what is quinapril hydrochloride tablets used for

Precautions

Quinapril is used to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack. Quinapril is also used together with other medications to treat heart failure. Quinapril may also be used for purposes not listed in this medication guide. Do not use if you are pregnant.

What are the uses of quinapril?

Quinapril oral tablet is available as a brand-name drug. It’s also available in a generic version. Brand name: Accupril. Quinapril only comes as a tablet you take by mouth. Quinapril is used to treat hypertension (high blood pressure) and heart failure. It may be taken alone or with other medications.

Is there a generic version of quinapril?

Quinapril may be taken in combination with other drugs for high blood pressure, such as diuretics. It may also be taken with other drugs for heart failure, such as digitalis. Quinapril is used to treat high blood pressure and heart failure. Quinapril belongs to a class of drugs called angiotensin-converting enzyme (ACE) inhibitors.

When should I take Quinapril with other medications?

This product contains 2 medications: quinapril and hydrochlorothiazide. Quinapril belongs to a class of drugs known as ACE inhibitors and works by relaxing blood vessels so blood can flow more easily. Hydrochlorothiazide belongs to a class of drugs known as diuretics /" water pills ." It works by causing you to make more urine.

What kind of drug is Quinapril hydrochlorothiazide?

What is Quinapril used for?

What is the mineral that helps the nerves, muscles, and other parts of the body work properly?

What happens if you don't take a blood pressure pill?

Can Quinapril make you dizzy?

Is Quinapril a prescription drug?

Can you take quinapril with gold?

Can you take potassium with quinapril?

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What are the side effects of the drug quinapril?

Quinapril may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:dizziness.excessive tiredness.cough.upset stomach.vomiting.

When is the best time to take quinapril?

It is best taken just before you go to sleep. Some painkillers and indigestion remedies could interfere with quinapril. Ask your pharmacist for advice before you buy any medicines 'over the counter'.

Who should not take quinapril?

For pregnant women: Quinapril is a category D pregnancy drug. That means two things: Research in humans has shown adverse effects to the fetus when the mother takes the drug. This drug should only be used during pregnancy in serious cases where it's needed to treat a dangerous condition in the mother.

Is quinapril hard on the kidneys?

This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood pressure can reduce the risk of stroke and heart attacks.

Does quinapril make you pee?

Quinapril belongs to a class of drugs known as ACE inhibitors and works by relaxing blood vessels so blood can flow more easily. Hydrochlorothiazide belongs to a class of drugs known as diuretics/"water pills." It works by causing you to make more urine. This helps your body get rid of extra salt and water.

What time of day is blood pressure highest?

Blood pressure has a daily pattern. Usually, blood pressure starts to rise a few hours before a person wakes up. It continues to rise during the day, peaking in midday. Blood pressure typically drops in the late afternoon and evening.

Is quinapril a good blood pressure medicine?

As a result, quinapril relaxes the blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart. Quinapril is also used to treat heart failure or may be used for other conditions as determined by your doctor.

Does quinapril cause joint pain?

ARROW - QUINAPRIL is available only with a doctor's prescription. containing quinapril, or any of the ingredients listed at the end of this leaflet. Symptoms of an allergic reaction may include skin rash, itchiness, shortness of breath, swelling of the face, lips or tongue, muscle pain or tenderness or joint pain.

How fast does quinapril work?

For the treatment of high blood pressure, it may take 1 to 2 weeks before you get the full benefit of this medication. For the treatment of heart failure, it may take weeks to months before you get the full benefit of this medication.

What are the 4 best blood pressure drugs?

In terms of prescriptions written, here are the top 4 high blood pressure medications,the ACE inhibitor lisinopril (Prinivil, Zestril) tops the list,followed by amlodipine besylate (Norvasc),a calcium channel blocker, and.generic hydrochlorothiazide (HCTZ).

Can you drink alcohol while taking quinapril?

You can take quinapril with or without food. Limit alcohol intake while you are taking quinapril. Alcohol can increase your chance of side effects such as dizziness and light-headedness. Missed dose: If you forget to take your dose, take it as soon as you remember.

Does quinapril increase blood sugar?

Although treatment with quinapril or metoprolol over 6 months was concomitant with a rise in the HbA1c, increased fasting blood glucose, decreased oral glucose tolerance and decreased C-peptide and insulin responses to a glucose challenge were observed only in patients treated with metoprolol.

How long does it take for quinapril to lower blood pressure?

For the treatment of high blood pressure, it may take 1 to 2 weeks before you get the full benefit of this medication. For the treatment of heart failure, it may take weeks to months before you get the full benefit of this medication.

Is quinapril a good blood pressure medicine?

As a result, quinapril relaxes the blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart. Quinapril is also used to treat heart failure or may be used for other conditions as determined by your doctor.

How many times a day can I take quinapril?

Adults—At first, 5 milligrams (mg) two times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 20 to 40 mg per day, divided into two doses.

Should quinapril be taken with food?

Take it as directed on the prescription label at the same time every day. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your health care provider tells you to stop.

Quinapril Uses, Side Effects & Warnings - Drugs.com

Quinapril side effects. Get emergency medical help if you have signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.. Quinapril may cause serious side effects. Call your doctor at once if you have: a light-headed feeling, like you might pass out;

Quinapril Side Effects: Common, Severe, Long Term - Drugs.com

Quinapril Side Effects. Medically reviewed by Drugs.com. Last updated on Jun 4, 2022. Warning; Serious side effects; Other side effects; Professional info; FAQ; Summary. More frequently reported side effects include: cough. Continue reading for a comprehensive list of adverse effects.

Quinapril Oral: Uses, Side Effects, Interactions, Pictures ... - WebMD

Find patient medical information for quinapril oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

Quinapril (Oral Route) Side Effects - Mayo Clinic

Side Effects. Drug information provided by: IBM Micromedex Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

What is quinapril?

Quinapril is an ACE inhibitor. ACE stands for angiotensin converting enzyme.

How should I take quinapril?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

What should I avoid while taking quinapril?

Drinking alcohol can further lower your blood pressure and may increase certain side effects of quinapril.

What are the side effects of Quinapril?

Quinapril side effects. Get emergency medical help if you have signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. low sodium-- headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady.

Can you take Quinapril with other medications?

Quinapril is also used together with other medications to treat heart failure.

Can you take Quinapril if you have angioedema?

You should not use quinapril if you have ever had angioedema. Do not take quinapril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).

Can quinapril cause low blood pressure?

You can easily become dehydrated while taking quinapril. This can lead to very low blood pressure, electrolyte disorders, or kidney failure. If you need surgery, tell the surgeon ahead of time that you are using quinapril. You may need to stop using the medicine for a short time.

What is Quinapril used for?

Quinapril is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This medication is also used to treat heart failure. Quinapril belongs to a class of drugs known as ACE inhibitors. It works by relaxing blood vessels so blood can flow more easily.

How to report quinapril side effects in Canada?

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Before taking quinapril, tell your doctor or pharmacist if you are allergic to it; or to other ACE inhibitors (such as benazepril ); or if you have any other allergies.

How long does it take to get the full benefit of a blood pressure medicine?

Most people with high blood pressure do not feel sick. For the treatment of high blood pressure, it may take 1 to 2 weeks before you get the full benefit of this medication.

Does quinapril cause kidney problems?

Although quinapril may be used to prevent kidney problems or treat people who have kidney problems, it may also rarely cause serious kidney problems or make them worse. Your doctor will check your kidney function while you are taking quinapril. Tell your doctor right away if you have any signs of kidney problems such as a change in the amount of urine.

Can Quinapril cause pregnancy?

Quinapril can cause serious (possibly fatal) harm to an unborn baby if used during pregnancy. It is important to prevent pregnancy while taking this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control while taking this medication. If you are planning pregnancy, become pregnant, or think you may be pregnant, tell your doctor right away.

Can ibuprofen raise blood pressure?

Some products have ingredients that could raise your blood pressure or worsen your heart failure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough -and-cold products, diet aids, or NSAIDs such as ibuprofen / naproxen ).

Are you currently using Quinapril HCL?

This survey is being conducted by the WebMD marketing sciences department .

What is the best medicine for high blood pressure?

Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.This product contains 2 medications: quinapril and hydrochlorothiazide. Quinapril belongs to a class of drugs known as ACE inhibitors and works by relaxing blood vessels so blood can flow more easily.

How long before taking cholestyramine?

See the Drug Interactions section and consult your pharmacist for more information. If you also take certain drugs to lower your cholesterol (bile acid-binding resins such as cholestyramine or colestipol ), take this product at least 4 hours before or at least 4 to 6 hours after these medications.

Can Quinapril harm a baby?

Warnings: Quinapril can cause serious (possibly fatal) harm to an unborn baby if used during pregnancy. It is important to prevent pregnancy while taking this product. Consult your doctor for more details and to discuss the use of reliable forms of birth control while taking this product.

Are you currently using Quinapril-Hydrochlorothiazide?

This survey is being conducted by the WebMD marketing sciences department.

What is Quinapril hydrochloride?

DESCRIPTION. Quinapril hydrochloride is the hydrochloride salt of Quinapril, the ethyl ester of a non-sulfhydryl, angiotensin-converting enzyme (ACE) inhibitor, Quinaprilat. ...

How much does Quinapril absorb?

Based on recovery of Quinapril and its metabolites in urine, the extent of absorption is at least 60%. The rate and extent of Quinapril absorption are diminished moderately (approximately 25–30%) when Quinapril tablets are administered during a high-fat meal.

How long does Quinapril inhibit ACE?

Hypertension: Single doses of 20 mg of Quinapril provide over 80% inhibition of plasma ACE for 24 hours. Inhibition of the pressor response to angiotensin I is shorter-lived, with a 20 mg dose giving 75% inhibition for about 4 hours, 50% inhibition for about 8 hours, and 20% inhibition at 24 hours.

What are the effects of Quinapril on the renin-angiotensin system?

Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Quinapril as soon as possible. These adverse outcomes are usually associated with use of these drugs in the second and third trimester of pregnancy. Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. Appropriate management of maternal hypertension during pregnancy is important to optimize outcomes for both mother and fetus.

What is the risk of hyperkalemia in Quinapril?

Hyperkalemia: In clinical trials, hyperkalemia (serum potassium ≥5.8 mmol/L) occurred in approximately 2% of patients receiving Quinapril. In most cases, elevated serum potassium levels were isolated values which resolved despite continued therapy. Less than 0.1% of patients discontinued therapy due to hyperkalemia. Risk factors for the development of hyperkalemia include renal insufficiency, diabetes mellitus, and the concomitant use of other drugs that raise serum potassium levels. Monitor serum potassium in such patients (see PRECAUTIONS, Drug Interactions ).

Is Quinapril a contraindication?

Quinapril tablets are contraindicated in patients who are hypersensitive to this product and in patients with a history of angioedema related to previous treatment with an ACE inhibitor.

Does Quinapril lower blood pressure?

These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including the class to which this drug principally belongs. There are no controlled trial s demonstrating risk reduction with Quinapril tablets.

What is Quinapril Hydrochloride?

Quinapril Hydrochloride is the hydrochloride salt form of quinapril, a prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Quinapril is hydrolized into its active form quinaprilat, which binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. Quinapril also causes a decrease in angiotensin II -induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis, and increases bradykinin levels.

How long does Quinapril take to absorb?

Absorption (bioavailability) of quinapril is 60% ; time to peak serum concn is 2 hr; half-life (elimination) is 2 hr; protein binding is 97%; metabolism is in the liver. /from table/ /Salt not specified/

Is Quinapril reduced in liver function?

Conversion of quinapril to quinaprilat is reduced in patients with diminished liver function. /Salt not specified/

Is quinapril a carboxylic acid?

A prodrug for quinaprilat hydrochloride (by hydrolysis of the ethyl ester to the corresponding carboxylic acid), it is used as an angiotensin-converting enzyme inhibitor (ACE inhibitor) for the treatment of hypertension and congestive heart failure. It has a role as an antihypertensive agent and an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. It contains a quinapril (1+).

Does Quinapril block angiotensin II?

Quinapril is hydrolized into its active form quinaprilat, which binds to and inhibits ACE, thereby blocking the conversion of angio tensin I to angiotensin I I. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation.

Does quinapril cause diuresis?

Quinapril also causes a decrease in angiotensin II -induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis, and increases bradykinin levels. Quinapril hydrochloride is a hydrochloride resulting from the reaction of equimolar amounts of quinapril and hydrogen chloride.

Is Quinapril a carcinogen?

/LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ Quinapril hydrochloride was not carcinogenic in mice or rats when given in doses up to 75 or 100 mg/kg/day (50-60 times the max human daily dose, respectively, on an mg/sq m basis and 3.8-10 times the max human daily dose when based on an mg/sq m basis) for 104 weeks. Female rats given the highest dose level had an increased incidence of mesenteric lymph node hemangiomas and skin/sc lipomas.

What is Quinapril hydrochloride?

Quinapril hydrochloride is the hydrochloride salt of quinapril, the ethyl ester of a non-sulfhydryl, angiotensin-converting enzyme (ACE) inhibitor, quinaprilat.

What is the purpose of Quinapril?

Hypertension - Quinapril tablets, USP are indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular ...

How long does quinapril inhibit ACE?

Single doses of 20 mg of quinapril hydrochloride provide over 80% inhibition of plasma ACE for 24 hours. Inhibition of the pressor response to angiotensin I is shorter-lived, with a 20 mg dose giving 75% inhibition for about 4 hours, 50% inhibition for about 8 hours, and 20% inhibition at 24 hours. With chronic dosing, however, there is substantial inhibition of angiotensin II levels at 24 hours by doses of 20 to 80 mg.

What is the mechanism of action of Quinapril?

Mechanism of Action - Quinapril is deesterified to the principal metabolite, quinaprilat, which is an inhibitor of ACE activity in human subjects and animals. ACE is a peptidyl dipeptidase ...

Does quinapril lower blood pressure?

Hemodynamic assessments in patients with hypertension indicate that blood pressure reduction produced by quinapril is accompanied by a reduction in total peripheral resistance and renal vascular resistance with little or no change in heart rate, cardiac index, renal blood flow, glomerular filtration rate, or filtration fraction.

Does quinapril affect creatinine clearance?

In patients with renal insufficiency, the elimination half-life of quinaprilat increases as creatinine clearance decreases. There is a linear correlation between plasma quinaprilat clearance and creatinine clearance. In patients with end-stage renal disease, chronic hemodialysis or continuous ambulatory peritoneal dialysis has little effect on the elimination of quinapril and quinaprilat. Elimination of quinaprilat may be reduced in elderly patients (≥65 years) and in those with heart failure; this reduction is attributable to decrease in renal function (see DOSAGE AND ADMINISTRATION ). Quinaprilat concentrations are reduced in patients with alcoholic cirrhosis due to impaired deesterification of quinapril. Studies in rats indicate that quinapril and its metabolites do not cross the blood-brain barrier.

Does Quinapril have antihypertensive effects?

While the principal mechanism of antihypertensive effect is thought to be through the renin-angiotensin-aldosterone system, quinapril exerts antihypertensive actions even in patients with low renin hypertension. Quinapril hydrochloride was an effective antihypertensive in all races studied, although it was somewhat less effective in blacks (usually a predominantly low renin group) than in nonblacks. ACE is identical to kininase II, an enzyme that degrades bradykinin, a potent peptide vasodilator; whether increased levels of bradykinin play a role in the therapeutic effect of quinapril remains to be elucidated.

What is Quinapril used for?

Quinapril is used to treat hypertension (high blood pressure) and heart failure. It may be taken alone or with other medications.

What is the mineral that helps the nerves, muscles, and other parts of the body work properly?

High potassium levels. Potassium is a mineral that helps the nerves, muscles, and other parts of the body work properly. Symptoms can include:

What happens if you don't take a blood pressure pill?

If high blood pressure isn’t treated, it can lead to stroke, heart attack, heart failure, kidney failure, and vision problems.

Can Quinapril make you dizzy?

Quinapril oral tablet may cause drowsiness. It may also cause low blood pressure, which can make you feel faint or dizzy. This is most likely to occur when you first start taking the drug or during dosage changes. Let your doctor know if you still feel dizzy or faint after your dosage is changed.

Is Quinapril a prescription drug?

Quinapril is a prescription drug. It comes as an oral tablet.

Can you take quinapril with gold?

Taking injectable gold with quinapril can increase the side effects of injectable gold.

Can you take potassium with quinapril?

Taking a potassium supplement with quinapril can increase the amount of potassium in your body too much. When taking quinapril, do not take a potassium supplement without talking to your doctor first.

Warning: Fetal Toxicity

Description

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Adverse Reactions

• Hypertension Quinapril tablets are indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic...

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