multifactorial Medspeak adjective Referring to the influence of multiple factors in the aetiology of a particular disease (e.g., diabetes, hypertension), attributable to genetic and environmental components.
What are the causes of multifactorial diseases?
Multifactorial diseases are caused by a combination of the effects of multiple genes or by interactions between genes and the environment. C.W. Duarte, ... H.K. Tiwari, in Reference Module in Biomedical Sciences, 2014 Multifactorial diseases are caused by multiple genetic and environmental factors.
What is the study of multifactorial disease?
Abstract. Multifactorial diseases are caused by multiple genetic and environmental factors. The study of multifactorial disease involves several steps, including determination of disease heritability, segregation analysis to determine the genetic model, linkage or association mapping to identify genetic loci underlying the disease,...
What is multifactorial aetiology?
multifactorial Medspeak adjective Referring to the influence of multiple factors in the aetiology of a particular disease (e.g., diabetes, hypertension), attributable to genetic and environmental components. Molecular biology
What is a multifactorial process?
2 or multifactor \ -ˈfak-tər \ : having, involving, or produced by a variety of elements or causes a multifactorial study a disease with a multifactorial etiology Ligament damage, particularly in a throwing arm, is a complex, multifactorial process. — Matt McCarthy Love words? Need even more definitions?
What is an example of multifactorial?
Types of multifactorial traits and disorders High blood pressure and high cholesterol. Diabetes. Alzheimer disease. Schizophrenia.
What is a multifactorial?
Multifactorial inheritance means that "many factors" (multifactorial) are involved in causing a birth defect. The factors are usually both genetic and environmental, where a combination of genes from both parents, in addition to unknown environmental factors, produce the trait or condition.
What diseases are multifactorial?
Some common multifactorial disorders include schizophrenia, diabetes, asthma, depression, high blood pressure, Alzheimer's, obesity, epilepsy, heart diseases, Hypothyroidism, club foot and even dandruff.
What is another word for multifactorial?
What is another word for multifactorial?compositecompoundmultipleintricatemultifacetedfusedmanifoldamassedmingledclustered32 more rows
How do you use multifactorial?
having or stemming from a number of different causes or influences: Some medical researchers regard cancer as a multifactorial disease. We have a challenge that will make you blush: do you know the many words and ways to describe the opposite of red?
What is the multifactorial model?
a model of inheritance positing that the genetic and environmental causes of a trait constitute a single continuous variable, the liability, and that if that liability is exceeded, the trait will manifest itself.
Definition of multifactorial
1 : caused or marked by a polygenic mode of inheritance dependent on a number of genes at different loci The essence of multifactorial (polygenic) inheritance is that a single component of the phenotype (a single character) can be controlled by several independent gene loci.
Examples of multifactorial in a Sentence
Recent Examples on the Web With climate change and overfishing dramatically reshaping marine ecosystems, the answer is almost always multifactorial. — Washington Post, 10 Feb. 2022 Those problems were multifactorial and mighty even before Covid-19 exposed them globally. — Praduman Jain, Forbes, 18 Jan. 2022
Medical Definition of multifactorial
1 : caused or marked by a polygenic mode of inheritance dependent on a number of genes at different loci The essence of multifactorial (polygenic) inheritance is that a single component of the phenotype (a single character) can be controlled by several independent gene loci.
What is multifactorial disease?
Multifactorial diseases are caused by a combination of the effects of multiple genes or by interactions between genes and the environment.
What are the factors that cause multifactorial disease?
Multifactorial diseases are caused by multiple genetic and environmental factors . The study of multifactorial disease involves several steps, including determination of disease heritability, segregation analysis to determine the genetic model, linkage or association mapping to identify genetic loci underlying the disease, fine mapping to determine the causal variants, and replication and functional analysis to confirm the initial findings. The HapMap and 1000 Genomes projects, which surveyed genetic variation in a diverse set of human populations, led to advances in affordable high-throughput genotyping technology that enabled myriad genome-wide association studies for many common diseases. Direct sequencing, which allows for unbiased assessment of all sources of genetic variation, has been used more recently. Important statistical considerations include adjusting for population admixture to prevent false positive associations, quality control, appropriate design and analysis of discovery and validation sets, and adjustment for multiple testing. The power and interpretability of genetic studies are improved by incorporating prior biological knowledge such as genes or pathways, and by performing cross-platform integration and functional assessment. Many changes and advances have occurred in the study of multifactorial diseases with advances in genotyping technology, and yet more change is likely in the years to come.
What are the genetic factors that cause MS?
MS is a multifactorial disease for which many susceptibility genes and environmental risk factors have been identified. The genetic risk factors with the strongest effect are found to be HLA alleles, most of the so far identified environmental risk factors also have a fairly strong effect on the risk of developing MS (Figure 6.1 ). The results from interaction analyses are beginning to allow us to group risk factors into hypothetical groups which act together to cause disease as is illustrated in Figure 6.2. For example, presence of HLA-DRB1*15, absence of HLA*A2, and smoking seem to all be included in the same sufficient cause. There will be many different sufficient causes and the same risk factor can be present in several different sufficient causes. Having identified risk factors acting together to cause disease will help us to better design experiments to test possible disease mechanisms, which in turn will help us to design ways to treat or prevent disease.
Is alcoholism a multifactorial disease?
Alcoholism is a multifactorial disease of unclear molecular underpinnings. Currently, we are witnessing a major shift in our understanding of the functional elements of the genome, which could help us to discover novel insights into the nature of alcoholism. In humans, the vast majority of the genome encodes non-protein-coding DNA with unclear function. Recent research has started to unveil this mystery by describing the functional relevance of microRNAs, and examining which genes are regulated by non-protein-coding DNA. Here, I describe alcohol regulation of microRNAs and provide examples of microRNAs that control the expression of alcohol-relevant genes. Emphasis is put on the potential of microRNAs in explaining the polygenic nature of alcoholism and prospects of microRNA research and future directions of this burgeoning field.
multifactorial
1. (Genetics) genetics of or designating inheritance that depends on more than one gene
multifactorial
English-Spanish/Spanish-English Medical Dictionary Copyright © 2006 by The McGraw-Hill Companies, Inc. All rights reserved.
What is multifactorial inheritance?
Multifactorial inheritance refers to disorders and genetic traits that occur and are determined by the interaction of environmental factors and multiple genes. In many cases, the specific genes involved in these disorders are unknown or their role is poorly characterized. Multifactorial inheritance, generally, is thought to encompass threshold traits, qualitative traits, and complex disorders of adulthood, such as diabetes and heart disease. A number of common birth defects are believed to be inherited in a multifactorial fashion as threshold traits. Threshold traits are present only if a certain level of the combination of genetic liability and environmental exposure is reached. Neural tube defects, congenital heart defects, cleft lip, and club foot are all most commonly due to multifactorial genetic inheritance, although some may be due to monogenic or chromosome disorders. In contrast, for qualitative traits that result from the interaction of multiple genes and the environment, the distribution and phenotype of the trait follows a normal, bell-shaped distribution. Many human traits (e.g., height, weight, blood pressure, intelligence) are inherited in this manner. Although it is clear that many disorders of adulthood have genetic and environmental interactions, with clear clustering in families and strong environmental influences, the underlying genes and genetic mechanisms are poorly characterized for most of these conditions.
Which haplotype is more frequent in reflux nephropathy?
The HLA haplotypes A2-B8 and A9-B12 are more frequent in patients with reflux nephropathy than in patients with other end-stage renal diseases. Kuroda et al. (116) found that individuals with the transforming growth factor-beta1-509CC and 869TT genotype may have an increased susceptibility to vesicoureteral reflux.
What is the coefficient of parentage?
Malécot defined the coancestry coefficient (coefficient of parentage) as the probability of a pair of the same alleles from both parents being identical by descent in 1948, with which the general relationship of covariance between relatives was established.
Is diabetes mellitus polygenic?
Type 2 diabetes mellitus has a polygenic inheritance, and an understanding of the patient’s family history of this condition should be ascertained as part of the history. First-degree relatives of persons with Type 2 diabetes mellitus already have evidence of insulin resistance [41].
Why is it so hard to identify the role of genetics in complex disorders?
It may be difficult to identify the role of genetics in these disorders, particularly because families often also share environments and may have similar lifestyles. This makes it difficult to determine a person’s risk ...
Why are complex disorders so difficult to treat?
Complex disorders are also difficult to study and treat because the specific factors that cause most of these disorders have not yet been identified. Researchers continue to look for major contributing genes for many common, complex disorders.
