Precautions
INTRALIPID® 20% (A 20% INTRAVENOUS FAT EMULSION) IS A STERILE, NON-PYROGENIC FAT EMULSION PREPARED FOR INTRAVENOUS ADMINISTRATION AS A SOURCE OF CALORIES AND ESSENTIAL FATTY ACIDS. IT IS MADE UP OF...
What does Intralipid 20% stand for?
Intralipid Description. Intralipid ® 10% (A 10% Intravenous Fat Emulsion) is a sterile, non-pyrogenic fat emulsion prepared for intravenous administration as a source of calories and essential fatty acids. It is made up of 10% Soybean Oil, 1.2% Egg Yolk Phospholipids, 2.25% Glycerin, and Water for Injection.
What is Intralipid 10% made of?
Uses of Intralipid: It is used to aid diet needs. It is used to give nutrition to the body.
What are the uses of Intralipid?
Intralipid prevents Essential Fatty Acid Deficiency (EFAD) and corrects the clinical manifestations of EFAD. However, for patients requiring complete parenteral nutrition, complementary vitamin supplements are required.
How is Intralipid used to treat essential fatty acid deficiency?
What are Intralipids used for?
This product is used to provide calories to patients who are getting their nutrition through an injection into the vein. Calories are needed to provide the body with energy so that the body can work properly.
What is Intralipid used for in IVF?
Intralipid is used to improve clinical outcomes in patients with recurrent pregnancy loss (RPL) or recurrent implantation failure (RIF) with elevated natural killer (NK) cells.
How do Intralipids make you feel?
Women undergoing Interlipid infusion may suffer the following reactions: Shortness of breath, Nausea, Vomiting, Headache, Hot flushes, Increase in temperature/Sweating, drowsiness, Pain in the chest and back, Slight pressure over the eyes, Dizziness or Irritation at the site of infusion.
How long is Intralipid good for?
STORAGE: Store the unopened container at room temperature between 68-77 degrees F (20-25 degrees C) away from light. The mixed product may be stored in the refrigerator between 36-46 degrees F (2-8 degrees C) for up to 24 hours. Finish giving the mixed product within 24 hours after removal from the refrigerator.
How does Intralipid help in pregnancy?
In vitro investigations have revealed the ability of intralipids to suppress NK cytotoxicity. Evidences from both animal and human studies suggest that intralipid administered intravenously may enhance implantation and maintenance of pregnancy when the patient has an abnormal NK cell level or function.
Can Intralipid prevent miscarriage?
Intralipid infusion is a therapy used to prevent recurrent miscarriages. It is a mixture of high calorific natural fats containing soybean oil, egg yolk phospholipids, glycerine and water.
How long do Intralipids take to work?
Intralipids are usually administered 1-4 days prior to a procedure (IVF retrieval, IUI, embryo transfer) and continued weekly until 12-14 weeks of pregnancy to keep the natural killer cells deactivated until the pregnancy can override the signals being sent by the immune system.
How long does Intralipid infusion take?
Administration: The drip rate is adjusted to 500 ml of a 20% solution should be infused over about 2-3 hours.
When do natural killer cells cause miscarriage?
There is a lack of evidence about the exact role that NK cells have in causing miscarriage. There are no official guidelines for what 'normal' NK cell activity is. It is difficult to measure the ideal level of NK cells and when an imbalance can cause infertility and miscarriage.
What is Intralipid used for in emergency?
The Intralipid® brand of fat emulsion is reserved solely for the emergency management of local anaesthetics inadvertently administered intravenously. No other brands of lipid emulsions are to be used.
How much does Intralipid therapy cost?
Intravenous EmulsionQuantityPer unitPrice1000 (10 x 100 milliliters)$0.34$339.912500 (10 x 250 milliliters)$0.20$505.656000 (12 x 500 milliliters)$0.08 – $0.09$473.48 – $535.76
How much does Intralipid therapy cost?
Intravenous EmulsionQuantityPer unitPrice1000 (10 x 100 milliliters)$0.34$339.912500 (10 x 250 milliliters)$0.20$505.656000 (12 x 500 milliliters)$0.08 – $0.09$473.48 – $535.76
What is Intralipid used for in emergency?
The Intralipid® brand of fat emulsion is reserved solely for the emergency management of local anaesthetics inadvertently administered intravenously. No other brands of lipid emulsions are to be used.
What are natural killer cells infertility?
NK cells in the uterus are known as uNK cells. They play an important role in helping the body become pregnant. In order to become pregnant, the womb lining needs to inflame slightly so the embryo can attach (or implant) to the uterine wall. uNK cells contribute to this process of inflammation.
What are some things I need to know or do while I take Intralipid?
Tell all of your health care providers that you take Intralipid (fat emulsion (plant based)). This includes your doctors, nurses, pharmacists, and dentists.
How is this medicine (Intralipid) best taken?
Use Intralipid (fat emulsion (plant based)) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
What are some other side effects of Intralipid?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if you have any side effects that bother you or do not go away.
Is intralipid a plant based drug?
This is not a list of all drugs or health problems that interact with Intralipid (fat emulsion (plant based)).
Does intralipid affect lab tests?
This medicine may affect certain lab tests. Be sure your doctor and lab workers know you use Intralipid (fat emulsion (plant based)). This medicine may contain aluminum. There is a chance of aluminum toxicity if you are on Intralipid (fat emulsion (plant based)) for a long time.
How long does intralipid 10% last?
Intralipid ® 10% is indicated as a source of calories and essential fatty acids for patients requiring parenteral nutrition for extended periods of time (usually for more than 5 days) and as a source of essential fatty acids for prevention of EFAD.
What is the fill size of Intralipid 10%?
Intralipid ® 10% is supplied as a sterile emulsion in the following fill sizes: 100 mL, 250 mL, and 500 mL.
How many calories are in 10% phospholipids?
The total caloric value, including fat, phospholipid and glycerin, is 1.1 kcal per mL of Intralipid ® 10%. The phospholipids present contribute 47 milligrams or approximately 1.5 mmol of phosphorus per 100 mL of the emulsion.
When to stop Intralipid 10%?
In the event of fat overload during therapy, stop the infusion of Intralipid ® 10% until visual inspection of the plasma, determination of triglyceride concentrations, or measurement of plasma light-scattering activity by nephelometry indicates the lipid has cleared. Re-evaluate the patient and institute appropriate corrective measures. See WARNINGS and PRECAUTIONS.
When Intralipid 10% is administered, the patients capacity to eliminate the infused fat from the circulation must be monitored?
When Intralipid ® 10% is administered, the patients capacity to eliminate the infused fat from the circulation must be monitored by use of an appropriate laboratory determination of serum triglycerides. Overdosage must be avoided.
What is purified egg phosphatide?
Purified egg phosphatides are a mixture of naturally occurring phospholipids which are isolated from the egg yolk. These phospholipids have the following general structure:
What is 10% fat emulsion?
Intralipid ® 10% (A 10% Intravenous Fat Emulsion) is a sterile, non-pyrogenic fat emulsion prepared for intravenous administration as a source of calories and essential fatty acids. It is made up of 10% Soybean Oil, 1.2% Egg Yolk Phospholipids, 2.25% Glycerin, and Water for Injection. In addition, sodium hydroxide has been added to adjust ...
What is intralipid in injections?
What it looks like. Intralipid is a milky white emulsion which is supplied in glass bottles or plastic bags. The active ingredient is soya oil. Intralipid comes in three strengths: 10%, 20% and 30%. It also contains egg lecithin, glycerol, sodium hydroxide and water for injections.
How is Intralipid given?
The dose of Intrapid which you will require will be determined by your doctor or pharmacist. Your doctor will supervise your treatment with Intralipid.
What is intralipid oil?
Intralipid is a sterile fat emulsion, which provides your body with energy and fatty acids. The active ingredient in Intralipid is soya oil. Soya oil consists of a mixture of mainly polyunsaturated fatty acids. It also contains egg lecithin as an emulsifier, which is isolated from egg yolk. It is available in 3 strengths namely 10%, 20% and 30%.
How cold should intralipid be stored?
Intralipid should be stored below 25ºC, but not frozen. Do not use Intralipid if it has been frozen.
How are intralipids eliminated?
Intralipid is eliminated from the circulation via a pathway similar to that of endogenous chylomicrons, at least early on in the catabolism. The exogenous fat particle is taken up by the LDL receptors and primarily hydrolysed in the peripheral circulation which removes the triglycerides. Thus a transient triglyceride level may be elevated after Intralipid infusion. The triglycerides are hydrolysed by lipoprotein lipase to fatty acids and glycerol. The free fatty acids are used by the muscle as an immediate source of energy or reconverted into triglycerides and stored as a fat in the subcutaneous tissue for energy reserve. The free fatty acids also undergo entero-hepatic recycling and re-enter the systemic circulation in the form of Very Low-Density Lipoproteins (VLDL).
What are the effects of intralipid?
Unwanted effects which have been reported to occur immediately or soon after Intralipid has been given include: allergic reactions (skin rash and hives); breathing difficulties (rapid breathing, shortness of breath); effects on blood pressure; abdominal pain; tiredness; headaches; flushing; slight pressure over the eyes and dizziness.
Where is intralipid administered?
This rarely happens as Intralipid is usually administered under the care of a trained professional in a hospital or clinic setting.
What is the role of lipid rescue?
5 Moreover, while lipid rescue may be the driving force behind successful cardiac resuscitation, the risk to the brain from prolonged circulatory collapse remains. 5 Thus we emphasize that primary therapy remains adherence to proven guidelines—cardiac and SpO 2 monitoring, proper availability and dosing of all local anesthetics, immediate means to support ventilation, proper cardiac compressions during CPR, and application of proven advanced life support techniques. Only then should lipid rescue be considered in the therapeutic algorithm.
How do lipids reverse local anesthetic cardiotoxicity?
This nonspecific, observed extraction of local anesthetics from aqueous plasma or cardiac tissues is termed a “lipid sink.” 4 Another proposed mechanism is that lipids counteract local anesthetic inhibition of myocardial fatty acid oxidation, thereby enabling energy production and reversing cardiac depression.
What is intralipids in a uterus?
Intralipids deactivate natural killer cells in a woman’s body which may prevent em bryos from implanting and growing properly in the uterus.
How much does intralipid cost?
Intralipids (approximately $100 per administration) are far less expensive than Intravenous Immunoglobulin (IVIG) (approximately $2000 per administration), and initial studies show comparable efficacy for deactivation of natural killer cells and pregnancy rates. Intralipids are well tolerated by patients with few side effects and are created synthetically, unlike IVIG which is a blood product. It takes about an hour and a half to two hours for the intralipids to be administered through the IV.
When to re-administer intralipids?
Intralipids are re-administered 4-5 weeks following a positive pregnancy test, to keep the natural killer cells deactivated until the pregnancy can override the signals being sent by the immune system.
Do intralipids help with IVF?
Intralipids deactivate natural killer cells in a woman’s body which may prevent embryos from implanting and growing properly in the uterus. New research has suggested that women who have experienced recurrent miscarriages or multiple failed IUI or IVF cycles as a result of natural killer cell activation may benefit from the use of intralipids.
When was intralipid first used?
Intralipid was invented by the Swedish physician and nutrition researcher Arvid Wretlind, and was approved for clinical use in Sweden in 1962. In the United States, the Food and Drug Administration initially declined to approve the product due to prior experience with another fat emulsion.
Why is intralipid used in optical experiments?
Intralipid is also widely used in optical experiments to simulate the scattering properties of biological tissues. Solutions of appropriate concentrations of intralipid can be prepared that closely mimic the response of human or animal tissue to light at wavelengths in the red and infrared ranges where tissue is highly scattering but has a rather low absorption coefficient.
What is lipid emulsion?
Lipid emulsion. Lipid emulsion or fat emulsion refers to an emulsion of lipid for human intravenous use. It is often referred to by the brand name of the most commonly used version, Intralipid, which is an emulsion of soy bean oil, egg phospholipids and glycerin, and is available in 10%, 20% and 30% concentrations.
Is propofol a lipid?
Propofol is dissolved in a lipid emulsion for intravenous use. Sometimes etomidate (the vehicle for etomidate is propylene glycol) is supplied using a lipid emulsion as a vehicle.
Intralipid Description
This product is used to provide calories to patients who are getting their nutrition through an injection into the vein.
May Treat: Essential fatty acid deficiency
Alternate Brand Names: Liposyn
Drug Class: Diagnostic Drugs - Biliary · Nutritional Product - Lipid Others · Parenteral Nutrition - Intravenous Fat Emulsions
Availability: Prescription sometimes needed
Pregnancy: Consult a doctor before using
May Treat: Essential fatty acid deficiency
Alternate Brand Names: Liposyn
Drug Class: Diagnostic Drugs - Biliary · Nutritional Product - Lipid Others · Parenteral Nutrition - Intravenous Fat Emulsions
Availability: Prescription sometimes needed
Pregnancy: Consult a doctor before using
Lactation: Consult a doctor before using
Alcohol: Limit intake while taking this medication
Driving: May cause drowsiness or dizziness. Use caution
Manufacturer: BAXTER HEALTHCA
- Discuss risks, benefits, and precautions with MD.
- Learn how to correctly take this medicine.
- Don't use if solution has particles or color change
- Discuss risks, benefits, and precautions with MD.
- Learn how to correctly take this medicine.
- Don't use if solution has particles or color change
- Do not use if oil bubbles are seen.
- Inquire about filters appropriate for IV fats
- Tell RPh if allergic to peanuts or soy.
- May make you drowsy or dizzy. Drive with caution
- Follow directions on best place to keep drug supply
Intralipid - Clinical Pharmacology
Indications and Usage For Intralipid
Contraindications
- Intralipid ®10% is metabolized and utilized as a source of energy causing an increase in heat production, decrease in respiratory quotient and increase in oxygen consumption. The infused fat particles are cleared from the blood stream in a manner thought to be comparable to the clearing of chylomicrons. Intralipid ®10% will prevent the biochemical lesions of essential fatty acid defici…
Warnings
- Intralipid ®10% is indicated as a source of calories and essential fatty acids for patients requiring parenteral nutrition for extended periods of time (usually for more than 5 days) and as a source of essential fatty acids for prevention of EFAD.
Precautions
- The administration of Intralipid ®10% is contraindicated in patients with disturbances of normal fat metabolism such as pathologic hyperlipemia, lipoid nephrosis or acute pancreatitis if accompanied by hyperlipidemia.
Adverse Reactions
- Caution should be exercised in administering Intralipid ®10% (A 10% Intravenous Fat Emulsion) to patients with severe liver damage, pulmonary disease, anemia or blood coagulation disorders, or when there is danger of fat embolism. WARNING:This product contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney functio…
Overdosage
- When Intralipid ®10% is administered, the patients capacity to eliminate the infused fat from the circulation must be monitored by use of an appropriate laboratory determination of serum triglycerides. Overdosage must be avoided. During long term intravenous nutrition with Intralipid ®10%, liver function tests should be performed. If these tests indicate that liver function is impair…
Intralipid Dosage and Administration
- The adverse reactions observed can be separated into two classes: 1. Those more frequently encountered are due: either to contamination of the intravenous catheter and result in sepsis, or to vein irritation by concurrently infused hypertonic solutions and may result in thrombophlebitis. These adverse reactions are inseparable from the hyper-alimentation procedure with or without I…
How Is Intralipid Supplied
- In the event of fat overload during therapy, stop the infusion of Intralipid ® 10% until visual inspection of the plasma, determination of triglyceride concentrations, or measurement of plasma light-scattering activity by nephelometry indicates the lipid has cleared. Re-evaluate the patient and institute appropriate corrective measures. See WARNINGS and PRECAUTIONS.