Precautions
No, ipratropium bromide is not a steroid. Ipratropium is a bronchodilator that relaxes muscles in the airways and increases air flow to the lungs. What is ipratropium and albuterol solution used for? Ipratropium Bromide and Albuterol Sulfate Inhalation Solution is indicated for the treatment of bronchospasm associated with COPD in patients requiring more than one bronchodilator. Can ipratropium bromide cause high blood pressure?
Why is is ipratropium bromide considered a steroid?
The active components in ipratropium bromide and albuterol sulfate inhalation solution, USP are albuterol sulfate USP and ipratropium bromide USP. Albuterol sulfate, is a salt of racemic albuterol and a relatively selective β 2 -adrenergic bronchodilator chemically described as α 1 -[(tert-butylamino)methyl]-4-hydroxy-m-xylene-α, α’-diol sulfate (2:1) (salt).
Is ipratropium bromide the same as albuterol sulfate?
Ipratropium and albuterol combination is used to help control the symptoms of lung diseases, such as asthma, chronic bronchitis, and emphysema. It is also used to treat air flow blockage and prevent the worsening of chronic obstructive pulmonary disease (COPD) in patients who need another medicine. Ipratropium and albuterol belong to the family ...
What is ipratropium and albuterol solution used for?
Searching... Ipratropium is a bronchodilator, which is used for treating shortness of breath, coughing, and chest tightness. It is generally prescribed in cases where these conditions are caused by Chronic Obstructive Pulmonary Disease (COPD).
What is ipratropium used for?
See more

Is ipratropium the same as albuterol?
Both Albuterol and Ipratropium bromide are fast-acting and provide immediate relief from severe symptoms and breathing problems. Ipratropium bromide is an anticholinergic medication and albuterol is a short-acting beta2-adrenergic agonist.
Is ipratropium bromide solution a steroid?
Is Atrovent (ipratropium) a steroid? No. Atrovent (ipratropium) is an anticholinergic, which is a different type of medication than steroids. Anticholinergic and steroid medications work in different ways to treat runny nose and allergies.
Does ipratropium bromide help coughs?
Ipratropium oral inhalation is used to prevent wheezing, shortness of breath, coughing, and chest tightness in people with chronic obstructive pulmonary disease (COPD; a group of diseases that affect the lungs and airways) such as chronic bronchitis (swelling of the air passages that lead to the lungs) and emphysema ( ...
What are the side effects of taking ipratropium?
Dizziness, nausea, stomach upset, dry mouth, or constipation may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects.
When should you not use ipratropium?
Previous severe allergic reaction symptoms upon using ipratropium or atropine and its other derivatives, such as angioedema, urticaria, severe shortness of breath, oropharyngeal edema, and ultimately anaphylaxis is a contraindication to ipratropium use.
Will ipratropium raise blood pressure?
This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high. Rarely, this medication may cause severe sudden worsening of breathing problems right after use. If you have sudden worsening of breathing, get medical help right away.
How long does it take ipratropium bromide to work?
Some patients using this medicine may feel better right away. For others, it may take 1 or 2 weeks before the medicine helps. Keep using the medicine on a regular schedule as your doctor ordered.
Does ipratropium bromide make you sleepy?
Common side effects may include: cold symptoms such as stuffy nose, sneezing, sore throat; cough with mucus, chest tightness, trouble breathing; or. tiredness, or headache.
Is ipratropium bromide better than albuterol?
Our study results confirm that a fixed-dose combination of ipratropium bromide and albuterol sulfate is more effective than albuterol base alone in patients with COPD. The mean peak response was 26% to 28% higher for the combination aerosol than for albuterol.
What drugs does ipratropium interact with?
Ipratropium has no known severe interactions with other drugs.
Does ipratropium increase heart rate?
Heart rate already started to rise during the injection of ipratropiumbromide. It increased by an average of 78% three minutes following the administration as compared to pretreatment control values. Mean heart rate still was markedly increased by an average of 26% at 120 min following the injection of the drug.
Can you use ipratropium bromide daily?
If you are taking this medicine every day to help control your symptoms, it must be taken at regularly spaced times as ordered by your doctor. For patients using ipratropium inhalation aerosol: If you do not understand the directions or you are not sure how to use the inhaler, ask your doctor to show you how to use it.
What kind of medication is ipratropium bromide?
Ipratropium belongs to the family of medicines known as bronchodilators. Bronchodilators are medicines that are breathed in through the mouth to open up the bronchial tubes (air passages) in the lungs. This medicine is available only with your doctor's prescription.
How long can you take ipratropium bromide?
Adults, teenagers, and children 5 years of age and older—2 sprays in each nostril three or four times a day. Do not use the medicine for more than 4 days.
How long does ipratropium bromide stay in your system?
Steroids Used for AsthmaHalf-Lives of Common Asthma MedicationsClassMedicationHalf-LifeAnticholinergicipratropium bromide3 to 5 hoursMethylxanthinetheophylline3 to 13 hoursControllers8 more rows•Jan 6, 2020
What drugs interact with ipratropium bromide?
There may be an interaction between ipratropium bromide aerosol and any of the following:aclidinium.amantadine.antihistamines (e.g,. ... antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)atropine.azelastine.belladonna.benztropine.More items...
What Is Ipratropium inhalation?
Ipratropium is a bronchodilator that relaxes muscles in the airways and increases air flow to the lungs.Ipratropium inhalation is used to prevent b...
Before Taking This Medicine
You should not use this medication if you are allergic to ipratropium or atropine.To make sure ipratropium is safe for you, tell your doctor if you...
How Should I Use Ipratropium inhalation?
Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.Ipratropium...
What Happens If I Miss A Dose?
Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to m...
What Should I Avoid While Using Ipratropium inhalation?
Avoid getting this medication in your eyes. If this happens, rinse with water.This medication may cause blurred vision and may impair your thinking...
Ipratropium Inhalation Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue,...
Ipratropium Inhalation Dosing Information
Usual Adult Dose for Chronic Obstructive Pulmonary Disease -- Maintenance:Inhalation aerosol: 2 inhalations (34 mcg) orally four times a day, or as...
What Other Drugs Will Affect Ipratropium inhalation?
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with ipratropium, especially: 1. bladder or u...
What is ipratropium bromide used for?
It is used to treat the symptoms of chronic obstructive pulmonary disease and asthma. It is used by inhaler or nebulizer. Onset of action is typically within 15 to 30 minutes and lasts for three to five hours.
How is ipratropium administered?
Ipratropium is administered by inhalation for the treatment of chronic obstructive pulmonary disease (COPD) and asthma exacerbation. It is supplied in a canister for use in an inhaler or in single dose vials for use in a nebulizer.
What is the propellant in Atrovent?
Previously atrovent inhalers used chlorofluorocarbon ( CFC) as a propellant and contained soy lecithin in the propellant ingredients. In 2008 all CFC inhalers were phased out and hydrofluoroalkane (HFA) inhalers replaced them. Allergy to peanuts was noted for the inhaler as a contraindication but now is not. It has never been a contraindication when administered as a nebulized solution.
Does ipratropium increase dilating effect?
Combination with beta- adrenergic agonists increases the dilating effect on the bronchi, as when ipratropium is combined with salbutamol ( albuterol — USAN) under the trade names Combivent (a non-aerosol metered-dose inhaler or MDI) and Duoneb ( nebulizer) for the management of COPD and asthma, and with fenoterol (trade names Duovent and Berodual N) for the management of asthma.
Is ipratropium a derivative of atropine?
Ipratropium is a derivative of atropine but is a quaternary amine and therefore does not cross the blood–brain barrier, which prevents central side effects (anticholinergic syndrome). Ipratropium should never be used in place of salbutamol (albuterol) as a rescue medication.
Does ipratropium cause headaches?
Also, effects such as skin flushing, tachycardia, acute angle-closure glaucoma, nausea, palpitations and headache have been observed. Inhaled ipratropium does not decrease mucociliary clearance. The inhalation itself can cause headache and irritation of the throat in a few percent of patients.
Is ipratropium a generic?
It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system. Ipratropium is available as a generic medication. In 2017, it was the 216th most commonly prescribed medication in the United States, with more than two million prescriptions.
What is ipratropium inhalation?
Ipratropium is a bronchodilator that is used to to prevent bronchospasm in people with COPD ( chronic obstructive pulmonary disease ), including bronchitis and emphysema.
How old do you have to be to take ipratropium?
Tell your doctor if you are pregnant or breastfeeding. Ipratropium inhalation aerosol is not approved for use by anyone younger than 18 years old. Ipratropium inhalation solution is not approved for use by anyone younger than 12 years old.
How to treat a breathing problem?
Use only fast-acting inhalation medicine for an attack . Seek medical attention if your breathing problems get worse quickly, or if you think your medications are not working as well. Store at room temperature away from moisture, heat, and light. Keep the cover on your inhaler when not in use.
How many inhalations of a sulfate solution in a 24-hour period?
Do not use more than 12 inhalations in a 24-hour period.
What are the signs of an allergic reaction?
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
What is the phone number for poisoning?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What are the side effects of a syringe?
Common side effects may include: cold symptoms such as stuffy nose, sneezing, sore throat; cough with mucus, chest tightness, trouble breathing; or. tiredness, or headache. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Are you currently using ipratropium bromide nasal?
This survey is being conducted by the WebMD marketing sciences department.
What is the best medicine for a runny nose?
Ipratropium is used to treat a runny nose caused by the common cold or seasonal allergies. It works by reducing the amount of fluid/ mucus released from inside your nose.This medication does not relieve symptoms of stuffy nose or sneezing.
What to tell your dentist before surgery?
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Older adults may be more sensitive to the side effects of this drug, especially problems urinating or constipation.
What to tell your doctor before taking glaucoma?
Before using this medication, tell your doctor or pharmacist your medical history, especially of: personal or family history of glaucoma (angle-closure type), difficulty urinating (for example, due to enlarged prostate ).
Can you take ipratropium if you are allergic to it?
Before using ipratropium, tell your doctor or pharmacist if you are allergic to it or to tiotropium; or to atropine or other belladonna -type drugs; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Can a syringe cause blurred vision?
It may cause eye pain /irritation, temporary blurred vision, and other vision changes. If this medication does get into your eyes, flush your eyes with water for a few minutes. Tell your doctor right away if any symptoms occur. Use this medication regularly in order to get the most benefit from it.
Can you change your medication without your doctor's approval?
Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
What is ipratropium bromide?
Ipratropium Bromide Inhalation Solution is an anticholinergic (parasympatholytic) agent that, based on animal studies, appears to inhibit vagally-mediated reflexes by antagonizing the action of acetylcholine, the transmitter agent released from the vagus nerve.
How much of a 2 mg nebulizer is absorbed?
Much of an administered dose is swallowed but not absorbed as shown by fecal excretion studies. Following nebulization of a 2 mg dose, a mean 7% of the dose was absorbed into the systemic circulation either from the surface of the lung or from the gastrointestinal tract.
How long does it take for FEV 1 to improve?
Combined therapy produced significant additional improvement in FEV 1 and FVC. On combined therapy, the median duration of 15% improvement in FEV 1 was 5 to 7 hours, compared with 3 to 4 hours in patients receiving a beta agonist alone.
Does ipratropium bromide cause a rash?
Headache, mouth dryness and aggravation of COPD symptoms are more common when the total daily dose of Ipratropium bromide equals or exceeds 2,000 mcg. Allergic-type reactions such as skin rash, angioedema of tongue, lips and face, urticaria, laryngospasm and anaphylactic reaction have been reported.
Is ipratropium bromide an adverse reaction?
Adverse reaction information concerning Ipratropium Bromide Inhalation Solution is derived from 12-week active-controlled clinical trials. Additional information is derived from foreign postmarketing experience and the published literature.#N#All adverse events, regardless of drug relationship, reported by three percent or more patients in the 12-week controlled clinical trials appear in the table.#N#Additional adverse reactions reported in less than three percent of the patients treated with Ipratropium bromide include tachycardia, palpitations, eye pain, urinary retention, urinary tract infection and urticaria. Cases of precipitation or worsening of narrow-angle glaucoma, mydriasis, and acute eye pain have been reported.#N#Lower respiratory adverse reactions (bronchitis, dyspnea and bronchospasm) were the most common events leading to discontinuation of Ipratropium bromide therapy in the 12-week trials. Headache, mouth dryness and aggravation of COPD symptoms are more common when the total daily dose of Ipratropium bromide equals or exceeds 2,000 mcg. Allergic-type reactions such as skin rash, angioedema of tongue, lips and face, urticaria, laryngospasm and anaphylactic reaction have been reported. Many of the patients had a history of allergies to other drugs and/or foods.
Is ipratropium bromide excreted in human milk?
It is not known whether Ipratropium bromide is excreted in human milk. Although lipid-insoluble quaternary bases pass into breast milk, it is unlikely that Ipratropium bromide would reach the infant to a significant extent, especially when taken by inhalation since Ipratropium bromide is not well absorbed systemically after inhalation or oral administration. However, because many drugs are excreted in human milk, caution should be exercised when Ipratropium bromide is administered to a nursing woman.
Does ipratropium bromide cause teratogenic effects?
Oral reproduction studies performed in mice, rats and rabbits at doses of 10, 100, and 125 mg/kg respectively and inhalation reproduction studies in rats and rabbits at doses of 1.5 and 1.8 mg/kg (or approximately 38 and 45 times the recommended human daily dose) respectively, have demonstrated no evidence of teratogenic effects as a result of Ipratropium bromide. However, no adequate or well controlled studies have been conducted in pregnant women. Because animal reproduction studies are not always predictive of human response, Ipratropium bromide should be used during pregnancy only if clearly needed.
How long does it take for ipratropium bromide to work?
In controlled 12-week studies in patients with bronchospasm associated with chronic obstructive pulmonary disease (chronic bronchitis and emphysema) significant improvements in pulmonary function (FEV 1 increases of 15% or more) occurred within 15 to 30 minutes, reached a peak in 1 to 2 hours, and persisted for periods of 4 to 5 hours in the majority of patients, with about 25% to 38% of the patients demonstrating increases of 15% or more for at least 7 to 8 hours. Continued effectiveness of ipratropium bromide inhalation solution was demonstrated throughout the 12-week period. In addition, significant increases in forced vital capacity (FVC) have been demonstrated. However, ipratropium bromide did not consistently produce significant improvement in subjective symptom scores nor in quality of life scores over the 12-week duration of study.
How much ipratropium bromide is safe for rats?
Two-year oral carcinogenicity studies in rats and mice have revealed no carcinogenic potential at dietary doses up to 6 mg/kg/day of ipratropium bromide.
What are the adverse reactions to ipratropium bromide?
Additional adverse reactions reported in less than three percent of the patients treated with ipratropium bromide include tachycardia, palpitations, eye pain, urinary retention, urinary tract infection and urticaria. Cases of precipitation or worsening of narrow-angle glaucoma, mydriasis, and acute eye pain have been reported.Lower respiratory adverse reactions (bronchitis, dyspnea and bronchospasm) were the most common events leading to discontinuation of ipratropium bromide therapy in the 12-week trials. Headache, mouth dryness and aggravation of COPD symptoms are more common when the total daily dose of ipratropium bromide equals or exceeds 2,000 mcg.
What is ipratropium bromide?
Ipratropium bromide is an anticholinergic (parasympatholytic) agent that , based on animal studies, appears to inhibit vagally mediated reflexes by antagonizing the action of acetylcholine, the transmitter agent released from the vagus nerve.
How to store a syringe?
Store between 59°F (15°C) and 86°F (30°). Protect from light. Store unused vials in the foil pouch.
How many vials are in a foil pouch?
NDC 0781-7157-64, 30 vials in a foil pouch.
How to squeeze contents into nebulizer?
Twist open the top of one unit dose vial and squeeze the contents into the nebulizer reservoir. (Figure 1).
What is ipratropium used for?
Uses. Ipratropium is used to treat a runny nose that occurs throughout the year. It works by reducing the amount of fluid/ mucus released from inside your nose.This medication does not relieve symptoms of stuffy nose, sneezing, or postnasal drip.
What to tell your dentist before surgery?
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Older adults may be more sensitive to the side effects of this drug, especially problems urinating or constipation.
What to tell your doctor before taking glaucoma?
Before using this medication, tell your doctor or pharmacist your medical history, especially of: personal or family history of glaucoma (angle-closure type), difficulty urinating (for example, due to enlarged prostate ).
How much can you save on prescriptions?
Save up to 80% on your prescriptions.
How long does it take for a syringe to work?
You may start to feel better on the first day after using this medication, but it may take up to 2 weeks before you get the full benefit of this medication. Tell your doctor if your condition does not improve or if it worsens. Side Effects. See also How to Use section.
Can you take ipratropium if you are allergic to it?
Before using ipratropium, tell your doctor or pharmacist if you are allergic to it or to tiotropium; or to atropine or other belladonna -type drugs; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Where to report side effects?
You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Precautions.
What is ß receptor blocking agent?
ß-receptor blocking agents: These agents and albuterol sulfate inhibit the effect of each other. β-receptor blocking agents should be used with caution in patients with hyperreactive airways, and if used, relatively selective β 1 selective agents are recommended.
What is ipratropium bromide and albuterol sulfate used for?
Ipratropium Bromide and Albuterol Sulfate Inhalation Solution is indicated for the treatment of bronchospasm associated with COPD in patients requiring more than one bronchodilator.
What is the mechanism of action of ipratropium bromide?
Mechanism of Action: Ipratropium bromide is an anticholinergic (parasympatholytic) agent, which blocks the muscarinic receptors of acetylcholine, and , based on animal studies, appears to inhibit vagally mediated reflexes by antagonizing the action of acetylcholine, the transmitter agent released from the vagus nerve.
How long does ipratropium bromide stay in the body?
Following intravenous administration, approximately one-half is excreted unchanged in the urine. The half-life of elimination is about 1.6 hours after intravenous administration. Ipratropium bromide that reaches the systemic circulation is reportedly removed by the kidneys rapidly at a rate that exceeds the glomerular filtration rate. The pharmacokinetics of Ipratropium Bromide and Albuterol Sulfate Inhalation Solution or ipratropium bromide have not been studied in the elderly and in patients with hepatic or renal insufficiency (see PRECAUTIONS ).
How much albuterol sulfate is in USP?
Each 3 mL vial of Ipratropium Bromide and Albuterol Sulfate Inhalation Solution, USP contains 3.0 mg (0.1%) of albuterol sulfate (equivalent to 2.5 mg (0.083%) of albuterol base) and 0.5 mg (0.017%) of ipratropium bromide in an isotonic, sterile, aqueous solution containing sodium chloride, hydrochloric acid to adjust to pH 4, and edetate disodium, USP (a chelating agent).
What are the active components of ipratropium bromide and albuterol sulfate in?
The active components in Ipratropium Bromide and Albuterol Sulfate Inhalation Solution, USP are albuterol sulfate and ipratropium bromide. Albuterol sulfate, is a salt of racemic albuterol and a ...
What is the action of albuterol?
Mechanism of Action: The prime action of β-adrenergic drugs is to stimulate adenyl cyclase, the enzyme that catalyzes the formation of cyclic-3', 5'-adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). The cAMP thus formed mediates the cellular responses. In vitro studies and in vivo pharmacologic studies have demonstrated that albuterol has a preferential effect on β 2 -adrenergic receptors compared with isoproterenol. While it is recognized that β 2 -adrenergic receptors are the predominant receptors in bronchial smooth muscle, recent data indicated that 10% to 50% of the β -receptors in the human heart may be β 2 -receptors. The precise function of these receptors, however, is not yet established. Albuterol has been shown in most controlled clinical trials to have more effect on the respiratory tract, in the form of bronchial smooth muscle relaxation, than isoproterenol at comparable doses while producing fewer cardiovascular effects. Controlled clinical studies and other clinical experience have shown that inhaled albuterol, like other β-adrenergic agonist drugs, can produce a significant cardiovascular effect in some patients.
What is ipratropium nasal?
Ipratropium nasal (for the nose) works by reducing mucus secretions in the nose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What other drugs will affect ipratropium nasal?
Other drugs may interact with ipratropium nasal, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
How long does ipratropium last?
Follow these directions carefully. Ask your doctor or pharmacist if you have any questions. Ipratropium nasal is usually used for only a short time, such as 4 days for the common cold or 3 weeks for allergy symptoms. Follow your doctor's dosing instructions very carefully.
How old do you have to be to take ipratropium nasal?
Ipratropium nasal should not be used by a child younger than 5 years old.
What are the side effects of ipratropium?
minor nosebleed; sore throat; blurred vision; or. unusual or unpleasant taste in the mouth. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Ipratropium nasal side effects (more detail)
What are the symptoms of an allergic reaction to a sulfate based sulfate solution?
Get emergency medical help if you have any of these signs of an allergic reaction: hives, rash; wheezing, difficult breathing; swelling of your face, lips, tongue, or throat. painful or difficult urination. unusual or un pleasant taste in the mouth. This is not a complete list of side effects and others may occur.
How should I use albuterol and ipratropium inhalation?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
What happens if I overdose?
Overdose symptoms may include chest pain, fast or pounding heartbeats, tremors, dry mouth, extreme thirst, muscle weakness or limp feeling, severe headache, pounding in your neck or ears, or feeling like you might pass out.
How many inhalations of albuterol in 24 hours?
Do not use more than 6 inhalations in a 24-hour period. Overuse of albuterol and ipratropium may increase the risk of death. It is critical that you use only the prescribed dose of this medicine. Read and carefully follow any Instructions for Use provided with your medicine.
What is the purpose of albuterol and ipratropium?
Albuterol and ipratropium are bronchodilators that relax muscles in the airways and increase air flow to the lungs. Albuterol and ipratropium inhalation is used to prevent bronchospasm in people with chronic obstructive pulmonary disease ( COPD) who are also using other medicines to control their condition.
How long do you have to keep a combivent inhaler?
Keep track of the number of sprays you have used. Throw away the Combivent Respimat inhaler canister after 3 months or 120 sprays, whichever comes first.
How to get rid of mist in nebulizer?
Breathe in slowly and evenly until no more mist is formed by the nebulizer and the drug chamber is empty.
How to put medicine in a nebulizer?
Empty the medicine into the chamber of the nebulizer. Attach the mouthpiece or face mask, then attach the drug chamber to the compressor. Sit upright in a comfortable position. Place the mouthpiece into your mouth or put on the face mask, covering your nose and mouth.

Overview
Ipratropium is used to treat a runny nose caused by the common cold or seasonal allergies.
May Treat: Rhinorrhea · Bronchospasm with COPD · Chronic non-allergic rhinitis · Maintenance therapy for asthma · Perennial allergic rhinitis
Brand Names: Atrovent · Atrovent HFA
Drug Class: Asthma/COPD - Anticholinergic Agents, Inhaled Short Acting · Nasal Anticholinergics
Availability: Prescription Required
Pregnancy: Consult a doctor before using
May Treat: Rhinorrhea · Bronchospasm with COPD · Chronic non-allergic rhinitis · Maintenance therapy for asthma · Perennial allergic rhinitis
Brand Names: Atrovent · Atrovent HFA
Drug Class: Asthma/COPD - Anticholinergic Agents, Inhaled Short Acting · Nasal Anticholinergics
Availability: Prescription Required
Pregnancy: Consult a doctor before using
Lactation: Consult a doctor before using
Driving: May cause drowsiness or dizziness. Use caution
Medical uses
Contraindications
Side effects
Interactions
Pharmacology
Ipratropium is administered by inhalation for the treatment of chronic obstructive pulmonary disease (COPD) and asthma exacerbation. It is supplied in a canister for use in an inhaler or in single dose vials for use in a nebulizer.
It is also used to treat and prevent minor and moderate bronchial asthma, especially asthma that is accompanied by cardiovascular system diseases, as it has been shown to produce fewer card…
External links
The main contraindication for inhaled ipratropium is hypersensitivity to atropine and related substances. For oral administration, contraindications are similar to other anticholinergics; they include narrow angle glaucoma and obstructions in the gastrointestinal tract and urinary system.
Previously atrovent inhalers used chlorofluorocarbon (CFC) as a propellant and contained soy lecithin in the propellant ingredients. In 2008 all CFC inhalers were phased out and hydrofluoroalk…
Ipratropium Description
If ipratropium is inhaled, side effects resembling those of other anticholinergics are minimal. However, dry mouth and sedation have been reported. Also, effects such as skin flushing, tachycardia, acute angle-closure glaucoma, nausea, palpitations and headache have been observed. Inhaled ipratropium does not decrease mucociliary clearance. The inhalation itself can cause headache and irritation of the throat in a few percent of patients.
Ipratropium - Clinical Pharmacology
Interactions with other anticholinergics like tricyclic antidepressants, anti-Parkinson drugs and quinidine, which theoretically increase side effects, are clinically irrelevant when ipratropium is administered as an inhalant.
Indications and Usage For Ipratropium
Chemically, ipratropium bromide is a quaternary ammonium compound (which is indicated by the -ium per the BAN and the USAN) obtained by treating atropine with isopropyl bromide, thus the name: isopropyl + atropine. It is chemically related to components of the plant Datura stramonium, which was used in ancient India for asthma.
Ipratropium exhibits broncholytic action by reducing cholinergic influence on the bronchial musc…
Contraindications
• "Ipratropium bromide". Drug Information Portal. U.S. National Library of Medicine.
Warnings
Precautions
- Ipratropium Bromide Inhalation Solution is an anticholinergic (parasympatholytic) agent that, based on animal studies, appears to inhibit vagally-mediated reflexes by antagonizing the action of acetylcholine, the transmitter agent released from the vagus nerve. Anticholinergics prevent the increases in intracellular concentration of cyclic guanosin...
Adverse Reactions
- Ipratropium Bromide Inhalation Solution administered either alone or with other bronchodilators, especially beta adrenergics, is indicated as a bronchodilator for maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease, including chronic bronchitis and emphysema.
Overdosage
- Ipratropium bromide is contraindicated in known or suspected cases of hypersensitivity to Ipratropium bromide, or to atropine and its derivatives.
Ipratropium Dosage and Administration
- The use of Ipratropium Bromide Inhalation Solution as a single agent for the relief of bronchospasm in acute COPD exacerbation has not been adequately studied. Drugs with faster onset of action may be preferable as initial therapy in this situation. Combination of Ipratropium Bromide Inhalation Solution and beta agonists has not been shown to be more effective than eit…
How Is Ipratropium Supplied
- General
Ipratropium bromide should be used with caution in patients with narrow angle glaucoma, prostatic hypertrophy or bladder neck obstruction. - Information for Patients
Patients should be advised that mydriasis, temporary blurring of vision, precipitation or worsening of narrow-angle glaucoma or eye pain may result if the solution comes into direct contact with the eyes. Use of a nebulizer with mouthpiece rather than face mask may be preferable, to reduce th…