Full Answer
Is flupenthixol decanoate a useful depot?
Flupenthixol decanoate is one of the most widely used depots in the UK. It is worth investigating the effects of flupenthixol decanoate in comparison with other antipsychotic medications with regards to clinical and non‐clinical outcomes for the benefits of clinicians, patients and managers/policy makers alike.
What is the difference between Flupenthixol and fluphenazine decanoate?
Flupenthixol decanoate has shown to have better tolerance and less side effects as compared to fluphenazine decanoate (Johnson 1975; Pinto 1979; Wistedt 1983). These might be due to the 'partial atypical' properties of flupenthixol and also resembling tricyclic antidepressants in some of its actions.
What is flupenthixol?
Flupenthixol belongs to the family of medications known as thioxanthenes. This medication is used in the treatment of schizophrenia. It is thought to work by affecting nerve pathways in certain areas of the brain to help correct certain chemical imbalances that cause the symptoms of schizophrenia.
What is the dose of flupenthixol decanoate?
Flupenthixol decanoate: dose mean 40 mg/IM (standard dose), biweekly. N = 11. Outcomes Adverse effects ‐ requiring anticholinergic medication. Unable to use ‐ Mental state (Hamilton‐Lorr Scale ‐ no data). Ward behaviour (Wing Sclae ‐ no data). Side effects (EPS ‐ no data). Blood samples (non‐clinical outcome, data not usable). Notes Risk of bias
What is flupenthixol decanoate used for?
Flupentixol is used to relieve the symptoms of schizophrenia and other similar mental health problems. It works on the balance of chemical substances in your brain. Long-acting, or 'depot', injections are used once your symptoms have been eased by taking tablets.
How do you administer flupenthixol decanoate?
Test dose 20 mg, dose to be injected into the upper outer buttock or lateral thigh, then 20–40 mg after at least 7 days, then 20–40 mg every 2–4 weeks, adjusted according to response, usual maintenance dose 50 mg every 4 weeks to 300 mg every 2 weeks; maximum 400 mg per week.
What type of antidepressant is flupentixol?
Flupentixol is a thioxanthene neuroleptic used to treat schizophrenia and depression. Flupentixol is an antipsychotic drug of the thioxanthene group. It exists in two geometric isomers, the trans(E) and pharmacologically active cis(Z) forms.
How does flupentixol work in the body?
Flupentixol is thought to work by affecting the activity of a natural compound called dopamine in the brain. Dopamine is known as a neurotransmitter, and is involved in transmitting messages between brain cells. It is known to be involved in regulating mood and behaviour, amongst other things.
Is flupentixol a sleeping pill?
The brand of flupentixol called Fluanxol® is prescribed for people with depression. The symptoms of depression can include low mood, poor sleep, and poor concentration. These are often eased by taking an antidepressant such as flupentixol....About flupentixol.Type of medicineA thioxanthene medicineAvailable asTablets2 more rows•May 29, 2020
What are the side effects of flupentixol decanoate?
Check with your doctor as soon as possible if any of the following side effects occur:blurred vision or other eye problems.circular eye movement.decreased blood pressure (fainting, dizziness, lightheadedness)difficult urination.fast, pounding, or irregular heartbeat.mask-like face.More items...
Is flupentixol an antipsychotic?
Flupentixol is a first generation antipsychotic. It is also known by the trade names Depixol, Fluanxol and Flupenthixol.
Does flupentixol lower blood pressure?
Rise slowly from sitting or lying position as FLUPENTIXOL causes orthostatic hypotension (sudden lowering in blood pressure leading to dizziness on standing). Inform your doctor before taking FLUPENTIXOL if you have diabetes as FLUPENTIXOL can cause an increase in blood sugar levels.
Does flupentixol cause weight gain?
Having been investigated in numerous studies, flupenthixol was found to be effective and well tolerated by people with schizophrenia. The main side effects are shaking, restlessness or the inability to sit still, a dry mouth and some weight gain.
Can flupentixol cause Parkinson's?
Of the 306 cases of parkinsonism seen, 56.8% were induced or aggravated by drugs. This side effects is more frequent in women and often occurs in old age. The drugs implicated most often were cinnarizine, sulpiride and flupentixol.
How long does it take for Fluanxol injection to work?
The effect of this medicine is cumulative and it usually takes 1 to 3 days before symptom improvement can be seen. The effect of this medicine lasts for an average duration of 2 to 4 weeks.
Does Fluanxol make you sleepy?
There is a risk of feeling drowsy and dizzy when using Fluanxol especially at the start of your treatment. If this happens do not drive or use any tools or machines until you know you are not affected in this way. Do not drive if you have blurred vision.
When was flupentixol first used?
It was introduced in 1965 by Lundbeck.
How often is flupentixol given?
Flupentixol's main use is as a long-acting injection given once in every two or three weeks to individuals with schizophrenia who have poor compliance with medication and suffer frequent relapses of illness, though it is also commonly given as a tablet.
What is the name of the drug that is a thioxanthene?
Flupentixol ( INN ), also known as flupenthixol (former BAN ), marketed under brand names such as Depixol and Fluanxol is a typical antipsychotic drug of the thioxanthene class. It was introduced in 1965 by Lundbeck. In addition to single drug preparations, it is also available as flupentixol/melitracen —a combination product containing both melitracen (a tricyclic antidepressant) and flupentixol. Flupentixol is not approved for use in the United States. It is, however, approved for use in the UK, Australia, Canada, Russian Federation, South Africa, New Zealand, Philippines and various other countries.
Is flupentixol approved in the US?
Flupentixol is not approved for use in the United States. It is, however, approved for use in the UK, Australia, Canada, Russian Federation, South Africa, New Zealand, Philippines and various other countries.
How do antipsychotics affect the hypothalamus?
Antipsychotic drugs may influence hypothalamic-pituitary function through their effects on neurotransmission, as a non-specific action mediated haemodynamically or via their influence on thermoregulation ( de Wied, 1967 ). Neuroleptics stimulate the release of prolactin, melanocyte-stimulating hormone (MSH) and antidiuretic hormone (ADH), while they suppress corticotrophin (ACTH), growth hormone (GH), thyrotrophin (TSH), follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
Where do antipsychotics come from?
The antipsychotic action of all conventional antipsychotic drugs arises primarily from dopamine D 2 receptor antagonist activity in the mesolimbic pathway of the brain. High affinity for D 2 receptors and slow dissociation from these receptors is a common feature of all conventional antipsychotics. The affinity of the drug for these receptors correlates well with its effective dose. At least 65% of D 2 -receptor occupancy in the mesolimbic system is required for clinical benefit during long-term treatment of psychotic disorders. However, these drugs also have D 2 -receptor antagonist activity in other CNS pathways, and 80% or more D 2 -receptor occupancy in the striatum will produce unwanted extrapyramidal effects (see later).
What is a depot in medicine?
Traditionally, the term ‘depot’ refers to a specific drug delivery system involving chemical alteration of the parent compound, the use of an oil-based storage vehicle and enzymatic release from intramuscular sites. The molecular structure of most newer drugs does not permit the first step in this process, so novel pharmaceutical methods have had to be employed. Technically, these newer formulations are not ‘depot’ per se but aqueous solutions more correctly termed ‘long-acting injectables’.
Can antipsychotics be used for hallucinations?
Acute psychotic symptoms such as hallucinations and delusions can be controlled relatively rapidly with an antipsychotic drug. However, reductions in thought disturbance, withdrawal, and apathy are delayed and clinical improvement is gradual over several weeks of treatment. Atypical antipsychotics should be considered in preference to conventional antipsychotics under the following circumstances:
What is Flupentixol decanoate?
Maintainance of symptoms in adults with schizophrenia and other similar mental health problems. Also called. Flupentixol decanoate: Depixol®; Psytixol®. Available as. Long-acting 'depot' injection. Flupentixol belongs to a group of medicines called antipsychotics. You will have been prescribed it to maintain symptom control of schizophrenia.
How often is flupentixol given?
Flupentixol long-acting injection. Flupentixol long-acting injection will be given to you by your clinic doctor or nurse every 2-4 weeks. If you miss an appointment for an injection, make another appointment as soon as possible. There are a number of side-effects which you could experience from the treatment.
How often do you need to take flupentixol?
The injection slowly releases flupentixol into your body and is given every 2-4 weeks. The main advantage of a depot injection is that you do not have to remember to take tablets every day.
Can you take flupentixol before long acting injection?
Before having flupentixol long-acting injection. Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start having flupentixol long-acting injections, it is important that your doctor knows:
Can flupentixol cause skin to be sensitive to sunlight?
Flupentixol could cause your skin to become more sensitive to sunlight than normal. Avoid strong sunlight and sunbeds, and use a sun cream with a high sun protection factor even on bright but cloudy days. If you drink alcohol, ask your doctor for advice about drinking while you are on flupentixol.
flupentixol
Flupentixol is a first generation antipsychotic. It is also known by the trade names Depixol, Fluanxol and Flupenthixol.
More information about antipsychotics
Our pages on antipsychotics have lots more information about this type of medication. This includes how they work, what they are prescribed for and what to know before taking them. It also covers their side effects and withdrawal effects, and lists alternative treatment options.
Flupentixol (Fluanxol) - Uses, Dose, Side effects, MOA, Brands
Flupentixol (Fluanxol) is a typical antipsychotic drug that is used in patients with schizophrenia and other psychotic behavioral problems.
Flupentixol Uses
Schizophrenia: Used in the maintenance therapy of chronic schizophrenic patients whose main manifestations do not include excitement, hyperactivity, or agitation.
Flupentixol (Fluanxol) Dose in the treatment of Schizophrenia
Note: Initiate with oral therapy; upon stabilization, patients may then be transitioned to the depot injection.
Use in Children
Not indicated. [/bg_collapse] [bg_collapse view="button-blue" color="#f7f2f2" icon="arrow" expand_text="Dose in Pregnancy & lactation" collapse_text="Dose in Pregnancy & lactation" ]
Flupentixol Pregnancy Category: C
Pregnant women are not subject to adequate, well-controlled studies. Use of antipsychotics during pregnancy's third trimester can lead to abnormal muscle movements and withdrawal symptoms in the newborns after delivery. The newborn can experience agitation, hypotonia or hypertonia as well as feeding disorder, respiratory distress and somnolence.
Dose in Kidney Disease
The manufacturer’s product labeling recommendations are unclear.
Dose in Liver disease
The manufacturer's labeling doesn't provide any dosage adjustments; flupentixol undergoes extensive hepatic metabolism. Use caution. [/bg_collapse] [bg_collapse view="button-blue" color="#f7f2f2" icon="arrow" expand_text="Side effects" collapse_text="Side effects" ]
How Does This Medication Work? What Will It Do For Me?
- Flupenthixol belongs to the family of medications known as thioxanthenes. This medication is used in the treatment of schizophrenia.It is thought to work by affecting nerve pathways in certain areas of the brain to help correct certain chemical imbalances that cause the symptoms of schizophrenia. This medication may be available under multiple bran...
How Should I Use This medication?
- The recommended starting dose of flupenthixol tablets is 1 mg 3 times a day.The doctor may increase this dose every 2 or 3 days depending on how you are doing. The usual maintenance dose is 3 mg to 6 mg daily, taken in divided doses. Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If yo…
Who Should Not Take This medication?
- Do not use this medication if you: 1. are allergic to flupenthixol or any ingredients of this medication 2. are allergic to other thioxanthines (e.g., thiothixine) 3. are intoxicated with alcohol or other medications (such as hypnotics, other opioids like codeine or morphine, or psychotropic medications for mental health conditions) 4. have brain damage 5. have liver damage 6. have se…
What Side Effects Are Possible with This medication?
- Many medications can cause side effects.A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor…
Are There Any Other Precautions Or Warnings For This medication?
- Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication. Abnormal heart rhythms: This medication can cause abnormal hear…
What Other Drugs Could Interact with This medication?
- There may be an interaction between flupenthixol and any of the following: 1. aclidinium 2. alcohol 3. alfuzosin 4. amantadine 5. amiodarone 6. amphetamines (e.g., dextroamphetamine, lisdexamfetamine) 7. anagrelide 8. antihistamines (e.g., cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine) 9. anti-Parkinson's medications (e.g., amantadine, apomorphine, bromo…