Precautions
INDICATIONS: Fungizone ® should be administered primarily to patients with progressive, potentially life-threatening fungal infections. This potent drug should not be used to treat noninvasive fungal infections, such as oral thrush, vaginal candidiasis, and esophageal candidiasis in patients with normal neutrophil counts.
What are the indications for Fungizone ®?
Indications and Usage for Fungizone. Fungizone Intravenous (Amphotericin B for Injection, USP) should be administered primarily to patients with progressive, potentially life-threatening fungal infections.
What is the USP for Fungizone?
Following intravenous infusion, the antibiotic is slowly excreted by the kidneys, and demonstrable blood levels persist for at least 18 hours after the infusion is discontinued. Fungizone ® (amphotericin B) is specifically intended for the treatment of disseminated mycotic infections, including:
How long does it take for Fungizone to leave the body?
Fungizone PubChem CID 5386092 Synonyms Fungizone Fungilin Ampho-Moronal 1397-89 ... Molecular Weight 924.1 Date s Modify 2021-06-19 Create 2005-03-26 4 more rows ...
What is the molecular weight of Fungizone?
Is fungizone an antibiotic?
Fungizone (amphotericin B) is an antifungal antibiotic used to treat serious, life-threatening fungal infections, and is usually given after other antifungal antibiotics have been unsuccessful. The brand name Fungizone is discontinued in the U.S. Generic forms may be available.
How do you use fungizone suspension?
How is Fungizone given? Fungizone is injected into a vein through an IV. A healthcare provider will give you this injection. The medicine must be given slowly through an IV infusion, and can take from 2 to 6 hours to complete.
What fungal infections does amphotericin B treat?
Amphotericin B is an antifungal prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of several types of fungal infections, such as histoplasmosis and cryptococcosis.
Is amphotericin same as fungizone?
Amphotericin B plays a central role in the prevention and treatment of severe, deep systemic fungal infections. The conventional formulation is amphotericin B deoxycholate (Fungizone®).
How do you administer fungizone?
Fungizone should be administered by intravenous infusion over a period of 2-6 hours. Reduction of the infusion rate may reduce the incidence of side-effects. Initial daily dose should be 0.25 mg/kg of body weight gradually increasing to a level of 1.0 mg/kg of body weight depending on individual response and tolerance.
What is the most serious adverse effect of amphotericin B?
The principal acute toxicity of AmB deoxycholate includes nausea, vomiting, rigors, fever, hypertension or hypotension, and hypoxia. Its principal chronic adverse effect is nephrotoxicity.
Why does amphotericin B affect the kidneys?
Amphotericin B binds to sterols in cell membranes, thereby creating pores that compromise membrane integrity and increase membrane permeability. It binds not only to ergosterol in fungal cell walls but also to cholesterol in human cell membranes; this is what accounts for its nephrotoxicity.
How long is amphotericin B treatment?
Mean duration of treatment with liposomal amphotericin B was 20 +/- 20 days, at an average dose of 2.3 mg/kg/d.
Is amphotericin B an antibiotic or antifungal?
Amphotericin B injection is used to treat serious and potentially life-threatening fungal infections. Amphotericin B injection is in a class of medications called antifungals. It works by slowing the growth of fungi that cause infection.
Why is amphotericin B so toxic to humans?
Because mammalian and fungal membranes are similar in structure and composition, this is one mechanism by which amphotericin B causes cellular toxicity. Amphotericin B molecules can form pores in the host membrane as well as the fungal membrane. This impairment in membrane barrier function can have lethal effects.
When should amphotericin B be prescribed?
Amphotericin should be used only to treat serious, possibly fatal fungal infections. This medication should not be used for less severe infections in limited areas of the body (such as fungal infection of the mouth/esophagus, vaginal yeast infections) in patients with normal white blood cell counts.
What is amphotericin B side effects?
More commonFever and chills.headache.increased or decreased urination.irregular heartbeat.muscle cramps or pain.nausea.pain at the place of injection.unusual tiredness or weakness.More items...•
How do you administer amphotericin infusion?
Amphotericin B injection comes as a solid powder cake to be made into a solution and then injected intravenously (into a vein) by a nurse or a doctor. Amphotericin B injection is usually infused (injected slowly) intravenously over a period of 2 to 6 hours once daily.
How do you dilute amphotericin B?
Dilute each 'mg' of drug with 10 ml. [1 mg/ 10 ml ] [4 - 6 hours] * dilute the reconstituted solution with 250-500 mL D5W; final concentration should not exceed 0.1 mg/mL (peripheral infusion) or 0.25 mg/mL (central infusion). Add 10 mL of SWFI (without a bacteriostatic agent) to each vial of amphotericin B.
What is itraconazole 100mg used to treat?
Itraconazole capsule is used to treat fungal infections, such as aspergillosis (fungal infection in the lungs), blastomycosis (Gilchrist's disease), or histoplasmosis (Darling's disease). Sporanox® capsule is also used to treat onychomycosis (fungal infection in the fingernails or toenails).
How long should amphotericin B be administered?
FUNGIZONE Intravenous (Amphotericin B for Injection) should be administered by slow intravenous infusion. Intravenous infusion should be given over a period of approximately 2 to 6 hours (depending on the dose) observing the usual precautions for intravenous therapy (see PRECAUTIONS: General).
What is fungizone used for?
What is Fungizone and how is it used? Fungizone is a prescription medicine used to treat the symptoms of fungal infections, Cryptococcal Meningitis and Visceral Leishmaniasis. Fungizone may be used alone or with other medications. Fungizone belongs to a class of drugs called Antifungals, Systemic.
Can a syringe be used for a fungal infection?
This drug should be used primarily for treatment of patients with progressive and potentially life-threatening fungal infections; it should not be used to treat noninvasive forms of fungal disease such as oral thrush, vaginal candidiasis, and esophageal candidiasis in patients with normal neutrophil counts.
Does fungizone cause bruising?
Side effects of Fungizone include: pale skin, easy bruising, blood in your stools, lightheadedness, seizures, yellowing of the skin or eyes (jaundice), anxiety, sweating,
Is amphotericin B safe for fungal infections?
Amphotericin B is frequently the only effective treatment available for potentially life-threatening fungal disease. In each case, its possible life-saving benefit must be balanced against its untoward and dangerous side effects.
Does fungizone cause stomach pain?
Get medical help right away, if you have any of the symptoms listed above. The most common side effects of Fungizone include: nausea, vomiting, stomach pain, diarrhea, upset stomach, loss of appetite, muscle or joint pain,
What is fungizone intravenous?
Fungizone Intravenous is specifically intended to treat potentially life-threatening fungal infections : aspergillosis, cryptococcosis (torulosis), North American blastomycosis, systemic candidiasis, coccidioido-mycosis, histoplasmosis, zygomycosis including mucormycosis due to susceptible species of the genera Absidia, Mucor, and Rhizopus, and infections due to related susceptible species of Conidiobolus and Basidiobolus, and sporotrichosis.
Which bacteria are inhibited by amphoteric spores?
Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro.
Is antifungal testing standardized?
Standardized techniques for susceptibility testing for antifungal agents have not been established and results of susceptibility studies have not been correlated with clinical outcomes.
Can a syringe be used for a fungal infection?
This drug should be used primarily for treatment of patients with progressive and potentially life-threatening fungal infections; it should not be used to treat noninvasive forms of fungal disease such as oral thrush, vaginal candidiasis, and esophageal candidiasis in patients with normal neutrophil counts.
warnings
You should not receive this medicine if you are allergic to any formulation of amphotericin B (Abelcet, AmBisome, Amphocin, Amphotec, or Fungizone).
Side Effects
Get emergency medical help if you have signs of an allergic reaction: hives; wheezing, difficult breathing; swelling of your face, lips, tongue, or throat.
Pregnancy & Breastfeeding
Amphotericin B is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
Interactions
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Dosage Guidelines & Tips
Use Fungizone (Intravenous) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Overdose Signs
If you think you or someone else may have overdosed on: Fungizone (Intravenous) , call your doctor or the Poison Control center
Fungizone Information
Fungizone is a prescription medicine that is available as a Injection. It is typically used for the treatment of Fungal Infections. Other than this, Fungizone has some other therapeutic uses, which have been discussed ahead.
Fungizone Dosage & How to Take
This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.
Is amphotericin B resistant to fungi?
Resistance to amphotericin B has been produced in vitro by serial passage of fungi in the presence of increasing concentrations of the drug, and resistant strains of some fungi (eg, Candida) have been isolated from patients who received long-term therapy with conventional amphotericin B. Amphotericin B -resistant Candida are reported relatively infrequently; however, primary resistance to the drug occurs in some strains of C. lusitaniae and also occurs in C. guilliermondii.
Is amphotericin B fungistatic?
Amphotericin B usually is fungistatic in action at concentrations obtained clinically, but may be fungicidal in high concentrations or against very susceptible organisms. Amphotericin B exerts its antifungal activity principally by binding to sterols (e.g., ergosterol) in the fungal cell membrane. As a result of this binding, the cell membrane is no longer able to function as a selective barrier and leakage of intracellular contents occurs. Cell death occurs in part as a result of permeability changes, but other mechanisms also may contribute to the in vivo antifungal effects of amphotericin B against some fungi. Amphotericin B is not active in vitro against organisms that do not contain sterols in their cell membranes (eg, bacteria).
Does fungizone cause kidney failure?
The incidence and mechanism of kidney failure attributed to amphotericin B (Fungizone), guidelines for reducing the risk of renal impairment when the drug is used, and the potential use of sodium, either as sodium chloride or ticarcillin disodium, to reduce the risk of nephrotoxicity are discussed.
How long can fungizone be stored?
The concentrate (5 mg amphotericin B per mL after reconstitution with 10 mL Sterile Water for Injection U.S.P.) may be stored in the dark, at room temperature for 24 hours, or at refrigerator temperature (2 – 8°C) for one week with minimal loss of potency and clarity. Any unused material should then be discarded. Solutions prepared for intravenous infusion (0.1 mg or less amphotericin B/mL) should be used promptly after preparation and should be protected from light during administration.
How long does it take to infuse fungizone?
DIRECTIONS: Fungizone ® should be administered by slow intravenous infusion over a period of approximately 2 to 6 hours (depending on the dose). The recommended concentration for intravenous infusion in 5 % Dextrose is 0.1 mg/mL (1 mg/10 mL) Product Info. Disease Info.
What is the name of the disease caused by sporotrichosis?
mucormycosis (phycomycosis) caused by species of the genera Mucor, Rhizopus, Absidia, Entomophthora, and Basidiobolus, sporotrichosis (Sporotrichum schenckii), and aspergillosis (Aspergillus fumigatus).
What organs are affected by fungus?
If fungi spread to the liver or kidneys, these organs may malfunction. Diagnosis usually involves an x-ray or computed tomography and, if possible, culture of a sample of infected material. Antifungal drugs are used, and sometimes surgery is needed to remove the fungal balls. Coccidioidomycosis.
Where can I find fungi in my garden?
These fungi are typically found in the soil and in association with decaying organic matter, such as leaves, compost piles or rotten wood. Mucormycosis needs to be treated with antifungal medication prescribed by a health care provider. These medications are given by mouth or through a vein.
Is amphotericin B fungistatic?
Amphotericin B is fungistatic or fungicidal depending on the concentration obtained in body fluids and the susceptibility of the fungus. It has been shown to exhibit a high order of in vitro activity against a broad spectrum of yeast and fungi.
Can fungizone be used for fungal infections?
Fungizone ® (amphotericin B) should be administered primarily to patients with progressive, potentially fatal infections and should not be used to treat non-serious fungal infections.
Fungizone Description
This medication is used to treat a variety of serious, possibly fatal fungal infections. It works by stopping the growth of fungi.
Status: Discontinued
May Treat: Candida peritonitis · Aspergillosis · Blastomycosis · Candidal endocarditis · Candidal meningitis and more
Drug Class: Antifungal - Amphoteric Polyene Macrolides · Dermatological - Antifungal Amphoteric Polyene Macrolides · Mouth and Throat - Antifungals
Availability: Prescription Required
Pregnancy: Consult your doctor
Status: Discontinued
May Treat: Candida peritonitis · Aspergillosis · Blastomycosis · Candidal endocarditis · Candidal meningitis and more
Drug Class: Antifungal - Amphoteric Polyene Macrolides · Dermatological - Antifungal Amphoteric Polyene Macrolides · Mouth and Throat - Antifungals
Availability: Prescription Required
Pregnancy: Consult your doctor
Lactation: Consult a doctor before using
Alcohol: Limit intake while taking this medication
Driving: May cause drowsiness or dizziness. Use caution
Manufacturer: BMS ONCO/IMMUN
- Call MD now for changes in the amount of urine.
- Tell MD of short breath, face swelling, or chills.
- For intravenous injection dilute prior to use.
- Call MD now for changes in the amount of urine.
- Tell MD of short breath, face swelling, or chills.
- For intravenous injection dilute prior to use.
- Drug is given by a nurse or a doctor.
- Success is dependent on completing therapy course
- Review all drugs you are taking with your doctor
- Lab tests may be ordered to monitor therapy
- Store in the refrigerator Do not freeze
Fungizone - Clinical Pharmacology
Indications and Usage For Fungizone
Contraindications
Warnings
- Microbiology
Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are … - Pharmacokinetics
Amphotericin B is fungistatic or fungicidal depending on the concentration obtained in body fluids and the susceptibility of the fungus. The drug acts by binding to sterols in the cell membrane of susceptible fungi with a resultant change in membrane permeability allowing leakage of intracell…
Precautions
- Fungizone Intravenous (Amphotericin B for Injection, USP) should be administered primarily to patients with progressive, potentially life-threatening fungal infections. This potent drug should not be used to treat noninvasive fungal infections, such as oral thrush, vaginal candidiasis, and esophageal candidiasis in patients with normal neutrophil counts. Fungizone Intravenous is spe…
Adverse Reactions
- This product is contraindicated in those patients who have shown hypersensitivity to amphotericin B or any other component in the formulation unless, in the opinion of the physician, the condition requiring treatment is life-threatening and amenable only to amphotericin B therapy.
Altered Laboratory Findings
- Amphotericin B is frequently the only effective treatment available for potentially life-threatening fungal disease. In each case, its possible life-saving benefit must be balanced against its untoward and dangerous side effects. EXERCISE CAUTION to prevent inadvertent Fungizone Intravenous overdose, which can result in potentially fatal cardiac or cardiorespiratory arrest. Ve…
Overdosage
- General
Amphotericin B should be administered intravenously under close clinical observation by medically trained personnel. It should be reserved for treatment of patients with progressive, potentially life-threatening fungal infections due to susceptible organisms (see INDICATIONS A… - Laboratory Tests
Renal function should be monitored frequently during amphotericin B therapy (see ADVERSE REACTIONS). It is also advisable to monitor on a regular basis liver function, serum electrolytes (particularly magnesium and potassium), blood counts, and hemoglobin concentrations. Labora…
Fungizone Dosage and Administration
- Although some patients may tolerate full intravenous doses of amphotericin B without difficulty, most will exhibit some intolerance, often at less than the full therapeutic dose. Tolerance may be improved by treatment with aspirin, antipyretics (e.g., acetaminophen), antihistamines, or antiemetics. Meperidine (25 to 50 mg IV) has been shown in some patients to decrease the dura…