Precautions
Generlac Solution (Lactulose Solution, USP) is a synthetic disaccharide in solution form for oral or rectal administration. Each 15 mL of Generlac Solution contains: 10 g lactulose (and not more than 1.6 g galactose, not more than 1.2 g lactose, not more than 0.8 g epilactose, and not more than 0.1 g fructose).
What is generlac solution used for?
Generlac Solution (Lactulose Solution, USP) is a synthetic disaccharide in solution form for oral or rectal administration. Each 15 mL of Generlac Solution contains: 10 g lactulose (and less than 1.6 g galactose, less than 1.2 g lactose, less than 0.8 g epilactose and 0.1 g or less of fructose).
Is generlac a disaccharide?
(lactulose) Solution, USP 10 g/15 mL. Lactulose is a synthetic disaccharide in solution form for oral administration. Each 15 mL of lactulose solution contains: 10 g lactulose (and less than 1.6 g galactose, less than 1.2 g lactose, and 0.1 g or less of fructose).
How many grams of lactulose are in a 10G solution?
Tell all of your health care providers that you take Generlac (lactulose solution (encephalopathy)). This includes your doctors, nurses, pharmacists, and dentists. Have your blood work checked if you are on Generlac (lactulose solution (encephalopathy)) for a long time.
What should I know before taking generlac (lactulose solution (encephalopathy)?
What is Generlac solution?
What is the pH of Generlac?
Can lactulose and neomycin be used together?
Does lactulose help with ammonia?
Does lactulose acidify the colon?
How much does a sulfate molecule weigh?
Is lactulose a hazard?
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About this website
What is Generlac used for?
This drug is used by mouth or rectally to treat or prevent complications of liver disease (hepatic encephalopathy). It does not cure the problem, but may help to improve mental status. Lactulose is a colonic acidifier that works by decreasing the amount of ammonia in the blood.
Is Generlac the same as lactulose?
Lactulose oral solution is a prescription drug that's available as the brand-name drug Generlac. It's also available as a generic drug.
What is lactulose solution used to treat?
Lactulose is a synthetic sugar used to treat constipation. It is broken down in the colon into products that pull water out from the body and into the colon. This water softens stools. Lactulose is also used to reduce the amount of ammonia in the blood of patients with liver disease.
What is lactulose 15ml?
Lactulose is a synthetic disaccharide in solution form for oral or rectal administration. Each 15 mL of Lactulose Solution USP contains 10 g lactulose (and less than 1.6 g galactose, less than 1.2 g lactose, and 0.1 g or less of fructose). It also contains D&C Yellow No.
How long after taking lactulose will I poop?
Lactulose works within 24 to 48 hours to produce a bowel movement. Other laxatives that may work more quickly are available over the counter at your local pharmacy. You can mix the liquid in juice, water, or milk to improve the taste.
What time of day should lactulose be taken?
The Lactulose is usually given twice each day. Give one dose in the morning and one in the evening. Ideally these times are 10–12 hours apart. For example, this could be between 7am and 8am and between 7pm and 8pm.
Does lactulose make you poop more?
Descriptions. Lactulose is used to treat constipation. It helps increase the number of bowel movements per day and the number of days on which bowel movements occur in patients with a history of chronic (long-lasting) constipation. This medicine is available only with your doctor's prescription.
What is the main side effect of lactulose?
A very common side effect of lactulose, particularly at high doses, is diarrhoea. This happens in more than 1 in 10 people. Drink lots of fluids, such as water or squash, to avoid dehydration. Signs of dehydration include peeing less than usual or having dark, strong-smelling pee.
Is it safe to take lactulose every day?
You can take lactulose for as long as your constipation lasts, or for as long as your doctor has recommended. This will usually be for up to a week. For more severe constipation, and if you're taking lactulose for hepatic encephalopathy, your doctor may recommend that you take it for many months.
How long does it take for lactulose to start working?
It takes a couple of days for lactulose to work. Talk to your doctor if you are still constipated after 3 days. If you take it for liver disease you may not feel better but it will help prevent you developing some of the symptoms of liver problems.
Who should not take lactulose?
You should not use lactulose if you are on a special diet low in galactose (milk sugar). Tell your doctor if you have ever had: diabetes; or. if you need to have any type of intestinal test using a scope (such as a colonoscopy).
How much lactulose can you take in a day?
Adults—15 to 30 milliliters (mL) or 1 to 2 tablespoons per day. Your doctor may increase your dose to 60 mL per day if needed.
What is the generic name for lactulose?
Lactulose is a colonic acidifier that works by decreasing the amount of ammonia in the blood. It is a man-made sugar solution. Lactulose is available under the following different brand names: Enulose, Kristalose, Constulose, and Generlac.
Is lactulose a laxative or stool softener?
Lactulose: laxative to treat constipation - NHS.
Is it OK to take lactulose every day?
You can take lactulose for as long as your constipation lasts, or for as long as your doctor has recommended. This will usually be for up to a week. For more severe constipation, and if you're taking lactulose for hepatic encephalopathy, your doctor may recommend that you take it for many months.
Can I get lactulose over the counter?
Lactulose works by drawing fluid into your bowel, which makes your stools softer and easier to pass. It is available on prescription, and it can also be bought without a prescription at pharmacies.
Are you currently using Generlac?
This survey is being conducted by the WebMD marketing sciences department.
How long does it take for a bowel movement to occur after taking a syringe?
If you are using this medication for constipation, it may take up to 48 hours to have a bowel movement. Inform your doctor if your condition persists or worsens. Side Effects. Gas, bloating, burping, stomach rumbling/pain, nausea, and cramps may occur.
How often should I take lactulose?
If you are taking this medication by mouth for constipation, take it usually once daily or as directed by your doctor. This medication can also be given rectally as an enema for liver disease. Mix the recommended amount of lactulose ...
How long does it take for a syringe to work?
When this drug is given rectally for liver disease, an improvement in your mental status may occur in as little as 2 hours, but if you are taking this medication by mouth, it may take up to 24 to 48 hours. If you are using this medication for constipation, it may take up to 48 hours to have ...
What to tell your doctor before taking a antacid?
Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: antacids containing aluminum and/or magnesium, other laxatives (e.g., cleansing enemas with soap suds).
What are the symptoms of an allergic reaction?
Symptoms of a serious allergic reaction may include: rash, itching /swelling (especially of the face/ tongue /throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US -.
How many times a day should I take a saline pill for liver disease?
If you are taking this medication by mouth for liver disease, take it usually 3-4 times a day or as directed by your doctor. To improve the taste, you may mix it into fruit juice, water, milk, or a soft dessert. The goal is to have 2-3 soft stools each day. Dosage is based on your medical condition and response to therapy (i.e., the number of soft stools each day).
What do I need to tell my doctor BEFORE I take Generlac?
If you have an allergy to lactulose or any other part of Generlac (lactulose solution ( encephalopathy )).
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
What are some other side effects of Generlac?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
What are the symptoms of high blood sugar?
Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit. Diarrhea . Dehydration and electrolyte problems can happen in people who have diarrhea.
What to do if your symptoms don't get better?
If your symptoms or health problems do not get better or if they become worse, call your doctor.
What to do if you think you have an overdose?
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
What are the symptoms of an allergic reaction?
Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
What is lactulose in a colon?
Lactulose is a colonic acidifier which promotes laxation.
How much lactulose is in a 15ml solution?
Lactulose is a synthetic disaccharide in solution form for oral administration. Each 15 mL of Lactulose Solution contains: 10 g lactulose (and less than 1.6 g galactose, less than 1.2 g lactose, and 1.2 g or less of other sugars). Also contains FD&C Yellow No. 6, purified water, and flavoring. Sodium hydroxide used to adjust pH.
How long does it take for lactulose to work?
Since lactulose does not exert its effect until it reaches the colon, and since transit time through the colon may be slow, 24 to 48 hours may be required to produce the desired bowel movement.
Can lactulose cause a drop in pH?
Results of preliminary studies in humans and rats suggest that nonabsorbable antacids given concurrently with lactulose may inhibit the desired lactulose-induced drop in colonic pH. Therefore, a possible lack of desired effect of treatment should be taken into consideration before such drugs are given concomitantly with lactulose solution.
Is lactulose a low galactose diet?
Since lactulose solution contains galactose (less than 1.6 g/15 mL), it is contraindicated in patients who require a low galactose diet.
Does lactulose help with constipation?
In patients with a history of chronic constipation, lactulose solution therapy increases the number of bowel movements per day and the number of days on which bowel movements occur .
Does lactulose reach the blood?
Lactulose solution given orally to man and experimental animals resulted in only small amounts reaching the blood.
What antibiotics stop lactulose from breaking down?
Antibiotics such as neomycin: These drugs may stop the breakdown of lactulose in your large intestine. Your doctor will watch you closely if you’re taking lactulose with an antibiotic.
What is lactulose used for?
Lactulose oral solution is used to treat constipation. It’s also used to treat a brain problem called portal-systemic encephalopathy. This problem is a complication of severe liver disease.
How to store lactulose?
Store lactulose in the refrigerator or at room temperature. Keep it between 36°F and 86°F (2°C and 30°C).
Can you take antacids with lactulose?
Antacids: You should not take antacids with lactulose. Antacids may prevent lactulose from working well.
What causes low water levels in the body?
Severe diarrhea. This can cause dehydration (very low water levels in your body).
What to do if you have serious side effects?
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:
How to avoid interactions with medications?
To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.
How much lactulose is in a 15ml solution?
Lactulose is a synthetic disaccharide in solution form for oral administration. Each 15 mL of lactulose solution contains: 10 g lactulose (and less than 1.6 g galactose, less than 1.2 g lactose, and 0.1 g or less of fructose ).
What is lactulose in a colon?
Lactulose is a colonic acidifier which promotes laxation.
How long does it take for lactulose to work?
Since lactulose does not exert its effect until it reaches the colon, and since transit time through the colon may be slow, 24 to 48 hours may be required to produce the desired bowel movement.
How many ounces of lactulose solution?
Lactulose Solution is a natural colored and an unflavored solution available in 8 fl oz (237 mL) and 1 quart (946 mL) bottles.
How much lactose is in lactulose?
General. Since lactulose solution contains galactose (less than 1.6 g/15 mL) and lactose (less than 1.2 g/15 mL) it should be used with caution in diabetics.
Is lactulose a hazard?
Although this complication has not been reported with lactulose, patients on lactulose therapy undergoing such procedures should have a thorough bowel cleansing with a non-fermentable solution.
Can lactulose cause a drop in pH?
Results of preliminary studies in humans and rats suggest that non-absorbable antacids given concurrently with lactulose may inhibit the desired lactulose-induced drop in colonic pH. Therefore, a possible lack of desired effect of treatment should be taken into consideration before such drugs are given concomitantly with lactulose solution.
How much lactulose is in a 15ml solution?
Lactulose is a synthetic disaccharide in solution form for oral administration. Each 15 mL of lactulose solution contains: 10 g lactulose (and less than 1.6 g galactose, less than 1.2 g lactose, and 1.2 g or less of other sugars). Also contains water. The pH range is 2.5 to 6.5.
What is lactulose in a colon?
Lactulose is a colonic acidifier which promotes laxation.
How long does it take for lactulose to work?
Since lactulose does not exert its effect until it reaches the colon, and since transit time through the colon may be slow, 24 to 48 hours may be required to produce the desired bowel movement.
How much lactose is in lactulose?
General. Since lactulose solution contains galactose (less than 1.6 g/15 mL) and lactose (less than 1.2 g/15 mL) it should be used with caution in diabetics.
What temperature does sugar solution darken?
Such darkening is characteristic of sugar solutions and does not affect therapeutic action. Prolonged exposure to temperatures above 30 °C (86 °F) or to direct light may cause extreme darkening and turbidity which may be pharmaceutically objectionable. If this condition develops, do not use.
Can lactulose cause a drop in pH?
Results of preliminary studies in humans and rats suggest that non-absorbable antacids given concurrently with lactulose may inhibit the desired lactulose-induced drop in colonic pH. Therefore, a possible lack of desired effect of treatment should be taken into consideration before such drugs are given concomitantly with lactulose solution.
Is lactulose a low galactose diet?
Since lactulose solution contains galactose (less than 1.6 g/15 mL), it is contraindicated in patients who require a low galactose diet.
What are the side effects of lactulose?
With any medication, there are risks and benefits. Even if the medication is working, you may experience some unwanted side effects.
What is lactulose?
Lactulose is an osmotic laxative that treats constipation and liver problems.
What are the risks and warnings for lactulose?
Lactulose can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options
How much does lactulose cost?
Unless there is a specific reason you need the brand, the generic medication will be a better value. For even more savings, use a GoodRx coupon and pay just a fraction of the retail price.
What is the name of the laxative that is derived from lactose?
Lactulose, Generlac. Generic Constulose, Enulose. LACTULOSE is a laxative derived from lactose. It helps to treat chronic constipation and to treat or prevent hepatic encephalopathy or coma. These are brain disorders that result from liver disease.
How long does it take for lactulose to work?
Lactulose may not produce laxative results for 24 to 48 hours. Polyethylene glycol may not produce laxative results for 2 to 4 days. Saline laxatives usually produce results within 30 minutes to 3 hours following a dose. When a larger dose is taken on an empty stomach, the results are quicker.
What is a stimulant laxative?
Stimulant laxatives are a popular type of laxative for self-treatment. However, they also are more likely to cause side effects. One of the stimulant laxatives, dehydrocholic acid, may also be used for treating certain conditions of the biliary tract.
What is Generlac solution?
Generlac Solution is a colonic acidifier for treatment and prevention of portal-systemic encephalopathy.
What is the pH of Generlac?
The pH range is between 2.5 and 6.5.
Can lactulose and neomycin be used together?
There have been conflicting reports about the concomitant use of neomycin and lactulose solution. Theoretically, the elimination of certain colonic bacteria by neomycin and possibly other anti-infective agents may interfere with the desired degradation of lactulose and thus prevent the acidification of colonic contents. Thus the status of the lactulose-treated patient should be closely monitored in the event of concomitant oral anti-infective therapy.
Does lactulose help with ammonia?
Controlled studies have shown that lactulose solution therapy reduces the blood ammonia levels by 25 to 50%; this is generally paralleled by an improvement in the patients' mental state and by an improvement in EEG patterns. The clinical response has been observed in about 75% of patients, which is at least as satisfactory as that resulting from neomycin therapy. An increase in patients' protein tolerance is also frequently observed with lactulose solution therapy. In the treatment of chronic portal-systemic encephalopathy, lactulose solution has been given for over 2 years in controlled studies.
Does lactulose acidify the colon?
Bacterial degradation of lactulose in the colon acidifies the colonic contents.
How much does a sulfate molecule weigh?
The molecular weight is 342.30. It is freely soluble in water.
Is lactulose a hazard?
A theoretical hazard may exist for patients being treated with lactulose solution who may be required to under go electrocautery procedures during proctoscopy or colonoscopy. Accumulation of H 2 gas in significant concentration in the presence of an electrical spark may result in an explosive reaction. Although this complication has not been reported with lactulose, patients on lactulose therapy undergoing such procedures should have a thorough bowel cleansing with a non-fermentable solution. Insufflation of CO 2 as an additional safeguard may be pursued but is considered to be a redundant measure.