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what is generalized demineralization

by Devin Shields DVM Published 2 years ago Updated 1 year ago
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Definitions. Decreased bone substance or mass; may be generalized or localized. In childhood, generalized demineralization (i.e., osteopenia) is either due to osteoporosis or to hyperparathyroidism. After physes have fused, osteomalacia is the third possible cause.

What is bone demineralization?

What is bone demineralization? What is bone demineralization? Imbalance between bone formation and bone resorption Homeostatic mechanisms such as mechanical forces, nutrition, hormonal function (e.g., parathyroid, gonads) work to progressively replace and restore bone tissue to an ideal density.

What causes demineralization in the body?

Osteoporosis is the most common cause of demineralization in human tissues and causes bones to gradually lose the minerals that make up a major part of their structure. Calcium, phosphorous and other minerals are slowly depleted from bones, making them brittle and weak.

How do you treat demineralization?

Treating the cause of demineralization and undergoing physical therapy may be used to strengthen brittle bones. When used to describe the loss of minerals from living tissue like bone or tooth enamel, demineralization is usually the result of a serious condition or disease.

What is demineralization of water?

Demineralization is a process in which any salts (e.g., potassium, chlorine, magnesium) and ions (cations and anions) are removed from water to make it suitable for home or industrial purposes. Demineralized water reduces the corrosion rate.

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What does generalized bone demineralization mean?

Demineralized bone is bone that has had the calcium removed and is used to make bone tissue more conducive to spinal fusion.

Is bone demineralization serious?

In addition to hip fractures, patients with demineralized bone are also at risk for fractures of the vertebrae and wrist and the resultant chronic pain, disability, poor quality of life, and mortality [12–14].

What is demineralization in the body?

Demineralization is the process of removing minerals ions from HA crystals of hard tissues, for example, enamel, dentin, cementum, and bone.

How is bone demineralization treated?

Primary treatment of bone demineralization is prevention. Calcium and vitamin D intake must be maintained throughout the patient's lifetime. Doses in the range of 800 IU of vitamin D daily, in combination with an average of about 1200 mg of calcium, are essential to maintaining strong bone.

Is bone demineralization painful?

Major signs and symptoms of bone demineralization in osteomalacia are achy bone pain and skeletal muscle weakness, fractures, and other complications (TABLE 1). Osteomalacia is most often caused by a vitamin D deficiency.

Is demineralization of bone osteoporosis?

Of 31 patients studied by bone densitometry, 16 showed moderate to severe osteoporosis. In approximately 20% of the total group, bone demineralization, including a bone fracture problem in some, was the dominant or a major indication for operation.

Does demineralization go away?

Fortunately, demineralization can generally be stopped and even reversed. The opposite process, in which minerals are reintroduced to the body, is known as remineralization.

Where does demineralization occur?

What is Demineralization? Demineralization of teeth occurs when the acidic by-product of plaque wears away at the enamel of the teeth. Enamel, which is formed by minerals, obtains much of its strength and hardness from mineral compounds such as calcium and phosphate.

Is bone demineralization reversible?

The short answer is no, osteoporosis cannot be completely reversed and is not considered curable, but there are a number of health and lifestyle adjustments you can make to improve bone loss. Your provider may also prescribe you medications to help rebuild and slow down bone loss.

What is bone demineralization called?

Osteoporosis, or weak bones, is a disease that causes bones to become brittle and more likely to fracture (break). With osteoporosis, the bones lose density.

What is the life expectancy of a person with osteoporosis?

This excess risk is more pronounced in the first few years on treatment. The average life expectancy of osteoporosis patients is in excess of 15 years in women younger than 75 years and in men younger than 60 years, highlighting the importance of developing tools for long-term management.

Is bone demineralization reversible?

The short answer is no, osteoporosis cannot be completely reversed and is not considered curable, but there are a number of health and lifestyle adjustments you can make to improve bone loss. Your provider may also prescribe you medications to help rebuild and slow down bone loss.

What is bone demineralization called?

Osteoporosis, or weak bones, is a disease that causes bones to become brittle and more likely to fracture (break). With osteoporosis, the bones lose density.

What hormone causes demineralization of bone?

The role of thyroid hormones (TH) in bone remodelling is controversial. Indeed, in humans, while they are necessary for normal growth and development, their overproduction can induce important mineral bone loss and osteoporosis.

How is osteoporosis disuse treated?

Treatment for disuse osteoporosis usually includes medications and calcium supplements to improve bone density. Electrical stimulation also can be used to build and strengthen the muscles surrounding the damaged area, which helps rebuild the bone.

What Does Demineralization Mean?

Demineralization is a process in which any salts (e.g., potassium, chlorine, magnesium) and ions (cations and anions) are removed from water to make it suitable for home or industrial purposes. Demineralized water reduces the corrosion rate.

Corrosionpedia Explains Demineralization

Demineralized water is preferable for industrial purposes because it has a lower salt content, which will reduce the conductivity of the water and decrease the corrosion rate.

Etiology

Bone mineral density loss in thoracic and lumbar vertebrae following radiation for abdominal cancers.

Diagnosis

TRPV6 compound heterozygous variants result in impaired placental calcium transport and severe undermineralization and dysplasia of the fetal skeleton.

Therapy

Bone mineral density loss in thoracic and lumbar vertebrae following radiation for abdominal cancers.

Prognosis

TRPV6 compound heterozygous variants result in impaired placental calcium transport and severe undermineralization and dysplasia of the fetal skeleton.

Clinical prediction guides

TRPV6 compound heterozygous variants result in impaired placental calcium transport and severe undermineralization and dysplasia of the fetal skeleton.

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Molecular Basis of Diseases of the Endocrine System

Neonatal severe primary hyperparathyroidism (NSHPT) represents the most severe expression of FHH. Symptoms manifest very early in life with severe hypercalcemia, bone demineralization, and failure to thrive. Most NSHPT patients have either homozygous or compound heterozygous CaSR inactivating mutations.

Iatrogenesis in older individuals

John O. Barr, ... LaDora V. Thompson, in Geriatric Rehabilitation Manual (Second Edition), 2007

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1.Demineralization - an overview | ScienceDirect Topics

Url:https://www.sciencedirect.com/topics/nursing-and-health-professions/demineralization

28 hours ago What is demineralization? Demineralization is the process of removing minerals ions from HA crystals of hard tissues, for example, enamel, dentin, cementum, and bone. Restoring these mineral ions again to the HA crystals is called remineralization.

2.What is Demineralization? - Definition from Corrosionpedia

Url:https://www.corrosionpedia.com/definition/368/demineralization

30 hours ago  · When used to describe the loss of minerals from living tissue like bone or tooth enamel, demineralization is usually the result of a serious condition or disease. Osteoporosis is the most common cause of demineralization in human tissues and causes bones to gradually lose the minerals that make up a major part of their structure. Calcium, phosphorous and other …

3.Generalized bone demineralization (Concept Id: C1833326)

Url:https://www.ncbi.nlm.nih.gov/medgen/371539

17 hours ago What is generalized demineralization? Decreased bone substance or mass; may be generalized or localized. In childhood, generalized demineralization (i.e., osteopenia) is either due to osteoporosis or to hyperparathyroidism. After physes have fused, osteomalacia is the third possible cause. What causes bones to disintegrate?

4.Bone Demineralization - an overview | ScienceDirect Topics

Url:https://www.sciencedirect.com/topics/nursing-and-health-professions/bone-demineralization

7 hours ago with enamel demineralization summarized as a net loss of enamel mineral due to the action of either intrinsic or extrinsic acids, leading to dental caries or erosion. Dental caries is primarily caused by lactic and acetic acids which diffuse through the plaque and into the enamel pores between the rods as neutral ion species, where they dissociate and decrease the pH of the fluid …

5.What is bone demineralization? - Lane Community College

Url:https://media.lanecc.edu/users/howardc/PTA104/104SkeletalDemineralization/104SkeletalDemineralization2.html

20 hours ago  · Demineralization is a process in which any salts (e.g., potassium, chlorine, magnesium) and ions (cations and anions) are removed from water to make it suitable for home or industrial purposes. Demineralized water reduces the corrosion rate. Demineralized water is also known as demi water. Advertisement.

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