what is quinidine used for

What is quinolone used for?

Quinidine is used to help keep the heart beating normally in people with certain heart rhythm disorders, usually after other treatments have failed. Quinidine has not been proven to lower the risks of stroke or death. Quinidine is also used to treat a life-threatening form of malaria. Quinidine may also be used...

How does quinidine work?

Mechanism of action Like all other class I antiarrhythmic agents, quinidine primarily works by blocking the fast inward sodium current (I Na). Quinidine's effect on I Na is known as a 'use dependent block'. This means at higher heart rates, the block increases, while at lower heart rates, the block decreases.

How are quinidine tablets used to treat malaria?

When quinidine tablets are used to treat malaria, they‘re used after initial treatment with the quinidine gluconate injection. Quinidine is used to help treat and prevent atrial fibrillation or flutter and ventricular arrhythmias, types of irregular heart rate.

What are the risks and benefits of quinidine?

Ask your doctor about the risks and benefits of using quinidine. Although quinidine can reduce episodes of irregular heart rhythm, this medicine may increase your risk of death. Your risk may be higher if you have heart problems affecting the tissues or valves of your heart (including heart problems you may have been born with).

What conditions does quinidine treat?

Quinidine is used to help treat and prevent atrial fibrillation or flutter and ventricular arrhythmias, types of irregular heart rate. It's used only after other medications have been tried, but didn't work to treat the condition. Quinidine sulfate is also used to treat malaria.

How does quinidine affect blood pressure?

Quinidine significantly increased the heart rate at rest and at low levels of exercise. Quinidine had no significant effect on the systolic blood pressure response to any work load.

What are quinidine like effects?

Side effects Quinidine can cause thrombocytopenia, granulomatous hepatitis, myasthenia gravis, and torsades de pointes (dangerous heart rhythm), so is not used much today. Torsades can occur after the first dose.

Is quinidine still used?

Quinidine is no longer widely used for the termination and prevention of arrhythmias because of concern about cardiac and systemic side-effects.

How long does quinidine stay in your system?

The consumption of 10oz. of tonic water can result in a quinine positive urine sample for a period of up to 96 hours (4 days) after intake....Common Products and Medications Containing Quinine or QuinidineCommon NameDrug NameAvailabilityMaso QuinQuinidine SulfatePrescription26 more rows•Apr 10, 2010

Is quinidine a beta blocker?

Is quinidine a beta-blocker? Quinidine doesn't belong to the class of medications called beta-blockers (medications that end in -lol such as metoprolol (Lopressor) or carvedilol (Coreg)). It doesn't have any beta-blocking effects.

What drugs contain quinidine?

Description and Brand NamesCardioquin.Quinaglute.Quinalan.Quinidex Extentabs.

What class of drug is quinine?

Quinine is in a class of medications called antimalarials.

Is quinine used for heart?

Conclusions Quinine is an effective and convenient antiarrhythmic drug for the suppression of ventricular arrhythmias in humans.

Why was quinine taken off the market?

In early 2007, FDA banned all prescription quinine products other than Qualaquin. FDA acted in this manner because of a perception that quinine is not effective for this condition and that its risk potential far exceeds its efficacy potential.

What is the difference between quinine and quinidine?

Quinidine is an antiarrhythmic agent, and quinine is used in the treatment of myotonic disorders.

Can quinine cause atrial fibrillation?

Quinine, like quinidine, is a chincona alkaloid that has anti-arrhythmic property, although it also pro-arrhythmic that can cause various arrhythmias, including severe arrhythmia such as multiple PVC.

Is quinidine a sodium channel blocker?

Quinidine is a “mixed” antiarrhythmic, with prominent sodium channel blocking (as well as potassium channel blocking) properties.

What are the contraindications of quinidine?

Who should not take Quinidine Gluconate?systemic mastocytosis.low amount of magnesium in the blood.low amount of potassium in the blood.decreased blood platelets.myasthenia gravis, a skeletal muscle disorder.complete heart block.partial heart block.torsades de pointes, a type of abnormal heart rhythm.More items...

Does quinidine cause bradycardia?

Decreased heart rate (bradycardia) has been reported during combination timolol and quinidine therapy. Additive hypotension is also possible. Additionally, quinidine is a known inhibitor of CYP2D6, and may impair the hepatic clearance of timolol (CYP2D6 substrate). Patients should be monitored for excess beta-blockade.

What are the other potential complications associated with the administration of quinidine?

Cinchonism (quinidine is a stereoisomer of quinine derived from the bark of the cinchona tree) which can present as tinnitus, high-frequency hearing loss, blurring of vision, diplopia, photophobia, confusion, headache, delirium, decreased hearing to profound deafness, lupus-like syndrome, Sjogren syndrome.

Is quinidine a beta-blocker?

Quinidine doesn't belong to the class of medications called beta-blockers (medications that end in -lol such as metoprolol (Lopressor) or carvedilo...

Is quinidine still used?

Quinidine isn't used very much these days for arrhythmias (abnormal heart rhythms). It's a very old drug with many potential side effects, and ther...

What is the generic name for quinidine?

Quinidine is the generic name of this medication. It's available as quinidine sulfate tablets and quinidine gluconate extended-release tablets. Qui...

What is the difference between quinine and quinidine?

The chemical structures of quinine and quinidine are very similar. Quinine (Qualaquin) is primarily used to treat malaria infections, while quinidi...

When to use quinidine?

When quinidine tablets are used to treat malaria, they‘re used after receiving initial treatment with the quinidine gluconate injection. Your doctor can tell you about dosage information.

What is quinidine?

Quinidine is a prescription drug. It comes as an oral tablet, an oral extended-release tablet, and a solution for injection.

What is quinone used for?

Quinidine is used to help treat and prevent atrial fibrillation or flutter and ventricular arrhythmias, types of irregular heart rate. It’s used only after other medications have been tried, but didn’t work to treat the condition.

Does quinidine increase the amount of medications in your body?

Taking certain antipsychotic drugs with quinidine can increase the amount of these medications in your body. This means you might have more side effects. Examples of these drugs include:

Does quinidine increase warfarin?

Taking warfarin with quinidine can increase the amount of warfarin in your body. This means that you might have more side effects.

Does Quinidine make you sleepy?

Quinidine oral tablet doesn’t cause drowsiness, but it can cause other side effects.

Is quinone a generic drug?

Quinidine oral tablet is only available as a generic drug. There is no brand-name version available.

What is quinidine?

Quinidine is an antiarrhythmic. It works by blocking sodium channels, which play a major part in your heart's electrical activity. It slows down abnormal electricity in your heart in order to treat or prevent abnormal rhythms.

What are the side effects of quinidine?

With any medication, there are risks and benefits. Even if the medication is working, you may experience some unwanted side effects.

How much does quinidine cost?

Quinidine is available as a generic medication and may be significantly cheaper compared to the brand version. Unless there is a specific reason you need the brand, the generic medication will be a better value. For even more savings, use a GoodRx coupon and pay just a fraction of the retail price.

What are alternatives to quinidine?

There are a number of medications that your doctor can prescribe in place of quinidine. Compare a few possible alternatives below.

How long do you have to stay in the hospital after quinidine?

When starting on quinidine, you may need to stay in the hospital for a few days so that providers can monitor your heart rhythm and watch for side effects more closely.

Does Quinidine have beta blockers?

Quinidine doesn't belong to the class of medications called beta-blockers (medications that end in -lol such as metoprolol (Lopressor) or carvedilol (Coreg) ). It doesn't have any beta-blocking effects. Some people may need to take this medication in combination with a beta-blocker.

Can quinidine cause diarrhea?

Diarrhea is a common side effect from both types of quinidine tablets. Let your provider know if it's bothersome, or if it is causing you to become dehydrated.

How does quinidine work?

Like all other class I antiarrhythmic agents, quinidine primarily works by blocking the fast inward sodium current (I Na ). Quinidine's effect on I Na is known as a 'use dependent block'. This means at higher heart rates, the block increases, while at lower heart rates, the block decreases.

Why is quinidine used for arrhythmia?

However, the use of quinidine to treat arrhythmia really only came into its own because a physician listened to the astute observation of one of his patients. In 1912, Karel Frederik Wenckebach saw a man with atrial fibrillation. He was a Dutch merchant, used to good order in his affairs.

What is quinone sulfate used for?

Quinidine sulfate is used in the treatment of atrial fibrillation in horses.

What is the ringing in the ears of a quinone?

Quinidine intoxication can lead to a collection of symptoms collectively known as cinchonism, with tinnitus (ringing in the ears) being among the most characteristic and common symptoms of this toxicity syndrome.

What is quinone used for?

Quinidine is also used to treat short QT syndrome.

Does quinone block sodium channels?

Quinidine acts as a blocker of voltage-gated sodium channels. Inhibition of the Na v 1.5 channel is specifically involved in its antiarrhythmic effects as a class I antiarrhythmic agent. Quinidine also blocks certain voltage-gated potassium channels (e.g., K v 1.4, K v 4.2, hERG, among others), acts as an antimuscarinic and alpha-1 blocker, and is an antimalarial.

Is quinone a class I drug?

Quinidine is occasionally used as a class I antiarrhythmic agent to prevent ventricular arrhythmias, particularly in Brugada Syndrome, although its safety in this indication is uncertain.

What is quinone used for?

Quinidine is used to treat certain types of irregular heartbeats. Quinidine is in a class of medications called antiarrhythmic medications. It works by making your heart more resistant to abnormal activity.

What to tell your doctor before taking quinidine?

tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutrition supplements you are taking or plan to take.

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

What are the side effects of quinolone?

Quinidine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: 1 diarrhea 2 nausea 3 vomiting 4 heartburm 5 fever 6 dizziness 7 lightheadedness 8 headache 9 fatigue 10 weakness 11 rash 12 difficulty sleeping 13 tremor

Does quinidine cause irregular heartbeats?

Talk to your doctor about the risks of taking quinidine. Quinidine may increase the chance of having arrhythmias (irregular heartbeats) and has not been proven to help people without life-threatening arrhythmias to live longer.

Can quinidine cause heart failure?

Taking antiarrhythmic drugs, including quinidine, may increase the risk of death. Tell your doctor if you have heart disease such as a valve problem or heart failure (HF; condition in which the heart cannot pump enough blood to other parts of the body). If you experience any of the following symptoms, call your doctor immediately: irregular ...

Can you get pregnant while taking quinidine?

If you become pregnant while taking quinidine, call your doctor. if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking quinidine.

How does quinidine work?

It works by blocking abnormal heartbeat signals. Before and while you are using quinidine, your doctor may prescribe other medications (e.g., " blood thinners "/ anticoagulants such as warfarin, beta blockers such as metoprolol) to shrink any blood clots in the heart and to slow your pulse.

What is quinone used for?

Uses. This medication is used to treat or prevent many types of irregular heartbeats ( heart arrhythmias such as atrial fibrillation ). Quinidine can greatly improve your ability to perform normal activities by decreasing the number of irregular heartbeats you have.

How to report quinidine side effects in Canada?

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Precautions. Before taking quinidine, tell your doctor or pharmacist if you are allergic to it; or to quinine; or if you have any other allergies.

What medical conditions can you have before taking quinine?

Before using this medication, tell your doctor or pharmacist your medical history, especially of: certain types of heart disease (e.g., incomplete or complete heart block without an artificial pacemaker, torsades-type irregular heartbeats, digitalis toxicity), very low blood pressure, history of easy bruising/bleeding (thrombocytopenic purpura) with use of quinine or quinidine, severe muscle weakness ( myasthenia gravis ), kidney disease, liver disease, a certain blood disorder ( G6PD deficiency ), asthma, current infection with fever.

What to do if you miss quinidine?

Laboratory and/or medical tests (e.g., complete blood count, liver / kidney function tests, quinidine blood levels, EKG) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details. Missed Dose. If you miss a dose, take it as soon as you remember.

Can you change quinidine without a doctor?

There are different brands and forms of this medication available. Not all have identical effects. Do not change quinidine products without talking to your doctor or pharmacist. Dosage is based on your medical condition and response to treatment.

Can quinidine cause an irregular heartbeat?

This drug should be used only in carefully selected patients. Many heart drugs like quinidine (antiarrhythmics) are very effective, but they can rarely cause new serious (possibly fatal) irregular heartbeats.

How to avoid quinidine?

Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy . Dizziness can cause falls, accidents, or severe injuries.

How old do you have to be to take quinidine?

Dextromethorphan and quinidine is not approved for use by anyone younger than 18 years old.

What is dextromethorphan and quinidine?

Dextromethorphan and quinidine is a combination medicine used to treat involuntary outbursts of crying or laughing in people with certain neurological disorders, including multiple sclerosis and amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease).

What are the side effects of quinidine and dextromethorphan?

Dextromethorphan and quinidine side effects. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);

How long after stopping MAO inhibitors can you take quinidine?

After you stop taking dextromethorphan and quinidine, you must wait at least 14 days before you start taking an MAOI. Dextromethorphan and quinidine can cause a serious heart problem.

Can you take quinidine and dextromethorphan at the same time?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Dextromethorphan and quinidine can cause a serious heart problem.

Can grapefruit be used with quinidine?

Grapefruit may interact with dextromethorphan and quinidine and lead to unwanted side effects. Avoid the use of grapefruit products. Ask a doctor or pharmacist before using any cough or cold medication that may contain dextromethorphan. Taking certain products together can cause you to get too much dextromethorphan.

What is Quinine used for?

Quinine is used to treat uncomplicated malaria, a disease caused by parasites. Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

What is the name of the disorder in which you have to take quinine?

a heart rhythm disorder called Long QT syndrome; an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G-6-PD); myasthenia gravis; optic neuritis (inflammation of the optic nerve); or. if you have taken quinine in the past and it caused a blood cell disorder, severe bleeding, or kidney problems.

What should I avoid while taking quinine?

Avoid taking other anti-malaria medications without your doctor's advice. This includes chloroquine, halofantrine, and mefloquine.

What other drugs will affect quinine?

Many drugs can interact with quinine. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with quinine, especially:

What happens if you take quinine?

if you have taken quinine in the past and it caused a blood cell disorder, severe bleeding, or kidney problems.

How long do you have to stop quinine?

If you need surgery or medical tests, tell your caregivers ahead of time that you are using quinine. You may need to stop using the medicine for a short time. Call your doctor if your symptoms do not improve after 2 days of treatment, or if your symptoms return after you have finished the medicine.

Can Quinine cause blurred vision?

Quinine may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Overview

Medical uses

Side effects

Pharmacology

History

Chemistry

Veterinary use

External links