Lutalyse
- Description. Lutalyse Sterile Solution is a natural estrus-synchronization product approved for use in horses. Lutalyse...
- Usage. Lutalyse is used to control estrus time in estrous-cycling mares. Mares treated with Lutalyse during diestrus...
- Dosage and Administration. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
- Interactions.
How to use Lutalyse in cows?
LUTALYSE is used to control the timing of estrus and ovulation in estrous cycling cattle that have a corpus luteum. Inject a dose of 5 mL LUTALYSE (25 mg PGF2α) intramuscularly either once or twice at a 10 to 12 day interval. With the single injection, cattle should be bred at the usual time relative to estrus.
How long does it take for Lutalyse to work in horses?
Controlling Time of Estrus of Estrous Cycling Mares: Mares treated with LUTALYSE Injection during diestrus (4 or more days after ovulation) will return to estrus within 2 to 4 days in most cases and ovulate 8 to 12 days after treatment. This procedure may be utilized as an aid to scheduling the use of stallions.
What is Lutalyse used for?
Lutalyse contains a well characterized prostaglandin that occurs naturally in nearly all mammalian tissue. Lutalyse is used to control estrus time in estrous-cycling mares.
When to give Lutalyse to Mare?
Thank you all for the advice, lutalyse is new to me and there's so much information on all sorts of topics when I google it. Lutalyse needs to be given to your mare during her cycle when a corpus luteum is present since lutalyse is a prostaglandin that will break down the CL, essentially causing your mare to come back into heat.
What is lutelyse sterile solution?
When is lutalyse ineffective?
How long does it take for a mare to return to estrus?
Can you use Lutalyse on Mares?
Can you give lutalyse to pregnant animals?
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When should I give my horse Lutalyse?
1. Controlling Time of Estrus of Estrous Cycling Mares: Mares treated with LUTALYSE during diestrus (4 or more days after ovulation) will return to estrus within 2 to 4 days in most cases and ovulate 8 to 12 days after treatment. This procedure may be utilized as an aid to scheduling the use of stallions. 2.
How long does Lutalyse take to work?
With the two injections cattle can be bred after the second injection either at the usual time relative to detected estrus or at about 80 hours after the second injection of LUTALYSE Injection. Estrus is expected to occur 1 to 5 days after injection if a corpus luteum was present.
Where do you inject Lutalyse?
LUTALYSE HighCon Injection is used to control the timing of estrus and ovulation in estrous cycling cattle that have a corpus luteum. Inject a dose of 2 mL LUTALYSE HighCon Injection (25 mg dinoprost) intramuscularly or subcutaneously either once or twice at a 10 to 12 day interval.
How do you bring a mare into heat?
The most common method used to bring transitional mares into estrus is a progestin, altrenogest, marketed as Regu-Mate or Altresyn. Squires said many managers and veterinarian put mares under artificial light for 60 days before administering altrenogest for 10 to 14 days. At that point, the mare should come into heat.
Does Lutalyse require prescription?
Each mL contains 5 mg of dinoprost tromethamine. Supplied as either a 30 mL or 100 mL bottle. Needles and syringes sold separately. This product requires a veterinarian's prescription for purchase.
What happens if you get Lutalyse on your skin?
LUTALYSE is readily absorbed through the skin and may cause abortion and/or bronchiospasms, therefore spillage on the skin should be washed off immediately with soap and water. Aseptic technique should be used to reduce the possibility of post-injection clostridial infections.
How long is Lutalyse good for?
After a bottle has been injected into, its contents are no longer considered sterile, but if there is a preservative added to the contents it can be used mulitple times, but after 6 months I would not trust it being sterile and probably pretty contaminated....but then again this is livestock.....don't know if this ...
What hormone is Lutalyse?
prostaglandin F2 alphaLUTALYSE ® HighCon Injection (12.5 mg dinoprost/mL) is a sterile solution containing the naturally occurring prostaglandin F2 alpha (dinoprost) as the tromethamine salt. Prostaglandins occur in nearly all mammalian tissues.
Can Lutalyse cause miscarriage?
Prostaglandins such as Lutalyse, Prostamate and Estrumate can lead to the abortion of a sow's pregnancy if there is an accidental exposure; they can also cause abortion in pregnant women.
Can a gelding bring a mare into season?
To answer your question specifically, exposure to another horse, be it a gelding, stallion or mare, does not necessarily induce estrus. A mare will cycle on her own, depending on her geographic location, when the day length is long enough to stimulate her natural cycle.
How many times a year do mares go into heat?
As a general rule, horses have their first heat cycle when they turn one year, and the cycle stops when the horse is about 20 years old. The cycle lasts three weeks, and the horse will be in heat for two to five days, but this may vary slightly depending on factors such as their age, season, and location.
How can I help my mare ovulate?
HCG aids in stimulating ovulation in mares. It is most often given at the same time the mare is bred. HCG will normally lead to ovulation of a mature follicle within 48 hours, aiding in appointment breeding and helping mares that tend to develop a follicle and fail to ovulate.
Can Lutalyse cause abortion?
Prostaglandins such as Lutalyse, Prostamate and Estrumate can lead to the abortion of a sow's pregnancy if there is an accidental exposure; they can also cause abortion in pregnant women. The drug Matrix can actually prolong pregnancy if absorbed in both sows and women.
How much Lutalyse does it take to abort a cow?
25 mgLUTALYSE is indicated for its abortifacient effect in feedlot and other non-lactating cattle during the first 100 days of gestation. Inject a dose of 25 mg intramuscularly. Cattle that abort will abort within 35 days of injection.
How long does it take Lutalyse to work in goats?
Lutalyse is a vet RX drug that begins the natural labor process by telling the doe's body that her kids are ready. Everything I'd read said to give 2ccs of lute as an intramuscular injection, and to expect kids within 36 hours.
How much Lutalyse do I need to induce a sow?
To induce sows and gilts to farrow, inject them with a half-dose (1ml in the case of Lutaylse) 24-30 hours BEFORE you would like them to begin farrowing. Follow-up with another half-dose 6 hours after the first shot. You can expect about 96% of the sows injected with this protocol to farrow the next day.
Lutalyse Question | The Horse Forum
I'm breeding with lutalyse for the first time this month and have a couple questions. I realize that there is a lower dose method of lutalyse commonly given (I believe it's 2 shots of .2cc). The dose recommended to me by my vet was 2 cc (preceded by 10 cc of banamine). The vet didn't mention...
Lutalyse Injection for Animal Use - Drugs.com
Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 6 July 2022), Cerner Multum™ (updated 27 July 2022), ASHP (updated 1 July ...
LUTALYSE® Injection (dinoprost injection) - Zoetis US
For estrus synchronization, inject 5 mL LUTALYSE intramuscularly (IM) either once or twice at 10- to 12-day intervals. For treatment of unobserved estrus, inject a 5 mL dose IM.
How to use lutealyse injection?
LUTALYSE Injection is used to control the timing of estrus and ovulation in estrous cycling cattle that have a corpus luteum. Inject a dose of 5 mL LUTALYSE Injection (25 mg dinoprost) intramuscularly either once or twice at a 10 to 12 day interval. With the single injection, cattle should be bred at the usual time relative to estrus. With the two injections cattle can be bred after the second injection either at the usual time relative to detected estrus or at about 80 hours after the second injection of LUTALYSE Injection. Estrus is expected to occur 1 to 5 days after injection if a corpus luteum was present. Cattle that do not become pregnant to breeding at estrus on days 1 to 5 after injection will be expected to return to estrus in about 18 to 24 days.
When to inject lutealyse in cows?
LUTALYSE Injection is indicated for its abortifacient effect in beef cows, beef heifers and replacement dairy heifers during the first 100 days of gestation. Inject a dose of 25 mg dinoprost (5 mL) intramuscularly. Cattle that abort will abort within 35 days of injection.
How much luteolytic injection is given to a mare?
Mares: LUTALYSE Injection is indicated for its luteolytic effect in mares. Administer a single intramuscular injection of 1 mg per 100 lbs (45.5 kg) body weight which is usually 1 mL to 2 mL LUTALYSE Injection. This luteolytic effect can be utilized to control the timing of estrus in estrous cycling and clinically anestrous mares that have a corpus luteum in the following circumstances:
How long after luteal injection can cattle be bred?
With the two injections cattle can be bred after the second injection either at the usual time relative to detected estrus or at about 80 hours after the second injection of LUTALYSE Injection. Estrus is expected to occur 1 to 5 days after injection if a corpus luteum was present.
How early can you administer lumalyse injection?
The product must be administered at a relatively specific time (treatment earlier than 3 days prior to normal predicted farrowing may result in increased piglet mortality). It is important that adequate records be maintained on (1) the average length of gestation period for the animals on a specific location, and (2) the breeding and projected farrowing dates for each animal. This information is essential to determine the appropriate time for administration of LUTALYSE Injection.
Is luteolytic injection effective for cattle?
Cattle: LUTALYSE Injection is indicated as a luteolytic agent. LUTALYSE Injection is effective only in those cattle having a corpus luteum, i.e., those which ovulated at least five days prior to treatment.
Is lutealyse safe for animals?
Animal Safety Warnings: Severe localized clostridial infections associated with injection of LUTALYSE Injection have been reported. In rare instances, such infections have resulted in death.
What is lutalyse injection?
Producers today have more options for using Lutalyse® Injection in reproduction programs than ever before. Lutalyse® is an entirely natural prostaglandin product for use in beef and dairy cattle, swine and horses. It is the most-used prostaglandin in the market.
What is lutalyse 5mg/ml used for?
Indications: Lutalyse® 5mg/ml is for intramuscular use for estrus synchronization, treatment of unobserved (silent) estrus and pyometra (chronic endometritis) in cattle; for abortion of feedlot and other non-lactating cattle; for parturition induction in swine; and for controlling the timing of estrus in estrous cycling mares and clinically anestrous mares that have a corpus luteum.
Does Lutalyse need to be discarded?
As per the label, no milk discard or pre-slaughter drug withdrawal period is required for labeled uses of Lutalyse in cattle.
Is Lutalyse sterile?
This ready to use, sterile solution contains prostaglandin in the form of dinoprost tromethamine. Each mL contains 5 mg of dinoprost tromethamine. Supplied as either a 30 mL or 100 mL bottle.
What is a lutealyse?
LUTALYSE® Injection (5 mg dinoprost/mL) is a sterile solution containing the naturally occurring prostaglandin F2 alpha (dinoprost) as the tromethamine salt. Each mL contains dinoprost tromethamine equivalent to 5 mg dinoprost: also, benzyl alcohol, 16.5 mg added as preservative and water for injection.
When to inject lutealyse in cows?
LUTALYSE Injection is indicated for its abortifacient effect in beef cows, beef heifers and replacement dairy heifers during the first 100 days of gestation. Inject a dose of 25 mg dinoprost (5 mL) intramuscularly. Cattle that abort will abort within 35 days of injection.
What happens to mares in extended diestrus?
Mares: In extended diestrus there is failure to exhibit regular estrous cycles which is different from true anestrus. Many mares described as anestrus during the breeding season have serum progesterone levels consistent with the presence of a functional corpus luteum. A proportion of “barren”, maiden, and lactating mares do not exhibit regular estrous cycles and may be in extended diestrus. Following abortion, early fetal death and resorption, or as a result of “pseudopregnancy”, there may be serum progesterone levels consistent with a functional corpus luteum. Treatment of such mares with LUTALYSE Injection usually results in regression of the corpus luteum followed by estrus and/or ovulation. Treatment of “anestrous” mares which abort subsequent to 36 days of pregnancy may not result in return to estrus due to presence of functional endometrial cups.
How long after luteal injection can cattle be bred?
With the two injections cattle can be bred after the second injection either at the usual time relative to detected estrus or at about 80 hours after the second injection of LUTALYSE Injection. Estrus is expected to occur 1 to 5 days after injection if a corpus luteum was present.
How early can you administer lumalyse injection?
The product must be administered at a relatively specific time (treatment earlier than 3 days prior to normal predicted farrowing may result in increased piglet mortality). It is important that adequate records be maintained on (1) the average length of gestation period for the animals on a specific location, and (2) the breeding and projected farrowing dates for each animal. This information is essential to determine the appropriate time for administration of LUTALYSE Injection.
What do cattle need to breed?
a. Cattle must be ready to breed—they must have a corpus luteum and be healthy;
Is luteolytic injection effective in cattle?
Cattle. LUTALYSE Injection is indicated as a luteolytic agent. LUTALYSE Injection is effective only in those cattle having a corpus luteum, i.e., those which ovulated at least five days prior to treatment.
What is lutealyse used for?
LUTALYSE is used to control the timing of estrus and ovulation in estrous cycling cattle that have a corpus luteum.
When to use luteallyse solution for swine?
LUTALYSE Sterile Solution is indicated for parturition induction in swine when injected within 3 days of normal predicted farrowing.
How effective is lutealyse?
LUTALYSE is effective only in those cattle having a corpus luteum , i.e., those which ovulated at least five days prior to treatment . Future reproductive performance of animals that are not cycling will be unaffected by injection of LUTALYSE.
What do cattle need to breed?
a. Cattle must be ready to breed-they must have a corpus luteum and be healthy;
How long does it take for cattle to recover from a lutealyse injection?
Most cattle that recovered in response to LUTALYSE recovered within 14 days after injection. After 14 days, recovery rate of treated cattle was no different than that of non-treated cattle. 4. For Intramuscular Use for Abortion of Feedlot and Other Non-Lactating Cattle.
How long after a second injection can cattle be bred?
With the two injections cattle can be bred after the second injection either at the usual time relative to detected estrus or at about 80 hours after the second injection of LUTALYSE.
Can you use pyometra in cattle?
For intramuscular use for estrus synchronization, treatment of unobserved (silent) estrus and pyometra ( chronic endometritis) in cattle; for abortion of feedlot and other non-lactating cattle; for parturition induction in swine;
What is lutelyse sterile solution?
Lutalyse Sterile Solution is a natural estrus-synchronization product approved for use in horses. Lutalyse contains a well characterized prostaglandin that occurs naturally in nearly all mammalian tissue.
When is lutalyse ineffective?
Lutalyse is ineffective when administered prior to the fifth day after ovulation.
How long does it take for a mare to return to estrus?
Mares treated with Lutalyse during diestrus will return to estrus within 2 to 4 days in most cases. This serves as an aid to scheduling stallions. In difficult-to-breed mares, treatment with Lutalyse usually results in regression of the corpus lutem followed by estrus and/or ovulation.
Can you use Lutalyse on Mares?
Mares that have either acute or subacute disorders of the vascular system, gastrointestinal tract, respiratory system or reproductive tract should not be treated with Lutalyse.
Can you give lutalyse to pregnant animals?
Do not administer Lutalyse in pregnant animals unless cessation of pregnancy is desired. Do not use intravenous administration. Women of childbearing age and persons with respiratory problems should exercise extreme caution when handling Lutalyse.
Description
Lutalyse Injection Indications For Use
Management Considerations
Lutalyse Injection Dosage and Administration
Warnings and Precautions
- Cattle:LUTALYSE Injection is indicated as a luteolytic agent. LUTALYSE Injection is effective only in those cattle having a corpus luteum, i.e., those which ovulated at least five days prior to treatment. Future reproductive performance of animals that are not cycling will be unaffected by injection of LUTALYSE Injection. ● For estrus synchronizati...
Adverse Reactions
- Many factors contribute to success and failure of reproduction management, and these factors are important also when time of breeding is to be regulated with LUTALYSE Injection. Some of these factors are: a. Cattle must be ready to breed-they must have a corpus luteum and be healthy; b. Nutritional status must be adequate as this has a direct effect on conception and the …
Contact Information
- As with any multi-dose vial, practice aseptic techniques in withdrawing each dose to decrease the possibility of post-injection bacterial infections. Adequately clean and disinfect the vial stopper prior to entry with a sterile needle and syringe. Use only sterile needles, and use each needle only once. No vial stopper should be entered more than 20 times. For this reason, the 100 mL bottle s…
Clinical Pharmacology
- User Safety: Not for human use. Keep out of the reach of children. Women of childbearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. In the early stages, women may be unaware of their pregnancies. Dinoprost tromethamine is readily absorbed through the skin and can cause aborti…
Target Animal Safety
- Cattle:Limited salivation has been reported in some instances. Swine:The most frequently observed side effects were erythema and pruritus, slight incoordination, nesting behavior, itching, urination, defecation, abdominal muscle spasms, tail movements, hyperpnea or dyspnea, increased vocalization, salivation, and at the 100 mg (10x) dose only, possible vomiting. These s…
Effectiveness
- For a copy of the Safety Data Sheet or to report adverse reactions, call Zoetis Inc. at 1-888-963-8471. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or www.fda.gov/reportanimalae.
Lutalyse Sterile Solution Caution
- General Biologic Activity: Prostaglandins occur in nearly all mammalian tissues. Prostaglandins, especially PGE’s and PGF’s, have been shown, in certain species, to 1) increase at time of parturition in amniotic fluid, maternal placenta, myometrium, and blood, 2) stimulate myometrial activity, and 3) to induce either abortion or parturition. Prostaglandins, especially PGF2α, have b…
Description
- Laboratory Animals:Dinoprost was non-teratogenic in rats when administered orally at 1.25, 3.2, 10.0 and 20.0 mg dinoprost/kg/day from day 6th-15th of gestation or when administered subcutaneously at 0.5 and 1.0 mg/kg/day on gestation days 6, 7 and 8 or 9, 10 and 11 or 12, 13 and 14. Dinoprost was non-teratogenic in the rabbit when administered either subcutaneously a…
Metabolism
- Cattle: For Treatment of Pyometra (chronic endometritis) in Cattle:In studies conducted with LUTALYSE Injection, pyometra was defined as presence of a corpus luteum in the ovary and uterine horns containing fluid but not a conceptus based on palpation per rectum. Return to normal was defined as evacuation of fluid and return of the uterine horn size to 40mm or less ba…
Lutalyse Sterile Solution Indications and Usage
Warnings
- This product contains the naturally occurring prostaglandin F2 alpha (dinoprost) as the tromethamine salt. Each mL contains dinoprost tromethamine equivalent to 5 mg dinoprost: also, benzyl alcohol, 16.5 mg added as preservative. When necessary, pH was adjusted with sodium hydroxide and/or hydrochloric acid. Dinoprost tromethamine is a white or slightly off-white cryst…
Precautions
- A number of metabolism studies have been done in laboratory animals. The metabolism of tritium labeled dinoprost (3H PGF2 alpha) in the rat and in the monkey was similar. Although quantitative differences were observed, qualitatively similar metabolites were produced. A study demonstrated that equimolar doses of 3H PGF2 alpha Tham and 3H PGF2 alpha free acid admi…
Adverse Reactions
- Cattle:LUTALYSE Sterile Solution is indicated as a luteolytic agent. LUTALYSE is effective only in those cattle having a corpus luteum, i.e., those which ovulated at least five days prior to treatment. Future reproductive performance of animals that are not cycling will be unaffected by injection of LUTALYSE. 1. For Intramuscular Use for Estrus Syn...
Lutalyse Sterile Solution Dosage and Administration
- User Safety: Not for human use. Women of childbearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme cautionwhen handling this product. In the early stages, women may be unaware of their pregnancies. Dinoprost tromethamine is readily absorbed through the skin and can cause abortion and/or bronchiospas…
Safety and Toxity
- - Do not administer intravenously (I.V.) as this route may potentiate adverse reactions. - No vial stopper should be entered more than 20 times. For this reason, the 100 mL bottle should only be used for cattle. The 30 mL bottle may be used for cattle, swine, or mares. - As with all parenteral products careful aseptic techniques should be used to decrease the possibility of post-injection …
Storage Conditions
- Cattle:Limited salivation has been reported in some instances. Swine:The most frequently observed side effects were erythema and pruritus, slight incoordination, nesting behavior, itching, urination, defecation, abdominal muscle spasms, tail movements, hyperpnea or dyspnea, increased vocalization, salivation, and at the 100 mg (10X) dose only, possible vomiting. These s…