What is Domitor 1 mg used for?
Domitor 1 mg/ml Solution for Injection 10ml. For restraint, sedation and analgesia associated with clinical examinations and procedures, minor surgery and pre-anaesthesia. As a premedicant before thiopentone-halothane general anaesthesia and as a premedicant before general anaesthesia with propofol.
What is Domitor used for in dogs?
Domitor Indications Domitor is indicated for use as a sedative and analgesic in dogs over 12 weeks of age to facilitate clinical examinations, clinical procedures, minor surgical procedures not requiring muscle relaxation, and minor dental procedures where intubation is not required.
What is the chemical name of Domitor?
Domitor (medetomidine hydrochloride) is a synthetic α2-adrenoreceptor agonist with sedative and analgesic properties. The chemical name is (±)-4-[1-(2,3-dimethylphenyl) ethyl]-1H-imidazole monohydrochloride. It is a white, or almost white, crystalline, water soluble substance having a molecular weight of 236.7.
How long does it take for Domitor to work in dogs?
Overview of Medetomidine (Domitor®) for Cats and Dogs Medetomidine, commonly known by the brand name Dormitor, is an injectable drug used for sedation in dogs and cats. After intramuscular (IM) injection, the effects of medetomidine are seen within 10 to 15 minutes.
What is DOMITOR sedation?
Domitor is indicated for use as a sedative and analgesic in dogs over 12 weeks of age to facilitate clinical examinations, clinical procedures, minor surgical procedures not requiring muscle relaxation, and minor dental procedures where intubation is not required.
What is a DOMITOR?
Noun. domitor m (genitive domitōris); third declension. tamer, breaker (of horses etc) subduer, vanquisher, conqueror.
What does Dexdomitor do to dogs?
PROVIDES SEDATION AND ANALGESIA, AND WORKS AS A PREANESTHETIC, FOR DOGS AND CATS. DEXDOMITOR is indicated for use as a sedative and analgesic in dogs and cats to facilitate clinical examinations, clinical procedures, minor surgical procedures and minor dental procedures.
How does medetomidine cause sedation?
Medetomidine is a relatively new sedative analgesic drug that is approved for use in dogs in Canada. It is the most potent α2-adrenoreceptor available for clinical use in veterinary medicine and stimulates receptors centrally to produce dose-dependent sedation and analgesia.
How long does DOMITOR last?
The analgesia associated with medetomidine only lasts 15 to 30 minutes but sedation can last 1 to 2 hours. Complete recovery can take 2 to 4 hours.
How long does ANTISEDAN last?
Dexmedetomidine is an α2-agonist that produces varying degrees of sedation, muscle relaxation, and analgesia. The duration of sedation is approximately 1 to 3 hours when administered at the recommended IM or IV doses (1-10 µg/kg), with IM administration providing longer periods of sedation.
Does Dexdomitor have pain control?
A large number of clinical studies have shown that intraoperative dexmedetomidine can significantly reduce postoperative pain intensity and opioid use, and the incidence of opioid-related adverse events.
What is the most common side effect of dexmedetomidine?
Commonly reported side effects of dexmedetomidine include: bradycardia, hypotension, agitation, hypertension, nausea, and tachycardia. Other side effects include: vomiting, and xerostomia.
Is Dexdomitor a tranquilizer?
What is dexmedetomidine? Dexmedetomidine is a sedative and tranquilizer (Sileo®) used in the treatment of fear and anxiety in dogs and as a sedative and pain medication (Dexdomitor®) in both dogs and cats. It is also used off-label as a pre-anesthetic or tranquilizer in exotic pets.
Can medetomidine be reversed?
Medetomidine, 0.06–0.08 mg/kg, IM administered with ketamine, 1–2 mg/kg, IM is a useful combination to sedate deer. The effects of medetomidine can be reversed by injection of atipamezole at a dose rate up to five times the medetomidine dose.
What type of drug is medetomidine?
Medetomidine is a synthetic compound used as a surgical anesthetic and analgesic. It is normally found as its hydrochloride salt, medetomidine hydrochloride. Medetomidine is an intravenously available alpha-2 adrenergic agonist. The drug has been developed by Orion Pharma.
Does medetomidine cause vomiting?
Alpha2-agonists such as medetomidine and dexmedetomidine are the most preferred sedative drugs in cats. Both drugs can induce vomiting and alter intraocular pressures (IOP) during vomiting and sedation period.
Why is atipamezole not used in humans?
In humans, atipamezole at doses up to 30 mg/subject produced no cardiovascular or subjective side effects, while at a high dose (100 mg/subject) it produced subjective symptoms, such as motor restlessness, and an increase in blood pressure.
Is medetomidine used in humans?
Medetomidine is a synthetic drug used as both a surgical anesthetic and analgesic. It is often used as the hydrochloride salt, medetomidine hydrochloride, a crystalline white solid....Medetomidine.Clinical dataPubChem CID68602DrugBankDB00633ChemSpider61868UNIIMR15E85MQM21 more rows
What is ANTISEDAN used for?
Atipamezole (Antisedan®) is an α-2 adrenergic antagonist labeled for use as a reversal agent for the sedative medetomidine. It has been used successfully in the treatment of amitraz toxicosis to reverse CNS depression, bradycardia, GI stasis and hyperglycemia (Grossman, 1993; Gwaltney-Brant, 2004).
Is Dexdomitor used in humans?
[1] Dexmedetomidine is a relatively new drug approved at the end of 1999 by the Food and Drug Administration (FDA) for humans use for short-term sedation and analgesia (<24 hours) in the intensive care unit (ICU).
What is medetomidine used for?
Uses of Medetomidine for Dogs and Cats. Medetomidine is used to produce sedation for short procedures and provides a short period of analgesia. It is also used as a preanesthetic before local or general anesthesia.
How long does it take for medetomidine to work?
After intramuscular (IM) injection, the effects of medetomidine are seen within 10 to 15 minutes. After intravenous injection, the effects are seen within 5 minutes.
What is the name of the drug that is used to treat a dog's sedation?
Overview of Medetomidine (Domitor®) for Cats and Dogs. Medetomidine, commonly known by the brand name Dormitor, is an injectable drug used for sedation in dogs and cats. Medetomidine belongs to a class of drugs known as alpha 2 adrenergic agonists and is similar to clonidine and xylazine. It is a sedative that provides pain relief as well as muscle ...
What are the side effects of medetomidine?
Adverse effects of medetomidine include slowed heart rate with partial heart block, low body temperature and slowed breathing rate.
Can medetomidine be given to animals with heart disease?
Extreme caution must be used if medetomidine is given to animals with heart disease , low blood pressure, shock, breathing problems, severe liver or kidney disease, a known seizure disorder or if the animal is severely debilitated.
Is medetomidine safe for animals?
While generally safe and effective when prescribed by a veterinarian, medetomidine can cause side effects in some animals.
Can medetomidine be reversed?
The effects of medetomidine can be reversed with the use of atipamezole. This can significantly reduce the amount of time needed for recovery. Despite appearing completely sedated, animals can still move, even kick, bite or scratch, in response to sharp auditory stimulation.
Why do we use a domitor?
Domitor is widely used for the sedation of animals and to reduce stress levels. It allows an animal to cope with a painful procedure without getting scared and upset.
Can antisedan be used to reverse domitor?
Once the procedure is finished, an injection of Antisedan will reverse the effects of Domitor. The animal will wake and can walk out of the clinic. Domitor is a very useful and versatile drug that I use multiple times a day.
Why use a graduated syringe for medetomidine?
An appropriately graduated syringe must be used to allow accurate administration of the required dose volume. This is particularly important when injecting small volumes. Medetomidine has marked anaesthetic sparing effects. It is essential to reduce the dose of induction and maintenance agents appropriately in animals that have been premedicated with Domitor.
What is the purpose of atipamezole?
Atipamezole (Antisedan) administered in the post-operative phase will hasten the recovery from anaesthesia.
How long before propofol can you give medetomidine?
Medetomidine (Domitor) is administered either IV at least 10 minutes before propofol (induction agent), or IM at least 20 minutes before propofol to allow sedation to develop. Medetomidine may be administered at a dose rate of 10, 20 or 40 mcg/kg (0.01, 0.02 or 0.04 ml/kg). The following table is a guideline for doses:
How much medetomidine should I give my dog?
Domitor may be administered at a dose rate of 10, 20 or 40 mcg/kg. The table below is a guideline for doses, however, the dose of thiopentone required may vary considerably in individual animals. The optimum dose of Domitor is in the range of 20 - 40 mcg/kg and will depend on the temperament of the dog. At higher doses of medetomdine, thiopentone may not be required for intubation, i.e. intubation may be possible under medetomidine alone.
How long does it take to inject propofol?
N.B. The induction time is increased following Domitor premedication; propofol should be administered by slow IV injection and up to 2.5 minutes should be allowed before a further dose is given.
How long does it take for thiopentone to work?
Thiopentone as a dilute solution (1.25 - 2.5%) is administered by the IV route slowly to effect over a period of 30 - 45 seconds. Once jaw relaxation is considered adequate, tracheal intubation can be undertaken.
Can you give butorphanol and medetomidine together?
Medetomidine (Domitor) and butorphanol can be administered together in the same syringe, by IM or SC injection.
How much do you give a domitor?from drugs.com
Domitor should be administered at the rate of 750 mcg IV or 1000 mcg IM per square meter of body surface . Use the table below to determine the correct dosage on the basis of body weight.
How long should dogs rest after a domitor injection?from drugs.com
Highly agitated dogs should therefore be put at ease and allowed to rest quietly prior to receiving Domitor. Allowing dogs to rest quietly for 10 to 15 minutes after injection may improve the response to Domitor. In dogs not responding satisfactorily to treatment with Domitor, repeat dosing is not recommended.
How long does it take for medetomidine to increase tidal volume?from drugs.com
Respiratory responses include an initial slowing of respiration within a few seconds to 1-2 minutes after administration, increasing to normal within 120 minutes. An initial decrease in tidal volume is followed by an increase. When medetomidine was given at 3 and 5 times the recommended dose IV, and 5 and 10 times IM, effects were not intensified but were prolonged.
What is medetomidine used for?from drugs.com
The pharmacological restraint and pain relief provided by medetomidine facilitates handling dogs and aids in the conduct of diagnostic or therapeutic procedures. It also facilitates minor surgical procedures (with or without local anesthesia) and dental care where intubation is not required. Spontaneous muscle contractions (twitching) can be expected in some dogs sedated with medetomidine.
How long before thiopentone can you give a dog a domitor?from noahcompendium.co.uk
Domitor as a premedicant before thiopentone in dogs, anaesthesia being maintained with halothane (with or without nitrous oxide) Medetomidine (Domitor) is administered at least 20 minutes before thiopentone (induction agent) to allow sedation to develop. Domitor may be administered at a dose rate of 10, 20 or 40 mcg/kg.
Does medetomidine cause bradycardia?from drugs.com
The bradycardia may be partially prevented by prior (at least 5 minutes before) intravenous administration of an anticholinergic agent (see PRECAUTIONS ). A transient change in the conductivity of the cardiac muscle may occur, as evidenced by atrioventricular blocks. Cardiovascular changes (such as profound bradycardia and second degree heart block) equally affect both heartworm negative and asymptomatic heartworm positive dogs.
How long before propofol can you give medetomidine?from noahcompendium.co.uk
Medetomidine (Domitor) is administered either IV at least 10 minutes before propofol (induction agent), or IM at least 20 minutes before propofol to allow sedation to develop. Medetomidine may be administered at a dose rate of 10, 20 or 40 mcg/kg (0.01, 0.02 or 0.04 ml/kg). The following table is a guideline for doses:
What is dexmedetomidine used for?
CLINICAL PHARMACOLOGY: Dexmedetomidine is a potent non-narcotic alpha 2 -adrenoceptor agonist which produces sedation and analgesia. These effects are dose dependent in depth and duration. Blood pressure is initially increased due to peripheral vasoconstriction, subsequently dropping to normal or slightly below normal levels. Vasoconstriction may cause mucous membranes to appear pale or mildly cyanotic. This initial vasopressor response is accompanied by a compensatory marked decrease in heart rate mediated by a vagal baroreceptor. The peripheral pulse may feel weak and a transient change in the conductivity of the cardiac muscle may occur, as evidenced by first and second degree atrioventricular blocks. Other arrhythmias may occur. Dexmedetomidine also decreases the respiratory rate and decreases body temperature. The magnitude and duration of the decrease in body temperature is dose dependent. Dexmedetomidine causes depression of gastrointestinal motility due to decrease in smooth muscle activity, increases in blood glucose levels due to inhibition of insulin release, and increases in production of urine. Spontaneous muscle contractions (twitching) can be expected in some dogs sedated with dexmedetomidine. Vomiting in cats has been associated with alpha 2 -adrenergic agonist central stimulation of the brain 4.
What is a dexdomitol for dogs?
INDICATIONS: DEXDOMITOR is indicated for use as a sedative and analgesic in dogs and cats to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental ...
What are the side effects of dexmedetomidine on cats?
The most frequently observed adverse reaction was vomiting in both fasted and fed cats. Other infrequent clinical signs observed in cats treated with dexmedetomidine included fatigue, anorexia, cystitis, and peripheral vascular disorder.
How long after dexmedetomidine injection should dogs rest?
Therefore, allow dogs and cats to rest quietly for 10 to 15 minutes after injection. Repeat dosing has not been evaluated.
What are the symptoms of dexmedetomidine in dogs?
Other clinical signs observed in dogs treated with dexmedetomidine include decreased respiratory rate and hypothermia.
How long does it take for dexmedetomidine to be absorbed?
In case of accidental eye exposure, flush with water for 15 minutes. In case of accidental skin exposure, wash with soap and water.
How old is a dog when they take dexmedetomidine?
Dexmedetomidine has not been evaluated in dogs younger than 16 weeks of age, in cats younger than 12 weeks of age, or in geriatric dogs and cats.
How much does dexmedetomidine IM reduce induction drug requirements?
Compared to saline controls, dexmedetomidine IM reduced induction drug requirements by 30-36% (at 125 mcg/m 2) and by 38-61% (at 375 mcg/m 2 ). Inhalation anesthetic requirements were 40-60% less for dexmedetomidine-preanesthetized dogs. The number of dogs with clinical signs of pain was less for at least 30 minutes after the procedure in dogs treated with 375 mcg/m 2 dexmedetomidine, compared to saline controls.
How long does it take for dexmedetomidine to be absorbed?
In case of accidental eye exposure, flush with water for 15 minutes. In case of accidental skin exposure, wash with soap and water.
How long after IV dexmedetomidine can you get a bddacardia?
Cardiac rhythms were evaluated by auscultation. Bradycardia occurred within 5 to 15 minutes after IV dexmedetomidine or medetomidine, and within 15 to 30 minutes after either drug given IM. Sixty-four dexmedetomidine-treated dogs and 50 medetomidine-treated dogs were observed with bradycardia.
What is the best medication for dogs to reverse dexmedetomidine?
Intramuscular ANTISEDAN (atipamezole) may be routinely used to rapidly reverse the effects of dexmedetomidine in dogs. Since analgesic as well as sedative effects will be reversed, pain management may need to be addressed.
What are the symptoms of dexmedetomidine in dogs?
Other clinical signs observed in dogs treated with dexmedetomidine include decreased respiratory rate and hypothermia.
How old is a dog when it is given dexmedetomidine?
Dexmedetomidine has not been evaluated in dogs younger than 16 weeks of age, in cats younger than 12 weeks of age, or in geriatric dogs and cats. Dexmedetomidine has not been evaluated for use in breeding, pregnant, or lactating dogs or cats.
Does dexmedetomidine reduce anesthesia?
The use of dexmedetomidine as a preanesthetic markedly reduces anesthetic requirements. Injectable induction drug requirements for intubation will be reduced between 30% and 60%, depending on the choice of anesthetic and the dexmedetomidine preanesthetic dose.
How much dexdomitor is given?
According to the drug's information leaflet, dexdomitor is administered at a dose of 500 mcg/m2 intramuscularly (IM) or 375 mcg/m2 intravenously (IV) for the purpose of sedation and analgesia and at a dose of 125 or 375 mcg/m2 intramuscularly as preanesthetic . Dosages as a preanesthetic tend to vary based on the duration and severity of the procedure as outlined below.
How long does it take for dexdomitor to work on dogs?
Three dogs were basically standing throughout the study. The drug had a slow onset of sedation in one dog out of 106 with the drug taking over 30 minutes to take effect. Finally, during recovery, one dog out of 106 sustained prolonged recovery times.
How old is a dog when given dexdomitor?
According to a study involving 106 dogs ranging in age from 16 weeks and 16 years, the administration of dexdomitor for sedation/analgesia purposes resulted is the several adverse reactions.
How long should dogs be fasted before taking Dexdomitor?
It is recommended that dogs are fasted for 12 hours before the use of Dexdomitor. Upon injected with dexdomitor, the sedation and analgesia effect tend to take place within 5 (when administered intravenously ) to 15 minutes (when administered intramuscularly), with peak effects at 15 to 30 minutes respectively.
