Geometric dilution is the process of diluting something based on its measured size. Most often, scientists and doctors employ this method when combining fine powders of unequal amounts to ensure equal distribution. Bakers sometimes use geometric dilution to equally combine the dry ingredients in a mixture.
What is geometric dilution with example?
Geometric dilution This first dilution is then mixed with an equal portion of diluents. This process is repeated until all the powders are intimately mixed. Example: Geometric dilution of one gram of a potent drug to be mixed with 20 g of the diluent lactose.
What is geometric dilution in powder formulation?
In practice, geometric dilution implies that the blending process starts by mixing equal portions of API and excipient blend. This small mass of blend (1:1 API:excipient ratio) is then further diluted in a stepwise manner until all excipient blend is consumed.
What is geometric addition in pharmacy?
Geometric addition refers to the procedure of blending small quantities of powder,15 where an API, is added to larger quantities of powder, usually diluents or excipients.
When using geometric dilution One should start with the?
Terms in this set (24) For geometric dilution, always start with: The ingredient of the smallest amount.
What are the methods used in the preparation of powders?
Grinding, the thermal decomposition of solids and the deposition of solids from the liquid or vapour phase are the commonest techniques used for the preparation of powders.
What is block and divide method?
Block and divide method: by this method the pharmacist places the entire amount of prepared powder on a flat surface such as a porcelain or glass plate, pill tile, or large sheet of paper, and with large spatula forms a rectangular or square – shaped block of powder having a uniform depth.
What is Levigation method?
Levigation is the process of grinding an insoluble substance to a fine powder, while wet. The material is introduced into the mill together with water, in which the powdered substance remains suspended, and flows from the mill as a turbid liquid or thin paste, according to the amount of water employed.
What is Spatulation method?
1 Spatulation:-In this method ,mixing of powders is done by the movement of a spatula throughout the powders on a sheet of a paper or on a porcelain tile.The method is very useful in mixing:- a)Small amount of powder.
What is the difference between trituration and Levigation?
The key difference between levigation and trituration is that levigation is important in mixing or triturating a powder with a liquid in which it is insoluble to reduce the particle size, whereas trituration is important in reducing the particle size of powders to make a greater surface area available.
Why is geometric dilution used?
Geometric dilution is the process of diluting something based on its measured size. Most often, scientists and doctors employ this method when combining fine powders of unequal amounts to ensure equal distribution. Bakers sometimes use geometric dilution to equally combine the dry ingredients in a mixture.
What is the difference between Bud and expiry date?
Jenny Ohler, PharmD candidate 2019, Christopher Miller, PharmD, and Daniel Sheridan, RPh, MS, reply: An expiration date reflects the stability of the product as prepared by the manufacturer; the beyond-use date (BUD) is the last date that a product can be safely used after it has been altered for patient use; for ...
What is the technique of starting with the ingredient of the smallest amount and doubling the portion by adding the other ingredients until fully mixed?
What are the 8 general compounding steps? Technique for mixing - starting with the ingredient of the smallest amount and double in the portion by asking the other ingredient, ignorer of quantity, until fully mixed.
What is doubling technique?
'Doubling-up' is used for mixing a small quantity of powder with a larger quantity. BA-FP-JU-C. Key Points. • Confusion can arise with different forms of the same material and the use of synonyms.
How do you compound divided powders?
The powdered form of a drug or chemical consists of finely divided components in dry form....One of the following methods may be used to mix the powders:Geometric dilution.Trituration.Sifting and tumbling.Speculation.
What is the difference between trituration and Levigation?
The key difference between levigation and trituration is that levigation is important in mixing or triturating a powder with a liquid in which it is insoluble to reduce the particle size, whereas trituration is important in reducing the particle size of powders to make a greater surface area available.
What is Efflorescent powder?
In the chemical world, efflorescent powders are crystallized powders containing water of hydration or crystallization, such as alums, atropine sulphate, citric acid, caffeine, and codeine.