Precautions
memantine Hydrochloride Tablets USP is indicated for the treatment of moderate to severe dementia of the Alzheimer’s type. The recommended starting dose of memantine Hydrochloride Tablet is 5 mg once daily.
What is memantine 5 mg used for?
- fatigue,
- pain,
- increased blood pressure,
- dizziness,
- headache,
- constipation,
- vomiting,
- back pain,
- confusion,
- sleepiness,
What are the side effects of memantine?
Symptoms are usually transient and most resolve after one to three weeks of continued treatment. Muscle cramps, weight loss, and fatigue are also common. May increase gastric acid secretion and increase the risk of gastrointestinal bleeding and stomach ulcers.
Does memantine cause weight loss?
Similarly, when should memantine be taken? Memantine helps to ease the symptoms of dementia in Alzheimer's disease. Take one dose every day, at the same time of day each day. You can take memantine either before or after meals. You will be given a small dose when you first start treatment. Also Know, can you take memantine on an empty stomach? You may take memantine with or without food. Swallow the extended-release capsules whole.
When should memantine be taken?
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How does memantine make you feel?
The more common side effects that can occur with memantine include: drowsiness. dizziness. headache.
What are the side effects of memantine 5mg?
AdvertisementBloating or swelling of the face, arms, hands, lower legs, or feet.headache.rapid weight gain.slow or fast heartbeat.tingling of the hands or feet.
Is memantine a good drug for dementia?
We analysed the results separately for people with mild dementia and those with moderate-to-severe dementia. Memantine has a small beneficial effect in people with moderate-to-severe AD. This benefit affects thinking, the ability to carry on normal daily activities, and the severity of behaviour and mood problems.
Is memantine a sleeping pill?
It is well known that memantine acts as a blocker on N-methyl-D-aspartate (NMDA) receptors. It produces wake promotion and insomnia in AD patients [10]. However, a few studies showed that memantine increases total awake time and reduces total sleep time [11,12].
What stage of dementia is memantine used for?
Memantine is indicated in the United States and Europe for moderate to severe AD, which is diagnosed if a patient has a Mini-Mental State Examination (MMSE) score of less than 15 or less than 20, respectively.
Is memantine worth taking?
Is memantine effective for all people with dementia? Memantine will not help everyone who takes it. It treats the symptoms of moderate to severe Alzheimer's disease only and is not a cure – there is no evidence that it can halt or reverse the process of cell damage that causes the disease.
Why would a doctor prescribe memantine?
Memantine is used to treat moderate to severe Alzheimer's disease. Memantine is not a cure for Alzheimer's disease but it can help people with the disease.
Does memantine calm you down?
Memantine augmentation resulted in clinically relevant reduction in anxiety symptoms when compared to baseline. Forty percent of patients achieved remission (HAM-A ≥ 7). Memantine improved sleep quality.
Who should not take memantine?
Memantine hydrochloride is not recommended for children and adolescents under the age of 18 years. Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
Is memantine best taken at night?
Should memantine be taken at night? Memantine can be taken at any time of the day, but always try to take the doses at the same time every day. The medication can be taken with or without food.
How quickly does memantine work?
It may take several weeks before memantine appears to take effect. Continue to take your doses every day until you are told otherwise by your doctor. Your doctor will want to check your progress every few weeks to make sure that the dose is right for you and that you are getting benefit from the treatment.
Does memantine improve mood?
Abstract. Background: We have recently provided preliminary clinical observations indicating that memantine, as augmenting agent, was associated with a meaningful antimanic and mood-stabilizing effect in treatment-resistant bipolar disorders.
When should memantine be stopped?
These medications should be stopped if the desired effects—stabilizing cognitive and functional status—are not perceived within a reasonable time, such as 12 weeks. In some cases, stopping cholinesterase inhibitor therapy may cause negative effects on cognition and neuropsychiatric symptoms.
What medications should not be taken with memantine?
Drug InteractionsAcetazolamide.Amantadine.Brinzolamide.Bupropion.Dextromethorphan.Dorzolamide.Ketamine.Methazolamide.More items...•
What does memantine do to the brain?
Memantine is in a class of medications called NMDA receptor antagonists. It works by decreasing abnormal activity in the brain. Memantine may improve the ability to think and remember or may slow the loss of these abilities in people who have AD.
Who should not take memantine?
Memantine hydrochloride is not recommended for children and adolescents under the age of 18 years. Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
What is the form of memantine?
Memantine is a prescription drug. It comes in three forms: immediate-release tablet, oral solution, and extended-release capsule.
What to tell your doctor before taking memantine?
Before taking memantine, be sure to tell your doctor and pharmacist about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.
Can memantine interact with other medications?
Different interactions can cause different effects. For instance, some can interfere with how well a drug works, while others can cause increased side effects.
Is memantine safe for pregnant women?
For pregnant women: There haven’t been enough studies done in humans to show if memantine poses a risk to a human fetus. Certain negative effects were observed in animal studies, but animal studies don’t always predict the way humans would respond.
Does memantine increase the amount of memantine in the body?
Taking these drugs with memantine can increase the amount of memantine in your body. This can lead to more side effects. Examples of these drugs include:
Can memantine cause side effects?
Memantine oral tablet can cause mild or serious side effects. The following list contains some of the key side effects that may occur while taking memantine. This list does not include all possible side effects.
Is memantine safe to take?
Memantine oral tablet is used for long-term treatment. It comes with serious risks if you don’t take it as prescribed.
Why is memantine prescribed?
Why is this medication prescribed? Expand Section. Memantine is used to treat the symptoms of Alzheimer's disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities). Memantine is in a class of medications called NMDA receptor antagonists.
Can you get pregnant while taking memantine?
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking memantine.
Can memantine cause hallucinations?
hallucination (seeing things or hearing voices that do not exist) Memantine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
Does memantine help with AD?
Memantine may improve the ability to think and remember or may slow the loss of these abilities in people who have AD. However, memantine will not cure AD or prevent the loss of these abilities at some time in the future.
Can you take memantine if you are allergic to it?
tell your doctor and pharmacist if you are allergic to memantine, any other medications, or any of the ingredients in memantine tablets, capsules, and oral solution. Ask your pharmacist or check the manufacturer's patient information for a list of the ingredients.
What is the formula for memantine hydrochloride?
The molecular formula is C 12 H 21 N•HCl and the molecular weight is 215.76. memantine hydrochloride occurs as a fine white to off-white powder and is soluble in water.
What pH level is memantine reduced?
The clearance of memantine was reduced by about 80% under alkaline urine conditions at pH 8.
How to report memantine hydrochloride side effects?
For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
How many patients were treated with memantine hydrochloride?
memantine hydrochloride was evaluated in eight double-blind placebo-controlled trials involving a total of 1862 dementia (Alzheimer’s disease, vascular dementia) patients (940 patients treated with memantine hydrochloride and 922 patients treated with placebo) for a treatment period up to 28 weeks.
What happens if you miss a memantine tablet?
If a patient misses a single dose of memantine Hydrochloride Tablet, that patient should not double up on the next dose. The next dose should be taken as scheduled. If a patient fails to take memantine Hydrochloride Tablet for several days, dosing may need to be resumed at lower doses and retitrated as described above.
How long does it take for memantine to absorb?
Following oral administration memantine is highly absorbed with peak concentrations reached in about 3-7 hours. memantine has linear pharmacokinetics over the therapeutic dose range. Food has no effect on the absorption of memantine.
Is memantine hydrochloride safe for pregnant women?
There are no adequate data on the developmental risk associated with the use of memantine hydrochloride in pregnant women.
How to take memantine?
Follow the directions exactly. Use the oral syringe that comes with the product to measure out your dose. Do not use a household spoon because you may not get the correct dose. Swallow the medication directly from the syringe. Do not mix it with water or other liquids. Rinse the syringe with water after each use. Consult your doctor or pharmacist if you have any questions.
How to report memantine side effects in Canada?
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Precautions. Before taking memantine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
What to do if you miss a memantine?
If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up. If you forget to take memantine for several days, talk to your doctor before your next dose.
Can memantine cause allergies?
Before taking memantine, tell your doctor or pharmacistif you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Does memantine help with dementia?
Uses. Memantine is used to treat moderate to severe confusion ( dementia) related to Alzheimer's disease. It does not cure Alzheimer's disease, but it may improve memory, awareness, and the ability to perform daily functions.
How to take memantine?
HOW TO USE: Read the Patient Information Leaflet if available from your pharmacist before you start taking memantine and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth with or without food as directed by your doctor. The dosage is based on your medical condition and response to treatment. When you first start taking this medication, you will usually take it once daily. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. Once your dose increases to more than 5 milligrams per day, take this medication twice daily or as directed by your doctor. If you are taking memantine oral liquid, read the manufacturer's instruction sheet that comes with the bottle. Follow the directions exactly. Use the oral syringe that comes with the product to measure out your dose. Do not use a household spoon because you may not get the correct dose. Swallow the medication directly from the syringe. Do not mix it with water or other liquids. Rinse the syringe with water after each use. Consult your doctor or pharmacist if you have any questions. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time (s) each day. Tell your doctor if your condition worsens.
How to report memantine side effects?
You may report side effects to Health Canada at 1-866-234-2345. PRECAUTIONS: Before taking memantine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
How to contact Memantine HCL?
If you contact our Customer Support by one of the methods below, we will be able to assist you in locating the product you are looking for. Customer Support. Phone: 1-800-748-7001.
What is the name of the drug that is used to treat dementia?
COMMON BRAND NAME (S): Namenda. USES: Memantine is used to treat moderate to severe confusion (dementia) related to Alzheimer's disease. It does not cure Alzheimer's disease, but it may improve memory, awareness, and the ability to perform daily functions.
Dosing
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
Missed Dose
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
What is MEMANTINE used for?
MEMANTINE (MEM an teen) is used to treat dementia caused by Alzheimer's disease.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
What should I watch for while using this medicine?
Visit your doctor or health care professional for regular checks on your progress. Check with your doctor or health care professional if there is no improvement in your symptoms or if they get worse.
Medical uses
Memantine is used to treat moderate to severe confusion (dementia) related to Alzheimer's disease.
May Treat: Moderate to severe Alzheimer's type dementia
Brand Names: Namenda · Namenda XR · Namenda Titration Pak
Drug Class: Alzheimer's Disease Therapy - NMDA Receptor Antagonists
Availability: Prescription Required
Pregnancy: Consult a doctor before using
May Treat: Moderate to severe Alzheimer's type dementia
Brand Names: Namenda · Namenda XR · Namenda Titration Pak
Drug Class: Alzheimer's Disease Therapy - NMDA Receptor Antagonists
Availability: Prescription Required
Pregnancy: Consult a doctor before using
Lactation: Consult a doctor before using
Alcohol: Limit intake while taking this medication
Driving: May cause drowsiness or dizziness. Use caution
- If available, read the patient package insert
- Tell doctor your complete medical history
- Review all drugs you are taking with your doctor
- If available, read the patient package insert
- Tell doctor your complete medical history
- Review all drugs you are taking with your doctor
- Swallow capsules whole.
- For capsule sprinkle, extended release 24 hr products : Do not chew or crush. May add contents to applesauce. Do not chew. May take with or without food. Take at the same time every day. May make you drowsy or dizzy. Drive with caution.
- For solution, oral products : Measure dose using a dosing spoon/cup/syringe.
- For tablet products : Take at the same time(s) daily as directed. May make you dizzy. Use caution when driving. Reduce or avoid drinking alcohol. Call doctor if you are not getting better.
Administration
Preparation
Treatment
Management
- Memantine is used to treat the symptoms of Alzheimer's disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities). Memantine is in a class of medications called NMDA receptor antagonists. It works by decreasing abnormal activity in the brain. Memantine may improve the abili...
Risks
- Memantine comes as a tablet, a solution (liquid), and an extended-release (long-acting) capsule to take by mouth. The solution and tablet are usually taken once or twice a day with or without food. The capsule is taken once a day with or without food. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. To …
Prevention
- If you are taking the oral solution, follow the manufacturer's directions to measure your dose using the oral syringe that is supplied with the medication. Slowly squirt the medication from the syringe into a corner of your mouth and swallow it. Do not mix the medication with any other liquid. After you take your medication, follow the manufacturer's directions to re-seal the bottle a…
Indications and Usage For Memantine
- Your doctor will probably start you on a low dose of memantine and gradually increase your dose, not more than once every week.
Memantine Dosage and Administration
- Memantine helps to control the symptoms of Alzheimer's disease but does not cure it. Continue to take memantine even if you feel well. Do not stop taking memantine without talking to your doctor.
Dosage Forms and Strengths
- Memantine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
Contraindications
- Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, t…
Warnings and Precautions
Adverse Reactions
- The recommended starting dose of memantine hydrochloride is 5 mg once daily. The dose should be increased in 5 mg increments to 10 mg/day (5 mg twice daily), 15 mg/day (5 mg and 10 mg as separate doses), and 20 mg/day (10 mg twice daily). The minimum recommended interval between dose increases is one week. The dosage shown to be effective in contro...
Drug Interactions
- memantine hydrochloride tablets USP, 5 mg are orange colored, capsule shaped, biconvex, film-coated tablets debossed with ‘RDY’ on one side and ‘596’ on other side. memantine hydrochloride tablets USP, 10 mg are grey colored, capsule shaped, biconvex, film-coated tablets debossed with ‘RDY’ on one side and ‘597’ on other side.
Use in Specific Populations
- memantine hydrochloride tablets are contraindicated in patients with known hypersensitivity to memantine hydrochloride or to any excipients used in the formulation.
Overdosage
- Genitourinary Conditions
Conditions that raise urine pH may decrease the urinary elimination of memantine resulting in increased plasma levels of memantine [see Drug Interactions (7.1)].
Memantine Description
- Clinical Trials Experience
memantine hydrochloride was evaluated in eight double-blind placebo-controlled trials involving a total of 1862 dementia (Alzheimer’s disease, vascular dementia) patients (940 patients treated with memantine hydrochloride and 922 patients treated with placebo) for a treatment period up … - Postmarketing Experience
The following adverse reactions have been identified during post-approval use of memantine. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug ex…