Does N-nitroso-N-methyl-4-aminobutyric acid (NMBA) have an MBA?
No, not an MBA, which is a business degree and would be strange for a medication to have, but N-Nitroso-N-methyl-4-aminobutyric acid (NMBA)? If it does, it really shouldn't.
Does your blood pressure medication have NMBA?
Does your blood pressure medication have NMBA? No, not an MBA, which is a business degree and would be strange for a medication to have, but N-Nitroso-N-methyl-4-aminobutyric acid (NMBA)? If it does, it really shouldn't.
What is the formula for N-nitroso-N-methyl-4-aminobutyric acid?
N-Nitroso-N-methyl-4-aminobutyric acid PubChem CID 43659 Molecular Formula C5H10N2O3 Synonyms 61445-55-4 N-NITROSO-N-METHYL-4-AMINOBUT ... Molecular Weight 146.14 Date s Modify 2021-07-10 Create 2005-08-08 2 more rows ...
Is NMBA in ARBs a carcinogen?
The FDA acknowledged that the detection of NMBA above acceptable levels in an active pharmaceutical ingredient in its ongoing review of ARBs is new and referred to it as "a known animal and potential human carcinogen.".
What does NMBA stand for in blood pressure medicine?
NMBA stands for N-Methylnitrosobutyric acid, something that you don’t want in your blood pressure medications. But alas, this probable carcinogen continues to appear in various medications at higher than acceptable levels. The latest news is that Torrent Pharmaceuticals Limited is further expanding its recall of Losartan Potassium Tablets USP ...
Is NDMA bad for you?
Short-term exposure to chemicals like NBMA, N-nitrosodimethylamine (NDMA), and N-nitrosodiethylamine (NDEA) at such levels may not have any bad health effects. Such chemicals can already be found as contaminants in many parts of our environment.
Losartan Lawsuits
After the initial valsartan recall was announced, some doctors switched their patients to losartan, which is in the same class of blood pressure medications (angiotensin II receptor blockers, or ARBs).
Irbesartan Lawsuits
Although some lots of irbesartan have also been recalled due to NDMA and NDEA contamination, there has been little action yet on the legal front. This is likely due to the fact that irbesartan is used by fewer people (3.6 million) than either valsartan or losartan, and fewer lots of it have been identified as containing cancer-causing contaminants.
Olmesartan Lawsuits
Olmesartan (brand name Benicar) is another ARB blood pressure drug that has been the subject of legal claims for several years now due to links between the drug and dangerous gastrointestinal side effects, including sprue-like enteropathy. Those Benicar lawsuits are unrelated to the current sartan recalls tied to NDMA, NDEA and NMBA.
What to Do If You Take a Sartan ARB Prescription
If you take any of the blood pressure drugs that are being recalled - valsartan, losartan, irbesartan or olmesartan - here are some things you should do:
Check If Your Blood Pressure Drugs Were Recalled
The FDA will continue to update the list of products included in the recall as more information becomes available from ongoing testing. If patients take Losartan, Valsartan, or Irbesartan products, they should check the list periodically, as information may change.
Losartan Recalls Due to NMBA
In September 2019, Torrent Pharma expanded a recall for Losartan after tests detected a cancer-causing impurity called NMBA.
FDA Finds New Type of Carcinogen (NMBA)
March 2019 — Another 87 lots of Losartan medications were recalled after the FDA detected a 3rd type of carcinogen called N-Nitroso-N-methyl-4-aminobutyric acid (NMBA) at dangerous levels.
What is Losartan?
Losartan is a generic medication that treats high blood pressure (hypertension) and helps protect the kidneys from damage due to diabetes (nephropathy). Losartan can also lower the risk of strokes in patients with an enlarged heart.
What is the Problem?
A small amount of blood pressure medications containing Losartan have been linked to a possible risk of cancer due to a toxic chemical impurity that was left over from the drug’s manufacturing process. Patients may have been exposed to this toxic chemical for years.
Losartan Recalls
April 2019 — Torrent Pharmaceuticals Ltd. announced a voluntary recall for Losartan Potassium Tablets USP and Losartan Potassium/Hydrochlorothiazide tablets. Teva Pharmaceuticals announced a recall for Losartan that was sold by Golden State Medical Supply. Legacy Pharmaceuticals also expanded its recall to include 1 additional lot of Losartan.
Hyzaar Recall
November 2018 — Sandoz Inc. announced a voluntary recall for 100-mg/25-mg tablets of Hyzaar (Losartan and Hydrochlorothiazide). The bottles are marked with NDC 0781-5207-10, Lot number JB8912; Exp. Date 06/2020, and distributed on or after October 8, 2018.
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