has been a buildup of toxins in the brain, your dog will start to show neurological symptoms, such as weakness, lethargy, ataxia, disorientation, tremors, seizures, blindness, and death. When any of these symptoms occur, call your veterinarian immediately.

Do you need to give MDR1 results to a puppy?from coxwellvet.com

If your breeder has completed the testing on either the puppy or the parents, please be sure you have a copy of the results to give to your veterinarian so they can be treated appropriately. If the puppy has been purchased for breeding, MDR1 testing should be considered as important as any other test for that breed.

When to use Dexdomitor?

Dexdomitor is used to sedate (calm down) dogs and cats in the following situations: when carrying out mildly to moderately painful procedures and examinations that require the animal to be restrained or sedated, and made less sensitive to pain (analgesia). It is used in noninvasive procedures.

How old is a puppy when it is given Dexdomitor?

The safety of the use of Dexdomitor has not been studied in puppies below 16 weeks of age or in kittens below 12 weeks of age.

How is Dexdomitor given?

In dogs, Dexdomitor is given by intravenous or intramuscular injection. In cats, it is given by intramuscular injection. The duration and depth of sedation and analgesia depend on the dose that is used.

What is dexdomitor 0.1 mg/ml?

It is a solution for injection (0.1 mg/ml and 0.5 mg/ml).

What is dexmedetomidine used for?

Dexmedetomidine is an alpha2-adrenoceptor agonist. It works by preventing the release of the neurotransmitter noradrenaline from nerve cells in the body. Neurotransmitters are chemicals that allow nerve cells to communicate with each other.

How is a dog's med dose chosen?

The dose is chosen according to the species being treated, the use, whether it is given by intravenous (into a vein) or intramuscular (into a muscle) injection and any other medicines that are also being used. The dose depends on the body surface area in dogs (calculated using bodyweight) and bodyweight in cats.

Is Dexdomitor as effective as Medetomidine?

Dexdomitor was at least as effective as medetomidine in inducing general anaesthesia in cats in combination with ketamine. Dexdomitor also showed adequate effectiveness for deep sedation of dogs in combination with butorphanol, and for premedication in dogs and cats before induction of general anaesthesia, reducing the amount of anaesthetic that the dogs and cats require.

What is the best medication for dogs to reverse dexmedetomidine?

Intramuscular ANTISEDAN (atipamezole) may be routinely used to rapidly reverse the effects of dexmedetomidine in dogs. Since analgesic as well as sedative effects will be reversed, pain management may need to be addressed.

How old is a dog when it is given dexmedetomidine?

Dexmedetomidine has not been evaluated in dogs younger than 16 weeks of age, in cats younger than 12 weeks of age, or in geriatric dogs and cats. Dexmedetomidine has not been evaluated for use in breeding, pregnant, or lactating dogs or cats.

How long after IV dexmedetomidine can you get a bddacardia?

Cardiac rhythms were evaluated by auscultation. Bradycardia occurred within 5 to 15 minutes after IV dexmedetomidine or medetomidine, and within 15 to 30 minutes after either drug given IM. Sixty-four dexmedetomidine-treated dogs and 50 medetomidine-treated dogs were observed with bradycardia.

How long does it take for a dog to recover from barbiturate?

Recovery times were dose dependent, averaging 15-32 minutes to extubation and 71-131 minutes to standing recovery (longer times correspond to higher dexmedetomidine dose). Recovery times also depended on the induction anesthetic. Recovery times following barbiturate induction were longer (30 minutes to extubation and 118 minutes to standing), compared to dogs induced with propofol (23 minutes to extubation and 84 minutes to standing).

How much does dexmedetomidine IM reduce induction drug requirements?

Compared to saline controls, dexmedetomidine IM reduced induction drug requirements by 30-36% (at 125 mcg/m 2) and by 38-61% (at 375 mcg/m 2 ). Inhalation anesthetic requirements were 40-60% less for dexmedetomidine-preanesthetized dogs. The number of dogs with clinical signs of pain was less for at least 30 minutes after the procedure in dogs treated with 375 mcg/m 2 dexmedetomidine, compared to saline controls.

What are the symptoms of dexmedetomidine in dogs?

Other clinical signs observed in dogs treated with dexmedetomidine include decreased respiratory rate and hypothermia.

How long does it take for dexmedetomidine to be absorbed?

In case of accidental eye exposure, flush with water for 15 minutes. In case of accidental skin exposure, wash with soap and water.

Dosage and Administration

• Dogs: DEXDOMITOR produces sedation and analgesia when administered intramuscularly (IM) at a dose of 500 mcg/m2, or intravenously (IV) at a dose of 375 mcg/m2. Doses for preanesthesia are 125 or 375 mcg/m2 IM. The choice of preanesthetic dose depends on the duration and sever…

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Contraindications

Precautions

Adverse Reactions

Effectiveness

Animal Safety

References

Domitor 0.1 Indications

• DEXDOMITOR is indicated for use as a sedative and analgesic in dogs and cats to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures. DEXDOMITOR is also indicated for use as a preanesthetic to general anesthesia in dogs and cats.

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Dosage and Administration

Contraindications

Warnings

Precautions

Adverse Reactions

Effectiveness

Animal Safety

How Supplied

References