PLO gel is similar to the system used in the testosterone preparation Androgel. PLO gel is non-irritating to the skin, absorbs quickly and is practically odorless. It is best used with drugs with molecular weights less that 400.
What does PLO stand for in PLO gel?
The introduction of pluronic lecithin organogel (PLO) to the compounding world promised to improve the systemic absorption of medications through the skin. Over the years, many medications and combinations have been incorporated into PLO gels and prescribed despite the lack of human bioavailability studies.
What is PLO transdermal cream?
Description: A smooth, off-white oil-in-water emulsion developed for percutaneous absorption. Its hydrophilicity and lipophilicity support both water and lipid soluble drugs in relatively low concentrations (=< 10%). Fragrance-free.
Is PLO gel aqueous?
Usually it is made up of two phase, first pluronic gel (aqueous phase) and second lecithin phase (oil phase), i.e. pluronic gel combined with a lecithin phase. PLO gels formed are liquid (sol) at cold temperatures and undergo a phase change (gel) when the temperature is elevated.
What is lecithin Organogel?
5. Lecithin organogels. LOs are gels consisting of an organic medium in liquid phase. LOs are thermodynamically stable, clear, viscoelastic, biocompatible and isotropic gels which are composed of lecithin (Fig. 1), an organic solvent, and a polar liquid.
Where do you apply transdermal?
Apply the patch to a dry, flat skin area on your upper arm, chest, or back. Choose a place where the skin is not very oily and is free of scars, cuts, burns, or irritation.
What are the side effects of transdermal?
See also Warning section. Nausea, vomiting, constipation, lightheadedness, dizziness, drowsiness, dry mouth, or headache may occur. Irritation, itching, or redness at the application site may also occur. Some of these side effects may decrease after you have been using this medication for a while.
How do you mix diclofenac in PLO gel?
Directions:Weigh diclofenac powder and PLO gel.Dissolve diclofenac powder in alcohol.Gradually add small amounts of PLO gel to diclofenac powder and levigate until completely mixed.Transfer to final container and label.
What is aqueous gel?
Deriva MS Aqueous Gel is a medication used in the treatment of mild to moderate acne. It prevents the formation of small pimples, blackheads and whiteheads on the skin. It reduces excessive oil production of the skin and reduces inflammation or cleans the blocked pores.
Is PLO a Diffusimax?
Diffusimax is pluronic lecithin organogel, often abbreviated as PLO gel. It is a liposomal base that is used as a vehicle for preparing a wide range of topical formulations.
Is lecithin a binding agent?
Lecithin is a phospholipid that can be found within eggs, avocados, soybeans, and sunflowers. The substance acts as a binding agent that keeps ingredients stuck together. It may even play a role in increasing the potency of edibles.
What is hydrogel Organogel?
Hydrogels and organogels are semi-solid systems, in which a liquid phase is immobilized by a three-dimensional network composed of self-assembled, intertwined polymer/gelator fibers.
What is lecithin and lysolecithin?
Lysolecithin is produced from the enzymatic conversion of lecithin, cleaving one of the fatty acids from the glycerol backbone of the phospholipids [5]. The resulting lysophospholipids are smaller and more hydrophilic molecules, with a lower critical micelle concentration than phospholipids [6].
What is transdermal cream used for?
Transdermal medicine transports medicine to the area of injury or pain. It is perfect for pain management, pediatric and sports medicine. This is one the fastest and effective way to manage medicine. This technique is widely used because of they absorb the medicine directly through the skin.
Which are benefits to using PLO to apply medications?
The introduction of pluronic lecithin organogel (PLO) to the compounding world promised to improve the systemic absorption of medications through the skin. Over the years, many medications and combinations have been incorporated into PLO gels and prescribed despite the lack of human bioavailability studies.
How does transdermal cream work?
Transdermal products utilize several methods of enhancing penetration through the Stratum Corneum, the primary barrier of the skin, allowing sufficient amounts of the drug to either reach systemic circulation or deeper underlying tissues.
What does PLO stand for pharmacy?
Invented in the early 1990s as an alternative to oral medications, PLO stands for Pluronic Lecithin Organogel, a mixture of oil and water that thickens to form a gel. The PLO gel can be applied to the skin at the site of the pain or to the inside of the wrist for a full-body effect.
What is a transdermal PLO gel?
Transderma PLO gel represents a ready-to-use PLO gel. This base is designed for transdermal delivery of lipophilic APIs such as NSAIDs and bioidentical hormones.
What is a TD PLO gel?
TD PLO gel represent a ready-to-use PLO gel (Premium Lecithin Organogel). This base is designed for the transdermal delivery of lipophilic APIs such as NSAIDs and bioidentical hormones. PLO gels have already gained acceptance as the transdermal vehicle of choice for a variety of drugs including Diclofenac, Ibuprofen, Ketamine, Progesterone and Testosterone.
What is ketoprofen?
Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat pain or inflammation caused by arthritis.
Warnings
Ketoprofen can increase your risk of fatal heart attack or stroke. Do not use ketoprofen just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Ketoprofen may also cause stomach or intestinal bleeding, which can be fatal.
Before taking this medicine
Ketoprofen can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
How should I take ketoprofen?
Use exactly as directed on the label, or as prescribed by your doctor. Use the lowest dose that is effective in treating your condition.
What happens if I miss a dose?
Since ketoprofen is used when needed, you may not be on a dosing schedule. Skip any missed dose if it's almost time for your next dose. Do not use two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking ketoprofen?
Do not take ketoprofen regular capsules and extended-release capsules at the same time.
Warnings
Diclofenac topical can increase your risk of fatal heart attack or stroke. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Diclofenac topical may also cause stomach or intestinal bleeding, which can be fatal.
Before taking this medicine
Diclofenac topical can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use diclofenac topical just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
How should I use diclofenac topical?
Follow all directions on your prescription label and read all medication guides. Use the lowest dose that is effective in treating your condition.
What happens if I miss a dose?
Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while using diclofenac topical?
Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to diclofenac (such as aspirin, ibuprofen, ketoprofen, or naproxen ).
Diclofenac topical side effects
Get emergency medical help if you have signs of an allergic reaction ( hives, sneezing, runny or stuffy nose, wheezing or trouble breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
