what is niacin inositol hexanicotinate used for

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What is the connection between niacin and inositol?

There are different types of cholesterol, and some are better than others.

• Low-density lipoprotein (LDL)— This “bad” cholesterol is in charge of transporting cholesterol particles through your body. ...
• Very-low-density lipoprotein (VLDL)— This lipoprotein is high in triglycerides, which is a type of fat. ...
• High-density lipoprotein (HDL)— This “good” cholesterol transports excess cholesterol back to your liver.

What foods are good sources of niacin?

The foods listed below are my ducks favorite treats and also a good sources of Niacin:

• Peas (a duck favorite!)
• sweet potatoes (raw or cooked)
• tuna fish (packed in water)
• salmon (ducks also love salmon skin)
• sardines (packed in water)
• Feeder Fish (another duck favorite! They love hunting for feeder fish in their kiddie pool)
• Pumpkin
• Nutritional Yeast (sprinkled on feed)

What are inositol side effects?

• One of the most commonly seen side effect of inositol is diarrhea, when high dosage of inositol is taken. • Inositol taken in high amount can cause nausea and vomiting. • Mega doses of inositol, hamper absorption of iron, calcium and zinc into the bloodstream. • High blood pressure is another side-effect of inositol.

What are the risks of niacin?

• Dizziness or faintness
• dryness of the skin
• fever
• frequent urination
• joint pain
• muscle aching or cramping
• side, lower back, or stomach pain
• swelling of the feet or lower legs
• unusual thirst
• unusual tiredness or weakness

More items...

What is inositol Hexanicotinate good for?

Inositol nicotinate is used for blood circulation problems, including a painful response to cold, especially in the fingers and toes (Raynaud syndrome). It is also used for high cholesterol, high blood pressure, and many other conditions, but there is no good scientific evidence to support these uses.

Is inositol Hexanicotinate the same as niacinamide?

Vitamin B3 is one of 8 B vitamins. It is also known as niacin (nicotinic acid) and has 2 other forms, niacinamide (nicotinamide) and inositol hexanicotinate, which have different effects from niacin. All B vitamins help the body convert food (carbohydrates) into fuel (glucose), which the body uses to produce energy.

What are the benefits of taking niacin?

5 health benefits of niacinImproves blood fat levels. Niacin may help to improve your blood fat levels by: ... May reduce blood pressure. ... May help treat type 1 diabetes. ... Boosts brain function. ... Improves skin health.

Is inositol and niacin the same thing?

Inositol nicotinate is a vasodilator and source of niacin found in dietary supplements. Inositol nicotinate, also known as Inositol hexaniacinate/hexanicotinate or "no-flush niacin", is a niacin ester and vasodilator.

Is 500 mg of inositol Hexanicotinate safe?

No adverse effects have been observed in clinical trials using inositol hexanicotinate up to 4000 mg daily for 3 months. Even though there is no genotoxicity data available on inositol hexanicotinate, there are no safety concerns.

What is the best niacin to take?

Best Niacin SupplementsBest Niacin Supplement Overall: Transparent Labs B Complex.Best Niacin Supplement for Pre-Workout: Kaged Muscle Pre-KAGED.Best Niacin Powder: BulkSupplements Niacin.Best Niacin for Slow Release: ENDUR-ACIN Niacin.Best Bulk Niacin Supplement: BulkSupplements Niacin.

Does niacin cause weight gain?

Niacin has been found to increase daily feed intake, weight gain and percentage of abdominal fat in chicken when increasing supplementation from 0 to 60 mg nicotinic acid per kilogram diet[24]. It has been found that formula feeding leads to more fat gain, which may account for increased risk of later obesity[81,82].

Will niacin help you lose weight?

Consuming higher doses of niacin by taking supplements is likely effective for treating high cholesterol -- and possibly effective for helping with osteoarthritis, hardening of your arteries, heart attack risks, diabetes and cataracts. But taking niacin supplements does not cause weight loss.

When should I take niacin morning or night?

In general, the immediate-release form of niacin should be taken after your evening meal and the extended-release form should be taken at bedtime after a low-fat snack. Taking it in the morning or on an empty stomach might cause you to experience more side effects such as flushing and stomach upset.

Can niacin damage your liver?

Because niacin has also been linked to liver damage and strokes, most doctors now recommend it only for people who can't take statins to treat high triglyceride levels. If you're concerned about taking niacin, talk to your doctor.

What are the health benefits of inositol?

Health Benefits of InositolLowering the risk of metabolic syndrome, which is a risk factor for a number of conditions including increased belly fat, high blood pressure, and high blood sugar.Lowering high cholesterol1.Helping the body regulate and process insulin.Helping relieve anxiety and symptoms of panic disorder.More items...•

Is inositol hard on liver?

Liver disease: Niacin, a chemical that is released when inositol nicotinate breaks down in the body, can cause liver damage. Don't use inositol nicotinate if you have liver disease. Sensitivity to niacin: Niacin is released when inositol nicotinate is processed by the body.

What is inositol hexanicotinate?

Inositol hexanicotinate is a popular form of food supplement where it acts as a source of niacin (vitamin B3), one of the essential human nutrients. Image Credit: Danijela Maksimovic / Shutterstock.com.

How much inositol hexanicotinate is absorbed into the bloodstream?

Although gastrointestinal absorption of inositol hexanicotinate can vary significantly, approximately 70% of an orally ingested dose absorbs into the bloodstream. Oral administration of inositol hexanicotinate results in a steady increase in the level of free nicotinic acid in blood and plasma. The compound appears to be metabolized slowly, ...

How long does inositol hexanicotinate last?

No adverse effects have been observed in clinical trials using inositol hexanicotinate up to 4000 mg daily for 3 months. Even though there is no genotoxicity data available on inositol hexanicotinate, there are no safety concerns.

How long does it take for nicotinic acid to be metabolized?

The compound appears to be metabolized slowly, with serum levels of nicotinic acid peaking roughly 6-10 hours after ingestion, compared to the intake of free nicotinic acid when plasma levels can peak after merely half an hour. The extent of hydrolysis of inositol hexanicotinate appears to be very low; therefore, ...

What is IHN in chemistry?

Inositol Hexanicotinate (IHN) Inositol hexanicotinate (also known as inositol hexaniacinate or inositol nicotinate) is the hexanicotinic acid ester of meso-inositol. This chemical compound consists of six molecules of nicotinic acid (niacin) with an inositol molecule in the center of the structure.

How many molecules are in nicotinic acid?

This chemical compound consists of six molecules of nicotinic acid (niacin) with an inositol molecule in the center of the structure. It is a popular form of food supplement where it acts as a source of niacin (vitamin B3), one of the essential human nutrients.

Does inositol hexanicotinate help with endothelium?

Clinical value and dosing. Inositol hexanicotinate has a proven beneficial effect on endothelium- dependent vasodilatation (widening of blood vessels), thus it improves blood flow in conditions where it is compromised. In Europe it is often prescribed for the symptomatic relief of Raynaud’s phenomenon and severe intermittent claudication.

What is inositol hexanicotinate?

Inositol hexanicotinate is a vasodilator when taken in large doses. It causes the release of the compound histamine, which relaxes the muscles around your arteries; this causes an increase of the interior diameter of arteries, improving blood flow. Inositol hexanicotinate also breaks up a protein that normally causes blood clotting.

Is inositol hexanicotinate a dietary supplement?

It is available as a dietary supplement that has several health benefits; it is used to reduce elevated blood lipids, improve circulation and reduce blood clotting. Speak to your doctor before taking inositol hexanicotinate or niacin supplements.

Does inositol hexanicotinate lower cholesterol?

Inositol hexanicotinate may be used to lower elevated blood levels of cholesterol and triglycerides. Elevated cholesterol and triglyceride levels are associated with an increased risk of cardiovascular disease. Inositol hexanicotinate may increase HDL or “good” cholesterol.

Can niacin cause a flush?

No-Flush Niacin. Regular niacin supplements, when taken in high dosages, can cause a niacin flush -- an uncomfortable reaction resulting in a burning sensation and reddening of the skin of your face and joints. Inositol hexanicotinate is less likely to cause the niacin flush; however, it may be more likely to cause liver damage with long-term use.

Does niacin help with heart disease?

According to “Natural Standard,” an evidence-based monograph that focuses on alternative medicine, niacin and inositol hexanicotinate may help to reduce the risk of atherosclerosis and cardiovascular events, such as: the development of heart disease or heart attack [1] (https://naturalmedicines.therapeuticresearch.com/index-abstract.asp?

How long does inositol nicotinate last?

Some research shows that taking a specific inositol nicotinate product (Hexopal) by mouth for up to 3 months improves walking distance and reduces symptoms. But other research does not show this effect.

What is nicotinate made of?

Overview. Inositol nicotinate is a compound made of niacin ( vitamin B3) and inositol. Inositol occurs naturally in the body and can also be made in the laboratory. Inositol nicotinate is used for blood circulation problems, including a painful response to cold, especially in the fingers and toes (Raynaud syndrome).

What is the effect of nicotinate on the body?

Inositol nicotinate releases niacin, or vitamin B3, when it is processed by the body. Niacin can widen blood vessels, lower blood levels of fats such as cholesterol, and break up a protein needed for the clotting of blood.

Is niacin released when inositol nicotinate is processed by the

Sensitivity to niacin: Niacin is released when inositol nicotinate is processed by the body. If you are sensitive to niacin, don't use inositol nicotinate. Stomach ulcers: Large amounts of niacin, a chemical that is released when inositol nicotinate breaks down in the body, might make peptic ulcer disease worse.

Can you take inositol nicotinate if you have kidney problems?

Don't use inositol nicotinate if you have kidney problems. Liver disease: Niacin, a chemical that is released when inositol nicotinate breaks down in the body, can cause liver damage. Don't use inositol nicotinate if you have liver disease .

Does inositol nicotinate cause heart problems?

In theory, inositol nicotinate might increase the risk of bleeding and make bleeding disorders worse. Heart disease/heart-related chest pain (unstable angina): Large amounts of niacin, a chemical that is released when inositol nicotinate breaks down in the body, can increase the risk of irregular heartbeat.

Does inositol nicotinate lower cholesterol?

Some research shows that inositol nicotinate can decrease cholesterol levels. But other research shows that inositol nicotinate does not have an effect. Leg pain during exercise due to poor blood flow (intermittent claudication). The effectiveness of inositol nicotinate for treating intermittent claudication is unclear.

What is a DRI for niacin?

DRI is the general term for a set of reference values used for planning and assessing nutrient intakes of healthy people. These values, which vary by age and sex, include:

Where is niacin absorbed?

Ingested niacin is absorbed primarily in the small intestine, but some is absorbed in the stomach [ 1-3 ]. Even when taken in very high doses of 3–4 g, niacin is almost completely absorbed. Once absorbed, physiologic amounts of niacin are metabolized to NAD.

How much niacin is in a serving of nuts?

Plant-based foods, such as nuts, legumes, and grains, provide about 2-5 mg niacin per serving, mainly as nicotinic acid. In some grain products, however, naturally present niacin is largely bound to polysaccharides and glycopeptides that make it only about 30% bioavailable [ 3, 4 ].

What is the role of NADP in cellular antioxidants?

NADP, in contrast, enables anabolic reactions, such as the synthesis of cholesterol and fatty acids, and plays a citical role in maintaining cellular antioxidant function. Most dietary niacin is in the form of nicotinic acid and nicotinamide, but some foods contain small amounts of NAD and NADP.

Is niacin a bioavailable substance?

Niacin that is added to enriched and fortified foods is in its free form and therefore highly bioavailable [ 2 ]. Tryptophan is another food source of niacin because this amino acid—when present in amounts beyond that required for protein synthesis—can be converted to NAD, mainly in the liver [ 3, 5 ].

Is nicotin a water soluble vitamin?

Niacin (also known as vitamin B3) is one of the water-soluble B vitamins. Niacin is the generic name for nicotinic acid (pyridine-3-carboxylic acid), nicotinamide (niacinamide or pyridine-3-carboxamide), and related derivatives, such as nicotinamide riboside [ 1-3 ]. Niacin is naturally present in many foods, added to some food products, and available as a dietary supplement.

Is niacin a reliable indicator of niacin?

Levels of niacin in the blood are not reliable indicators of niacin status. The most sensitive and reliable measure of niacin status is the urinary excretion of its two major methylated metabolites, N1-methyl-nicotinamide and N1-methyl-2-pyridone-5-carboxamide [ 2 ].

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing , call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

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Niacin vs Niacinamide

Niacinamide (aka nicotinamide or nicotinic acid amide) is derived from niacin. The body has the ability to convert niacin to niacinamide. However, there are some critical differences between these two vitamin B3 components. Niacinamide can also be made by our body from an amino acid known as tryptophan.

Niacinamide Benefits

High niacin doses can cause flushing, which is a condition that causes blood vessels to widen. This makes the capillaries under the skin expand to allow more blood to flow, causing the skin to become red and itchy.

Niacin and Niacinamide Dosage

If you are just starting to take niacin, begin at a low dose and gradually increase the dose as recommended by your health practitioner to help minimize flushing.

How Niacin Affects the Body - Using Niacin for Anxiety

Both niacin and niacinamide can be used in treating physical and emotional stress. Often niacin or niacinamide are used for treating anxiety and depression as they promote calmness and better sleep by increasing blood flow, reducing blood pressure, eliminating excess adrenaline and regulating hormones.

What are the health problems associated with inositol niacinate?

If you have any of these health problems: Bleeding problems, liver problems or rise in liver enzymes, or ulcer disease. This is not a list of all drugs or health problems that interact with inositol niacinate. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems.

Can you take inositol niacinate with all your medications?

You must check to make sure that it is safe for you to take inositol niacinate with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What is the effect of inositol hexaniacinate?

When six niacin molecules are bound to a large molecule of inositol, inositol hexaniacinate is the result. Inositol hexaniacinate delivers niacin in a natural slow-release manner, allowing for all the cholesterol-modulating benefits of niacin with little potential for side-effects such as flushing (itching, heat and redness in the skin) ...

Does inositol hexaniacinate increase gastric acid?

Hydrochloric Acid Deficiency. Inositol hexaniacinate might play a role in both the reduction of achlorhydria-related symptoms and in augmenting gastric acid secretion. It may enhance the production of hydrochloric acid in a manner that cannot be explained by it simply being an acid.

Is inositol hexaniacinate the same as niacin?

Preliminary research has shown that inositol hexaniacinate has similar actions to niacin. Inositol hexaniacinate is used primarily as flush-free niacin, having the same cholesterol-lowering abilities as niacin without the flushing common to high-dose niacin therapy.

Does inositol hexanicotinate cause flushing?

Inositol Hexaniacinate (also known as inositol hexanicotinate) is a newer form of vitamin B-3 ( niacin ), which does not cause flushing. Diagnose your symptoms now! see your health summarized and in detail. understand what's happening to your body. let The Analyst™ find what's wrong.

Does niacin help with dysmenorrhea?

There is evidence that niacin may be beneficial for the treatment of dysmenorrhea . Hudgins reported on a group of 80 women suffering from painful menstrual cramps who were supplemented with 100mg niacin twice daily, beginning 7 to 10 days before the onset of menses and then every 2 to 3 hours during heavy cramps . 90% of participants experienced significant relief. It should be noted that the dosage required during heavy cramping is high enough to cause unpleasant side effects and that it would seem that the use of flush-free niacin ( inositol hexaniacinate) might be indicated. In addition, the inositol would provide lipotropic effects. Lipotropic agents help in the metabolism of hormones by the liver, important for the prevention of PMS.

What is the effect of niacin on the body?

The niacin can widen blood vessels, lower blood levels of fats such as cholesterol, and break up a protein needed for the clotting of blood.

Why does inositol nicotinate cause leg cramps?

Cramping pain and weakness in the legs due to poor circulation (intermittent claudication). The effectiveness of inositol nicotinate for treating intermittent claudication is controversial.

What is nicotinate made of?

Inositol nicotinate is a compound made of niacin (vitamin B3) and inositol. Inositol occurs naturally in the body and can also be made in the laboratory. Inositol nicotinate is used for treating blood circulation problems, including pain when walking due to poor circulation in the legs (intermittent claudication);

Can you take inositol nicotinate if you have kidney problems?

Don't use inositol nicotinate if you have kidney problems. Liver disease: Niacin, a chemical that is released when inositol nicotinate breaks down in the body, can cause liver damage. Don't use inositol nicotinate if you have liver disease .

Can nicotinate cause low blood pressure?

Low blood pressure: Niacin, a chemical that is released when inositol nicotinate breaks down in the body, can cause low blood pressure. Use with caution. Kidney disease: Niacin, a chemical that is released when inositol nicotinate breaks down in the body, might accumulate in people with kidney disease and make their condition worse.

Does inositol nicotinate cause heart problems?

In theory, inositol nicotinate might increase the risk of bleeding and make bleeding disorders worse. Heart disease/heart-related chest pain (unstable angina): Large amounts of niacin, a chemical that is released when inositol nicotinate breaks down in the body, can increase the risk of irregular heartbeat.

Does inositol nicotinate lower cholesterol?

The effectiveness of inositol nicotinate for treating high cholesterol is controversial. While some research suggests that inositol nicotinate taken by mouth may decrease cholesterol levels, others research shows that inositol nicotinate does not have an effect.

Metabolism of The Inositol Hexanicotinate

Clinical Value and Dosing

• Inositol hexanicotinate has a proven beneficial effect on endothelium-dependent vasodilatation (widening of blood vessels), thus it improves blood flow in conditions where it is compromised. In Europe it is often prescribed for the symptomatic relief of Raynaud’s phenomenon and severe intermittent claudication. A common dose of inositol hexanicotin...

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