Precautions
Protonix (pantoprazole) is a proton pump inhibitor that decreases the amount of acid produced in the stomach. Protonix is used to treat erosive esophagitis (damage to the esophagus from stomach acid caused by gastroesophageal reflux disease, or GERD) in adults and children who are at least 5 years old.
What is Protonix used to treat?
Protonix. Protonix (pantoprazole sodium) is a drug in a class of powerful acid-suppressing medications called proton pump inhibitors (PPIs). These medicines can cause rare but life-threatening side effects. Protonix is one of several PPIs named in lawsuits over serious kidney conditions.
Is Protonix a proton pump inhibitor?
Recommended Dosage The dosage of PROTONIX I.V. for Injection in patients with pathological hypersecretory conditions including Zollinger-Ellison Syndrome varies with individual patients. The recommended adult dosage is 80 mg intravenously every 12 hours.
What is the recommended dosage for Protonix IV?
The active ingredient in PROTONIX® I.V. (intravenous pantoprazole sodium) for Injection is a substituted benzimidazole, sodium 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl] sulfinyl]-1H-benzimidazole, a compound that inhibits gastric acid secretion.
What is the active ingredient in Protonix?
Why is iv Protonix given?
What is Protonix IV and how is it used? Protonix IV is a prescription medicine used to treat the symptoms of Erosive Esophagitis associated with GERD, short-term treatment of GERD, and Zollinger-Ellison Syndrome. Protonix IV may be used alone or with other medications.
What conditions does Protonix treat?
What Conditions does Protonix Treat?heartburn.inflammation of the esophagus with erosion.medication treatment for healing erosive esophagitis.gastroesophageal reflux disease.a stomach ulcer.an ulcer of the duodenum.ulcer of duodenum caused by bacteria Helicobacter pylori.More items...
How fast does Protonix work IV?
PROTONIX I.V. for Injection had an onset of antisecretory activity within 15 to 30 minutes of administration.
How often is iv Protonix given?
The recommended adult dosage of PROTONIX I.V. is 40 mg given once daily by intravenous infusion for 7 to 10 days. Discontinue treatment with PROTONIX® I.V. as soon as the patient is able to receive treatment with PROTONIX Delayed-Release Tablets or Oral Suspension.
Why does everyone in the hospital get Protonix?
Many patients who are admitted into hospitals are put on proton pump inhibitors (PPIs) both to prevent gastrointestinal bleeding and as heartburn/gastroesophageal reflux disease relief after discharge.
What is the most common side effect of Protonix?
The following are the most commonly reported Protonix side effects: Nausea or vomiting. Diarrhea or constipation. Stomach pain.
What are side effects of PROTONIX?
The most common side effects of PROTONIX in adults include: headache, diarrhea, nausea, stomach-area (abdominal) pain, vomiting, gas, dizziness, and joint pain.
When is the best time of day to take PROTONIX?
It's best to take pantoprazole an hour before a meal. Swallow tablets whole with a drink of water.
Why is PROTONIX given for GI bleed?
PPIs reduce gastric acid secretion for up to 36 hours,41 thereby promoting healing of ulcers and erosions as well as stabilizing thrombi and decreasing rates of GI bleeding in patients on DAPT.
Does Protonix stop bleeding ulcers?
In conclusion, IV pantoprazole provides an effective option in the treatment of upper GI bleeding and the prevention of rebleeding, and for the prophylaxis of acute bleeding stress ulcers.
How long does Protonix stay in system?
How long does Protonix stay in your system? Protonix has a half-life of one hour in the body. This means that after one hour of taking Protonix by mouth or IV, about 50% of the medication will be remaining in the body.
What should you assess before giving Protonix?
Assess the patient for signs and symptoms of stomach pain, heartburn or reflux, stomach upset, nausea or vomiting, and GI bleeding. To confirm the indication for administering pantoprazole. Check the patient's allergy status. Previous allergic reaction to pantoprazole will render the patient unable to take them.
When should Protonix be taken?
Protonix oral granules should be taken 30 minutes before a meal; sprinkle directly onto one teaspoonful of applesauce or apple juice, stir and swallow straight away. Swallow delayed-release tablets whole; do not crush or chew. Usually taken once a day. May be taken with or without food.
Is Protonix better than omeprazole?
Does Pantoprazole Work Better Than Omeprazole? Generally, pantoprazole and omeprazole are equally effective. Studies comparing pantoprazole and omeprazole have found pantoprazole as effective as omeprazole in treating GERD as well as treating stomach ulcers.
How long does it take for Protonix to start working?
You should start to feel better within 2 to 3 days. It may take up to 4 weeks for pantoprazole to work properly so you may still have some symptoms during this time. If you bought pantoprazole without a prescription, and feel no better after 2 weeks, tell your doctor.
Does Protonix make you gain weight?
You may have weight gain while you're taking pantoprazole oral tablets. Both weight gain and weight loss were reported after the drug's initial studies were done. Additionally, you may gain weight if you have edema (swelling) or bloating, which are possible side effects of pantoprazole.
What Do I Need to Tell My Doctor Before I Take Protonix I.V.?
1. If you have an allergy to pantoprazole or any other part of Protonix I.V. (pantoprazole injection). 2. If you are allergic to any drugs like thi...
What Are Some Things I Need to Know Or Do While I Take Protonix I.V.?
1. Tell all of your health care providers that you take Protonix I.V. (pantoprazole injection). This includes your doctors, nurses, pharmacists, an...
How Is This Medicine (Protonix I.V.) Best Taken?
Use Protonix I.V. (pantoprazole injection) as ordered by your doctor. Read all information given to you. Follow all instructions closely. 1. Keep t...
What Are Some Side Effects That I Need to Call My Doctor About Right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor o...
What Are Some Other Side Effects of Protonix I.V.?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help i...
How Do I Store and/or Throw Out Protonix I.V.?
1. If you need to store Protonix I.V. (pantoprazole injection) at home, talk with your doctor, nurse, or pharmacist about how to store it.
When should you take pantoprazole?
Take pantoprazole tablets immediately before a meal, preferably in the morning. Pantoprazole tablets may be taken with food or on an empty stomach....
Can pantoprazole cause anxiety?
Pantoprazole may cause side effects, but it does not seem to cause anxiety. Some people in clinical trials reported headaches while taking pantopra...
How long does pantoprazole take to work?
Pantoprazole starts to work within 2 and a half (2.5) hours – this is the time it takes for it to block the secretion of acid in the stomach - and...
Pantoprazole vs. omeprazole: What's the difference between them?
Pantoprazole and omeprazole are both medicines from the class of medications called proton pump inhibitors (PPIs). The approved uses for pantoprazo...
Can you take pantoprazole 40 mg twice a day?
The usual dosage for pantoprazole 40mg is 40mg once a day if you are buying it without a prescription or a physician's evaluation of your symptoms....
How long can I take pantoprazole?
You should only take pantoprazole for up to 8 weeks if you are buying it without a prescription or a physician evaluation of your symptoms. This is...
Does pantoprazole cause bloating?
Bloating has been reported as a side effect of regular pantoprazole use. One study reported bloating in 43% of patients taking a similar proton pum...
What is Protonix used for?
Uses of Protonix I.V.: It is used to treat gastroesophageal reflux disease ( GERD; acid reflux ). It is used to treat syndromes caused by lots of stomach acid. It may be given to you for other reasons. Talk with the doctor.
How is this medicine (Protonix I.V.) best taken?
Use Protonix I.V. (pantoprazole injection) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
What are some other side effects of Protonix I.V.?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
What do I need to tell my doctor BEFORE I take Protonix I.V.?
If you have an allergy to pantoprazole or any other part of Protonix I.V. (pantoprazole injection).
How long can you take Protonix?
The chance may be higher if you take Protonix I.V. (pantoprazole injection) in high doses or for longer than a year, or if you are older than 50 years old. Use care if you have risks for soft, brittle bones (osteoporosis).
Do you need blood work for Protonix?
You will need to have blood work if you take Protonix I.V. (pantoprazole injection) for a long time or with certain other drugs. Long-term treatment (for instance longer than 3 years) with drugs like this one has rarely caused low vitamin B-12 levels. Talk with the doctor.
Can you take Protonix I.V. for longer than you were told by your doctor?
Tell all of your health care providers that you take Protonix I.V. (pantoprazole injection). This includes your doctors, nurses, pharmacists, and dentists. Do not take Protonix I.V. (pantoprazole injection) for longer than you were told by your doctor . This medicine may affect certain lab tests.
What is Protonix?
Protonix (pantoprazole) is a proton pump inhibitor that decreases the amount of acid produced in the stomach.
How should I use Protonix?
Take Protonix exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
What other drugs will affect Protonix?
Tell your doctor about all your other medicines. Some may interact with pantoprazole, especially:
What are the side effects of pantoprazole?
severe stomach pain, diarrhea that is watery or bloody; sudden pain or trouble moving your hip, wrist, or back; bruising or swelling where intravenous pantoprazole was injected; kidney problems - fever, rash, nausea, loss of appetite, joint pain, urinating less than usual, blood in your urine, weight gain;
How is Protonix taken?
Protonix is taken by mouth (oral) or given as an infusion into a vein (injection). A healthcare provider may teach you how to properly use the injection by yourself.
Does Protonix cause kidney problems?
Talk with your doctor if you need long-term Protonix treatment and you have concerns about vitamin B-12 deficiency. Pantoprazole can cause kidney problems.
Can you take pantoprazole for 3 years?
If you use pantoprazole for longer than 3 years, you could develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition if you develop it. Common Protonix side effects may include: headache, dizziness; stomach pain, gas, nausea, vomiting, diarrhea; joint pain; or.
What is Protonix IV?
Protonix IV is a prescription medicine used to treat the symptoms of Erosive Esophagitis associated with GERD, short-term treatment of GERD, and Zollinger-Ellison Syndrome. Protonix IV may be used alone or with other medications. Protonix IV belongs to a class of drugs called Proton Pump Inhibitors. It is not known if Protonix IV is safe and ...
What is Protonix I.V. used for?
PROTONIX I.V. for Injection is indicated for the treatment of pathological hypersecretory conditions including Zollinger-Ellison Syndrome in adults.
What is the effect of pantoprazole on gastric acid production?
This effect leads to inhibition of both basal and stimulated gastric acid secretion irrespective of the stimulus. The binding to the (H +, K + )-ATPase results in a duration of antisecretory effect that persists longer than 24 hours for all doses tested (20 mg to 120 mg).
What are the side effects of Protonix IV?
Get medical help right away, if you have any of the symptoms listed above. The most common side effects of Protonix IV include: headache, diarrhea, redness, pain, or swelling at the injection site, nausea, abdominal pain,
How long does it take to take 40 mg of pantoprazole?
The recommended adult dose is 40 mg pantoprazole given once daily by intravenous infusion for 7 to 10 days. Treatment with PROTONIX® I.V. (pantoprazole sodium) for Injection should be discontinued as soon as the patient is able to receive treatment with PROTONIX Delayed-Release Tablets or Oral Suspension.
How much pantoprazole is in Protonix?
PROTONIX® I.V. (pantoprazole sodium) for Injection is supplied as a freeze-dried powder containing 40 mg of pantoprazole per vial.
How many people have been treated with pantoprazole?
Worldwide, approximately 80,500 patients have been treated with pantoprazole in clinical trials involving various dosages and duration of treatment.
How many people have been treated with pantoprazole?
Worldwide, approximately 80,500 patients have been treated with pantoprazole in clinical trials involving various dosages and duration of treatment.
Can you estimate the frequency of adverse reactions to protonix?
Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Can you breastfeed while taking Protonix IV?
During pregnancy, Protonix IV should be used only when prescribed. This medication passes into breast milk and could have undesirable effects on a nursing infant. Breastfeeding is not recommended while using this drug.
How much pantoprazole is in Protonix?
PROTONIX I.V. (pantoprazole sodium) is supplied in a single-dose vial as a white to off-white freeze-dried powder for reconstitution containing 40 mg of pantoprazole.
How often should I take Protonix?
The recommended adult dosage of PROTONIX I.V. is 80 mg intravenously every 12 hours. The frequency of dosing can be adjusted to individual patient needs based on acid output measurements. In those patients who need a higher dosage, 80 mg intravenously every 8 hours is expected to maintain acid output below 10 mEq/h. Daily doses higher than 240 mg or administered for more than 6 days have not been studied [see Clinical Studies (14)]. Transition from oral to intravenous and from intravenous to oral formulations of gastric acid inhibitors should be performed in such a manner to ensure continuity of effect of suppression of acid secretion. Patients with ZE Syndrome may be vulnerable to serious clinical complications of increased acid production even after a short period of loss of effective inhibition.
How much sodium chloride is in Protonix?
Reconstitute each vial of PROTONIX I.V. with 10 mL of 0.9% Sodium Chloride Injection, USP.
How much pantoprazole is in a single dose?
For Injection: 40 mg of pantoprazole white to off-white freeze-dried powder in a single-dose vial for reconstitution.
What is the PPI that suppresses the final step in gastric acid production?
Pantoprazole is a PPI that suppresses the final step in gastric acid production by covalently binding to the (H...
What is the Pfizer Rxpathways number?
Patients and physicians can contact RxPathways at (866) 706-2400 or visit the website for more information on these programs www.pfizerrxpathways.com.
Is Protonix I.V. short term?
PROTONIX I.V. is indicated for short-term treatment (7 to...
What is pantoprazoleis used for?
Pantoprazoleis used to treat certain stomachand esophagusproblems (such as acid reflux). It works by decreasing the amount of acid your stomachmakes. This medicationrelieves symptoms such as heartburn, difficulty swallowing, and persistent cough. It helps heal acid damage to the stomach and esophagus, helps prevent ulcers, and may help prevent cancerof the esophagus. Pantoprazole belongs to a class of drugs known as proton pump inhibitors (PPIs).
How to report pantoprazole side effects in Canada?
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Before taking pantoprazole, tell your doctor or pharmacist if you are allergic to it; or to similar drugs (such as lansoprazole, omeprazole ); or if you have any other allergies.
What is protonix used for?
Protonix (pantoprazole sodium) is a drug in a class of powerful acid-suppressing medications called proton pump inhibitors (PPIs). These medicines can cause rare but life-threatening side effects. Protonix is one of several PPIs named in lawsuits over serious kidney conditions. By Terry Turner. Edited By Emily Miller.
How long does Protonix last?
Doctors may also prescribe Protonix for long-term use to treat excess stomach acid. Long-term treatment is anything lasting more than eight weeks. There is no research on the effects of taking Protonix for more than 12 months.
What is the generic name for Protonix?
The generic name for Protonix is pantoprazole. Pfizer’s patent on pantoprazole ran out in 2010. The FDA approved the first generic versions of pantoprazole that same year. The agency has approved several generic pantoprazole applications since then. All generic versions require a prescription.
What is PRN in medical?
PRN is a nationally recognized leader in providing independent medical reviews. Reviewer specialties include internal medicine, gastroenterology, oncology, orthopedic surgery and psychiatry. Protonix (pantoprazole sodium) is a proton pump inhibitor (PPI). PPIs are powerful medications that block the production of acid in the stomach.
What are the side effects of Protonix?
Less Serious Side Effects of Protonix. Headache. Diarrhea.
Is Protonix still taking cases?
Protonix lawyers are still taking new cases. They expect to file thousands more PPI lawsuits before the first case goes to trial.
Does Protonix cause kidney problems?
Studies dating back to the 1990s have linked PPIs like Protonix to kidney problems. Protonix kidney side effects may include kidney damage or injury.
